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Acupoint catgut-embedding therapy ameliorates DNCB-induced atopic dermatitis in BALB/c mice by regulating Th2 type immune response and reducing infiltration of CD4^(+)and CD8^(+)cells

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Traditional Medicine Research 2024年第9期9卷 14-20页

作者： Cheng Qin xiang-yi kong Fang Wang Jin Xu Zhuo Zhang Xue-Song Yang Jian-Zhou Ye College of First Clinical Medicine Yunnan University of Traditional Chinese MedicineKunming 650500China Yunnan Key Laboratory of Dai and yi Medicines Yunnan University of Chinese MedicineKunming 650500China Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine Yunnan University of Chinese MedicineKunming 650500China Department of Dermatology The First Affiliated Hospital of Yunnan University of Traditional Chinese MedicineKunming 650021China

Background:This study aimed to assess how acupoint catgut-embedding therapy influences Th2-type immune response and the infiltration of CD4^(+)and CD8^(+)cells in DNCB-induced atopic dermatitis in BALB/c *** also conducted an initial examination of the underlying molecular ***:Seventy-two mice were randomly divided into four groups:normal control,DNCB-induced atopic dermatitis model(AD),AD with acupoint catgut-embedding treatment(ADA),and AD with sham-acupoint catgut-embedding *** DNCB challenge to induce AD,the ADA group received acupoint catgut-embedding therapy treatment at Zusanli(ST 36)and Quchi(LI 11)acupoints every other week from day *** in the AD with sham-acupoint catgut-embedding treatment group underwent the same procedure as the ADA group but without catgut *** was assessed using SCORAD on treatment days 1,10,and *** day 18,nine mice per group were euthanized,and the remaining on day *** changes were observed using hematoxylin-eosin and immunohistochemistry ***-α,IL-4,IL-6,and IL-13 levels were analyzed by ELISA,and GATA3 and STAT6 protein levels by western ***:After 20 days of acupoint catgut-embedding therapy treatment,mice showed reduced dermatitis scores compared to DNCB-induced AD-like *** decreases occurred in serum IL-4,IL-6,IL-13,and TNF-α*** analysis revealed marked reductions in CD4^(+)and CD8^(+)cell infiltration,as well as GATA3 and STAT6 protein ***:Acupoint catgut-embedding therapy may effectively alleviate atopic dermatitis by suppressing Th2 immune responses via the STAT6-GATA3 pathway and reducing CD4^(+)and CD8^(+)T cell infiltration in skin lesions.

关键词： atopic dermatitis acupoint catgut-embedding therapy Th2 type immune response

Plasma miR-216a as a potential marker of pancreatic injury in a rat model of acute pancreatitis

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World Journal of Gastroenterology 2010年第36期16卷 4599-4604页

作者： xiang-Yu kong,yi-Qi Du,Lei Li,Xiao-Hua Man,Yan-Fang Gong,Li-Ning Xiao,Yong-Zhi Zheng,Shang-Xin Deng,Jun-Jun Gu,Zhao-Shen Li,Department of Gastroenterology,Changhai Hospital,Second Military Medical University,Shang-hai 200433,China Jian-Qiang Liu,Department of Gastroenterology,Fuzhou General Hospital of Nanjing Military Command,Fuzhou 350025,Fujian Province,China Guo-Kun Wang,Jia-Qi Zhu,Department of Cardiology,Changhai Hospital,Second Military Medical University,Shang-hai 200433,China Department of Gastroenterology Changhai Hospital Second Military Medical University 168 Changhai Road Shanghai 200433 China. zhaoshenli.smmu.edu@***

AIM:To study the potential value and specificity of plasma miR-216a as a marker for pancreatic ***:Two rat models were applied in this article:L-arginine-induced acute pancreatitis was used as one model to explore the potential value of plasma miR-216a for detection of pancreatic injury;nonlethal sepsis induced in rats by single puncture cecal ligation and puncture(CLP)was used as the other model to evaluate the specificity of plasma miR-216a compared with twocommonly used markers(amylase and lipase)for acute *** were sampled from rats at indicated time points and total RNA was ***-Time Quantitative reverse transcriptase-polymerase chain reaction was used to quantify miR-216a in ***:In the acute pancreatitis model,among five time points at which plasmas were sampled,miR-216a concentrations were significantly elevated 24 h after arginine administration and remained significantly increased until 48 h after operation(compared with 0 h time point,P<0.01,Kruskal-Wallis Test).In the CLP model,plasma amylase and lipase,two commonly used biomarkers for acute pancreatitis,were significantly elevated 24 h after operation(compared with 0 h time point,P<0.01 and 0.05 respectively,Pairwise Bonferroni corrected ttests),while miR-216a remained undetectable among four tested time ***:Our article showed for the first time that plasma miR-216a might serve as a candidate marker of pancreatic injury with novel specificity.

关键词： MiR-216a Plasma miRNA Pancreatic injury Acute pancreatitis Biomarker

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金华北山阔叶林大型土壤动物群落的初步研究

土壤 2005年第5期37卷 545-550页

作者：郑祥鲍毅新孔军苗葛宝明浙江师范大学化学与生命科学学院浙江金华321004

2003年10～11月,对金华北山落叶阔叶林和常绿阔叶林大型土壤动物进行了调查,共获得大型土壤动物1445只,隶属3门,7纲,18目.其中近孔寡毛目(线蚓科)、鞘翅目为优势类群,正蚓目、弹尾目、膜翅目、双翅目、蜘蛛目、蜱螨目为常见类群.通过对... 详细信息

2003年10～11月,对金华北山落叶阔叶林和常绿阔叶林大型土壤动物进行了调查,共获得大型土壤动物1445只,隶属3门,7纲,18目.其中近孔寡毛目(线蚓科)、鞘翅目为优势类群,正蚓目、弹尾目、膜翅目、双翅目、蜘蛛目、蜱螨目为常见类群.通过对两个样地大型土壤动物的对比分析,落叶阔叶林和常绿阔叶林的大型土壤动物优势类群、常见类群组成成分及类群数基本相同,群落多样性和均匀性指数差异不大.在垂直分布上,两者的变化基本一致,类群数和个体数量随土层的加深呈递减趋势,且表聚现象明显.土壤养分和pH值与大型土壤动物群落组成和结构密切相关.

关键词：阔叶林大型土壤动物群落结构

Neuropeptide S promotes active waking through activation of histaminergic and orexinergic neurons

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Neuropeptide S promotes active waking through activation of ...

circT P63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Peng ZHAO,Yu-Feng SHAO,Min ZHANG,Kun FAN,xiang-Pan kong,yi-Ping HOU~* Department of Neuroscience,Anatomy,Histology and Embryology,Key Laboratory of Preclinical Study for New Drugs of Gansu Province,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China

＜正＞Objective The effect of neuropeptide S（NPS） on characteristics and mechanisms in the regulation of sleep-waking cycle are unclear,though the initial findings that NPS promotes arousal associated to locomotor activity and a genuine anxiolytic-like action have recently been *** hypothesized that NPS activated posterior hypothalamic arousal systems involved histaminergic（HAergic） neurons in tuberomammilary nucleus（TMN） and orexinergic（OXergic） neurons in perifornical（PeF） and lateral hypothalamic（LH） area,where NPSR mRNA has been reported to be highly expressed,to regulate sleep-wakefulness *** present studies were designed to provide more information regarding the NPS-induced sleep-waking characteristics and potential targets in posterior hypothalamus by analyzing each state across sleep-waking cycle,especially focusing on active waking（aW） and quiet waking（qW） states since the rather unique behavioral profile challenges the common idea that anxiolytics are also sedative or that stimulants are also anxiogenic,during the 24 h period after a range dose of NPS intracerebroventricular （ICV） injection and by observing earlier genes c-fos *** Four stainless-steel screws as electroencephalogram（EEG） electrodes were screwed into the animals skull and three silver wire as electromyogram （EMG） electrodes were inserted into the dorsal cervical neck muscles to monitor the sleep-wake cycle,and the EEG and EMG signals were amplified and digitalized with a resolution of 256 and 128 Hz respectively using a CED 1401 MKⅡ.After sleep-waking recording,c-fos immunereactive（Fos-IR）,histidine decarboxylase（HDC）-IR,orexin-A （OX-A）-IR,and dual labeling of Fos-IR+HDC-IR and Fos-IR+OX-A-IR neurons were respectively labeled to identify the active sites in the brain for the NPS effects on *** The sleep-wake profile after an ICV injection of NPS at 10:00 h was examined,when rats with saline injection spend most of their time in *** given at 0.1 a

关键词： neuropeptide S sleep-wake states EEG power spectra immunohistochemistry histamine orexin

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Science China Life Sciences 2025年

作者： Dan Wang Sicheng Zuo Junshang Ge Hongke Qu Jie Wu Na yi Lei Shi Yumin Wang Yongzhen Mo Chunmei Fan yi He Pan Chen Ming Zhou Bo xiang Wei Xiong Wenjia Guo Zhaoyang Zeng Can Guo NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education Cancer Research Institute and School of Basic Medicine Sciences Central South University Furong Laboratory Cancer Research Institute Affiliated Cancer Hospital of Xinjiang Medical University Xinjiang Key Laboratory of Translational Biomedical Engineering

Circular RNAs(circRNAs) play pivotal roles in the development and progression of various diseases, including malignant tumors. However,the biological functions and the underlying mechanisms of many circRNAs remain elusive. In this study, we identified a novel circRNA,circTP63-N, generated through the splicing of exons 2–4 of the TP63 gene in nasopharyngeal carcinoma(NPC). circTP63-N was found to be downregulated in clinical samples of NPC. Both in vitro and in vivo experiments unequivocally demonstrated that circTP63-N inhibits the proliferation and metastasis of NPC cells. Further investigations revealed that circTP63-N interacted with the HSP90AB1 protein, leading to the recruitment of LATS/YAP1 proteins. This, in turn, induced phosphorylation and ubiquitination-dependent degradation of YAP1, resulting in reduced nuclear translocation of YAP1 and inhibition of the transcriptional activation of downstream oncogenic genes, including INHBA, MMP3, and CCNE2. Our findings highlight the identification of circTP63-N, a novel circRNA encoded by an important tumor-relevant gene TP63 and elucidate its molecular mechanism as a tumor suppressor in NPC. These insights offer novel potential molecular markers and therapeutic targets for the clinical diagnosis and treatment of NPC.

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Gut microbiota in cancer initiation,development and therapy

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Science China Life Sciences 2025年

作者： Ruyi Zhang xiang Zhang Harry Cheuk Hay Lau Jun Yu Institute of Digestive Disease and Department of Medicine and Therapeutics State Key Laboratory of Digestive DiseaseLi Ka Shing Institute of Health SciencesCUHK Shenzhen Research InstituteThe Chinese University of Hong Kong

Cancer has long been associated with genetic and environmental factors,but recent studies reveal the important role of gut microbiota in its initiation and *** 13%of cancers are linked to infectious agents,highlighting the need to identify the specific microorganisms *** microbiota can either promote or inhibit cancer growth by influencing oncogenic signaling pathways and altering immune *** can lead to cancer,while certain probiotics and their metabolites may help reestablish microecological balance and improve anti-tumor immune *** into targeted approaches that enhance therapy with probiotics is ***,the effects of probiotics in humans are complex and not yet fully ***,methods to counteract harmful bacteria are still in *** clinical trials also indicate that modifying gut microbiota may help manage side effects of cancer *** research is crucial to understand better how gut microbiota can be used to improve cancer prevention and treatment outcomes.

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Removal of virus aerosols by the combination of filtration and UV-c irradiation

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Frontiers of Environmental Science & Engineering 2023年第3期17卷 1-9页

作者： Min Shang Yadong kong Zhijuan Yang Rong Cheng xiang Zheng yi Liu Tongping Chen School of Environment and Natural Resources Renmin University of ChinaBeijing 100872China Sichuan Solid Waste and Chemicals Management Center Chengdu 610031China Biogas Institute of Ministry of Agriculture and Rural Affairs Chengdu 610041China

The COVID-19 pandemic remains ever prevalent and afflicting—partially because one of its transmission pathways is *** the widely used central air conditioning systems worldwide,indoor virus aerosols can rapidly migrate,thus resulting in rapid infection *** is therefore important to install microbial aerosol treatment units in the air conditioning systems,and we herein investigated the possibility of combining such filtration with UV irradiation to address virus *** showed that the removal efficiency of filtration towards f2 and MS2 phages depended on the type of commercial filter material and the filtration speed,with an optimal velocity of 5 cm/s for virus ***,it was found that UV irradiation had a significant effect on inactivating viruses enriched on the surfaces of filter materials;MS2 phages had greater resistance to UV-C irradiation than f2 *** optimal inactivation time for UV-C irradiation was 30 min,with higher irradiation times presenting no substantial increase in inactivation ***,excessive virus enrichment on the filters decreased the inactivation *** inactivation is therefore *** general,the combined system involving filtration with UV-C irradiation demonstrated a significant removal effect on virus ***,the system is simple and economical,making it convenient for widespread implementation in air-conditioning systems.

关键词： Filtration system UV-C irradiation Virus aerosol Public health COVID-19

Investigation of L/D-threonine substituted L-serine octamer ions by mass spectrometry and infrared photodissociation spectroscopy

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Chinese Chemical Letters 2017年第3期28卷 537-540页

作者： Juan Ren yi-Yun Wang Ru-Xia Fenga xiang-Lei kong The State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 China Collaborative Innovation Center of Chemical Science and Engineering Nankai University Tianjin 300071 China

Threonine-substituted serine octamer ions were generated by electrospray ionization（ESI） and investigated by mass spectrometry and infrared photodissociation（IRPD） spectroscopy. IRPD spectra of[L-Ser_7＋ L/D-Thr_1]H~＋and [L-Ser_6＋ L/D-Thr_2]H~＋were obtained in the range of 2700–3600 cm^（-1）. Chiral differentiation was achieved by comparing their IRPD spectra. The main difference located in the range of 3300–3500 cm^（-1）. And the results indicate the substitution of L-Ser by D-Thr could weaken the intermolecular H-bonds and loosen the original structures of serine octamers.

关键词： IRPD spectroscopy Threonine Serine octamer Chiral differentiation Mass spectrometry

Superconductivity in electron-doped arsenene

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Chinese Physics B 2018年第4期27卷 127-133页

作者： Xin kong Miao Gao Xun-Wang Yan Zhong-yi Lu Tao xiang Institute of Physics Chinese Academy of Sciences Beijing 100190 China Department of Microelectronics Science and Engineering Faculty of Science Ningbo University Ningbo 315211 China College of Physics and Engineering Qufu Normal University Qufu 273165 China Department of Physics Renmin University of China Beijing 100872 China Collaborative lnnovation Center of Quantum Matter Beijing 100190 China

Based on the first-principles density functional theory electronic structure calculation,we investigate the possible phonon-mediated superconductivity in arsenene,a two-dimensional buckled arsenic atomic sheet,under electron *** find that the strong superconducting pairing interaction results mainly from the pz-like electrons of arsenic atoms and the A1 phonon mode around the K point,and the superconducting transition temperature can be as high as 30.8 K in the arsenene with 0.2 doped electrons per unit cell and 12%-applied biaxial tensile *** transition temperature is about ten times higher than that in the bulk arsenic under high *** is also the highest transition temperature that is predicted for electron-doped two-dimensional elemental superconductors,including graphene,silicene,phosphorene,and borophene.

关键词： arsenene phonon-mediated superconductivity first-principles calculation maximally localized Wannier functions