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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang Hui-Na Liu yu-Fan yang Zhi-Cheng Zhang Qi Dai Xiao-yan Bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Morphology engineering of ZnO micro/nanostructures under mild conditions for optoelectronic application

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 498-503页

作者： Liang Chu Haoyu Shen Hudie Wei Hongyu Chen Guoqiang Ma Wensheng yan Institute of Carbon Neutrality and New Energy&School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China School of Applied Physics and Materials Wuyi UniversityJiangmen 529020China

Zinc oxide(ZnO)serves as a crucial functional semiconductor with a wide direct bandgap of approximately 3.37 *** reaction is commonly used in the synthesis of ZnO micro/nanostructures,given its low cost,simplicity,and easy ***,ZnO morphology engineering has become desirable through the alteration of minor conditions in the reaction process,particularly at room *** this work,ZnO micro/nanostructures were synthesized in a solution by varying the amounts of the ammonia added at low temperatures(including room temperature).The formation of Zn^(2+)complexes by ammonia in the precursor regulated the reaction rate of the morphology engineering of ZnO,which resulted in various structures,such as nanoparticles,nanosheets,microflowers,and single ***,the obtained ZnO was used in the optoelectronic application of ultraviolet detectors.

关键词： morphology engineering low temperature ZnO nanosheets microflowers ultraviolet detector

Relationship Between Microstructures and Microhardness in High-Speed Friction Stir Welding of AA6005A-T6 Aluminum Hollow Extrusions

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Acta Metallurgica Sinica(English Letters) 2020年第1期33卷 115-126页

作者： xiang-Qian Liu Hui-Jie Liu yan yu Luoyang Ship Material Research Institute Luoyang 471023China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China

AA6005 A-T6 aluminum hollow extrusions were friction stir welded at a fixed high welding speed of 2000 mm/min and various rotation *** results showed that the heat-aff ected zone(HAZ)retained the similar grain structure as the base material except some grain coarsening,and the density of dislocations andβ′precipitates were almost unchanged,indicating that the high welding speed inhibited the coarsening and dissolution ofβ″precipitates via fast cooling *** thermo-mechanically aff ected zone(TMAZ)was characterized by elongated and rotated grains,in which a low density ofβ′precipitates and the highest density of dislocations were *** highest heat input and severest plastic deformation occurring in the nugget zone(NZ)resulted in the occurrence of dynamic recrystallization and a high density of ***,all theβ″precipitates and most of theβ′precipitates dissolved into the matrix,and a fewβ′precipitates were transformed intoβ*** microhardness was controlled by the precipitation and solution strengthening in the HAZ,by the dislocation and precipitation strengthening in the TMAZ,and by the fine-grain and dislocation strengthening in the *** the increase in rotation speed,the peak and the lowest microhardness value increased monotonously.

关键词： Aluminum hollow extrusions High-speed friction stir welding Grain structure Dislocation and precipitates Microhardness distribution

Advances in ethnopharmacology,phytochemistry and pharmacology of Erigerontis Herba and its Chinese medicine prescriptions

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Traditional Medicine Research 2025年第1期10卷 44-61页

作者： yang Zhou yuan-yan Huang Ding-yue Shang Ying Chen Meng Tian Cheng-yu Jin Xin Lu Bing-Chun yan Han-Qing Pang Institute of Translational Medicine School of MedicineYangzhou UniversityYangzhou 225009China Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases Yangzhou UniversityYangzhou 225009China School of Medicine Nanjing University of Chinese MedicineNanjing 210023China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal UniversityGuiling 541004China.

Erigerontis Herba(EH),the dried whole plant of Erigeron breviscapus,is well-known for circulating blood,activating meridians to alleviate pain,expelling wind,and clearing away *** has been extensively utilized in southern China for the treatment of stroke hemiplegia,chest stuffiness and pains,rheumatic arthralgia,headache,and *** review focuses on the botany,ethnopharmacology,phytochemistry,pharmacology and toxicity of EH and its related prescriptions to offer new insights for prospective research of *** information about EH was retrieved from ancient records and books,PubMed,China National Knowledge Infrastructure,Chinese Pharmacopoeia,Web of Science,Doctoral and Master’s Theses,and various electronic *** is a member of Compositae family and is mainly grown in southern *** Chinese medicine records that EH has the effects of circulating blood and removing blood stasis,expelling wind,and removing cold,as well as relieving rigidity of muscle and relieving *** now,nearly 200 ingredients have been characterized from EH,including flavonoids,caffeoyls,aromatic acids,coumarins,pentacyclic terpenoids,volatile oil and other *** extracts,EH related prescriptions(Dengzhan Xixin injection,Dengzhan Shengmai capsules,etc.)or compounds(scutellarin,scutellarein,etc.)possessed obvious therapeutic effects of ischemic stroke,cerebral hemorrhage,myocardial infarction,Alzheimer’s disease,diabetes and its complications,gastric cancer,bone,and joint degenerative ***,the major active compound of EH,has been used as a quality *** no obvious toxicity of EH has been *** to its traditional applications,ethnopharmacology,phytochemistry,pharmacology,and toxicity,EH was applied as a valuable herb for clinical application in food and medicine *** several compounds have been shown to possess diverse biological activities,the underlying mechanisms of their actions remain *** fully exploi

