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LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p

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BIOCELL 2024年第3期48卷 501-511页

作者： YAN li HUZHI CAI XIAOliNG PENG YOUHUI liU QINGYANG CHEN Xiangdong LiN XINYU CHEN Department of Vascular and Tumor Intervention The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensive Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Nursing Research The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensivie Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Endocrinology The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Preventive Treatment Center The First Hospital of Hunan University of Chinese MedicineChangsha410007China

Background:Renalﬁbrosis is an important process in the development of chronic kidney disease.Understanding the pathogenesis andﬁnding effective treatments for renalﬁbrosis is crucial.This study aims to investigate whether a newly discovered long non-coding RNA(lncRNA)called LOC103694972 could be a potential target for treatingﬁbrosis of NRK-49F cells.Methods:LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal cells.The dual-luciferase assay conﬁrmed the binding between miR-29c-3p and signal transducer and activator of transcription(STAT3),as well as between miR-29c-3p and lncRNA LOC103694972.Si-LOC103694972 and miR-29c-3p mimic were then transfected into TGF-β1-induced NRK-49F cells.Results:The study found that LOC103694972 was highly expressed in TGF-β1-induced NRK-49F cells.These cells exhibited increased cell length and activity compared to the control group.The expression levels of Collagen I,α-Smooth muscle actin(α-SMA),and tissue inhibitor of metalloproteinase(TIMP-1)were increased,while matrix Metalloproteinase 2(MMP2)and matrix Metalloproteinase 9(MMP9)expression was decreased.However,transfection with si-LOC103694972 and miR-29c-3p mimics restored cell morphology and reduced cell viability.This led to a decrease in the levels of Collagen I,α-SMA,and TIMP-1,as well as an increase in MMP2 and MMP9 expression.Additionally,TGF-β1-induced NRK-49F cells transfected with miR-29c-3p mimics activated the STAT3-Smad3/CTGF pathway.Conclusion:Based on theseﬁndings,lncRNA LOC103694972 shows promise as a target for treating renalﬁbrosis.It negatively regulates miR-29c-3p and activates the STAT3-Smad3/CTGF pathway.

关键词： Renal fibrosis lncRNA LOC103694972 lncRNA Chip miR-29c-3p STAT3-Smad3/CTGF

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Recent active thermal management technologies for the development of energy-optimized aerospace vehicles in China

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Chinese Journal of Aeronautics 2021年第2期34卷 1-27页

作者： Jixiang WANG Yunze li Xiangdong LiU Chaoqun SHEN Hongsheng ZHANG Kai XIONG College of Electrical Energyand Power EngineeringYangzhou UniversityYangzhou 225009China School of Aeronautic Science and Engineering Beihang UniversityBeijing 100083China Institute of Engineering Thermophysics North China University of Water Conservancy and Electrical PowerZhengzhou 450045China HiWING General Aviation Equipment Corporation limited Beijing 100074China School of Mechanical Engineering and Automation Harbin Institute of TechnologyShenzhen Graduate SchoolShenzhen 518117China

Recently, the development of modern vehicles has brought about aggressive integration and miniaturization of on-board electrical and electronic devices. It will lead to exponential growth in both the overall waste heat and heat flux to be dissipated to maintain the devices within a safe temperature range. However, both the total heat sinks aboard and the cooling capacity of currently utilized thermal control strategy are severely limited, which threatens the lifetime of the on-board equipment and even the entire flight system and shrink the vehicle’s flight time and range. Facing these thermal challenges, the USA proposed the program of "INVENT" to maximize utilities of the available heat sinks and enhance the cooling ability of thermal control strategies. Following the efforts done by the USA researchers, scientists in China fought their ways to develop thermal management technologies for Chinese advanced energy-optimized airplanes and spacecraft. This paper elaborates the available on-board heat sinks and aerospace thermal management systems using both active and passive technologies not confined to the technology in China. Subsequently, active thermal management technologies in China including fuel thermal management system, environment control system, non-fuel liquid cooling strategy are reviewed. At last, space thermal control technologies used in Chinese Space Station and Chang’e-3 and to be used in Chang’e-5 are introduced.Key issues to be solved are also identified, which could facilitate the development of aerospace thermal control techniques across the world.

