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Preoperative lymphocyte to C-reactive protein ratio as a new prognostic indicator in patients with resectable gallbladder cancer

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 267-272页

作者： Wen-Yan Yao xiang-song wu Shi-Lei Liu Zi-You wu Ping Dong Wei Gong Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Shanghai Key Laboratory of Biliary Tract Disease Research Shanghai 200092China

Background:Inflammation is often related to cancer,and several inflammatory scores have been established to predict the prognosis of various types of *** study aimed to determine the prognostic value of the preoperative lymphocyte to C-reactive protein ratio(LCR)for predicting postoperative outcomes in patients with resectable gallbladder cancer(GBC).Methods:A retrospective analysis of 104 GBC patients who received curative surgery at Xinhua Hospital,Affiliated to Shanghai Jiao Tong University School of Medicine from January 2000 to December 2016 was performed.A time-dependent receiver operating characteristic curve was constructed to evaluate the accuracy of different *** and multivariate Cox proportional hazard models were used to define factors associated with overall ***:Among the assessed variables,the preoperative LCR showed the highest accuracy in predicting the overall survival of GBC patients(AUC:0.736).Decreased preoperative LCR was significantly associated with advanced tumor stage,including tumor invasion(P=0.018),lymph node metastasis(P=0.011)and TNM stage(P=0.022).A low preoperative LCR(cutoff threshold=145.5)was an independent risk factor for overall survival in patients with resectable GBC(P<0.001).Conclusions:The preoperative LCR is a novel and valuable prognostic indicator of postoperative survival in patients with resectable GBC.

关键词： Gallbladder neoplasms Inflammation Lymphocyte to C-reactive protein ratio Overall survival

Comparison of postoperative complications between internal and external pancreatic duct stenting during pancreaticoduodenectomy: a meta-analysis

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Chinese Journal of Cancer Research 2015年第4期27卷 397-407页

作者： Fa-Yong Ke xiang-song wu Yong Zhang Hong-Cheng Zhang Ming-Zhe Weng Ying-Bin Liu Christopher Wolfgang Wei Gong Department of General Surgery Xinhua Hospital Shanghai Jiao Tong University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Johns Hopkins School of Medicine

Background：Two types of pancreatic duct stents are used to improve postoperative outcomes of pancreatic *** aim of this meta-analysis was to evaluate and compare the postoperative outcomes of patients with internal or external stenting during pancreaticoduodenectomy（PD）.Methods：We searched Pub Med,EMBASE,the Cochrane Library and Web of Science databases until the end of December,*** comparing outcomes of external *** stent placement in PD were eligible for *** literature was extracted and assessed by two independent ***：Seven articles were identified for inclusion：three randomized controlled trials（RCTs）and four observational clinical studies（OCS）.The meta-analyses revealed that use of external stents had advantage on reducing the incidences of pancreatic fistula（PF）in total[odds ratio（OR）=0.69;95%confidence interval（CI）,0.48-0.99;P=0.04],PF in soft pancreas（OR=0.30;95%CI,0.16-0.56;P=0.0002）and delayed gastric emptying（DGE）（OR=0.58;95%CI,0.38-0.89;P=0.01）compared with internal *** were no significant differences in other postoperative outcomes between two stenting methods,including postoperative morbidity（OR=0.93;95%CI,0.39-2.23;P=0.88）,overall mortality（OR=0.70;95%CI,0.22-2.25;P=0.55）,and intra-abdominal collections（OR=0.67;95%CI,0.26-1.71;P=0.40）.Conclusions：Based upon this meta-analysis,the use of external pancreatic stents might have potential benefit in reducing the incidence of PF and *** to the limited number of original studies,more RCTs are needed to further support our result and clarify the issue.

关键词： Pancreatic duct stent pancreaticoduodenectomy(PD) meta-analysis

Scheme of Optical Fiber Temperature Sensor Employing Deep-Grooved Process Optimization

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Photonic Sensors 2015年第1期5卷 6-11页

作者： Yu LIU Cong LIU Gaolin xiang Ruijie WANG Yibing WANG Lei xiang Linzhi wu song LIU Chongqing Municipal Level Key Laboratory of Photoelectronic Information Sensing & Transmitting Technology Chongqing University of Posts and Telecommunications Chongqing 400065 China

To optimize the optical fiber temperature sensor employing the deep-grooved process, a novel scheme was proposed. Fabricated by the promising CO2 laser irradiation system based on the two-dimensional scanning motorized stage with high precision, the novel deep-grooved optical fiber temperature sensor was obtained with its temperature sensitivity of the transmission attenuation -0.107dB/℃, which was 18.086 times higher than the optical fiber sensor with the normal depth of grooves while other parameters remained unchanged. The principal research and experimental testing showed that the designed temperature sensor measurement unit had the ability of high sensitivity in transmission attenuation and insensitivity to the wavelength, which offers possible applications in engineering.

关键词： OFTS temperature sensitivity transmission attenuation deep-grooved process

Impact of being overweight on the surgical outcomes of patients with gastric cancer: A meta-analysis

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World Journal of Gastroenterology 2013年第28期19卷 4596-4606页

作者： xiang-song wu Wen-Guang wu Mao-Lan Li Jia-Hua Yang Qi-Chen Ding Lin Zhang Jia-Sheng Mu Jun Gu Ping Dong Jian-Hua Lu Ying-Bin Liu Department of General Surgery Xinhua Hospital Shanghai Jiao Tong University School of Medicine

AIM: To investigate the effect of being overweight on the surgical results of patients with gastric cancer. METHODS: Comprehensive electronic searches of the PubMed, Web of Science, and Cochrane Library databases were conducted. Studies were identified that included patients with surgical complications from gastric cancer who were classified as normal weight [body mass index (BMI) < 25 kg/m 2 ] or overweight (BMI ≥ 25 kg/m 2 ). The operative time, retrieved lymph nodes, blood loss, and long-term survival were analyzed. A subgroup analysis was conducted based on whether patients received laparoscopic or open gastrectomy procedures. All statistical tests were performed using ReviewerManager 5.1.2 software. RESULTS: This meta-analysis included 23 studies with 20678 patients (15781 with BMI < 25 kg/m 2 ; 4897 with BMI ≥ 25 kg/m 2 ). Overweight patients had significantly increased operation times [MD: -29.14; 95%CI: -38.14-(-20.21); P < 0.00001], blood loss [MD: -194.58; 95%CI: -314.21-(-74.95); P = 0.001], complications (RR: 0.75; 95%CI: 0.66-0.85; P < 0.00001), anastomosis leakages (RR: 0.59; 95%CI: 0.42-0.82; P = 0.002), and pancreatic fistulas (RR: 0.486; 95%CI: 0.34-0.63; P < 0.00001), whereas lymph node retrieval was decreased significantly in the overweight group (MD: 1.69; 95%CI: 0.75-2.62; P < 0.0001). In addition, overweight patients had poorer long-term survival (RR: 1.14; 95%CI: 1.07-1.20; P < 0.0001). No significant difference was detected for the mortality and length of hospital stay. CONCLUSION: This meta-analysis demonstrates that a high BMI not only increases the surgical difficulty and complications but also impairs the long-term survival of patients with gastric cancer.

关键词： Overweight Body mass index Gastric cancer Gastrectomy

Duct-to-duct biliary reconstruction after radical resection of Bismuth Ⅲ a hilar cholangiocarcinoma

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World Journal of Gastroenterology 2013年第15期19卷 2441-2444页

作者： Wen-Guang wu Jun Gu Ping Dong Jian-Hua Lu Mao-Lan Li xiang-song wu Jia-Hua Yang Lin Zhang Qi-Chen Ding Hao Weng Qian Ding Ying-Bin Liu Depatment of General Surgery Xinhua HospitalAffiliated to School of MedicineShanghai Jiaotong University

At present, radical resection remains the only effective treatment for patients with hilar cholangiocarcinoma. The surgical approach for R0 resection of hilar cholangiocarcinoma is complex and diverse, but for the biliary reconstruction after resection, almost all surgeons use Roux-en-Y hepaticojejunostomy. A viable alternative to Roux-en-Y reconstruction after radical resection of hilar cholangiocarcinoma has not yet been proposed. We report a case of performing duct-to-duct biliary reconstruction after radical resection of Bismuth Ⅲa hilar cholangiocarcinoma. End-to-end anastomosis between the left hepatic duct and the distal common bile duct was used for the biliary reconstruction, and a singlelayer continuous suture was performed along the bile duct using 5-0 prolene. The patient was discharged favorably without biliary fistula 2 wk later. Evidence for tumor recurrence was not found after an 18 mo follow- up. Performing bile duct end-to-end anastomosis in hilar cholangiocarcinoma can simplify the complex digestive tract reconstruction process.

关键词： Hilar cholangiocarcinoma Biliary reconstruction Duct-to-duct Radical resection Digestive tract reconstruction Hepaticojejunostomy Bile duct anastomosis

Surgical management of patients with bowel obstructions secondary to gastric cancer

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World Journal of Gastroenterology 2013年第28期19卷 4559-4567页

作者： Wen-Guang wu Ping Dong xiang-song wu Mao-Lan Li Qi-Chen Ding Lin Zhang Jia-Hua Yang Hao Weng Qian Ding Zhu-Jun Tan Jian-Hua Lu Jun Gu Ying-Bin Liu Laboratory of General Surgery Department of General Surgery Xinhua Hospital Affiliated to School of Medicine Shanghai Jiaotong University

AIM: To assess whole-body fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in the management of small bowel obstructions (SBOs) secondary to gastric cancer and its role in treatment strategies. METHODS: The medical records of all of the patients who were admitted for an intestinal obstruction after curative resection for gastric cancer were retrospectively reviewed. PET/CT was performed before a clinical treatment strategy was established for each patient. The patients were divided into 2 groups: patients with no evidence of a tumor recurrence and patients with evidence of a tumor recurrence. Tumor recurrences included a local recurrence, peritoneal carcinomatosis or distant metastases. The primary endpoint was the 1-year survival rate, and other variables included patient demographics, the length of hospital stay, complications, and mortality. RESULTS: The median time between a diagnosis of gastric cancer and the detection of a SBO was 1.4 years. Overall, 31 of 65 patients (47.7%) had evidence of a tumor recurrence on the PET/CT scan, which was the only factor that was associated with poor survival. Open and close surgery was the main type of surgical procedure reported for the patients with tumor recurrences. R0 resections were performed in 2 patients, including 1 who underwent combined adjacent organ resection. In the group with no evidence of a tumor recurrence on PET/CT, bowel resections were performed in 7 patients, adhesiolysis was performed in 7 patients, and a bypass was performed in 1 patient. The 1-year survival curves according to PET/CT evidence of a tumor recurrence vs no PET/CT evidence of a tumor recurrence were significantly different, and the 1-year survival rates were 8.8% vs 93.5%, respectively. There were no significant differences (P = 0.71) in the 1-year survival rates based on surgical vs nonsurgical management (0% with nonoperative treatment vs 20% after exploratory laparotomy). CONCLUSION: 18 F-FDG PET/CT c

关键词： Positron emission tomography/computed tomography Small bowel obstructions Gastric cancer Clinical treatment strategy

Modified FOLFIRINOX for unresectable locally advanced or metastatic gallbladder cancer,a comparison with GEMOX regimen

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Hepatobiliary Surgery and Nutrition 2021年第4期10卷 498-506页

作者： Xu-Ya Cui Xue-Chuan Li Jiu-Jie Cui xiang-song wu Lu Zou Xiao-Ling song Tai Ren Yi-Di Zhu Huai-Feng Li Yang Yang Ke Liu Xu-Sheng Han Zi-Yao Jia Wen-Guang wu Xu-An Wang Wei Gong Li-Wei Wang Mao-Lan Li Ying-Bin Liu Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina Shanghai Key Laboratory of Biliary Tract Disease Research ShanghaiChina State Key Laboratory of Oncogenes and Related Genes ShanghaiChina Shanghai Research Center of Biliary Tract Disease ShanghaiChina Shanghai Cancer Institute ShanghaiChina Department of Medical Oncology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background:The first-line chemotherapy regimen for advanced gallbladder cancer(GBC)is gemcitabine plus platinum(GP),despite its efficacy is *** current investigation is a retrospective study to compare the safety and efficacy between the modified FOLFIRINOX(mFOLFIRINOX)and gemcitabine plus oxaliplatin(GEMOX)as the first-line chemotherapy for unresectable locally advanced or metastatic ***:The data of patients with unresectable locally advanced or metastatic GBC,who were treated with mFOLFIRINOX or GEMOX as the first-line therapy between April 2014 and April 2018 at Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,were *** retrospective study evaluated the clinical characteristics,survival outcomes and adverse ***:A total of 44 patients(n=25 in mFOLFIRINOX,n=19 in GEMOX)were *** were no significant differences between groups in baseline *** median progression free survival(mPFS)was 5.0 months in the mFOLFIRINOX group and 2.5 months in the GEMOX group[P=0.021;hazard ratio(HR),0.499;95%CI,0.266 to 0.937].The median overall survival(mOS)was 9.5 months in the mFOLFIRINOX group and 7.0 months in the GEMOX group(P=0.019;HR,0.471;95%CI,0.239 to 0.929).Disease control rate(DCR)was 76.0%in the mFOLFIRINOX group and 47.4%in the GEMOX group(P=0.051).The rate of grade 3-4 adverse events was 48%in the mFOLFIRINOX group and 36.8%in the GEMOX group(P=0.459).The incidence of grade 3-4 neutropenia and diarrhea were more common in the mFOLFIRINOX group,while the incidence of grade 3-4 thrombocytopenia and peripheral neuropathy were more common in the GEMOX ***:mFOLFIRINOX might improve the poor prognosis of unresectable locally advanced or metastatic GBC,and the results need to be further verified by prospective clinical studies.

关键词： Gallbladder cancer(GBC) modified FOLFIRINOX(mFOLFIRINOX) gemcitabine plus oxaliplatin(GEMOX) chemotherapy

ACTIVE OXYGEN ON Li/La2O3 CATALYST SURFACE AND ITS BEHAVIOR IN OXIDATIVE COUPLING OF METHANE

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Journal of Energy Chemistry 1992年第1期 83-87页

作者： WANG,Lian-Chi WANG,Ji-xiang YUAN,song-Yue wu,Yue Changchun Institute of Applied Chemistry,Academia Sinica Changchun,Jilin 130022 Received March 9,1991

The coupling selectivity was greatly enhanced by adding Li to LaO,compared with thesingle *** Ospecies was found on the Li/LaObut not on the single *** low temperaturedesorption,ethane desorbed trom the Li/LaObut was not detected with the single *** isconsidered that the addition of Li gave rise to some basic sites which are favorable for the couplingreaction.

关键词： Li ACTIVE OXYGEN ON Li/La2O3 CATALYST SURFACE AND ITS BEHAVIOR IN OXIDATIVE COUPLING OF METHANE La ITS

Neuronal regulated cell death in aging-related neurodegenerative diseases:key pathways and therapeutic potentials

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Neural Regeneration Research 2025年第8期20卷 2245-2263页

作者： Run song Shiyi Yin Jiannan wu Junqiang Yan Department of Neurology The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina Neuromolecular Biology Laboratory The First Affiliated HospitalCollege of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan ProvinceChina

Regulated cell death(such as apoptosis,necroptosis,pyroptosis,autophagy,cuproptosis,ferroptosis,disulfidptosis)involves complex signaling pathways and molecular effectors,and has been proven to be an important regulatory mechanism for regulating neuronal aging and ***,excessive activation of regulated cell death may lead to the progression of aging-related *** review summarizes recent advances in the understanding of seven forms of regulated cell death in age-related ***,the newly identified ferroptosis and cuproptosis have been implicated in the risk of cognitive impairment and neurodegenerative *** forms of cell death exacerbate disease progression by promoting inflammation,oxidative stress,and pathological protein *** review also provides an overview of key signaling pathways and crosstalk mechanisms among these regulated cell death forms,with a focus on ferroptosis,cuproptosis,and *** instance,FDX1 directly induces cuproptosis by regulating copper ion valency and dihydrolipoamide S-acetyltransferase aggregation,while copper mediates glutathione peroxidase 4 degradation,enhancing ferroptosis ***,inhibiting the Xc-transport system to prevent ferroptosis can increase disulfide formation and shift the NADP^(+)/NADPH ratio,transitioning ferroptosis to *** insights help to uncover the potential connections among these novel regulated cell death forms and differentiate them from traditional regulated cell death *** conclusion,identifying key targets and their crosstalk points among various regulated cell death pathways may aid in developing specific biomarkers to reverse the aging clock and treat age-related neurodegenerative conditions.

关键词： apoptosis autophagy cuproptosis disulfidptosis ferroptosis necroptosis neurodegenerative disease neurological aging diseases PANoptosis pyroptosis