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Biomarkers for neuromyelitis optica:a visual analysis of emerging research trends

Neural Regeneration Research 2024年第12期19卷 2735-2749页

作者： xiangjun li Jiandong Zhang Siqi Zhang Shengling Shi Yi’an Lu Ying Leng Chunyan li Department of Ophthalmology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina Department of Ophthalmology Changchun Bright Eye HospitalChangchunJilin ProvinceChina Departemt of Endocrinology Affiliated Hospital of Beihua UniversityJilinJilin ProvinceChina

Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system that differs from multiple sclerosis.Over the past 20 years,the search for biomarke rs for neuromyelitis optica has been ongoing.Here,we used a bibliometric approach to analyze the main research focus in the field of biomarkers for neuromyelitis optica.Research in this area is consistently increasing,with China and the United States leading the way on the number of studies conducted.The Mayo Clinic is a highly reputable institution in the United States,and was identified as the most authoritative institution in this field.Furthermore,Professor Wingerchuk from the Mayo Clinic was the most authoritative expe rt in this field.Keyword analysis revealed that the terms "neuro myelitis optica"(261 times), "multiple sclerosis"(220 times), "neuromyelitis optica spectrum disorder"(132 times), "aquaporin4"(99 times),and "optical neuritis"(87 times) were the most frequently used keywords in literature related to this field.Comprehensive analysis of the classical literature showed that the majority of publications provide conclusive research evidence supporting the use of aquaporin-4-IgG and neuromyelitis optica-IgG to effectively diagnose and differentiate neuromyelitis optica from multiple sclerosis.Furthermore,aquaporin-4-IgG has emerged as a highly specific diagnostic biomarker for neuromyelitis optica spectrum disorder.Myelin oligodendrocyte glycoprotein-IgG is a diagnostic biomarke r for myelin oligodendrocyte glycoprotein antibody-associated disease.Recent biomarkers for neuromyelitis optica in clude cerebrospinal fluid immunological biomarkers such as glial fibrillary acidic protein,serum astrocyte damage biomarkers like FAM19A5,serum albumin,and gammaaminobutyric acid.The latest prospective clinical trials are exploring the potential of these biomarkers.Preliminary results indicate that glial fibrillary acidic protein is emerging as a promising candidate biomarker for neuromyelitis optica spectrum disorder.The ultimate goal of

关键词： aquaporin-4 autoantibody multiple sclerosis myelin oligodendrocyte glycoprotein antibody-associated disease neuromyelitis optica neuromyelitis optica spectrum disorder optical coherence tomography

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Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

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Neural Regeneration Research 2024年第4期19卷 923-928页

作者： xiangjun li Chunyan li Hai Huang Dan Bai Jingyi Wang Anqi Chen Yu Gong Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua University Department of Endocrinology Affiliated Hospital of Beihua University

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting vision.The major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser photocoagulation.However,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many patients.This might result from the incomplete recovery of retinal ganglion cell injury.Therefore,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision recovery.In this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their combination.All patients will be followed up for 12 months.The primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after treatment.The secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after treatment.Safety measure is the incidence of adverse events at 1,3,6,9,and 12 months after treatment.The study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up period.The trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal ganglion cells and best-corrected visual acuity.

关键词： choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity

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Celastrol regulates the oligomeric state and chaperone activity of 𝛼B-crystallin linked with protein homeostasis in the lens

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Fundamental Research 2024年第2期4卷 394-400页

作者： Huaxia Wang Qing Tian Ying Zhang Yibo Xi lidan Hu Ke Yao Jingyuan li xiangjun Chen Eye Center of the Second Affiliated Hospital Zhejiang University School of Medicine88 Jiefang RoadHangzhou 310009China Institute of Translational Medicine Zhejiang University School of Medicine268 Kaixuan RoadHangzhou 310020China. State Key Laboratory of Membrane Biology School of Life SciencesTsinghua UniversityBeijing 100084China The Children’s Hospital Zhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Zhejiang Province Key Laboratory of Quantum Technology and Device Department of PhysicsZhejiang UniversityZheda Road 38Hangzhou 310027China

