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Magnetic resonance-guided focused ultrasound for essential tremor:a prospective,single center,single-arm study

Neural Regeneration Research 2024年第9期19卷 2075-2080页

作者： Rui Zong Xuemei Li Chunyu Yin Jianfeng He Dekang Zhang xiangbing bian Lichao Huang Jiayou Zhou Zhipei Ling Lin Ma Xin Lou Longsheng Pan Xinguang Yu Seniro Department of Neurosurgery The First Medical Center of the PLA General HospitalBeijingChina Clinics of Cadre Department of OutpatientThe First Medical Center of the PLA General HospitalBeijingChina Department of Radiology The First Medical Center of the PLA General HospitalBeijingChina

The safety and effectiveness of magnetic resonance-guided focused ultrasound thalamotomy has been broadly established and validated for the treatment of essential *** 2018,the first magnetic resonance-guided focused ultrasound system in Chinese mainland was installed at the First Medical Center of the PLA General *** prospective,single center,open-label,single-arm study was part of a worldwide prospective multicenter clinical trial(*** Identifier:NCT03253991)conducted to confirm the safety and efficacy of magnetic resonance-guided focused ultrasound for treating essential tremor in the local *** 2019 to 2020,10 patients with medication refractory essential tremor were recruited into this open-label,single arm *** treatment efficacy was determined using the Clinical Rating Scale for *** was evaluated according to the incidence and severity of adverse *** of the subjects underwent a unilateral thalamotomy targeting the ventral intermediate *** the baseline assessment,the estimated marginal mean of the Clinical Rating Scale for Tremor total score was 58.3±3.6,and this improved after treatment to 23.1±6.4 at a 12-month follow-up assessment.A total of 50 adverse events were recorded,and 2 were defined as *** most common intraoperative adverse events were nausea and *** most frequent postoperative adverse events were paresthesia and equilibrium *** of the adverse events were mild and usually disappeared within a few *** findings suggest that magnetic resonance-guided focused ultrasound for the treatment of essential tremor is effective,with a good safety profile,for patients in Chinese mainland.

关键词： efficacy essential tremor magnetic resonance-guided focused ultrasound(MRgFUS) movement disorder safety stereotactic therapy thalamotomy ventral intermediate nucleus

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脑小血管病总负荷及影像标志物与大脑中动脉狭窄程度关系的MRI研究

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中华放射学杂志 2024年第1期58卷 34-40页

作者：邢新博王雪扬吕晋浩段祺段曹辉边祥兵程焜杨明亮张汀阳田成林娄昕解放军总医院第一医学中心放射诊断科北京100853 解放军总医院第一医学中心神经内科北京100853 解放军总医院第四医学中心放射诊断科北京100048

目的探讨脑小血管病(CSVD)总负荷及影像标志物与单侧大脑中动脉(MCA)狭窄程度的关系。方法该研究为横断面研究。回顾性分析2015年10月至2019年1月就诊于解放军总医院第一医学中心并接受多模态MRI检查的慢性单侧MCA狭窄患者的临床及影像... 详细信息

目的探讨脑小血管病(CSVD)总负荷及影像标志物与单侧大脑中动脉(MCA)狭窄程度的关系。方法该研究为横断面研究。回顾性分析2015年10月至2019年1月就诊于解放军总医院第一医学中心并接受多模态MRI检查的慢性单侧MCA狭窄患者的临床及影像资料。共纳入261例患者,男187例、女74例。根据MCA狭窄程度将患者分为重度狭窄-闭塞组(狭窄程度≥70%)102例和轻中度狭窄组(狭窄程度0.05)。多因素二元logistic回归分析显示,CSVD总负荷评分(OR=1.300,95%CI 1.047~1.613,P=0.017)、半卵圆中心血管周围间隙评分(OR=2.099,95%CI 1.540~2.860,P<0.001)和血管源性腔隙(OR=2.609,95%CI 1.294~5.261,P=0.007)与MCA重度狭窄-闭塞独立相关。结论CSVD总负荷评分、半卵圆中心血管周围间隙评分和血管源性腔隙评分高与MCA患者重度狭窄-闭塞有关。

