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Refracture of osteoporotic vertebral body concurrent with cement fragmentation at the previously treated vertebral level after balloon kyphoplasty:a case report

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Refracture of osteoporotic vertebral body concurrent with ce...

2014浙江省骨质疏松与骨矿盐疾病学术年会暨国家级继教...

作者： Xigong Li Xianfeng Lou xiangjin lin Junhua Du Department of Orthopaedic Surgery The First Affiliated Hospital of Zhejiang University

Kyphoplasty has been shown to provide symptomatic relief of vertebral compression fractures refractory to medical therapy.However,few reports have focused on refracture of cemented vertebrae after kyphoplasty.The presence of cemented vertebrae refracture concurrent with cement fragmentation is an extremely rare condition.We reported an 86-year-old man with a T12 osteoporotic compression fracture undergoing the kyphoplasty treatment.The patient postoperatively continued to have back pain at the same level.The solid lumped polymethylmethacrylate(PMMA) mass and inadequate use and insufficient filling of PMMA cement were observed in postoperative radiographs and magnetic resonance image(MRI) examination.He refused to receive the surgical intervention,but had not strict compliance with oral anti-osteoporotic medications.Ten months postoperatively,refracture of osteoporotic vertebral body concurrent with cement fragmentation occurred at the previously kyphoplastytreated vertebral level.Bone mineral analysis showed severe osteoporosis with a T-score of-4.0.The patient finally obtained therapeutic benefit of pain relief and bony union of T12 vertebral body by consistently adhering to anti-osteoporotic medication treatment.This case illustrated that patients who underwent kyphoplasty to treat osteoporotic vertebral compression fractures with intravertebral fracture should be strictly followed up and supervised in their anti-osteoporotic medication treatment.The interdigitation injection pattern of PMMA and sufficient PMMA filling with trabeculae in the kyphoplasty procedure also might prevent refracture of the cemented vertebrae concurrent with PMMA fragmentation.

关键词： Cement fragmentation Intervertebral cleft Kyphoplasty Osteoporotic vertebral compression fracture Refracture

Results of operative treatment of avulsion fractures of the anterior superior iliac spine in adolescents

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Results of operative treatment of avulsion fractures of the ...

2013中国工程院科技论坛暨浙江省骨科学学术年会

作者： Sanzhong Xu Xigong Li xiangjin lin Quan Wang Jun Pan

Background:Avulsion fracture of the anterior superior iliac spine(ASIS) is a rare condition that commonly occurs in adolescent athletes.Conservative treatment for this injury can produce excellent functional outcomes. However,the rehabilitation process requires a rather long immobilization period.This study aimed to evaluate the use of lag screws for fixation of avulsion fractures of ASIS. Methods:Ten patients with ASIS avulsion fractures were treated by open reduction and internal fixation using lag screws. Results:The mean intraoperative blood loss was 14.9 ml(range,10-25 ml).The mean operative time was 40.3(range,33-52 minutes) minutes.The mean follow-up period was 11.2 months(range,6-20 months). At the 4-week follow-up,all the patients returned to previously normal activity without pain and had no evidence of lower extremity muscle weakness.At the final follow-up,ten patients resumed their athletic activity without any complications. Conclusion:Open reduction and internal fixation for the treatment of avulsion fracture of ASIS can be recommended for patients requiring rapid rehabilitation.

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Perineural invasion:a potential reason of hepatocellular carcinoma bone metastasis

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Perineural invasion:a potential reason of hepatocellular car...

2015年浙江省骨科学学术年会

作者： Xuanwei Wang Tong Shen Pengcheng Gu Fang Guo xiangjin lin

The nervous system plays an important role in the regulation of epithelial homeostasis and has also been postulated to play a role in tumorigenesis.Perineural invasion(PNI) is the only interaction between cancer cells and nerves studied to date.It is a symbiotic relationship between cancer cells and nerves that result in growth advantage for both.The potential association between HCC bone metastases and PNI is unknown.In this study,we investigate the nerve density in HCC and paired bone metastases to reveal the potential association of HCC bone metastases and PNI.The nerve density was evaluated by immunohistochemistry in formalin-fixed paraffin embedded(FFPE) hepatocellular carcinoma(HCC) and paired bone metastases tissues from 13 HCC patients with synchronous or metachronous bone metastases that underwent surgical resection.FFPE specimens of HCC bone metastases tissues express higher perineural density than HCC tissues,pointing to a potential role of the PNI in bone metastases from HCC.This is the first description of the potential association of PNI and HCC bone metastases.