关键词： Aerospace engineering Efficiency promotion Fluid dynamics Heat and mass transfer Thermal management

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Timing and splitting of nitrogen fertilizer supply to increase crop yield and efficiency of nitrogen utilization in a wheat–peanut relay intercropping system in China

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The Crop Journal 2019年第1期7卷 101-112页

作者： Zhaoxin liu Fang Gao Yan liu Jianqun Yang Xiaoyu Zhen Xinxin li Ying li Jihao Zhao Jinrong li Bichang Qian Dongqing Yang Xiangdong Li State Key Laboratory of Crop Biology Shandong Agricultural University College of Agronomy Shandong Agricultural University

Agronomically optimizing the timing and rates of nitrogen(N) fertilizer application can increase crop yield and decrease N loss to the environment. Wheat(Triticum aestivum L.)–peanut(Arachis hypogaea L.) relay intercropping systems are a mainstay of economic and food security in China. We performed a field experiment to investigate the effects of N fertilizer on N recovery efficiency, crop yield, and N loss rate in wheat–peanut relay intercropping systems in the Huang-Huai-Hai Plain, China during 2015–2017. The N was applied on the day before sowing, the jointing stage(G30) or the booting stage(G40) of winter wheat, and the anthesis stage(R1) of peanut in the following percentage splits: 50-50-0-0(N1), 35-35-0-30(N2), and 35-0-35-30(N3), using 300 kg N ha-1, with 0 kg N ha-1(N0) as control. ^(15)N-labeled(20.14 atom %) urea was used to trace the fate of N in microplots. The yields of wheat and peanut increased by 12.4% and 15.4% under the N2 and N3 treatments, relative to those under the N1 treatment. The ^(15)N recovery efficiencies( ^(15)NRE) were 64.9% and 58.1% for treatments N2 and N3, significantly greater than that for the N1 treatment(45.3%). The potential N loss rates for the treatments N2 and N3 were23.7% and 7.0%, significantly lower than that for treatment N1(30.1%). Withholding N supply until the booting stage(N3) did not reduce the wheat grain yield; however, it increased the N content derived from ^(15)N-labeled urea in peanuts, promoted the distribution of ^(15)N to pods, and ultimately increased pod yields in comparison with those obtained by topdressing N at jointing stage(N2). In comparison with N2, the N uptake and N recovery efficiency(NRE) of N3 was increased by 12.0% and 24.1%,respectively, while the apparent N loss decreased by 16.7%. In conclusion, applying N fertilizer with three splits and delaying topdressing fertilization until G40 of winter wheat increased total grain yields and NRE and reduced N loss. This practice could be an environment-friendly N management strategy for wheat–pea

关键词： Nitrogen management Wheat–peanut relay intercropping system Crop yield Nitrogen recovery efficiency Apparent N loss

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Integration of GaN analog building blocks on p-GaN wafers for GaN ICs

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Journal of Semiconductors 2021年第2期42卷 113-116页

作者： Xiangdong Li Karen Geens Nooshin Amirifar Ming Zhao Shuzhen You Niels Posthuma Hu liang Guido Groeseneken Stefaan Decoutere imec Leuven 3001Belgium Department of Electrical Engineering KU LeuvenLeuven 3001Belgium

We demonstrate the key module of comparators in GaN ICs,based on resistor-transistor logic(RTL)on E-mode wafers in this work.The fundamental inverters in the comparator consist of a p-GaN gate HEMT and a 2DEG resistor as the load.The function of the RTL comparators is finally verified by a undervoltage lockout(UVLO)circuit.The compatibility of this circuit with the current p-GaN technology paves the way for integrating logic ICs together with the power devices.

关键词： p-GaN resistor-transistor logic(RTL) comparator undervoltage lockout(UVLO) GaN ICs

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Co-templating Ionothermal Synthesis and Crystal Structure of a New Layered Aluminophosphate from a Protic Deep Eutectic Solvent

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Chinese Journal of Chemistry 2016年第4期34卷 419-424页

作者： Yuan li xiangdong Gong Lei liu Jinxiang Dong Research Institute of Special Chemicals Taiyuan University of Technology Taiyuan Shanxi 030024 China

Protic deep eutectic mixtures are usually composed of organic amine hydrochloride salts and hydrogen bond donors in a specific molar ratio. Ionothermal synthesis of aluminophosphate as an example, herein, was reported for the first time from an urea-based protic eutectic mixture, consisting of diethylammonium chloride （DEACI） and 1,3-dimethyl urea （DMU）. As a result, a new two dimensional aluminophosphate with 4.8-network, [CH3NH3]2[（C2H5）2NH2]Al3（PO4）4, has been successfully synthesized by co-templating the DEA and methylamine in situ generated from the decomposition of DMU in the absence of HF. Compared to alkyl quaternary ammonium salts with more alkyl-group connected with N atom, this kind of organic amine salts are more likely as the struc- ture-directing agents to synthesize aluminophosphates in urea-based deep eutectic mixtures. It was also found that HF is crucial to the phase selectivity, a known compound with chain-like structure was obtained with the single methylamine as a structure-directing agent in the presence of HF. These materials were characterized by powder XRD, SEM, TG-DSC, 13C CP-MAS NMR and CHN analyses.

