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浅议制度安排:是和谐社会构建的理性必然

兰州交通大学学报 2011年第2期30卷 17-19页

作者：向文梅青海省乌兰县委党校青海乌兰817100

为了寻求社会的和谐协调发展,保证中国特色社会主义事业健康可持续发展,必须努力寻找社会运动内在的客观规律,充分注意考虑运用制度安排所能起的稳定性、长期性、和根本性作用,同时发挥人的主观能动性,以真正实现社会主义物质文明、政... 详细信息

为了寻求社会的和谐协调发展,保证中国特色社会主义事业健康可持续发展,必须努力寻找社会运动内在的客观规律,充分注意考虑运用制度安排所能起的稳定性、长期性、和根本性作用,同时发挥人的主观能动性,以真正实现社会主义物质文明、政治文明、精神文明的协调全面发展。

关键词：制度安排和谐社会理性

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毛泽东宗教观探析

青海师范大学学报（哲学社会科学版） 2011年第1期33卷 40-43页

作者：向文梅青海省乌兰县委党校青海乌兰817100

本文将毛泽东的宗教观概括为少年时代的佛教信仰、世界观转变时期的宗教理解以及革命和建设年代的宗教政策与理论探索三个阶段加以阐述,力求准确展现毛泽东研究、把握宗教问题的思想历程,为尽可能全面地理解伟人的精神世界提供新的视角。

关键词：毛泽东宗教观佛教

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Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期68卷 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang Xia Ning Xu wen Sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

关键词： NIR fluorescent probe ER viscosity hepatic fibrosis gender difference estrogen

艺术类专业实践性课程融入思政元素的方法研究——以《景观设计实务》课程思政为例

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张家口职业技术学院学报 2020年第2期33卷 40-42页

作者：项文梅无锡商业职业技术学院艺术设计学院江苏无锡214153

就艺术类实践性课程实施课程思政的方法进行研究,从艺术类课程特点入手,以《景观设计实务》课程为例,从学校管理层面出发,依托景观设计项目模拟,探讨艺术类专业实践性课程融入思政元素方法,为高校实施课程思政提供理论引领和实践推广经验。

关键词：艺术类专业实践性课程思政元素

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Methylation-independent ITGA2 overexpression is associated with poor prognosis in de novo acute myeloid leukemia

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Methylation-independent ITGA2 overexpression is associated w...

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Xin-yue Lian Wei Zhang De-hong Wu Ji-chun Ma Jing-dong Zhou Zhi-hui Zhang xiang-mei wen Zi-jun Xu Jiang Lin Jun Qian Department of Hematology Affiliated People's Hospital of Jiangsu University The Key Lab of Precision Diagnosis and Treatment of Zhenjiang City Laboratory Center Affiliated People's Hospital of Jiangsu University

Background: Previous studies have been indicated that Integrin alpha2(ITGA2) maybe important in cell migration, invasion, survival and angiogenesis. However, the correlation between ITGA2 expression and acute myeloid leukemia(AML) is still unclear. Methods: Real-time quantiative PCR(RQ-PCR) was carried out to analyze ITGA2 m RNA level. Methylation-specific PCR(MSP) and bisulfite sequencing PCR(BSP) were performed to detect the methylation of ITGA2 promoter. Results: ITGA2 expression was significantly upregulated in 134 de novo AML patients compared to 33 controls(P=0.007). There were no significant differences in sex, hemoglobin, white blood cells(WBC), platelet count, percentage of marrow blasts, karyotypes and eight gene mutations between ITGA2 highexpressed(ITGA2 high) and ITGA2 low-expressed(ITGA2 low) patients(P>0.05). However, the median age in ITGA2 high cohort was significantly higher than that in ITGA2 low cohort(P<0.001). ITGA2 high group had markedly lower complete remission(CR) rate than ITGA2 low group(P=0.011). Furthermore, the overall survival(OS) in ITGA2 high patients was significantly shorter than ITGA2 low patients throughout AML cohort, non-acute promyelocytic leukemia(APL) and cytogenetic normal(CN) AML(P=0.001, P=0.002, and P=0.044, respectively). Multivariate analysis confirmed that ITGA2 overexpression served as an independent prognostic factor in both whole-cohort AML patients(P = 0.018) and non-APL AML patients(P = 0.021). Besides, ITGA2 expresssion level was significantly decreased in AML patients after CR(P=0.014). Moreover, unmethylated ITGA2 promoter was identified in normal controls, leukemic cell lines and primary leukemic cells with low or high ITGA2 expression. Conclusions: Methylation-independent ITGA2 overexpression is associated with poor prognosis in AML.

关键词： acute myeloid leukemia ITGA2 expression methylation prognosis

Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies

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Epigenetic dysregulation of ID4 predicts disease progression...

