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Journal of Energy Chemistry 2024年第4期91卷 194-202页

作者： Guangtong Hai xiangdong xue Zhenyu Wu Canyang Zhang Xin Liu Xiubing Huang Institute of Zhejiang University-Quzhou Zhejiang UniversityQuzhou 324000ZhejiangChina Beijing Key Laboratory of Membrane Materials and Engineering Department of Chemical EngineeringTsinghua UniversityBeijing 100084China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and TechnologyBeijing 100083China CentreÉnergie Matériaux et Télécommunications(EMT) Institut national de la recherche scientifique(INRS)Varennes J3X1P7QuébecCanada

Electrocatalytic water splitting is crucial for H2generation via hydrogen evolution reaction(HER)but subject to the sluggish dynamics of oxygen evolution reaction(OER).In this work,single Fe atomdoped MoS_(2)nanosheets(SFe-DMNs)were prepared based on the high-throughput density functional theory(DFT)calculation *** to the synergistic effect between Fe atom and MoS_(2)and optimized intermediate binding energy,the SFe-DMNs could deliver outstanding activity for both HER and *** assembled into a two-electrode electrolytic cell,the SFe-DMNs could achieve the current density of 50 mA cm^(-2)at a low cell voltage of 1.55 V under neutral *** results not only confirmed the effectiveness of high-throughput screening,but also revealed the excellent activity and thus the potential applications in fuel cells of SFe-DMNs.

关键词： High-throughput calculation Overall water splitting Single atom doped catalyst Molybdenum disulfide nanosheet

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青少年举重训练中存在的不足与对策探究

当代体育科技 2024年第15期14卷 22-25页

作者：薛向东北京市密云区青少年业余体校北京100000

举重训练作为一项对身体素质要求极高的体育运动项目,在青少年体育训练中占据重要地位。然而,在实际的青少年举重训练过程中,还存在着诸多不足之处,例如,训练强度不合理、训练周期和频率不足、缺乏核心和稳定性训练、忽视正确的举重技... 详细信息

举重训练作为一项对身体素质要求极高的体育运动项目,在青少年体育训练中占据重要地位。然而,在实际的青少年举重训练过程中,还存在着诸多不足之处,例如,训练强度不合理、训练周期和频率不足、缺乏核心和稳定性训练、忽视正确的举重技术等问题。鉴于此,该文将针对以上不足之处,结合现有研究和实践经验的分析,提出相应的改善对策,以期提高青少年举重训练效果。

关键词：青少年举重训练不足对策

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基于改进SSA-BP神经网络的钠硫电池拆解刀具温度预测模型研究

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机床与液压 2024年第9期52卷 100-107,127页

作者：屈朝阳胡光忠王平薛祥东四川轻化工大学机械工程学院四川宜宾644000 攀枝花市先进制造技术重点实验室四川攀枝花617000

钠硫电池中含有大量的高纯度钠,在自动化拆解过程中存在燃烧、爆炸等安全风险。针对钠硫电池在车削拆解时存在的安全性问题,提出一种改进SSA-BP神经网络算法来预测刀具加工的最高温度。利用ABAQUS软件计算出刀具加工的实时温度,通过电... 详细信息

钠硫电池中含有大量的高纯度钠,在自动化拆解过程中存在燃烧、爆炸等安全风险。针对钠硫电池在车削拆解时存在的安全性问题,提出一种改进SSA-BP神经网络算法来预测刀具加工的最高温度。利用ABAQUS软件计算出刀具加工的实时温度,通过电池拆解实验验证仿真数据的可靠性;然后以仿真温度数据建立样本,利用Tent混沌映射对SSA-BP神经网络算法进行优化,建立刀具温度仿真预测模型。实验结果表明:该仿真预测模型收敛速度快,鲁棒性强,模型误差小。

关键词：钠硫电池刀具温度预测模型改进SSA-BP神经网络 Tent混沌映射

Charge-reversible crosslinked nanoparticle for pro-apoptotic peptide delivery and synergistic photodynamic cancer therapy

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Nano Research 2023年第12期16卷 13267-13282页

作者： Haijing Qu Han Chen Wei Cheng Yuqing Pan Zhiran Duan Yanjun Wang Xing-Jie Liang xiangdong xue Shanghai Frontiers Science Center of Drug Target Identification and Delivery School of PharmacyShanghai Jiao Tong UniversityShanghai 200240China National Key Laboratory of Innovative Immunotherapy Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Ninth People’s Hospital Shanghai Jiao Tong University School of MedicineShanghai 200011China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China

Although anti-cancer nanotherapeutics have made breakthroughs,many remain clinically unsatisfactory due to limited delivery efficiency and complicated biological ***,we prepared charge-reversible crosslinked nanoparticles(PDC NPs)by supramolecular self-assembly of pro-apoptotic peptides and photosensitizers,followed by crosslinking the self-assemblies with polyethylene glycol to impart tumor microenvironment responsiveness and *** resultant PDC NPs have a high drug loading of 68.3%,substantially exceeding that of 10%–15%in conventional drug delivery *** NPs can overcome the delivery hurdles to significantly improve the tumor accumulation and endocytosis of payloads by surface charge reversal and responsive crosslinking ***-apoptotic peptides target the mitochondrial membranes and block the respiratory effect to reduce local oxygen consumption,which extensively augments oxygen-dependent photodynamic therapy(PDT).The photosensitizers around mitochondria increased along with the peptides,allowing PDT to work with pro-apoptotic peptides synergistically to induce tumor cell death by mitochondria-dependent apoptotic *** strategy would provide a valuable reference for improving the delivery efficiency of hydrophilic peptides and developing mitochondrial-targeting cancer therapies.

关键词： charge-reversible nanoparticle crosslinked nanoparticle peptide delivery photodynamic therapy synergistic cancer treatment

Excipient-free porphyrin/SN-38 based nanotheranostics for drug delivery and cell imaging

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Nano Research 2020年第2期13卷 503-510页

作者： Ye Yuan Ruonan Bo Di Jing Zhao Ma Zhongling Wang Tzu-yin Lin Lijie Dong xiangdong xue Yuanpei Li Center for Smart Materials and Devices State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of TechnologyWuhan 430070China Department of Biochemistry and Molecular Medicine UC Davis Comprehensive Cancer CenterUniversity of California DavisSacramento 95817USA School of Veterinary Medicine Yangzhou UniversityYangzhou 225009Chino Department of Oncolog) Xiangya HospitalCentral South UniversityChangsha 410008China Department of Radiology Shanghai General HospitalShanghai jiao Tong University School of MedicineShanghai 200080China Division of Hematology/Oncology Department of Internal MedicineUniversity of California DavisSacramento 95817USA College of Life Sciences Northwest UniversityXian 710069China

Nanotheranostics with comprehensive diagnostic and therapeutic capabilities show exciting cancer treatment ***,we develop an excipient-free drug delivery system for cancer diagnosis as well as therapy,in which a near infra-red photosensitizer and a chemotherapeutic drug can be self-delivered without any *** building block of the drug delivery system was synthesized by covalently conjugating four anticancer drugs(7-ethyl-10-hydroxy-camptothecin,SN-38)with a photosensitizer(porphyrin)via hydrolyzable ester linkage,which endows the drug delivery system with 100%active pharmaceutical ingredients,excellent imaging,and therapeutic *** conjugates can readily self-assemble into nanosheets(PS NSs)and remain stable for at least 20 days in aqueous *** PS NSs,fluorescence resonance energy transfer(FRET)dominates the fluorescence of SN-38 and enables to monitor the drug release *** PS NSs also show excellent anticancer activity in vitro,due to the increased cell uptake with the synergistic effect of photodynamic therapy and chemotherapy.

关键词： porphyrin 7-ethyl-10-hydroxy-camptothecin(SN-38) drug delivery self-indication nanotheranostics photodynamic therapy

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天然气管网仿真分层计算方法

石油工程建设 2024年第1期50卷 65-74页

作者：阎涛刘天尧王雪莉薛向东康阳朱峰国家管网集团科学技术研究总院分公司河北廊坊065000 西安交通大学软件学院陕西西安710049

随着用气需求的日益增加,天然气管网的规模逐渐复杂化,管网仿真消耗的计算资源和计算时间亦趋庞大。对于管网仿真过程中出现的大型代数方程组,结合天然气管网的拓扑结构特征,提出一种分层计算方法,该方法将管网自上而下分解为若干层,每... 详细信息

随着用气需求的日益增加,天然气管网的规模逐渐复杂化,管网仿真消耗的计算资源和计算时间亦趋庞大。对于管网仿真过程中出现的大型代数方程组,结合天然气管网的拓扑结构特征,提出一种分层计算方法,该方法将管网自上而下分解为若干层,每层又包含若干独立的子管网,从而使得每个子管网的计算可以独立执行。这种处理方法降低单次求解方程组的规模,同时也使得每层中各子管网的求解可以并行实现,从而有效提高仿真计算的效率。最后基于一个复杂管网的数值案例对算法的计算精度和效率进行分析,结果表明:相比于传统直接求解方法,分层算法可以在维持同等计算精度的前提下,提高仿真求解速度,在该案例中平均加速比达到了2倍左右。

