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Functionalized gadofullerene ameliorates impaired glycolipid metabolism in type 2 diabetic mice

Journal of Genetics and Genomics 2022年第4期49卷 364-376页

作者： Jin Wu Yingbo Chen Xue Li Liyuan Ran xiangdong liu Xiaoshuang Wang Mingming Zhen Shanshan Shao Li Zeng Chunru Wang Bin Liang Jiajun Zhao Yingjie Wu Shandong Provincial Hospital Shandong Laboratory Animal CenterScience and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250021China Institute for Genome Engineered Animal Models of Human Diseases Dalian Medical UniversityDalianLiaoning 116044China Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and NanotechnologyCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China Center for Life Sciences School of Life SciencesYunnan UniversityKunmingYunnan 650091China Department of Molecular Pathobiology New York University College of DentistryNew York 10010USA

The soaring global prevalence of diabetes makes it urgent to explore new drugs with high efficacy and ***-derived bioactive agents are emerging as one of the most promising candidates for biomedical *** the present study,we investigated the anti-diabetic effects of a functionalized gadofullerene(GF)using obese db/db and non-obese mouse model of type 2 diabete mellitus(MKR)mouse type 2 diabetes mellitus(T2DM)*** both mouse models,the diabetic phenotypes,including hyperglycemia,impaired glucose tolerance,and insulin sensitivity,were ameliorated after two or four weeks of intraperitoneal administration of *** lowered blood glucose levels in a dose-dependent ***,the restored blood glucose levels could persist ten days after withdrawal of GF *** hepatic AKT/GSK3β/FoxO1 pathway is shown to be the main target of GF for rebalancing gluconeogenesis and glycogen synthesis in vivo and in ***,GF treatment significantly reduced weight gain of db/db mice with reduced hepatic fat storage by the inhibition of de novo lipogenesis through m TOR/S6K/SREBP1 *** data provide compelling evidence to support the promising application of GF for the treatment of T2DM.

关键词： Functionalized gadofullerene Type 2 diabetes Glycolipid metabolism AKT De novo lipogenesis

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Association of KIR Genotypes and Haplotypes with Susceptibility to Chronic Hepatitis B Virus Infection in Chinese Han Population

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Cellular & Molecular Immunology 2008年第6期5卷 457-463页

作者： Zhiming Lu Bingchang Zhang Shijun Chen Zhongtao Gai Zhaolei Feng xiangdong liu Yiqing liu Xin Wen Li Li Yulian Jiao Chunyan Ma Song Shao Xiangfa Cui Guojian Chen Jianfeng Li Yneran Zhao Department of Laboratory Medicine Shandong Provincial HospitalShandong University Jinan China Department of Laboratory Medicine Jinan Infectious Disease HospitalJinan China Department of Center Laboratory Shandong Provincial Hospital ShandongUniversity Jinan China These authors contributed equally to this work.

Killer immunoglobulin-like receptor （KIR） genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus （HBV） infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction （SSP-PCR） was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B （CHB） patients, 251 spontaneously recovered （SR） controls, and 412 healthy controls. The frequencies of genotype G7 M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV. Cellular ＆ Molecular Immunology. 2008;5（6）：457-463.

关键词： HBV KIR KIR genotype KIR haplotype

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Research and Application of Control Systems of Auxiliary Engines in Cogeneration Power Station

Research and Application of Control Systems of Auxiliary Eng...

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2012年计算机应用与系统建模国际会议

作者： Sun Jianjun liu xiangdong Jiangsu Datang International Power Generation lvsi port Co. Ltd WuHan KAIDI Electric Power Engineering Co. Ltd

For the control unit in the level of automationassisted workshop relatively backward status quo and Put forward its own solution. Auxiliary control of the integrated development of the need for an analysis, the use of Planning and design theory. Based on the current status quo at home and abroad auxiliary control system. Combined with large A power plant refining Power center for specific circumstances. from the system on a high degree of integration of the auxiliary control architecture as well as the feasibility study carried out feasibility studies Proposed Des Net control system design Program. Through the auxiliary control Program with the traditional comparison. The Paper Proposes major oi1 refinery. A power plant refining Power Center to be used controlled auxiliary control system. Implementation of the system in the traditional auxiliary system control and monitoring Based on the use of today’s industry most Powerful Siemens PCS7 system with high reliability. A power plant refining Power center is now generating a Project. Auxiliary systems are mostly single-loop control and Process control requirements fail to take up a lot of manpower .This article will also be Practical Problems to solve on-site as a Starting Point. Choose recycled water dosing system as the research objectives. combined with fuzzy control theory. The dosing system to analyze the Process, to find a suitable site control methods.