关键词： Hepatocellular carcinoma bone metastasis perineural invasion nerve density

Is it likely to become a savior of large-sized and fullthickness cartilage defect in young adult knee?

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Is it likely to become a savior of large-sized and fullthick...

2015年浙江省骨科学学术年会

作者： Youzhi Cai Chi Zhang Xuanwei Wang Junsong Wu Pengcheng Gu xiangjin lin Department of Orthopedic Surgery The First Affiliated HospitalZhejiang University

Purpose A literature review of first,second and third-generation autologous chondrocyte implantation(ACI)technique for the treatment of large-sized(>4cm)and full-thickness of knee cartilage defects in young adults was conducted,examining the current literature on features,clinical scores,complications,magnetic resonance image(MRI)and histological outcomes,rehabilitation and cost-effectiveness.Methods A literature review was carried out in the main medical databases to evaluate the several studies concerning ACI treatment of large-sized and full-thickness of knee cartilage defects in young adults.Results ACI technique has been shown to relieve symptoms and improve functional assessment in large-sized(>4cm)and full-thickness knee articular cartilage defect of young adults in short and median-term follow-up.Besides,low level of evidence demonstrated its efficiency and durability at long-term follow-up after implantation.Furthermore,MRI and histological evaluations provided the evidence that graft can return back to the previous nearly normal cartilage via ACI techniques.Clinical outcomes tend to be similar in different ACI techniques,but with simplified procedure,low complication rate and better graft quality in third-generation ACI technique.Conclusion ACI based on the experience of cell-based therapy,with the high potential to regenerate hyalinelike tissue,represents clinical development in treatment of large-sized and full-thickness knee cartilage defects.Level of evidence LevelⅣ

关键词： autologous chondrocyte implantation large-sized cartilage defects cell therapy regenerative medicine

877例髋部骨折患者发病情况及其流行病学特征分析

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中华流行病学杂志 2014年第4期35卷 446-448页

作者：杨洋林向进浙江大学附属第一医院骨科杭州310006

目的分析髋部骨折患者发病情况及其流行病学分布特征.方法调查杭州市2012年1-12月所有省市级医院收治的髋部骨折患者临床资料,统计分析髋部骨折患者的性别、年龄、骨折部位和骨折诱因等相关数据.结果共纳入研究髋部骨折患者877例,其... 详细信息

目的分析髋部骨折患者发病情况及其流行病学分布特征.方法调查杭州市2012年1-12月所有省市级医院收治的髋部骨折患者临床资料,统计分析髋部骨折患者的性别、年龄、骨折部位和骨折诱因等相关数据.结果共纳入研究髋部骨折患者877例,其中男性516例（58.84％）,女性361例（41.16％）;年龄（62.1±11.2）岁;髋部骨折患病率为10.0/10万,男性为11.2/10万,女性为8.8/10万,男性患病率明显高于女性,差异有统计学意义（f=4.281,P=0.033）.髋部骨折患者数量居前3位的年龄段分别为71～ 82岁（344例,39.22％）、61～70岁（196例,22.35％）和51 ～ 60岁（185例,占21.09％）.患者中股骨颈骨折显著多于股骨粗隆间骨折,差异有统计学意义（x2=21.423,P＜0.001）;男性发病构成比高于女性,差异有统计学意义（分别为x2=12.816,P＜0.001;f=13.773,P＜0.001）.造成髋部骨折前3位的因素分别为跌倒、坠落和车祸,其构成比分别为64.88％、20.07％和10.49％.结论年龄是发生髋部骨折的重要因素.老年人群髋部骨折以股骨颈骨折为主,多以跌倒引发.