关键词： Erigeron breviscapus traditional applications ethnopharmacology phytochemistry pharmacology

Exploiting comments information to improve legal public opinion news abstractive summarization

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Frontiers of Computer Science 2022年第6期16卷 31-40页

作者： yuxin HUANG Zhengtao yu yan xiang Zhiqiang yu Junjun GUO Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China yunnan Key Laboratory of Artificial Intelligence Kunming University of Science and TechnologyKunming650500China

Automatically generating a brief summary for legal-related public opinion news(LPO-news,which contains legal words or phrases)plays an important role in rapid and effective public opinion *** LPO-news,the critical case elements which are significant parts of the summary may be mentioned several times in the reader ***,we investigate the task of comment-aware abstractive text summarization for LPO-news,which can generate salient summary by learning pivotal case elements from the reader *** this paper,we present a hierarchical comment-aware encoder(HCAE),which contains four components:1)a traditional sequenceto-sequence framework as our baseline;2)a selective denoising module to filter the noisy of comments and distinguish the case elements;3)a merge module by coupling the source article and comments to yield comment-aware context representation;4)a recoding module to capture the interaction among the source article words conditioned on the *** experiments are conducted on a large dataset of legal public opinion news collected from micro-blog,and results show that the proposed model outperforms several existing state-of-the-art baseline models under the ROUGE metrics.

关键词： legal public opinion news abstractive summarization comment comment-aware context case elements bidirectional attention

清咳平喘颗粒联合拔罐疗法治疗慢性支气管炎急性发作的临床观察

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世界中西医结合杂志 2020年第9期15卷 1730-1733,1738页

作者：候悦悦耿立梅于向艳张宇宇张依梦闫红倩河北中医学院河北石家庄050000 河北省中医院河北石家庄050011

目的观察清咳平喘颗粒联合拔罐疗法对慢性支气管炎急性发作患者的临床疗效。方法选取2017年1月—2018年1月期间呼吸科门诊收治的慢性支气管炎急性发作期(痰热壅肺型)患者90例,随机分为Ⅰ组、Ⅱ组及Ⅲ组,每组30例。三组均给予西医常规治... 详细信息

目的观察清咳平喘颗粒联合拔罐疗法对慢性支气管炎急性发作患者的临床疗效。方法选取2017年1月—2018年1月期间呼吸科门诊收治的慢性支气管炎急性发作期(痰热壅肺型)患者90例,随机分为Ⅰ组、Ⅱ组及Ⅲ组,每组30例。三组均给予西医常规治疗,在此基础上,Ⅰ组加用拔火罐治疗,Ⅱ组加用清咳平喘颗粒口服,Ⅲ组加用清咳平喘颗粒口服联合拔火罐治疗,10 d为1个疗程。结果治疗后,Ⅰ组总有效率为73.33%(22/30);Ⅱ组总有效率为80.00%(24/30);Ⅲ组总有效率为96.67%(29/30),Ⅰ组与Ⅱ组总有效率比较差异无统计学意义(P>0.05),Ⅰ组、Ⅱ组与Ⅲ组总有效率比较差异有统计学意义(P0.05);Ⅲ组咳嗽、咳痰、喘息、发热缓解时间均早于Ⅰ组及Ⅱ组,差异有统计学意义(P0.05);治疗后三组患者血清中IL-1β、IL-8、CRP含量均较治疗前下降,差异有统计学意义(P0.05),Ⅲ组IL-1β、IL-8、CRP含量低于Ⅰ组及Ⅱ组,差异有统计学意义(P<0.05)。结论清咳平喘颗粒联合拔罐疗法可改善慢性支气管炎急性发作患者的临床症状,降低其炎症反应。

关键词：清咳平喘颗粒拔罐疗法慢性支气管炎急性发作

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Neural Regeneration Research 2025年第2期20卷 366-377页

作者： Samuel Abokyi Dennis yan-yin Tse School of Optometry The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Research Center for SHARP Vision The Hong Kong Polytechnic UniversityKowloonHong Kong Special Administrative RegionChina Center for Eye and Vision Research Sha TinHong Kong Special Administrative RegionChina

