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Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C

Cancer Communications 2021年第7期41卷 615-630页

作者： Hong Zhang Shi-Hui Zhang Jia-Li Hu Yu-Tong wu Xiao-Yan Ma Yang Chen Bing Yu Shuang Liao Huilin Huang song Gao State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China Department of Oncology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006P.R.China Guangzhou Regenerative Medicine and Health Guangdong Laboratory GuangzhouGuangdong 510530P.R.China

Background:Multiple myeloma(MM)is a hematologic malignancy characterized by the accumulation of aberrant plasma cells within the bone *** high frequent mutation of family with sequence similarity 46,member C(FAM46C)is closely related with the occurrence and progression of ***,FAM46C has been identified as a non-canonical poly(A)polymerase(PAP)that functions as a tumor suppressor in *** study aimed to elucidate the structural features of this novel non-canonical PAP and how MM-related mutations affect the structural and biochemical properties of FAM46C,eventually advancing our understandings towards FAM46C mutation-related MM ***:We purified and crystallized a mammalian FAM46C construct,and solved its ***,we characterized the property of FAM46C as a PAP through a combination of structural analysis,site-directed mutagenesis and biochemical assays,and by comparison with its homolog ***,we structurally analyzed MM-related FAM46C mutations and tested the enzymatic activity of corresponding ***:We determined the crystal structure of a mammalian FAM46C protein at 2.35 A,and confirmed that FAM46C preferentially consumed adenosine triphosphate(ATP)and extended A-rich RNA ***46C showed a weaker PAP activity than its homolog FAM46B,and this difference was largely dependent on the residue variance at particular *** them,residues at positions 77,290,and 298 of mouse FAM46C weremost important for the divergence in enzymatic *** the MM-associated FAM46C mutants,those residing at the catalytic site(D90G and D90H)or putative RNA-binding site(I155L,S156F,D182Y,F184L,Y247V,andM270V)showed abolished or compromised PAP activity of FAM46C,while N72A and S248A did not severely affect the PAP ***46C mutants D90G,D90H,I155L,S156F,F184L,Y247V,and M270V had significantly lower inhibitory effect on apoptosis of RPMI-8226 cells as compared to wild-type ***:FAM46C is a prokaryot

关键词： apoptosis crystal structure FAM46C miRNA multiple myeloma poly(A)polymerase PTEN

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Additive manufacturing and foundry innovation

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China Foundry 2021年第4期18卷 286-295页

作者： Yu-sheng Shi Jin-liang Zhang Shi-feng Wen Bo song Chun-ze Yan Qing-song Wei Jia-min wu Ya-jun Yin Jian-xin Zhou Rui Chen Wei Zhou He-ping Jia Huan-qing Yang Hai Nan State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Engineering Research Center of Ceramic Materials for Additive Manufacturing Ministty of EducationWuhan 430074China Shenyang Research Institute of Foundry Co. Ltd.Shenyang 110011China Liaoning Senyuan Additive Manufacturing Technology Co.Ltd.Anshan 114000LiaoningChina Jiangsu Jiuyu Machinery Co. LtdSuzhou 215300China Xi'an Space Engine Company Co. Ltd.Xi'an 710100China Beijing Institute of Aeronautical Materials Beijing 100095China

Additive manufacturing is expected to transform and upgrade the traditional foundry industry to realize the integrated manufacturing and rapid and low-cost development of high-performance components with complex *** additive manufacturing technology commonly applied in casting mold preparation(fusible molds,sand molds/cores and ceramic cores)mainly includes selective laser sintering(SLS)and binder injection three-dimensional printing(3DP).In this work,the research status of SLS/3DP-casting processes on material preparation,equipment development,process optimization,simulation and application cases in aerospace,automotive and other fields were ***,the developing trends of the additive manufacturing technology in the future of foundry field are introduced,including multi-material sand molds(metal core included),ceramic core-shell integration and die-casting dies with conformal cooling runners.

关键词： additive manufacturing foundry selective laser sintering 3D printing multiple materials die-casting dies

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Intestinal Permeability of Glycosides(aglycone) from Rhodiola in the Human Caco-2 Cell Monolayer Model

Intestinal Permeability of Glycosides(aglycone) from Rhodiol...

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2013全国中药与天然药物高峰论坛暨第十三届全国中药和天然药物学术研讨会

作者： Tian-xiang Ma Jiu-Hong wu Department of Pharmacy 306 Hospital of PLA

The bidirectional intestinal permeability of 4 glycosides(aglycone) from anti-radiation Chinese medicinal herb Rhodiola,including Salidroside,Rosavin,Rosarin,and Tyrosol, was studied by using the Caco-2 cell *** compo... 详细信息

关键词： Rhodiola glycosides oral absorption Caco-2 cell monolayer

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Lagrangian analysis of the fluid transport induced by the interaction of two co-axial co-rotating vortex rings

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Journal of Hydrodynamics 2020年第6期32卷 1080-1090页

作者： Hai-yan Lin Yang xiang Su-yang Qin Hui Xu Hong Liu J.C.wu center for aerodynamics school of aeronautics and astronauticsshanghai jiao tong universityshanghai200240china

In this paper,the fluid transport in the interaction of two co-axial co-rotating vortex rings are *** rings are generated using the piston-cylinder apparatus,and the resulting velocity fields are measured using digital particle image *** interaction process is analysed by means of vorticity contour,as well by investigation of the Lagrangian coherent structures(LCSs)defined by the ridges of the finite-time Lyapunov exponent(FTLE).Experimental results demonstrate that two types of vortex interaction are identified,namely strong and weak interactions,*** the strong interaction,the Lagrangian boundaries of the two vortex rings are merged together and form a flux window for fluid *** weak interaction,only the Lagrangian drift induced by the motion of the front vortex ring is observed and affects the Lagrangian boundary of the rear vortex ***,the fluids transported in the strong interaction carry considerable momentum but no *** contrast,there are nearly no fluxes occurring in the weak *** tracking the variations of circulation and impulse occupied by the separated regions distinguished by the LCSs,it is found that the circulation nearly has no change,but the impulse occupied by vortex core region has significant *** the strong interaction,the impulse of rear vortex ring decreases but the impulse of the front vortex ring *** on the impulse law,it is speculated that the fluid force generated by the formation of the rear vortex rings can be ***,the strong interaction between wake vortices can actually improve the propulsive efficiency of the biological systems by operating the formation of large-scale vortices.

关键词： Vortex rings Lagranagian coherent structures(LCSs) fluid transport

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Lipschitzness of *-homomorphisms between C*-metric algebras

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Science China Mathematics 2011年第11期54卷 2473-2485页

作者： wu Wei Department of Mathematics East China Normal University Shanghai 200241 China

A C*-metric algebra consists of a unital C*-algebra and a Leibniz Lip-norm on the C*-algebra. We show that if the Lip-norms concerned are lower semicontinuous, then any unital *-homomorphism from a C*-metric algebra to another one is necessarily Lipschitz. We come to the result that the free product of two unital completely Lipschitz contractive *-homomorphisms from upper related C*-metric algebras coming from *-filtrations to those which are lower related is a unital Lipschitz *-homomorphism.

关键词： C^*-metric algebra unital ^*-homomorphism lower semicontinuous seminorm Leibniz seminorm reduced free product Lipschitz map

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CATALYTIC COLOR REACTION OF THE SYSTEM OF MIMETIC PEROXIDASE(Fe-T(3MPy)P)-LEUCO CRYSTAL VIOLET-HYDROGEN PEROXIDE

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Chinese Chemical Letters 1992年第12期3卷 993-996页

作者： Shu Sheng SUN Xiao Wei wu An WANG Yun xiang CI Department of Chemistry,Peking University,Beijing,100871

The mimetic peroxidase iron-tetrakis(3-N-methylpyridyl)- porphyrin (Fe-T(3MPy)P)can be used as a catalyst in the spectrophoto- metric determination of H_2O_2 and *** method is based on the formation of crystal violet from leuco crystal *** glucose in human serum is determined by this reaction combined with catalytic reaction of glucose oxidase.

关键词： Fe-T CATALYTIC COLOR REACTION OF THE SYSTEM OF MIMETIC PEROXIDASE LEUCO CRYSTAL VIOLET-HYDROGEN PEROXIDE

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A simple formula for predicting settling velocity of sediment particles

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Water Science and Engineering 2008年第1期1卷 37-43页

作者： song Zhiyao wu Tingting Xu Fumin Li Ruijie State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 P. R. China College of Ocean Hohai University Nanjing 210098 P. R. China Key Laboratory of Coastal Disaster and Defence Ministry of Education Hohai University Nanjing 210098 P. R. China

Based on the general relationship described by Cheng between the drag coefficient and the Reynolds number of a particle, a new relationship between the Reynolds number and a dimensionless particle parameter is proposed. Using a trial-and-error procedure to minimize errors, the coefficients were determined and a formula was developed for predicting the settling velocity of natural sediment particles. This formula has higher prediction accuracy than other published formulas and it is applicable to all Reynolds numbers less than 2× 10^5.

关键词： settling velocity spherical particle sediment particle sediment transport trial-and-errormethod

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Ultra-robust Metallosupramolecular Hydrogels with Unprecedented Self-recoverability using Asymmetrically Distributed Carboxyl-Fe3+Coordination Interactions

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Chinese Journal of Polymer Science 2023年第2期41卷 250-257页

作者： Zhao-Yang Yuan Zhen-Xing Cao Rui wu Hui Li Qiong-Jun Xu Hai-Tao wu Jing Zheng Jin-Rong wu State Key Laboratory of Polymer Materials Engineering College of Polymer Science and EngineeringSichuan UniversityChengdu610065China

Recently,numerous mechanically robust synthetic hydrogels have been ***,unlike natural loading-bearing materials such as cartilages and muscles,most hydrogels have inherently contradictory requirements,obstructing the design of hydrogels with characteristics of robustness and rapid ***,we present a facile strategy for constructing mechanically robust and rapidly self-recoverable *** linear poly(acrylamide-co-itaconic acid)chains crosslink via coordination bonds and minimal chemical crosslinkers to form the hydrogel *** design endows the coordination interactions to be asymmetrically *** deformation,the coordination interactions exhibit a reversible dissociation-and-reorganization property,demonstrating a new mechanism for energy dissipation and stress ***,the hydrogels possess tensile strength up to 12.5 MPa and toughness up to 28.2 MJ/***,the inherent dynamic nature of the coordination bonds imparts these hydrogels with stretch rate-and temperature-dependent mechanical behavior as well as excellent self-recovery *** method employed in this study is universal and is applicable to other polymers with load-bearing yet rapid recovery *** study will facilitate diverse applications of most metallosupramolecular hydrogels.

关键词： Metallosupramolecular hydrogels Coordination interactions Self-recoverability

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An Expansion of Boundary Theory and the Application of Joint Condition

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Open Journal of Applied Sciences 2015年第12期5卷 844-859页

作者： R. song S. X. wu Springer Publishing Company Germany Ethan Publishing Company Rowland Heights USA Self-Employed (Engineer)

The manuscript reviews the history and quo of the theory of Timoshenko’s method in stability analysis of compressive levers first, taking an example to explain the m-simulation method and putting forward the 3rd-7th boundary conditions demonstrating their superiorities in improving the precision through examples, followed by proposing and applying the join conditions in the stability analysis of combined axial force compressive levers gaining success. Through a brief example showing the effect of some related theories in a simple structural stability analysis, its application prospect is discussed.

关键词： Stability Analysis Energy Method BC. (Abbreviation of Boundary Condition) m-Simulation Method y(n)-Simulation Method Trial Function JC. (Abbreviation of Join Condition)

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Genome Warehouse: A Public Repository Housing Genome-scale Data

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Genomics, Proteomics & Bioinformatics 2021年第4期19卷 584-589页

作者： Meili Chen Yingke Ma song wu Xinchang Zheng Hongen Kang Jian Sang Xingjian Xu Lili Hao Zhaohua Li Zheng Gong Jingfa Xiao Zhang Zhang Wenming Zhao Yiming Bao National Genomics Data Center Beijing Institute of GenomicsChinese Academy of Sciences/China National Center for BioinformationBeijing 100101China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Division of Cancer Epidemiology and Genetics National Cancer InstituteNational Institutes of Health.Bethesda.MD 20X92.USA College of Computer Science Technology Inner Mongolia Normal UniversityHohhot 010010China

The Genome Warehouse(GWH)is a public repository housing genome assembly data for a wide range of species and delivering a series of web services for genome data submission,storage,release,and *** one of the core resources in the National Genomics Data Center(NGDC),part of the China National Center for Bioinformation(CNCB;https://***),GWH accepts both full and partial(chloroplast,mitochondrion,and plasmid)genome sequences with different assembly levels,as well as an update of existing genome *** each assembly,GWH collects detailed genome-related metadata of biological project,biological sample,and genome assembly,in addition to genome sequence and *** archive high-quality genome sequences and annotations,GWH is equipped with a uniform and standardized procedure for quality *** basic browse and search functionalities,all released genome sequences and annotations can be visualized with *** May 21,2021,GWH has received 19,124 direct submissions covering a diversity of 1108 species and has released 8772 of ***,GWH serves as an important resource for genomescale data management and provides free and publicly accessible data to support research activities throughout the *** is publicly accessible at https://***/gwh.

关键词： Genome submission Genome sequence Genome annotation Genome Warehouse Quality control

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