关键词： structure-directing agent ionothermal synthesis deep eutectic solvent crystal structure

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Mapping Human Pluripotent Stem Cell-derived Erythroid Differentiation by Single-cell Transcriptome Analysis

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Genomics, Proteomics & Bioinformatics 2021年第3期19卷 358-376页

作者： Zijuan Xin Wei Zhang Shangjin Gong Junwei Zhu Yanming li Zhaojun Zhang xiangdong Fang CAS Key Laboralory of Genome Science and Information Beijing Institute of GenomicsChinese Academy of Sciences/China National Center of BioinformationBeijing 100101China College of life Sciences University of Chinese Academy of SciencesBejing 100049China Sino-Danish College University of Chinese Academy of SciencesBejing 100190.China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Bejig Key Laboratory of Genome and Precision Medicine Technologies Beijing 100101China

There is an imbalance between the supply and demand of functional red blood cells(RBCs)in clinical applications.This imbalance can be addressed by regenerating RBCs using several in vitro methods.Induced pluripotent stem cells(iPSCs)can handle the low supply of cord blood and the ethical issues in embryonic stem cell research,and provide a promising strategy to eliminate immune rejection.However,no complete single-cell level differentiation pathway exists for the iPSC-derived erythroid differentiation system.In this study,we used iPSC line BC1 to establish a RBC regeneration system.The 10X Genomics single-cell transcriptome platform was used to map the cell lineage and differentiation trajectory on day 14 of the regeneration system.We observed that iPSC differentiation was not synchronized during embryoid body(EB)culture.The cells(on day 14)mainly consisted of mesodermal and various blood cells,similar to the yolk sac hematopoiesis.We identified six cell classifications and characterized the regulatory transcription factor(TF)networks and cell-cell contacts underlying the system.iPSCs undergo two transformations during the differentiation trajectory,accompanied by the dynamic expression of cell adhesion molecules and estrogen-responsive genes.We identified erythroid cells at different stages,such as burst-forming unit erythroid(BFU-E)and orthochromatic erythroblast(ortho-E)cells,and found that the regulation of TFs(e.g.,TFDP1 and FOXO3)is erythroid-stage specific.Immune erythroid cells were identified in our system.This study provides systematic theoretical guidance for optimizing the iPSC-derived erythroid differentiation system,and this system is a useful model for simulating in vivo hematopoietic development and differentiation.

关键词： scRNA-seq iPSC Hematopoiesis Erythropoiesis Differentiation trajectory

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A non-contact flexible pyroelectric sensor for wireless physiological monitoring system

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Science China(Information Sciences) 2022年第2期65卷 162-172页

作者： Jian HE Sen li Xiaojuan HOU Yongjun ZHOU Hao li Min CUI Tao GUO xiangdong WANG Jiliang MU Wenping GENG Xiujian CHOU Science and Technology on Electronic Test and Measurement Laboratory North University of China Science and Technology on Near-Surface Detection Laboratory China Institute of Sport Science

Recently, human physiological information wireless monitoring in real-time is particularly important in health analysis. As a solution, a non-contact wireless physiological monitoring system based on pyroelectric generator(Py G), whose core part consists of a wireless circuit processing module and a polyvinylidene fluoride(PVDF) film, has been successfully designed. Owing to the temperature change under the stimulation of an external heat source, the output voltage of the Py G self-powered flexible sensor increases with the heat source temperature variation in the range of 295–355 K. Furthermore, based on the natural temperature oscillation between the living body and surrounding environment, the sensor can realize human physiological information assessment, for example, temperature monitoring of the palms, fingers, respiratory heat signals from mouth or nose or non-contact spatial heat mapping recognition of finger movement via sensor array. On this basis, a portable wireless monitoring system was designed by integrating the intelligent sensor with a signal conditioning circuit, data conversion storage module, Bluetooth module,and power module. This system can acquire real-time human oral or nasal breathing signals in the personal mobile app to evaluate the physiological state of individuals. Additionally, the wireless monitoring system can be activated within 10 m, demonstrating the application of Py G sensors in remote data transmission.