Retinal aging has been recognized as a significant risk factor for various retinal disorders,including diabetic retinopathy,age-related macular degeneration,and glaucoma,following a growing understanding of the molecular underpinnings of their *** comprehensive review explores the mechanisms of retinal aging and investigates potential neuroprotective approaches,focusing on the activation of transcription factor *** meta-analyses have demonstrated promising outcomes of transcription factor EB-targeted strategies,such as exercise,calorie restriction,rapamycin,and metformin,in patients and animal models of these common retinal *** review critically assesses the role of transcription factor EB in retinal biology during aging,its neuroprotective effects,and its therapeutic potential for retinal *** impact of transcription factor EB on retinal aging is cell-specific,influencing metabolic reprogramming and energy homeostasis in retinal neurons through the regulation of mitochondrial quality control and nutrient-sensing *** vascular endothelial cells,transcription factor EB controls important processes,including endothelial cell proliferation,endothelial tube formation,and nitric oxide levels,thereby influencing the inner blood-retinal barrier,angiogenesis,and retinal ***,transcription factor EB affects vascular smooth muscle cells,inhibiting vascular calcification and *** retinal pigment epithelial cells,transcription factor EB modulates functions such as autophagy,lysosomal dynamics,and clearance of the aging pigment lipofuscin,thereby promoting photoreceptor survival and regulating vascular endothelial growth factor A expression involved in *** cell-specific functions of transcription factor EB significantly impact retinal aging mechanisms encompassing proteostasis,neuronal synapse plasticity,energy metabolism,microvasculature,and inflammation,ultimately offering pro

关键词： age-related macular degeneration anti-aging interventions autophagy calorie restriction diabetic retinopathy exercise glaucoma neuromodulation phagocytosis photoreceptor outer segment degradation retinal aging transcription factor EB

Socio-economic and energy-environmental impacts of technological change on China's agricultural development under the carbon neutrality strategy

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Petroleum Science 2023年第2期20卷 1289-1299页

作者： Hong-Dian Jiang Rui yu xiang-yan Qian School of Economics and Management China University of Geosciences(Beijing)Bejing100083China Center for Eergy and Environmental Policy Resarch Beijing Insttute of TechnoogyBeijing100081China School of Management and Economics Beijing Institute of TechnologyBejing100081China

Promoting agricultural modernisation through technological change is an important strategy for ***'s carbon neutrality strategy is leading to systemic socio-economic changes that could exacerbate the uncertainty of agricultural ***,applying a computable general equilibrium(CGE)model,this study characterises the agricultural sector in detail,introducing endogenous technological change proxied by research and development(R&D)to assess the impact of different technological change scenarios on agricultural development under the carbon neutrality *** results show that allocating carbon revenue for R&D inputs can mitigate the significant negative impact of achieving carbon neutrality on knowledge capital and production in agricultural ***,using carbon revenue only for R&D input in crop sectors has the optimal effect on increasing the agricultural sectors'knowledge capital,improving crop production and profit,reducing crop external dependence and promoting the synergistic reduction of carbon and pollutant ***,this scenario has the largest negative impact on macro-economics and household *** contrast,allocating carbon revenue to promote technological change in broader non-energy sectors or both crops and non-energy sectors can effectively mitigate negative socio-economic impacts,but the positive impact on agricultural development is *** findings provide practical insights for the rational use of carbon revenue to expand agricultural R&D investment and ensure balanced agricultural and economic development under the carbon neutrality target.

关键词： Endogenous technological change R&D investment Agriculture development Computable general equilibrium

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： yan Chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

参芪扶正注射液联合紫杉醇加顺铂治疗晚期非小细胞肺癌的临床观察

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肿瘤研究与临床 2006年第3期18卷 181-183页

作者：罗世政龙金华余祥艳黔东南苗族侗族自治州人民医院肿瘤科贵州凯里556000

目的观察参芪扶正注射液联合紫杉醇(TAX)加顺铂(DDP)治疗晚期非小细胞肺癌(NSCLC)的临床效果及减毒增效作用。方法50例晚期NSCLC患者随机分为中药加化疗组和单纯化疗组,每组25例,化疗采用TAX135mg/m2,第1天,DDP30mg/m2,第1￣3天;中药加... 详细信息

目的观察参芪扶正注射液联合紫杉醇(TAX)加顺铂(DDP)治疗晚期非小细胞肺癌(NSCLC)的临床效果及减毒增效作用。方法50例晚期NSCLC患者随机分为中药加化疗组和单纯化疗组,每组25例,化疗采用TAX135mg/m2,第1天,DDP30mg/m2,第1￣3天;中药加化疗组于化疗前3天开始应用参芪扶正注射液250ml/次,1次/d,连用21d;两个疗程后评价疗效。结果中药加化疗组和单纯化疗组近期有效率分别为48%和40%;中药加化疗组能改善体能状态,外周血白细胞、血小板下降程度减轻、恢复快,胃肠道反应减轻。结论参芪扶正注射液能提高TAX+DDP方案对晚期NSCLC的近期疗效,能有效改善临床症状,减轻化疗的毒副反应,提高生存质量。

关键词：参芪扶正注射液紫杉醇顺铂非小细胞肺癌