关键词： Thermal Power Plants Auxiliary control Fuzzy control Siemens PCS7 Anxiliary control net

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Mining rice new germplasm containing S_5~n gene by functional molecular marker and sequencing

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Chinese Science Bulletin 2009年第15期54卷 3258-3264页

作者： YANG YouXin WU JinWen CHEN ZhiXiong WANG Lan LI JinQuan liu xiangdong LU YongGen Guangdong Provincial Key Laboratory of Plant Molecular Breeding South China Agricultural University Guangzhou 510642 China

Inter-subspecific hybrids between indica and japonica varieties yield strong biological heterosis, but it is difficult to utilize the hybrids directly in commercial production due to sterility of F1. A special gene S5n may overcome the hybrids sterility, which is caused by the interaction between S5 loci. Recently, S5n had been cloned, and it was revealed containing a large DNA deletion sequence that made the gene nonfunctional, compared to S5i or S5j. We designed a pair of primers flanking the deletion sequence of S5n, and then applied to distinguish the varieties with S5n or non-S5n, convincing result suggested that the primers could be served as functional molecular marker to efficiently identify the new germplasm with S5n. Using the functional marker, we surveyed 197 varieties from China National Micro-core Rice Collection, and found ten of which represented S5n including following varieties: Haobuka, Sanbangqishiluo, Mubanggu, Xiaohonggu, Mowanggu’neiza, Laozaogu, Fanhaopi, Feie’nuo2, Baoxie-7B, Teqingxuanhui. Among them, two varieties Sanbangqishiluo and Laozaogu was previously reported to contain S5n gene. Further sequence analysis on the DNA sequence covering both sides of deletion in S5n of the 10 varieties confirmed that the detected sequences in above varieties was identical with those of varieties containing S5n, such as 02428 and Linglun. These results suggested that the gene in S5 locus of the ten varieties was also nonfunctional and it proved the presence of S5n gene.

关键词：基因测序分子标记新种质水稻品种产量序列分析矿业杂种不育

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基于非对称跳跃粗糙随机波动率模型的期权定价研究

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系统工程理论与实践 2023年第2期43卷 350-370页

作者：柳向东洪绍鹏暨南大学经济学院统计与数据科学系广州510632

基于资产价格存在的非对称跳跃与资产波动率存在的粗糙特性,本文提出了粗糙带非对称跳Heston模型(rHeston-AEDJ),在风险中性测度中推导出该模型的特征函数.由于模型的非马尔可夫且非半鞅性质,不能使用传统的欧拉方法进行逼近,本文使用... 详细信息

基于资产价格存在的非对称跳跃与资产波动率存在的粗糙特性,本文提出了粗糙带非对称跳Heston模型(rHeston-AEDJ),在风险中性测度中推导出该模型的特征函数.由于模型的非马尔可夫且非半鞅性质,不能使用传统的欧拉方法进行逼近,本文使用混合模拟方法对该模型进行逼近,并解决粗糙波动率下奇异期权的定价问题.在风险中性测度下,基于Fourier-SINC推导了欧式期权的拟闭解.实证研究结果表明,上证50ETF价格存在跳跃、波动率Hurst指数远小于1/2,即波动率存在粗糙性,并基于拟闭解对上证50ETF期权进行定价实验发现本文所提出的rHeston-AEDJ模型在样本内外均有较好的定价精度.本文的研究对国内外期权产品定价与精确风险管理具有重要的现实意义和应用价值.