关键词：磁共振成像脑小血管病大脑中动脉狭窄

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Association of fluid-attenuated inversion recovery vascular hyperintensity with ischaemic events in internal carotid artery or middle cerebral artery occlusion

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Stroke & Vascular Neurology 2023年第1期8卷 69-76页

作者： Jinhao Lyu Jianxing Hu Xinrui Wang xiangbing bian Mengting Wei Liuxian Wang Qi Duan Yina Lan Dekang Zhang Xueyang Wang Tingyang Zhang Chenglin Tian Xin Lou Radiology Chinese PLA General Hospital/Chinese PLA Medical SchoolBeijingChina Radiology Chinese PLA General HospitalBeijingChina Neurology Chinese PLA General HospitalBeijingChina

Background and purpose Individuals with intracranial artery occlusion have high rates of ischaemic events and *** has been challenging to identify patients who had high-risk stroke using a simple,valid and non-invasive screening *** study aimed to investigate whether fluid-attenuated inversion recovery(FLAIR)vascular hyperintensity(FVH),a specific imaging sign on the FLAIR sequence,could be a predictor of ischaemic events in a population with internal carotid artery(ICA)or middle cerebral artery(MCA)*** We retrospectively analysed 147 patients(mean 60.43±12.83 years)with 149 lesions,including 37 asymptomatic and 112 symptomatic cases of ICA or MCA *** occlusion was considered if ischaemic events were present in the relevant territory within 90 *** Alberta Stroke Program Early Computed Tomography Score(FVH-ASPECTS:0-7,with 0 indicating absence of FVH and 7 suggesting prominent FVH)and collateral circulation grade were assessed for each *** logistic regression analysis was performed to detect independent markers associated with symptomatic *** A lower FVH-ASPECTS was associated with a more favourable collateral circulation grade(rho=−0.464,p<0.0001).The FVH-ASPECTS was significantly lower in the asymptomatic occlusion group than in the symptomatic occlusion group(p<0.0001).FVH-ASPECTS(Odd ratio,2.973;95%confidence interval,1.849 to 4.781;p<0.0001)was independently associated with symptomatic status after adjustment for age,sex,lesion location and collateral circulation grade in the multivariate logistic *** area under the curve was 0.861 for the use of FVH-ASPECTS to identify symptomatic *** The ability to discriminate symptomatic from asymptomatic occlusion suggests that FVH may be a predictor of *** a simple imaging sign,FVH may serve as a surrogate for haemodynamic impairments and can be used to identify high-risk stroke cases early in ICA or

关键词： occlusion fluid cerebral

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Development of wet adhesion of honeybee arolium incorporated polygonal structure with three-phase composite interfaces

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Friction 2024年第2期12卷 215-230页

作者： Lulu LIANG Jieliang ZHAO Qun NIU Li YU xiangbing WU Wenzhong WANG Shaoze YAN Zhenglei YU School of Mechanical Engineering Beijing Institute of TechnologyBeijing 100081China Division of Intelligent and Biomechanical Systems State Key Laboratory of TribologyDepartment of Mechanical EngineeringTsinghua UniversityBeijing 100084China Key of Bionic Engineering Ministry of EducationJilin UniversityChangchun 130022China