关键词： non-contact pyroelectric generator human body heat environmental thermal energy wireless monitoring system

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An oxide-based heterojunction optoelectronic synaptic device with wideband and rapid response performance

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Journal of Materials Science & Technology 2022年第28期123卷 159-167页

作者： Chunmei li Jinyong Wang Dongyang li Nasir Ilyas Zhiqiang Yang Kexin Chen Peng Gu xiangdong Jiang Deen Gu Fucai liu Yadong Jiang Wei li School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu 611731China Key Laboratory of Information Materials of Sichuan Province and School of Preparatory Education Southwest Minzu UniversityChengdu 610041China

With the rapid development of science and technology,the emergence of new application scenarios,such as robots,driverless vehicles and smart city,puts forward high requirements for artificial visual systems.Optoelectronic synaptic devices have attracted much attention due to their advantages in sensing,memory and computing integration.In this work,via band structure engineering and heterostructure designing,a heterojunction optoelectronic synaptic device based on Cu doped with n-type SrTiO_(3)(Cu:STO)film combined with p-type CuAlO_(2)(CAO)thin film was fabricated.It is found surprisingly that the optoelectronic device based on Cu:STO/CAO p-n heterojunction exhibits a rapid response of 2 ms,and that it has a wideband response from visible to near-infrared(NIR)region.Additionally,a series of important synaptic functions,including excitatory postsynaptic current(EPSC),paired-pulse facilitation(PPF),shortterm potentiation(STP)to long-term potentiation(LTP)transition,learning experience behavior and image sharpening,have been successfully simulated on the device.More importantly,the performance of the device remains still stable and reliable after several months which were stored at room temperature and atmospheric pressure.Based on these advantages,the optoelectronic synaptic devices demonstrated here provide great potential in the new generation of artificial visual systems.

关键词： Cu:STO/CAO heterojunction Optoelectronic synaptic devices Vis to NIR wideband Rapid response Artificial visual system

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Trace metals in soil,dust,and tree leaves of the urban environment,Guangzhou,China

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Chinese Science Bulletin 2013年第2期58卷 222-230页

作者： BI XiangYang liANG SiYuan li xiangdong Department of Civil and Environmental Engineering The Hong Kong Polytechnic University State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences(Wuhan)

Metals have been constantly introduced to urban environments via various point and non-point sources of pollution,and have contaminated different urban compartments(sample types).However,most research projects have focused on a single environmental compartment to characterize urban metal contamination.In the present study,an integrated sampling program that includes surface soils,different size fractions of soil and road dust( soil dust ≥ surface soils ≈ top soils > grasses ≥ tree leaves.As for the relationships among the trace metals,different combinations were seen among the sample types,indicating different loadings of trace metals in the sampling medium.Significant correlations of metal concentrations were found between tree leaves and the smallest(<50 μm) fraction of road dust,and between soil dust(50-100 μm) and surface soils,suggesting that trace metals in these samples may influence each other.

关键词：微量金属元素表层土壤城市环境树叶灰尘广州中国非点源污染

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Identification of surgical patients at high risk of OSAS using the Berlin Questionnaire to detect potential high risk of adverse respiratory events in post anesthesia care unit

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Frontiers of Medicine 2018年第2期12卷 189-195页

作者： Fei liu li liu Fang Zheng xiangdong Tang Yongxin Bao Yunxia Zuo Department of Anesthesiology West China Hospital Sichuan University Chengdu 610041 China School of Computing Chongqing University Chongqing 400044 China School of Information Science & Engineering Lanzhou University Lanzhou 730000 China Sleep Medicine Center Mental Health Center Translational Neuroscience Center West China Hospital Sichuan University Chengdu 610041China Qingdao Women's and Children's Hospital Qingdao 266000 China

Obstructive sleep apnea syndrome （OSAS） increases the risk of post-surgery complications. This study uses Berlin Questionnaire （BQ） to identify Chinese adult surgical patients who are at a high risk of OSAS and to determine if the BQ could be used to detect potential high risk of adverse respiratory events in the post anesthesia care unit （PACU）. Results indicated that only 11.4% of the patients were considered at a high risk of OSAS. Age and body mass index are the key factors for the risk of OSAS prevalence in China and also gender specific. Furthermore, the incidence of adverse respiratory events in the PACU was higher in patients with high risk of OSAS than others （6.8% vs. 0.9%, P 〈 0.001）. They also stayed longer than others in the PACU （95 ~ 28 min vs. 62 ~ 19 min, P 〈 0.001）. Age, high risk for OSAS, and smoking were independent risk factors for the occurrence of adverse respiratory events in the PACU. The BQ may be adopted as a screening tool for anesthesiologists in China to identify patients who are at high risk of OSAS and determine the potential risk of developing postoperative respiratory complications in the PACU.

关键词： obstructive sleep apnea Berlin Questionnaire Chinese surgical patients adverse respiratory event

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