关键词：粗糙波动率模型非对称指数分布复合泊松跳跃 Fourier-SINC 上证50ETF期权定价

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Decentralized H∞ control for attitude coordination of spacecraft formation

Decentralized H∞ control for attitude coordination of space...

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第36届中国控制会议

作者： Pingli Lu Gang liu xiangdong liu School of Automation Beijing Institute of Technology

In this paper, a robust H decentralized controller is proposed for attitude coordination of spacecraft formation flying with external disturbance based on the relative attitudes and angular velocities of neighboring spacecraft. The controller is composed of nonlinear terms for performance enhancement and linear terms for attitude coordination and stabilization. The proposed control method guarantees the attitude alignment with zero final angular velocity and robust disturbance attenuation for spacecraft formation when the communication topology is connected. A feature of the proposed approach is that the robust Hcontroller parameters can be obtained by solving linear matrix inequalities(LMIs), which makes the design more ***, the numerical simulations of a spacecraft formation are provided to show the effectiveness of the proposed consensus algorithm.

关键词： Attitude coordination linear matrix inequality nonlinear H∞ control multiple spacecraft spacecraft formation

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Few Problems in Accelerating Foreign Economic & Trade Development

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China's Foreign Trade 1995年第2期 3-4页

作者： liu xiangdong, Assistant Minister of Foreign Trade and Economic Cooperation

China’s economic reform has progressed to setting up a socialist market economy. Since 1994, a series of reform measures in taxation, finance, planning, foreign exchange and foreign trade adopted by the State have promoted the development of the national economy, as well as foreign economic and trade development. The furtherance of the good situation of the economy and foreign trade relies on the following work: 1, Speeding up the development

关键词： Few Problems in Accelerating Foreign Economic Trade Development

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宽频带超导重力仪的研制进展

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地球物理学报 2018年第7期61卷 3037-3043页

作者：刘习凯马东陈亮刘向东华中科技大学物理学院基本物理量测量教育部重点实验室武汉430074

本文报道一种构建宽频带高分辨率超导重力仪(SG)的方法.与已商业化的GWR超导重力仪类似,新型超导重力仪同样使用磁悬浮超导检验质量来构建弹簧振子结构,不同的是弹簧振子的固有频率更高,可以有效覆盖地脉动频带.同时,利用基于超导量子... 详细信息

本文报道一种构建宽频带高分辨率超导重力仪(SG)的方法.与已商业化的GWR超导重力仪类似,新型超导重力仪同样使用磁悬浮超导检验质量来构建弹簧振子结构,不同的是弹簧振子的固有频率更高,可以有效覆盖地脉动频带.同时,利用基于超导量子干涉器件(SQUID)的位移传感技术,大幅提高了位移传感灵敏度,以保证仪器在测量带宽扩展之后仍具有与GWR仪器相当的测量分辨率,从而实现对时变重力信号与地球背景噪声信号的同时高分辨观测.宽频带超导重力仪核心部件垂向超导加速度计(VSA)的设计、组装和初步测试已经完成.结果表明,加速度计的噪声本底为8μGal/Hz1/2@0.1Hz,实现了对地脉动信号的高分辨率测量.而为了将仪器噪声本底降低到GWR仪器水平,加速度计的固有频率需要进一步减小,该部分参数优化工作正在进行.本文将对垂向超导加速度计的工作原理、结构和测试结果进行详细介绍.

关键词：宽频带垂向超导加速度计分析测试

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Mapping of de novo mutations in primary biliary cholangitis to a disease-specific co-expression network underlying homeostasis and metabolism

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Journal of Genetics and Genomics 2022年第2期49卷 145-154页