Protein misfolding and aggregation are crucial pathogenic factors for cataracts,which are the leading cause of visual impairment worldwide.α-crystallin,as a small molecular chaperone,is involved in preventing protein misfolding and maintaining lens transparency.The chaperone activity of α-crystallin depends on its oligomeric state.Our previous work identified a natural compound,celastrol,which could regulate the oligomeric state of αB-crystallin.In this work,based on the UNcle and SEC analysis,we found that celastrol induced𝛼αB-crystallin to form large oligomers.Large oligomer formation enhanced the chaperone activity of αB-crystallin and prevented aggregation of the cataract-causing mutant αA3-G91del.The interactions between𝛼αB-crystallin and celastrol were detected by the FRET(Fluorescence Resonance Energy Transfer)technique,and verified by molecular docking.At least 9 binding patterns were recognized,and some binding sites covered the groove structure of αB-crystallin.Interestingly,αB-R120G,a cataract-causing mutation located at the groove structure,and celastrol can decrease the aggregates of αB-R120G.Overall,our results suggested celastrol not only promoted the formation of large αB-crystallin oligomers,which enhanced its chaperone activity,but also bound to the groove structure of its α-crystallin domain to maintain its structural stability.Celastrol might serve as a chemical and pharmacological chaperone for cataract treatment.

关键词： αB-crystallin Celastrol Interactions Oligomeric state Chaperone activity Structural stability

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Optimal Dispatch for Battery Energy Storage Station in Distribution Network Considering Voltage Distribution Improvement and Peak Load Shifting

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Journal of Modern Power Systems and Clean Energy 2022年第1期10卷 131-139页

作者： xiangjun li Rui Ma Wei Gan Shijie Yan State Key Laboratory of Control and Operation of Renewable Energy and Storage Systems China Electric Power Research InstituteBeijingChina College of Information and Engineering Northeastern UniversityShenyangChina

Distribution networks are commonly used to demonstrate low-voltage problems.A new method to improve voltage quality is using battery energy storage stations(BESSs),which has a four-quadrant regulating capacity.In this paper,an optimal dispatching model of a distributed BESS considering peak load shifting is proposed to improve the voltage distribution in a distribution network.The objective function is to minimize the power exchange cost between the distribution network and the transmission network and the penalty cost of the voltage deviation.In the process,various constraints are considered,including the node power balance,single/two-way power flow,peak load shifting,line capacity,voltage deviation,photovoltaic station operation,main transformer capacity,and power factor of the distribution network.The big M method is used to linearize the nonlinear variables in the objective function and constraints,and the model is transformed into a mixed-integer linear programming problem,which significantly improves the model accuracy.Simulations are performed using the modified IEEE 33-node system.A typical time period is selected to analyze the node voltage variation,and the results show that the maximum voltage deviation can be reduced from 14.06%to 4.54%.The maximum peak-valley difference of the system can be reduced from 8.83 to 4.23 MW,and the voltage qualification rate can be significantly improved.Moreover,the validity of the proposed model is verified through simulations.

关键词： Energy storage station distribution network voltage regulation peak load shifting mixed integer programming

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Nano-Au-decorated hierarchical porous cobalt sulfide derived from ZIF-67 toward optimized oxygen evolution catalysis:Important roles of microstructures and electronic modulation

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Carbon Energy 2024年第5期6卷 1-14页

作者： Hongyu Gong Guanliang Sun Wenhua Shi Dongwei li xiangjun Zheng Huan Shi Xiu liang Ruizhi Yang Changzhou Yuan Department of New Energy Materials School of Environmental and Chemical EngineeringJiangsu University of Science and TechnologyZhenjiangJiangsuChina Advanced Materials Institute Qilu University of Technology(Shandong Academy of Sciences)JinanShandongChina Shandong Saikesaisi Hydrogen Energy Co. Ltd.JinanShandongChina Department of Materials Science and Engineering School of Materials Science&EngineeringUniversity of JinanJinanShandongChina Department of New Energy Science and Engineering College of EnergySoochow Institute for Energy and Materials InnovationsSoochow UniversitySuzhouJiangsuChina

