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An overview of studies on psychological well-being in children born following assisted reproductive technologies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第11期14卷 947-960页

作者： Qi-tao ZHAN Pei-pei PAN xiang-rong xu Hang-ying LOU Yi-yun LOU Fan JIN Department of Reproductive Endocrinology Women's HospitalSchool of MedicineZhejiang University

Over the course of the past 35 years,assisted reproductive technologies(ARTs)have been increasingly used worldwide,while debates on their safety have been *** defects and imprinting disorders were reported in previous ***,the psychological development of children born following ARTs has become a major concern *** review gives a systematic view of psychological well-being of children conceived by different types of ART,including in vitro fertilization,intracytoplasmic sperm injection(ICSI),preimplantation genetic diagnosis/screening,and in vitro *** previous studies are analyzed in three sections:(1)cognitive,motor,and language developments,(2)behavior problems and socio-emotional development,and(3)parent-child *** conclude that although the majority of the studies on cognitive,motor,and language developments reported comparable achievements in the ART group *** naturally conceived group,lower intelligence quotient(IQ)scores,worse visual-motor ability or locomotor development,and delayed receptive language competence were found in the ART *** results on the socio-emotional development were *** for the behavior problems,a higher prevalence of behavior problems existed in ART children;moreover,ICSI children were found to be at a higher risk of autism than the general ***,ART parents tended to have positive parental attitudes and be more protective of their *** suggestions for further research are also given in this review.

关键词： Assisted reproductive technologies, Psychological well-being, Behavior problems, Parent-child relationship

Intraperitoneal hyaline vascular Castleman disease: Three case reports

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World Journal of Clinical Cases 2023年第36期11卷 8527-8534页

作者： Jia-Wei Gao Zhe-Yi Shi Zhao-Bi Zhu xiang-rong xu Wei Chen Department of General Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215004Jiangsu ProvinceChina Department of General Surgery Kunshan Hospital Affiliated to Jiangsu UniversitySuzhou 215300Jiangsu ProvinceChina

BACKGROUND Castleman disease(CD)was first reported in *** is a rare non-malignant lymphoproliferative disease with unclear *** the clinical manifestations of CD are different,there are difficulties in its diagnosis and ***,for patients with CD,it is important to establish the diagnosis in order to choose the appropriate *** SUMMARY In this report,three patients with intraperitoneal CD treated at our center from January 2018 to June 2023 were reviewed,and the clinical and paraclinical exa-minations,diagnosis,and treatment were analyzed,and all three patients were diagnosed with CD by routine histopathological and immunohistochemical *** CD is a complex and rare *** there are no special clinical symptoms and laboratory abnormalities,the diagnosis often depends on routine pathological and immunohistochemical findings.

关键词： Castleman disease Intraperitoneal mass Lymph node Case report

Normal epigenetic inheritance in mice conceived by in vitro fertilization and embryo transfer

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 796-804页

作者： Lei LI Fang LE Li-ya WANG xiang-rong xu Hang-ying LOU Ying-ming ZHENG Jiang-zhong SHENG He-feng HUANG Fan JIN Centre of Reproductive Medicine Women＇s Hospital School of Medicine Zhejiang University Hangzhou 310006 China Department of Gynecologic Oncology Henan Cancer Hospital Zhengzhou 450003 China Department of Cell Biology School of Medicine Zhejiang University Hangzhou 310006 China

An association between assisted reproductive technology （ART） and neurobehavioral imprinting disorders has been reported in many studies, and it seems that ART may interfere with imprint reprogramming. However, it has never been explored whether epigenetic erros or imprinting disease susceptibility induced by ART can be inherited transgenerationally. Hence, the aim of this study was to determine the effect of in vitro fertilization and embryo transfer （IVF-ET） on transgenerational inheritance in am inbred mouse model. Mice derived from IVF-ET were outcrossed to wild-type C57BL/6J to obtain their female and male line F2 and F3 generations. Their behavior, morphology, histology, and DNA methylation status at several important differentially methylated regions （DMRs） were analyzed by Morris water maze, hematoxylin and eosin （H＆E） staining, and bisulfite genomic sequencing. No significant differences in spatial learning or phenotypic abnormality were found in adults derived from IVF （F1） and female and male line F2 and F3 generations. A borderline trend of hypomethylation was found in H19 DMR CpG island 3 in the female line-derived F3 generation （0.40±0.118, P=0.086）. Methylation status in H19/Igf2 DMR island 1, Igf2 DMR, KvDMR, and Snrpn DMR displayed normal patterns. Methylation percentage did not differ significantly from that of adults conceived naturally, and the expression of the genes they regulated was not disturbed. Transgenerational integrity, such as behavior, morphology, histology, and DNA methylation status, was maintained in these generations, which indicates that exposure of female germ cells to hormonel stimulation and gamete manipulation might not affect the individuals and their descendents.