作者： Lu Wang Jinchen Li Chan Wang Ruqi Tang Jialong Liang Yuhua Gong Yaping Dai Ningling Ding Jian Wu Na Dai Lei liu Yi Zhao Youlin Shao Weifeng Zhao Peng Jiang Xingjuan Shi Weichang Chen Ye Tian xiangdong liu Xiong Ma Zhongsheng Sun Key Laboratory of Developmental Genes and Human Diseases Institute of Life SciencesSoutheast University2 Sipailou RoadNanjingJiangsu 210096China Beijing Institutes of Life Science Chinese Academy of SciencesNo.1 West Beichen RoadChaoyang DistrictBeijing 100101China Department of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai Jiao Tong University School of Medicine Afﬁliated Renji Hospital145 Shandong Middle RoadShanghai 200001China Department of Laboratory Medicine The Third People’s Hospital of Zhenjiang300 DaijiamenZhenjiangJiangsu 212021China Department of Laboratory Medicine The Fifth People’s Hospital of Wuxi1215 Guangrui RoadWuxiJiangsu 214000China Department of Hepatology The Fifth People’s Hospital of SuzhouSoochow University10 Guangqian RoadSuzhouJiangsu 215131China Department of Rheumatology First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Gastroenterology Jiangsu University Afﬁliated Kunshan Hospital91 Qianjin West RoadKunshanJiangsu 215300China Department of Gastroenterology Yixing People’s Hospital75 Tongzhenguan RoadYixinJiangsu 214200China Department of Gastrointestinal Endoscopy Eastern Hepatobiliary Surgery Hospital700 Moyu North RoadShanghai 201800China Department of Hepatology The Third People’s Hospital of Changzhou300 Lanling North RoadChangzhouJiangsu 213001China Department of Infectious Diseases First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Gastroenterology First Afﬁliated Hospital of Soochow University188 Shizi RoadSuzhouJiangsu 215006China Department of Radiology Second Afﬁliated Hospital of Soochow University1055 Sanxiang RoadSuzhouJiangsu 215004China Institute of Genomic Medicine Wenzhou Medical UniversityUniversity TownChashanWenzhouZhejiang 325035China

Primary biliary cholangitis(PBC) is an autoimmune disease involving dysregulation of a broad array of homeostatic and metabolic processes. Although considerable single-nucleotide polymorphisms have been unveiled, a large fraction of risk factors remains enigmatic. Candidate genes with rare mutations that tend to confer more deleterious effects need to be identified. To help pinpoint cellular and developmental mechanisms beyond common noncoding variants, we integrate whole exome sequencing with integrative network analysis to investigate genes harboring de novo mutations. Prominent convergence has been revealed on a network of disease-specific co-expression comprised of 55 genes associated with homeostasis and metabolism. The transcription factor gene MEF2 D and the DNA repair gene PARP2 are highlighted as hub genes and identified to be up-and down-regulated, respectively, in peripheral blood data set. Enrichment analysis demonstrates that altered expression of MEF2 D and PARP2 may trigger a series of molecular and cellular processes with pivotal roles in PBC pathophysiology. Our study identifies genes with de novo mutations in PBC and suggests that a subset of genes in homeostasis and metabolism tend to act in synergy through converging on co-expression network, providing novel insights into the etiology of PBC and expanding the pool of molecular candidates for discovering clinically actionable biomarkers.

关键词： Primary biliary cholangitis de novo mutations Whole exome sequencing Transcriptional networks Co-expression

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某工程抗浮修复实例及经验总结

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建筑结构 2014年第16期44卷 77-80页

作者：柳向东天津市天友建筑设计股份有限公司天津300384

某工程项目接近完工时发现其有较大上浮变形,对此工程抗浮修复的过程进行了详细介绍。通过对事故原因的查找,分析了保证预应力管桩抗拔效果的关键措施。在首次抗浮方案中尝试采用桩心内插锚杆的方法,探讨了桩与锚杆连接的可行性。由于... 详细信息

某工程项目接近完工时发现其有较大上浮变形,对此工程抗浮修复的过程进行了详细介绍。通过对事故原因的查找,分析了保证预应力管桩抗拔效果的关键措施。在首次抗浮方案中尝试采用桩心内插锚杆的方法,探讨了桩与锚杆连接的可行性。由于锚杆施工过程中出现异常,又进行了进一步的加固,介绍了二次补充处理方案采取的增加压重和增加刚度措施。经过两次加固后,建筑的抗浮问题得到彻底解决。

关键词：预应力管桩抗拔锚杆压重抗浮加固

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