Enhancing both the number of active sites available and the intrinsic activity of Co-based electrocatalysts simultaneously is a desirable goal.Herein,a ZIF-67-derived hierarchical porous cobalt sulfide decorated by Au nanoparticles(NPs)(denoted as HP-Au@CoxSy@ZIF-67)hybrid is synthesized by low-temperature sulfuration treatment.The well-defined macroporous-mesoporous-microporous structure is obtained based on the combination of polystyrene spheres,as-formed CoxSy nanosheets,and ZIF-67 frameworks.This novel three-dimensional hierarchical structure significantly enlarges the three-phase interfaces,accelerating the mass transfer and exposing the active centers for oxygen evolution reaction.The electronic structure of Co is modulated by Au through charge transfer,and a series of experiments,together with theoretical analysis,is performed to ascertain the electronic modulation of Co by Au.Meanwhile,HP-Au@CoxSy@ZIF-67 catalysts with different amounts of Au were synthesized,wherein Au and NaBH4 reductant result in an interesting“competition effect”to regulate the relative ratio of Co^(2+)/Co^(3+),and moderate Au assists the electrochemical performance to reach the highest value.Consequently,the optimized HP-Au@CoxSy@ZIF-67 exhibits a low overpotential of 340 mV at 10 mA cm^(-2)and a Tafel slope of 42 mV dec-1 for OER in 0.1 M aqueous KOH,enabling efficient water splitting and Zn-air battery performance.The work here highlights the pivotal roles of both microstructural and electronic modulation in enhancing electrocatalytic activity and presents a feasible strategy for designing and optimizing advanced electrocatalysts.

关键词： Au nanoparticles cobalt sulfide electronic modulation hierarchical porous structure oxygen evolution reaction

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Polyoxymethylene dimethyl ethers synthesis from methanol and formaldehyde solution over one-pot synthesized spherical mesoporous sulfated zirconia

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Chinese Journal of Chemical Engineering 2022年第6期35卷 161-172页

作者： xiangjun li Shujun li Xiaoping Wang Muhammad Asif Nawaz Dianhua liu State Key Lab of Chemical Engineering East China University of Science and TechnologyShanghai 200237China

The synthesis of polyoxymethylene dimethyl ethers as an ideal diesel fuel additive is the current hot topic of modern petrochemical industry for their expedient properties in mitigating air pollutants emission during combustion.In this work,a series of spherical sulfated zirconia catalysts were prepared by a one-pot hydrothermal method assisted with surfactant cetyltrimethylammonium bromide(CTAB).The prepared sulfated zirconia catalysts were used to catalyze PODEn synthesis from methanol and formaldehyde solution.Various characterization(XRD,BET,SEM,TGA,NH_(3)-TPD,FTIR,and Py-IR)were employed to elaborate the structure–activity relationship of the studied catalytic system.The results demonstrated that S/Zr molar ratio in precursor solution played an effective role on catalyst morphology and acidic properties,where the weak Brønsted acid sites and strong Lewis acid sites were favorable to the conversion of methanol and formation of long-chain PODEn,respectively.The reaction parameters such as catalyst amount,molar ratio of FA/MeOH,reaction time,temperature and pressure were optimized.The speculated reaction pathway for PODEn synthesis was proposed based on the synergy of Brønsted and Lewis acid sites,which suggested that Brønsted and Lewis acid sites might be advantageous to the activation of polyoxymethylene hemiformals[CH_(3)(OCH_(2))_(n)OH]and methylene glycol(HOCH_(2)OH),respectively.

关键词： Polyoxymethylene dimethyl ethers Spherical sulfated zirconia Methanol Formaldehyde Reaction pathway Synergistic effect

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Capacity Configuration of Energy Storage Systems for Echelon Utilization Based on Accelerated life Test in Microgrids

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CSEE Journal of Power and Energy Systems 2023年第3期9卷 1139-1150页

作者： Ning Yan xiangjun li Shaohua Ma Haichuan Zhao Bo Zhang College of Electrical Engineering Shenyang University of TechnologyShenyang 110870China China Electric Power Research Institute Beijing 100192China

Retired power battery construction energy storage systems(ESSs)for echelon utilization can not only extend the remaining capacity value of the battery,and decrease environmental pollution,but also reduce the initial cost of energy storage systems.In this paper,an ESS constructed of retired power batteries for echelon utilization in microgrids(MGs)is considered.Firstly,considering the influence of different discharge depths on the battery life cycle,the correlation equation between the state of charge(SOC)and the state of health(SOH)is established.Secondly,the accelerated life test method,based on the inverse power law coefficient equation,is proposed,and it is used to evaluate the reliability of the ESS.Finally,according to the SOC characteristics,the dynamic security margin of the ESS is established.The life cycle cost,supply-demand balance and ESS balanced control are comprehensively considered,and the location and capacity of energy storage in MGs are determined.It is simulated using the IEEE-RTS 24 node system;the results show that the investment cost of the ESS is reduced and the operational life is prolonged.