Inspired by the dynamic wet adhesive systems in nature,various artificial adhesive surfaces have been developed but still face different ***,the theoretical mechanics of wet adhesives has never been sufficiently ***,we develop a novel adhesive mechanism for governing wet adhesion and investigate the biological models of honeybee arolium for reproducing the natural wet adhesive ***-nano structures of honeybee arolium and arolium-prints were observed by Cryogenic scanning electron microscopy(Cryo-SEM),and the air pockets were found in the contact interface ***,the adhesive models with a three-phase composite interface(including air pockets,liquid secretion,and hexagonal frames of arolium),were formed to analyze the wet adhesion of honeybee *** results of theoretical calculations and experiments indicated an enhanced adhesive mechanism of the honeybee by liquid self-sucking effects and air-embolism *** these effects,normal and shear adhesion can be adjusted by controlling the proportion of liquid secretion and air pockets in the contact ***,the air-embolism effects contribute to the optimal coupling of smaller normal adhesion with greater shear adhesion,which is beneficial for the high stride frequency of *** works can provide a fresh perspective on the development of bio-inspired wet adhesive surfaces.

关键词： honeybee arolium air pockets wet adhesion a three-phase interface self-sucking effects air-embolism effects

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The protective role of prebiotics and probiotics on diarrhea and gut damage in the rotavirus-infected piglets

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1424-1448页

作者： Heng Yang Xiangqi Fan xiangbing Mao Bing Yu Jun He Hui Yan Jianping Wang Institute of Animal Nutrition Sichuan Agricultural UniversityKey Laboratory for Animal Disease-Resistance Nutrition of China Ministry of EducationKey Laboratory of Animal Disease-Resistant Nutrition and Feed of China Ministry of Agriculture and Rural AffairsKey Laboratory of Animal Disease-Resistant Nutrition of Sichuan ProvinceNo.211Gongpinghuimin RoadWenjiang DistrictChengduSichuan Province 611130People’s Republic of China

Rotavirus is one of the pathogenic causes that induce diarrhea in young animals, especially piglets, worldwide. However, nowadays, there is no specific drug available to treat the disease, and the related vaccines have no obvious efficiency in some countries. Via analyzing the pathogenesis of rotavirus, it inducing diarrhea is mainly due to disturb enteric nervous system, destroy gut mucosal integrity, induce intracellular electrolyte imbalance, and impair gut microbiota and immunity. Many studies have already proved that prebiotics and probiotics can mitigate the damage and diarrhea induced by rotavirus infection in hosts. Based on these, the current review summarizes and discusses the effects and mechanisms of prebiotics and probiotics on rotavirus-induced diarrhea in piglets. This information will highlight the basis for the swine production utilization of prebiotics and probiotics in the prevention or treatment of rotavirus infection in the future.

关键词： Diarrhea Piglet Prebiotics Probiotics Rotavirus

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7.0 T氢质子磁共振波谱成像在中枢神经系统疾病中的应用进展

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中华放射学杂志 2023年第11期57卷 1254-1258页

作者：李晨曦马笑笑边祥兵娄昕解放军医学院北京100853 解放军总医院第一医学中心放射诊断科北京100853

在中枢神经系统疾病的发生发展过程中,功能代谢改变常早于形态学改变,磁共振波谱(MRS)成像是目前唯一能够无创检测活体组织器官代谢物种类及其含量的影像学手段。相较于3.0 T,7.0 T MRS成像的信噪比和分辨率明显提高,能够更加精准评估... 详细信息

在中枢神经系统疾病的发生发展过程中,功能代谢改变常早于形态学改变,磁共振波谱(MRS)成像是目前唯一能够无创检测活体组织器官代谢物种类及其含量的影像学手段。相较于3.0 T,7.0 T MRS成像的信噪比和分辨率明显提高,能够更加精准评估微量代谢物、降低克拉默-拉奥下限以及分离因化学结构相似而具有重叠共振的物质。该文就7.0 T1H-MRS在脑肿瘤、脱髓鞘、癫痫等中枢神经系统疾病的发病机制、早期诊断、治疗决策及疗效评估中的最新研究进展进行综述,以期为进一步的临床应用提供参考。

关键词：中枢神经系统疾病磁共振波谱成像超高场强

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All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1131-1144页

作者： Junning Pu Daiwen Chen Gang Tian Jun He Ping Zheng Zhiqing Huang xiangbing Mao Jie Yu Yuheng Luo Junqiu Luo Hui Yan Aimin Wu Bing Yu Institute of Animal Nutrition Sichuan Agricultural UniversityChengdu 611130SichuanPeople’s Republic of China Key Laboratory of Animal Disease-Resistance Nutrition Ministry of EducationMinistry of Agriculture and Rural AffairsKey Laboratory of Sichuan Province611130 ChengduSichuanPeople’s Republic of China

Background Transmissible gastroenteritis virus(TGEV)is one of the main pathogens causing severe diarrhea of *** pathogenesis of TGEV is closely related to intestinal ***-trans retinoic acid(ATRA)is the main active metabolite of vitamin A,which has immunomodulatory and anti-inflammatory ***,it is unclear whether ATRA can alleviate TGEV-induced intestinal inflammation and barrier dysfunction in *** study aimed to investigate the effects of ATRA on growth performance,diarrhea,intestinal inflammation and intesti-nal barrier integrity of TGEV-challenged *** In a 19-d study,32 weaned piglets were randomly divided into 4 treatments:Control group(basal diet),TGEV group(basal diet+TGEV challenge),TGEV+ATRA5 group(basal diet+5 mg/d ATRA+TGEV challenge)and TGEV+ATRA15 group(basal diet+15 mg/d ATRA+TGEV challenge).On d 14,piglets were orally administered TGEV or the sterile *** Feeding piglets with 5 and 15 mg/d ATRA alleviated the growth inhibition and diarrhea induced by TGEV(P<0.05).Feeding piglets with 5 and 15 mg/d ATRA also inhibited the increase of serum diamine oxidase(DAO)activ-ity and the decrease of occludin and claudin-1 protein levels in jejunal mucosa induced by TGEV,and maintained intestinal barrier integrity(P<0.05).Meanwhile,5 mg/d ATRA feeding increased the sucrase activity and the expres-sions of nutrient transporter related genes(GLUT2 and SLC7A1)in jejunal mucosa of TGEV-challenged piglets(P<0.05).Furthermore,5 mg/d ATRA feeding attenuated TGEV-induced intestinal inflammatory response by inhibit-ing the release of interleukin(IL)-1β,IL-8 and tumor necrosis factor-α(TNF-α),and promoting the secretion of IL-10 and secretory immunoglobulin A(sIgA)(P<0.05).Feeding 5 mg/d ATRA also down-regulated the expressions of Toll-like receptors and RIG-I like receptors signaling pathway related genes(TLR3,TLR4,RIG-I,MyD88,TRIF and MAVS)and the phosphorylation level of nuclear factor-κB-p65(NF-κB p65),and

关键词： All-trans retinoic acid Inflammation Intestinal barrier Piglets Transmissible gastroenteritis virus

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光氧化还原镍催化的Stille交叉偶联反应

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有机化学 2024年第1期44卷 323-325页

作者：柯月娥齐湘兵北京生命科学研究所北京102206

过渡金属催化的交叉偶联反应是构建C—C键的高效方法,是有机合成中最基础和重要的转化之一.其中,Suzuki-Miyaura偶联、Negishi偶联和Mizoroki-Heck反应在C(sp2)—C(sp2)键的构筑中应用广泛,得到了合成化学家的认可,并因在“Pd催化的交... 详细信息

过渡金属催化的交叉偶联反应是构建C—C键的高效方法,是有机合成中最基础和重要的转化之一.其中,Suzuki-Miyaura偶联、Negishi偶联和Mizoroki-Heck反应在C(sp2)—C(sp2)键的构筑中应用广泛,得到了合成化学家的认可,并因在“Pd催化的交叉偶联反应”中的贡献获得2010年诺贝尔化学奖[1].自Stille偶联反应提出以来[2],众多化学家对反应条件、立体控制以及反应机理进行了深入探索.尽管在过去几十年中取得了显著的进步,但Stille偶联仍然面临一些巨大的挑战:(1)反应主要依赖使用贵金属Pd催化剂,而储量丰富、毒性低的廉价金属Ni等因缓慢的转金属过程限制其应用.(2)开发无添加剂、低毒或无毒的Stille反应对建立更加环保的催化体系至关重要.