关键词：髋部骨折患病率流行病学

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扩大禽肉出口的对策研究

中国家禽 2005年第9期27卷 5-10页

作者：林祥金中国社会科学院农村发展研究所北京100732

禽肉是我国具有出口优势的农产品,努力扩大禽肉出口对解决“三农”问题具有重要的战略意义。本文论述了我国禽产品的进出口形势,同时提出了扩大禽肉出口的对策,研究成果系统、全面。

关键词：出口对策研究 20世纪90年代 “三农”问题 2002年战略意义禽肉生产农产品产量千克

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扩大禽肉出口的对策研究(续)

中国家禽 2005年第10期27卷 4-7页

作者：林祥金中国社会科学院农村发展研究所北京100732

禽肉是我国具有出口优势的产品,努力扩大禽肉出口对解决“三农”问题具有重要的战略意义。本文论述了我国禽产品的进出口形势,同时提出了扩大禽肉出口的对策,研究成果系统、全面。

关键词：禽肉贸易出口贸易中国饲料安全政府职能农产品安全

基于磁共振表观扩散系数图影像组学的机器学习模型对临床显著性前列腺癌的鉴别诊断价值

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现代肿瘤医学 2023年第22期31卷 4202-4206页

作者：林香瑾朱光斌张楚若杜国新罗锦文关玉宝广州医科大学第五临床学院广东广州510700 广州医科大学附属第五医院医学影像科广东广州510700 广州医科大学第二临床学院广东广州510700

目的:探讨基于磁共振表观扩散系数图影像组学的机器学习模型对临床显著性前列腺癌的临床应用价值。方法:回顾性分析本院2017年10月至2022年12月经病理证实的182例前列腺癌磁共振检查资料,其中临床显著性前列腺癌(clinically significant... 详细信息

目的:探讨基于磁共振表观扩散系数图影像组学的机器学习模型对临床显著性前列腺癌的临床应用价值。方法:回顾性分析本院2017年10月至2022年12月经病理证实的182例前列腺癌磁共振检查资料,其中临床显著性前列腺癌(clinically significant prostate cancer,CsPCa)126例,非临床上显著性前列腺癌(clinically insignificant prostate cancer,CiPCa)56例;采用ITK-SNAP软件对磁共振ADC图进行感兴趣区分割,使用pyradiomics软件包,提取包括一阶特征(First Order)、形状特征(Shape)、灰度共生矩阵(GLCM)、灰度区域矩阵(GLSZM)、灰度游程矩阵(GLRLM)、灰度相依矩阵(GLDM)、邻域灰度差分矩阵(NGTDM)影像组学特征;采用一致性检验及最小绝对收缩与选择算子算法(LASSO)筛选出的最佳特征,按7∶3的比例随机分为训练组和验证组,构建逻辑回归(Logistic regression,LR)模型,采用受试者工作特征曲线下面积(area under the curve,AUC)验证其鉴别诊断价值。结果:从ADC图像中提取了1 835个影像组学特征,筛选出15个最佳特征构建逻辑回归机器学习模型。训练集和测试集的准确性分别为0.727、0.700;曲线下面积分别为0.768(95%可信区间:0.700~0.837)、0.719(95%可信区间:0.562~0.875);特异度分别为0.902、0.875;阳性预测值分别为0.683、0.636;阴性预测值分别为0.739、0.718;精确度分别为0.683、0.636。结论:前列腺癌磁共振表观扩散系数图影像组学的逻辑回归机器学习模型,对鉴别临床显著性前列腺癌提供潜在的有效信息。

关键词：临床显著性前列腺癌非临床上显著性前列腺癌磁共振成像表观扩散系数机器学习模型

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加快我国畜禽防疫体系建设的对策研究(上)

中国动物保健 2003年第7期5卷 13-17页

作者：林祥金中国社会科学院农村发展研究所

一、我国兽医防疫体系建设进展情况我国的兽医防疫体系包括防疫、检疫、监督三个方面的系统,始建于20世纪50年代中期,经过几十年的建设和积累,当前已初具规模,相对完整.(一)从队伍建设及机构设置来看,从中央到省(市、自治区)、地(市)、... 详细信息

一、我国兽医防疫体系建设进展情况我国的兽医防疫体系包括防疫、检疫、监督三个方面的系统,始建于20世纪50年代中期,经过几十年的建设和积累,当前已初具规模,相对完整.(一)从队伍建设及机构设置来看,从中央到省(市、自治区)、地(市)、县、乡(镇)的防疫、检疫、监督机构共有45万人.其中,农业部的畜牧兽医局和各省、市、区畜牧兽医局属于国家行政编制,其他属于全民所有制的事业单位.在机构设置方面,形式较多,有的防检监(防疫、检疫和执法监督)合设;有的防检与监督或防疫与检疫、监督分设.

关键词：中国畜类禽类防疫体系体系建设对策