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Jing-dong Zhou Ting-juan Zhang Xi-xi Li Ji-chun Ma Hong Guo xiang-mei wen Wei Zhang Lei Yang Yang Yan Jiang Lin Jun Qian Department of Hematology Affiliated People's Hospital of Jiangsu University School of Medicine Jiangsu University Laboratory Center Affiliated People's Hospital of Jiangsu University

Background: Promoter hypermethylation-mediated inactivation of ID4 plays a crucial role in the development of solid tumors. The current study aimed to investigate ID4 methylation and its clinical relevance in myeloid malignancies. Results: ID4 hypermethylation was associated with higher IPSS scores, but was not an independent prognostic biomarker affecting overall survival(OS) in myelodysplastic syndrome(MDS). However, ID4 hypermethylation correlated with shorter OS and leukemia-free survival(LFS) time, and acted as an independent risk factor affecting OS in acute myeloid leukemia(AML). Moreover, ID4 methylation was significantly decreased in the follow-up paired AML patients who achieved complete remission(CR) after induction therapy. Importantly, ID4 methylation was increased during MDS progression to AML and chronic phase(CP) progression to blast crisis(BC) in chronic myeloid leukemia(CML). Epigenetic studies showed that ID4 methylation might be one of the mechanisms silencing ID4 expression in myeloid leukemia. Functional studies in vitro showed that restoration of ID4 expression could inhibit cell proliferation and promote apoptosis in both K562 and HL60 ***: These findings indicate that ID4 acts as a tumor suppressor in myeloid malignancies, and ID4 methylation is a potential biomarker in predicting disease progression and treatment outcome.

关键词： ID4 methylation progression prognosis myeloid malignancies

High bone marrow ID2 expression predicts poor chemotherapy response and prognosis in acute myeloid leukemia

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High bone marrow ID2 expression predicts poor chemotherapy r...

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Jing-dong Zhou Ji-chun Ma Ting-juan Zhang Xi-xi Li Wei Zhang De-hong Wu xiang-mei wen Zi-jun Xu Jiang Lin Jun Qian Department of Hematology Affiliated People's Hospital of Jiangsu University The Key Lab of Precision Diagnosis and Treatment of Zhenjiang City Laboratory Center Affiliated People's Hospital of Jiangsu University Department of Hematology The Third People's Hospital of KunShan CitySuzhou

Background: Dysregulation of ID proteins is a frequent event in various human cancers and has a direct role in cancer initiation, maintenance, progression and drug resistance. Our previous study has revealed ID1 expression and its prognostic value in acute myeloid leukemia(AML). Herein, we further reported ID2 expression and its clinical significance in AML. Methods: Real-time quantitative PCR was performed to detect ID2 transcript level in bone marrow mononuclear cells of 145 de novo AML patients. ID2 expression was significantly up-regulated in AML patients compared with controls. Results: ID2 overexpression occurred with the highest frequency in poor karyotype(10/17, 59%), lower in intermediate karyotype(35/83, 42%), and the lowest in favorable karyotype(7/40, 18%). Moreover, high ID2 expression correlated with lower complete remission(CR) rate, shorter overall survival, and acted as an independent prognostic biomarker in whole-cohort AML and non-M3-AML patients. Importantly, the prognostic value of ID2 expression in AML was validated by The Cancer Genome Atlas(TCGA) data. In the follow-up of patients, ID2 expression at CR phase was decreased than at the time of diagnosis, and was increased again at the time of relapse. Conclusions: These findings demonstrated that bone marrow ID2 overexpression was a frequent event in AML patients, and predicts poor chemotherapy response and prognosis.

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Hypomethylation-mediated H19 overexpression increases the risk of disease evolution through the association with BCRABL transcript in chronic myeloid leukemia

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Hypomethylation-mediated H19 overexpression increases the ri...

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青年科学家论坛

作者： Jing-dong Zhou Jiang Lin Ting-juan Zhang Ji-chun Ma Xi-xi Li xiang-mei wen Hong Guo Zi-jun Xu Zhao-qun Deng Wei Zhang Jun Qian Department of Hematology Affiliated People's Hospital of Jiangsu University The Key Lab of Precision Diagnosis and Treatment of Zhenjiang City Laboratory Center Affiliated People's Hospital of Jiangsu University

Backgroud: Previous study has revealed that H19 expression is required for efficient tumor growth induced by BCR-ABL in chronic myeloid leukemia (CML). Herein, we further determined H19 expression and its clinical implication in patients with CML. Methods: H19 expression and methylation were detected by real-time quantitative PCR and real-time quantitative methylation-specific PCR, and then clinical implication of H19 expression was further analyzed.

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-Min Lin Mai xiang wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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