关键词： ESS echelon utilization accelerated life test balanced control capacity configuration

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Adaptive Fault Detection Scheme Using an Optimized Self-healing Ensemble Machine Learning Algorithm

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CSEE Journal of Power and Energy Systems 2022年第4期8卷 1145-1156页

作者： Levent Yavuz Ahmet Soran AhmetÖnen xiangjun li S.M.Muyeen Electrical and Computer Engineering Department in Abdullah Gül University Kayseri 38080Turkey Department of Electrical and Computer Engineering College of EngineeringSultan Qaboos UniversityAl-KhoudMuscat123Oman Department of Electrical Engineering Qatar UniversityDoha 2713Qatar State Key Laboratory of Control and Operation of Renewable Energy and Storage Systems China Electric Power Rescarch InstituteBeijing 100192China

This paper proposes a new cost-efficient,adaptive,and self-healing algorithm in real time that detects faults in a short period with high accuracy,even in the situations when it is difficult to detect.Rather than using traditional machine learning(ML)algorithms or hybrid signal processing techniques,a new framework based on an optimization enabled weighted ensemble method is developed that combines essential ML algorithms.In the proposed method,the system will select and compound appropriate ML algorithms based on Particle Swarm Optimization(PSO)weights.For this purpose,power system failures are simulated by using the PSCA D-Python co-simulation.One of the salient features of this study is that the proposed solution works on real-time raw data without using any pre-computational techniques or pre-stored information.Therefore,the proposed technique will be able to work on different systems,topologies,or data collections.The proposed fault detection technique is validated by using PSCAD-Python co-simulation on a modified and standard IEEE-14 and standard IEEE-39 bus considering network faults which are difficult to detect.

关键词： Decision tree(DT) ensemble machine learning algorithm fault detection islanding operation k-Nearest Neighbor(kNN) linear discriminant analysis(LDA) logistic regression(LR) Naive Bayes(NB) self-healing algorithm

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Nonlinear Relationship and Its Evolutionary Trace between Node Degree and Average Path Length of China Aviation Network Based on Complex Network

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Journal of Traffic and Transportation Engineering 2024年第1期12卷 11-22页

作者： Cheng xiangjun Zhang Xiaoxuan li Yangqi Beijing Jiaotong University Beijing 100044China China Highway&Transportation Society Beijing 100011China

In order to reveal the complex network characteristics and evolution principle of China aviation network,the relationship between the node degree and the average path length of China aviation network in 1988,1994,2001,2008 and 2015 was studied.According to the theory and method of complex network,the network system was constructed with the city where the airport was located as the network node and the airline as the edge of the network.On the basis of the statistical data,the node average path length of China aviation network in 1988,1994,2001,2008 and 2015 was calculated.Through regression analysis,it was found that the node degree had a logarithmic relationship with the average length of node path,and the two parameters of the logarithmic relationship had linear evolutionary trace.Key word:China aviation network,complex network,node degree,average length of node path,logarithmic relationship,evolutionary trace.

关键词： China aviation network complex network node degree average length of node path logarithmic relationship evolutionary trace.

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Energy Management and Operational Control Methods for Grid Battery Energy Storage Systems

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CSEE Journal of Power and Energy Systems 2021年第5期7卷 1026-1040页

作者： xiangjun li Shangxing Wang State Key Laboratory of Control and Operation of Renewable Energy and Storage Systems Energy Storage and Electrical Engineering DepartmentChina Electric Power Research Institute.Beijing 100192China.

Energy storage is one of the key means for improving the flexibility,economy and security of power system.It is also important in promoting new energy consumption and the energy Internet.Therefore,energy storage is expected to support distributed power and the micro-grid,promote open sharing and flexible trading of energy production and consumption,and realize multi-functional coordination.In recent years,with the rapid development of the battery energy storage industry,its technology has shown the characteristics and trends for large-scale integration and distributed applications with multi-objective collaboration.As a grid-level application,energy management systems(EMS)of a battery energy storage system(BESS)were deployed in real time at utility control centers as an important component of power grid management.Based on the analysis of the development status of a BESS,this paper introduced application scenarios,such as reduction of power output fluctuations,agreement to the output plan at the renewable energy generation side,power grid frequency adjustment,power flow optimization at the power transmission side,and a distributed and niohile energy storage system at the power distribution side.The studies and application status of a BESS in recent years were reviewed.The energy management,operation control methods,and application scenes of large-scale BESSs were also examined in the study.

关键词： Battery energy storage system(BESS) energy management systems(EMS) multi-objective collaborative control new energy integration power grid ancillary service.

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