关键词：交叉偶联反应 Heck反应诺贝尔化学奖过渡金属催化 Pd催化镍催化立体控制

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连续时间的IS-LM模型可控制性与仿真研究

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运筹与管理 2024年第3期33卷 76-81页

作者：王祥兵怀化学院商学院湖南怀化418000 广州番禺职业技术学院财经学院广东广州511483

在现代经济学的标准假设下,建立连续时间的IS-LM动态模型,分析IS-LM动态模型的系统结构特征,设计连续时间的IS-LM动态模型的控制律,得到控制律的解析解并进行仿真分析。研究表明:连续时间的IS-LM动态模型具有能控性、能达性和完全能观... 详细信息

在现代经济学的标准假设下,建立连续时间的IS-LM动态模型,分析IS-LM动态模型的系统结构特征,设计连续时间的IS-LM动态模型的控制律,得到控制律的解析解并进行仿真分析。研究表明:连续时间的IS-LM动态模型具有能控性、能达性和完全能观性等系统结构特征;连续时间IS-LM动态模型系统可以任意配置其极点,使模型系统渐进稳定,达到输出调节并具有满意的动态性能,即在现代经济学的标准假设下,证实了IS-LM动态模型的可控性。根据模型假设及模型参数的经济意义设计仿真实验,仿真实验结果验证了所设计反馈控制律对连续时间IS-LM动态模型控制的有效性。因而,针对复杂多变的经济形势,科学设计经济政策,能有效实现经济调控的目标。

关键词：连续时间的IS-LM模型反馈控制能控性能达性能观性

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7T磁共振磁敏感加权成像技术在帕金森病中的应用

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中华老年心脑血管病杂志 2023年第2期25卷 122-125页

作者：李凤珠尹西段曹辉王晓玉王淼边祥兵娄昕高中宝王振福解放军总医院第二医学中心神经内科国家老年疾病临床医学研究中心北京100853 解放军总医院第一医学中心放射诊断科

目的通过7 T磁共振磁敏感加权成像技术分析帕金森病(PD)患者黑质铁沉积情况。方法收集2021年12月至2022年8月解放军总医院PD门诊确诊的原发性PD患者18例(PD组),选取同期年龄和性别匹配的健康体检者18例(对照组)。用7 T磁敏感加权成像... 详细信息

目的通过7 T磁共振磁敏感加权成像技术分析帕金森病(PD)患者黑质铁沉积情况。方法收集2021年12月至2022年8月解放军总医院PD门诊确诊的原发性PD患者18例(PD组),选取同期年龄和性别匹配的健康体检者18例(对照组)。用7 T磁敏感加权成像序列扫描获取相位图并测量相位值,分析PD患者Hoehn-Yahr(H-Y)分期、统一帕金森病评定量表(UPDRS)总分和Ⅰ、Ⅱ、Ⅲ评分、39项帕金森病生活质量问卷(PDQ-39)评分等资料。结果与对照组比较,PD组黑质面积较大[(223.03±30.60)mm^(2)vs(202.08±27.47)mm^(2),P0.05)。PD组2、3、5层相位值较对照组明显降低[0.110(-0.009,0.226)vs 0.224(0.126,0.360),-0.022(-0.060,0.026)vs 0.042(-0.028,0.114),-0.112(-0.154,0.036)vs-0.030(-0.088,0.019),P<0.05]。结论 PD患者黑质铁沉积不均匀增加,体积增大,7 T磁敏感加权成像对PD有一定诊断价值。

关键词：磁共振成像帕金森病多巴胺能神经元铁

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