关键词：天然气管网数值仿真分层求解

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A unique Janus PdZn-Co catalyst for enhanced photocatalytic syngas production from CO_(2) and H_(2)O

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Chinese Chemical Letters 2023年第7期34卷 265-268页

作者： Dongxue Zhou xiangdong xue Qingjie Luan Liguo Zhang Baozhen Li Xing Wang Wenjun Dong Ge Wang Changmin Hou Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Function Materials for Molecule&Structure ConstructionSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijing 100083China Shunde Graduate School of University of Science and Technology Beijing Foshan 528399China State Key Laboratory of Inorganic Synthesis&Preparative Chemistry College of Chemistry.Jilin UniversityChangchun 130012China

The development of excellent catalyst to achieve photocatalytic syngas production from CO_(2) and H_(2)O is a prospective and sustainable strategy to alleviate environment and energy crisis. In this study, a unique Janus PdZn-Co catalyst is prepared by annealed the Pd/IRMOF-3(Co, Zn) precursor. Due to the strong interaction, the electron transfers from PdZn terminal to Co terminal in the Janus structure. The electron-received Co terminal facilitates Co sites coordinate with the electrophilic C atom of CO_(2) and the electron-donated PdZn center is easier to coordinate with nucleophilic O atoms of H_(2)O or C=O *** charge redistribution enhances the absorption of CO_(2) and H2O, which promotes H_(2) evolution and CO production. In addition, the carbon shell effectively suppresses the metal core agglomeration and facilitates the electron transmission from photosensitizer to metallic active sites. Meanwhile, the ratio of CO/H_(2) can be regulated(~3:1 to 2:1) by adjusting the proportion of Co and PdZn. The Janus structure and graphite carbon synergistically play a profound impact on improving the photocatalytic *** optimized PdZn-Co catalyst exhibits a superior photocatalytic CO production rate(20.03 μmol/h) and the H_(2) generation rate(9.90 μmol/h) with a ratio of CO/H_(2)= 2.02.

关键词： PdZn@C catalyst Janus structure Charge redistribution Absorption modulation Photocatalyst

Deep tumor-penetrating nano-delivery strategy to improve diagnosis and therapy in patient-derived xenograft(PDX)oral cancer model and patient tissue

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Nano Research 2023年第2期16卷 2927-2937页

作者： Longmeng Li Aaron R.Lindstrom Andrew C.Birkeland Menghuan Tang Tzu-Yin Lin Yikai Zhou Bai Xiang xiangdong xue Yuanpei Li State Key Laboratory of Environment Health(Incubation) Key Laboratory of Environment and HealthMinistry of EducationKey Laboratory of Environment and Health(Wuhan)Ministry of Environmental ProtectionSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Biochemistry and Molecular Medicine UC Davis Comprehensive Cancer CenterUniversity of California Davis2700 Stockton BlvdSacramentoCalifornia 95817USA Department of Otolaryngology-Head and Neck Surgery University of California Davis2521 Stockton BlvdSacramentoCalifornia 95817USA Division of Hematology and Oncology Department of Internal MedicineSchool of MedicineUniversity of California Davis2700 Stockton BlvdSacramentoCalifornia 95817USA Key Laboratory of Hebei Province for Innovative drug research and evaluation School of Pharmaceutical SciencesHebei Medical UniversityShijiazhuang 050017China School of Pharmacy Pharm-X CenterShanghai Jiao Tong UniversityShanghai 200240China

Nanoprodrugs that are directly assembled by prodrugs attract considerable attention with high anticancer ***,their stability and efficiency of tumor-targeted delivery remain a major challenge in practical biomedical ***,we report a new deep tumor-penetrating nano-delivery strategy to achieve enhanced anti-cancer performance by systematic optimization of a porphyrin-doxorubicin-based nanoprodrug using various PEGylations/crosslinks and co-administration of targeting peptide *** glycols(PEGs)with different molecular weights and grafts are employed to crosslink the nanoprodrug and optimize size,charge,tumor accumulation and penetration,and anti-cancer efficiency,*** tumor penetration was validated in syngeneic oral cancer mouse models,patient-derived xenograft(PDX)models,and oral cancer tissue from *** optimized nanoprodrug co-administrated with iRGD remarkably enhances the accumulation and penetration both in tumor vascular and PDX tumor *** is effective and safe to improve in vivo therapeutic efficacy via the passive tumor targeting dependent and independent *** tumor-penetrating nano-delivery strategy is promising to strengthen the nanoprodrugs in clinical implementation.

关键词： nanoprodrug tumor-penetrating tumor-targerting multilevel delivery optimization drug delivery

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双嘧达莫对川崎病患儿临床指标的影响

血管与腔内血管外科杂志 2024年第7期10卷 812-815,825页

作者：程渊博任树萍王利红吴迎爽薛向东张家口市第一医院儿科河北张家口075000

目的探讨双嘧达莫对川崎病患儿临床指标的影响。方法收集2019年1月至2023年12月张家口市第一医院收治的80例川崎病患儿的临床资料,根据治疗方法的不同将80例川崎病患儿分为常规组(n=36,采用常规治疗)和观察组(n=44,在常规治疗的基础上... 详细信息

目的探讨双嘧达莫对川崎病患儿临床指标的影响。方法收集2019年1月至2023年12月张家口市第一医院收治的80例川崎病患儿的临床资料,根据治疗方法的不同将80例川崎病患儿分为常规组(n=36,采用常规治疗)和观察组(n=44,在常规治疗的基础上应用双嘧达莫治疗)。比较两组患儿的主要症状消退时间、住院时间以及治疗1个疗程后血清炎性反应指标、凝血功能指标、免疫功能指标。结果观察组患儿的黏膜充血消退时间、颈淋巴结肿大消退时间、手足肿胀消退时间、退热时间和住院时间均短于常规组患儿,差异均有统计学意义(P﹤0.05)。治疗后,观察组患儿的C反应蛋白(CRP)水平、降钙素原(PCT)水平、白细胞介素-6(IL-6)水平、白细胞计数(WBC)、红细胞沉降率(ESR)、免疫球蛋白(Ig)G、IgM、补体C3水平、血小板(PLT)及纤维蛋白原(FIB)水平均低于常规组患儿,凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)均长于常规组患儿,差异均有统计学意义(P﹤0.05)。结论双嘧达莫可有效改善川崎病患儿的凝血功能,增强患儿的免疫功能,从而更加有效地拮抗炎性反应,促进症状尽快缓解。

关键词：川崎病双嘧达莫全身性血管炎凝血功能免疫功能

叶酸联合维生素B_(12)治疗伴高同型半胱氨酸血症的勃起功能障碍患者的效果

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河南医学研究 2024年第12期33卷 2113-2116页

作者：唐钊吴春磊余沁楠朱峰薛向东贺俊张会清新乡医学院第一附属医院泌尿外科河南新乡453100 新乡医学院第一附属医院新乡市前列腺疾病精准诊疗重点实验室河南新乡453100 南阳市第二人民医院泌尿外科河南南阳457300

目的探究叶酸联合维生素B_(12)治疗伴高同型半胱氨酸血症(HHcy)的勃起功能障碍(ED)患者的效果。方法选择2021年6月至2022年8月于新乡医学院第一附属医院门诊确诊的61例伴有HHcy的ED患者,按照患者意愿分为观察组及对照组。最终观察组入... 详细信息

目的探究叶酸联合维生素B_(12)治疗伴高同型半胱氨酸血症(HHcy)的勃起功能障碍(ED)患者的效果。方法选择2021年6月至2022年8月于新乡医学院第一附属医院门诊确诊的61例伴有HHcy的ED患者,按照患者意愿分为观察组及对照组。最终观察组入组37例,对照组入组22例。观察组口服叶酸片及维生素B_(12)片;对照组无药物干预。分别测定两组治疗前和治疗12周后的血浆同型半胱氨酸(Hcy)、维生素B_(12)、叶酸水平,使用国际勃起功能评分量表(IIEF-5)评定勃起功能状态。结果治疗前后,对照组血浆Hcy、叶酸、维生素B_(12)水平及IIEF-5评分比较差异无统计学意义(P>0.05);治疗后观察组血浆叶酸、维生素B_(12)水平及IIEF-5评分升高,且高于对照组(P<0.01),血浆Hcy水平下降,且低于对照组(P<0.01)。结论叶酸联合维生素B_(12)治疗方案可以降低伴HHcy的ED患者的血浆Hcy水平,改善勃起功能。

关键词：勃起功能障碍高同型半胱氨酸血症叶酸维生素B_(12)