关键词： Differentially methylated regions (DMRs), In vitro fertilization and embryo transfer (IVF-ET), Centralnervous system (CNS), Neurobe havioral imprinting disorders, Transgenerational epigenetic inheritance

Depression and anxiety,peripheral blood inflammatory factors,and stress levels on therapeutic outcomes in patients with chronic wounds

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World Journal of Psychiatry 2024年第12期14卷 1836-1844页

作者： Bo Li Cha Li Xian-Jiang Zhong xiang-rong xu Department of Burns and Plastic Surgery Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Pediatric Intensive Care Unit Changde HospitalXiangya School of MedicineCentral South University(The First People’s Hospital of Changde City)Changde 415000Hunan ProvinceChina Department of Psychiatry The First People’s Hospital of XiantaoXiantao 433099Hubei ProvinceChina

BACKGROUND The incidence of chronic wounds is rising due to an aging population and lifestyle changes in our *** addition,as the disease spectrum evolves,chronic wounds have become common clinical issues that seriously threaten health and impose significant social and economic *** To investigate how depression,anxiety,peripheral blood inflammatory factors,and stress levels affect therapeutic outcomes in patients with chronic *** Retrospectively collected clinical data from 110 patients with chronic wounds treated at Changde Hospital,xiangya School of Medicine,Central South University(The First People’s Hospital of Changde City)between January 2021 and December 2023,categorizing them into effective and ineffective groups based on treatment *** between both groups were analyzed using univariate analysis,independent risk factors identified via logistic regression,and their predictive value assessed through receiver operating characteristic *** Following treatment,95 cases were classified as the effective group(cured or improved),while 15 cases with improvement formed the ineffective *** differences between both groups were noted in wound area,infection status,daily bed time,Hamilton Anxiety Rating Scale(HAMA)scores,Hamilton Depression Rating Scale(HAMD)scores,and levels of interleukin-6,tumor necrosis factor-alpha,and superoxide dismutase(P<0.05).Logistic regression analysis identified a wound area≥7 cm^(2),HAMA≥9 scores,and HAMD≥8 scores were independent risk factors for ineffective treatment in patients with chronic wounds(P<0.05).The receiver operating characteristic curve analysis revealed that the area under the curve for ineffective treatment based on wound area,HAMA,and HAMD was 0.767,0.805,and 0.768 *** Wound size,anxiety,and depression are significant factors influencing the therapeutic outcomes in patients with chronic wounds that require careful attention,alongside the d

关键词： Chronic wound Depression Anxiety Inflammatory factors Stress level Clinical effect

Persistence and intergenerational transmission of differentially expressed genes in the testes of intracytoplasmic sperm injection conceived mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第5期14卷 372-381页

作者： Li-ya WANG Ning WANG Fang LE Lei LI Le-jun LI Xiao-zhen LIU Ying-ming ZHENG Hang-ying LOU xiang-rong xu Xiao-ming ZHU Yi-min ZHU He-feng HUANG Fan JIN Key Laboratory of Reproductive Genetics (Zhejiang) Ministry of Educationand Centre of Reproductive Medicine Women's HospitalSchool of MedicineZhejiang University Department of Gynecologic Oncology Henan Cancer Hospital

Intracytoplasmic sperm injection (ICSI) is commonly used to solve male infertility problems. Previous studies showed that early environmental exposure of an embryo may influence postnatal development. To detect whether ICSI operations affect the reproductive health of a male or his offspring, we established assisted reproductive technologies (ART) conceived mouse models, and analyzed gene expression profiles in the testes of both ICSI and naturally conceived (NC) newborn F1 mice using micro-array analysis. Among the differentially expressed genes, we focused on the expression of eight male reproduction-related genes. Quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) was used to analyze the expression of these genes in the testes of both adult and old F1 generation mice and adult F2 generation mice. Our results showed that down-regulated and somatic cell-expressed genes in newborn mice retained their differential expression patterns in adult and old F1 generation individuals, implying the persistence and fetal origin of the alteration in the expression of these genes. The intergenerational transmission of differential gene expression was observed, but most changes tended to be reduced in adult F2 generations. Controlled ovarian hyperstimulation (COH) and in vitro fertilization (IVF) mice models were added to explore the precise factors contributing to the differences in ICSI offspring. The data demonstrated that superovulation, in vitro culture, and mechanical stimulation involved in ICSI had a cumulative effect on the differential expression of these male reproductive genes.

关键词： Intracytoplasmic sperm injection Testis Intergenerational transmission

Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun xu Desmond Loke Bin Yu Yishu Zhang rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

Six patients with X;7 translocation in a three-generation family discovered through an infertile azoospermic man

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Six patients with X;7 translocation in a three-generation fa...

Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

2013浙江省医学遗传学学术年会

作者： Yu-Qin Luo Chen-Ming xu Hai-Yan Shi Hong-Ge Li Department of Reproductive Genetics,Women’s Hospital,Zhejiang University School of Medicine Song-Chang Chen xiang-rong xu Fan Jin Department of Reproductive Genetics Women’s HospitalZhejiang University School of Medicine Department of clinical labrotory Women’s HospitalZhejiang University School of Medicine

Objective:To characterize X;7 translocation found in an infertile azoospermic man and five other familial carriers. Design:Case report. Setting:Reproductive research center in a university-affiliated hospital. Patient(s):Infertile man with azoospermia and his family Intervention(S):Peripheral blood lymphocytes were obtained for karyotyping,and metaphases were studied by fluorescence in situ hybridization procedure. Main Outcome Measure(s):Seminal analysis,GBG banding,FISH procedure,and pathologic analysis of testis were performed. ReSUlt(s):The semen analysis revealed *** lymphocytic karyotype showed a man with X-autosome *** examination of the testis sample showed maturation arrest. Conclusion(s):We report the first case of X/autosome translocation in six familial *** addition, this is the only one that presented with azoospermia and having offspring in men with the same X-autosome *** translocation may be a direct genetic risk factor for infertility.

关键词： Infertility translocation maturation arrest azoospermia

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting xiang xiangxin Xing xuyun Hua Yuwen Zhang Xin xue Jiajia Wu Mouxiong Zheng He Wang Jianguang xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity