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Single Particle Colorimetric Acid Phosphatase Activity Assay with CeO_(2)-modified Gold Nanoparticles

Chemical Research in Chinese Universities 2024年第2期40卷 320-325页

作者： ZHU Tang Jiayao yuan xiang MAO Guojiang WEI Lin XIAO Lehui Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research National and Local Joint Engineering Laboratory for New Petrochemical Materials and Fine Utilization of ResourcesCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha410081P.R.China Henan Key Laboratory of Organic Functional Molecule and Drug Innovation Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine ChemicalsKey Laboratory of Green Chemical Media and ReactionsMinistry of EducationSchool of Chemistry and Chemical EngineeringHenan Normal UniversityXinxiang453007P.R.China College of Chemistry and Chemical Engineering Central South UniversityChangsha410083P.R.China

Acid phosphatase(ACP)is a ubiquitous phosphatase in living *** abnormal variation of ACP is related to various ***,we propose a colorimetric method based on CeO_(2)-modified gold core shell nanoparticles(Au@CeO_(2)NPs)to analyze ACP activity with high sensitivity and *** this design,2-phospho-L-ascorbic acid trisodium salt(AAP)is dephosphorylated by ACP and produces reductive ascorbic acid(AA),which makes the CeO_(2)shell decomposition.A remarkable blue shift of localized surface plasmon resonance peak(LSPR,from yellow to green)along with the scattering intensity ratio changes from individual Au@CeO_(2)NPs are *** activity can be quantified by calculating the ratio changes of individual Au@CeO_(2)*** assay reveals limit of detection(LOD)of 0.044 mU/mL and the linear range of 0.05–5.0 mU/mL,which are much lower than most of spectroscopic measurements in bulk ***,the recovery measurements in real samples are satisfactory and the capacity for practical application is *** a consequence,Au@CeO_(2)NPs used in this assay will find new applications for the ultrasensitive detection of enzyme activity.

关键词： Single particle imaging Dark field Gold nanoparticle Enzyme activity Colorimetric detection

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Ballistic performance of spaced multi-ply soft fabrics: Experimental and numerical investigation

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Defence Technology（防务技术） 2024年第4期34卷 143-155页

作者： Zhongwei Zhang Xiaoning Yang yuan Lin Ziming Xiong Yuhang xiang Yi Zhou Mingyang Wang State Key Laboratory of Explosion&Impact and Disaster Prevention&Mitigation Army Engineering University of PLANanjing 210007China School of Mechanical Engineering Nanjing University of Science&TechnologyNanjing 210007China State Key Laboratory of New Textile Materials and Advanced Processing Technologies Wuhan Textile UniversityWuhan 430200China Postdoctoral Station of Civil Engineering Army Engineering University of PLANanjing 210007China

It has been reported that the ply gap influences the ballistic resistance of spaced multi-ply fabric systems,but its working mechanism was not well-understood. This paper reports the experimental and numerical approaches and results of an investigation on the mechanisms that enable the improved ballistic performance of spaced multi-ply systems. Penetration tests were performed over a range of impact velocities ranging from 200 m/s to 400 m/s. The results confirmed that the ply gap is beneficial to the energy absorption capability of the systems. This is because the front plies tend to absorb more energy when they are not immediately constrained by the rear plies. During a ballistic event, the gap relieves the reflection of the compressive pulse, prolonging the projectile engagement time with the front plies;on the other hand, the rear plies become increasingly less active in dissipating energy as the gap *** the gap is sufficiently widened to avoid any interference between the plies before the failure of the front ply, the responses of the whole system no longer vary. It was also found that the ballistic performance of the spaced systems is influenced by ply thickness, impact velocity, and the stacking order of the ply gap.

关键词： Energy absorption capability Ply gap Ballistic performance The front ply The rear ply

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Triggering triplet excitons of carbon nanodots through nanospace domain confinement for multicolor phosphorescence in aqueous solution

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Nano Research 2024年第7期17卷 6534-6543页

作者： Ya-Chuan Liang Qing Cao yuan Deng Yong Wang Kai-Kai Liu Chong-Xin shan School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002China Henan Key Laboratory of Diamond Optoelectronic Material and Devices Key Laboratory of Material PhysicsMinistry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China Academy for Quantum Science and Technology Zhengzhou University of Light IndustryZhengzhou 450002China Institute of Quantum Materials and Physics Henan Academy of SciencesZhengzhou 450046China

Easy non-radiative decay property of long-lived triplet excitons in aqueous solution obstructs their applications in aquatic *** reported phosphorescence phenomena in aqueous solution have excited researchers enormously but achieving full-color water-soluble phosphorescent carbon nanodots(CNDs)is still a challenging ***,full-color phosphorescence of water-soluble CNDs has been demonstrated by triggering their triplet excitons through nanospace domain confinement,and Förster energy resonance transfer is used for further tuning phosphorescence *** phosphorescence spans across most of the visible spectrum,ranging from 400 to 700 *** an aqueous solution,the CNDs exhibits blue,green,and red phosphorescence,lasting for approximately 6,10,and 7 s,***,the phosphorescence quantum yields are 11.85%,8.6%and 3.56%,making them readily discernible to the naked eyes and laying a solid foundation for practical ***,phosphorescence flexible optical display and bioimaging have been demonstrated by using the multicolor CNDs-based nanomaterials,showing distinct superiority for accuracy and complete display and imaging in complex emission background.

关键词： carbon nanodots triplet excitons multicolor aqueous solution

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Coexistence of All-Order Topological States in a Three-Dimensional Phononic Topological Crystalline Insulator

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Research 2024年第2期2023卷 511-518页

作者： Hua-shan Lai Hao Chen Chu-Hao Xia Si-yuan Yu Cheng He Yan-Feng Chen National Laboratory of Solid State Microstructures&Department of Materials Science and Engineering Nanjing UniversityNanjng 210093China Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjng 210093China Jiangsu Key Laboratory of Artificial Functional Materials Nanjing University Nanjing 210093China

Classical-wave topological materials lacking intrinsic half-integer spins are less robust while more ***,we explore a single 3-dimensional phononic topological crystalline insulator that simultaneously exhibits a whole family of first-order quadratic surface,second-order hinge,and third-order corner states within the same *** a topological crystalline insulator hosting all-order phases originates from the different topological nature when hierarchically projected onto different facets and lower dimensions,thus free from trivial cladding *** work offers an ideal platform for either robust wave propagation or localization in on-demand dimensions and may facilitate dimension division multiplexing technology.

关键词： topological dimensions crystalline

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Roles of Adenosine A2A Receptor in Sleep-wake Regulation

Roles of Adenosine A2A Receptor in Sleep-wake Regulation

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中国神经科学学会第十二届全国学术会议

作者： Wei-Min QU xiang-shan yuan Jian-Pin ZHANG Zhi-Li HUANG Department of Pharmacology School of Basic Medical Sciences Fudan University

Adenosine acts as a homeostatic regulator of sleep. Activation of adenosine A receptor(AR) by its agonist infused into the brain potently increases sleep. The arousal effect of caffeine, an AR and AR antagonist, is dependent on the AR. AR is highly expressed in the striatum. However, the role of AR in the striatum in sleepwake regulation has been paid little attention. We found that optogenetic activation of AR expressing neurons in the nucleus accumbens(NAc) increased non-rapid eye movement(NREM) sleep. Projections of AR neurons from the NAc distributed to nuclei in the forebrain, diencephalon, and brainstem using AAV-hr GFP as a tracer. Moreover, chemogenetic activation of AR neurons in the rostral and central dorsal striatum, but not caudal, induced remarkable increase in NREM sleep. We revealed that dorsal striatal AR neurons innervated the external globus pallidus(GPe) in topographic organizations, and preferentially formed inhibitory synapses with parvarlbumin(PV)-positive neurons in the GPe. Lesions of PV-positive neurons in the GPe abolished an increase in NREM sleep caused by activation of AR neurons in the striatum. In contrast, chemogenetic inhibition of striatal AR neurons increased wakefulness in the active period. Taking together, these findings reveal a prominent contribution of the striatal AR neurons to the control of sleep, and provide these neurons as a therapeutic target to treat sleep disturbances, such as excessive daytime sleepiness in Parkinson’s patients.

关键词： adenosine A2A receptor sleep striatum optogenetics chemogenetics

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Sevoflurane Depresses Neurons in the Medial Parabrachial Nucleus by Potentiating Postsynaptic GABAA Receptors and Background Potassium Channels

Sevoflurane Depresses Neurons in the Medial Parabrachial Nuc...

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中国睡眠研究会第十一届全国学术年会

作者： Wei Xu xiang-shan yuan Wei-Min Qu Zong-yuan Hong Lu Wang Zhi-Li Huang School of Basic Medical Sciences State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and Institutes of Brain Science Fudan University Laboratory of Quantitative Pharmacology Department of Pharmacology Wannan Medical College

Background Despite persistent clinical use for over 170 years, the neuronal mechanisms by which general anesthetics produce hypnosis remain unclear. Previous studies suggest that anesthetics exert hypnotic effects by acting on endogenous arousal circuits. Recently, it has been shown that the medial parabrachial nucleus（MPB） is a novel wake-promoting component in the dorsolateral pons. However, it is not known whether and how the MPB contributes to anesthetic-induced hypnosis. Methods The actions of sevoflurane, a widely used volatile anesthetic agent that best represents the drug class of halogenated ethers, were investigated in mice. The calcium signals of MPB neurons were examined using in vivo fiber photometry during sevoflurane exposure. The action potential firing, the membrane potential, the membrane input resistance, and the inhibitory postsynaptic currents mediated by GABAA receptors were recorded from MPB neurons using in vitro whole-cell patch-clamp recordings during infusion of sevoflurane. Results The population activities of MPB neurons were inhibited during sevoflurane anesthesia. Sevoflurane suppressed the firing rate of MPB neurons in a concentration-dependent and reversible manner. At a concentration of 0.22 mM, sevoflurane potentiated synaptic GABAA receptor-mediated inhibition, and the inhibitory effect of sevoflurane on the firing rate of MPB neurons was completely abolished by picrotoxin（100 μM）, a selective GABAA receptor antagonist. At a concentration of 0.44 mM, sevoflurane directly hyperpolarized MPB neurons and induced a significant decrease in membrane input resistance by increasing a basal potassium conductance. Conclusions Sevoflurane inhibits neurons in the MPB through postsynaptic GABAA receptors and background potassium channels, suggesting that the MPB is involved in sevoflurane-induced hypnosis.

关键词： sevoflurane GABAA receptors potassium channels medial parabrachial nucleus

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Mitophagy in intracerebral hemorrhage:a new target for therapeutic intervention

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Neural Regeneration Research 2024年第2期19卷 316-323页

作者： Yiyang Chen Wenxuan Tang Xinqi Huang Yumei An Jiawen Li Shengye yuan Haiyan shan Mingyang Zhang Institute of Forensic Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu ProvinceChina shanghai Key Lab of Forensic Medicine Key Lab of Forensic ScienceMinistry of Justice(Academy of Forensic Science)ShanghaiChina Department of Obstetrics and Gynecology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu ProvinceChina

Intracerebral hemorrhage is a life-threatening condition with a high fatality rate and severe ***,there is currently no treatment available for intracerebral hemorrhage,unlike for other stroke *** studies have indicated that mitochondrial dysfunction and mitophagy likely relate to the pathophysiology of intracerebral ***,or selective autophagy of mitochondria,is an essential pathway to preserve mitochondrial homeostasis by clearing up damaged *** markedly contributes to the reduction of secondary brain injury caused by mitochondrial dysfunction after intracerebral *** review provides an overview of the mitochondrial dysfunction that occurs after intracerebral hemorrhage and the underlying mechanisms regarding how mitophagy regulates it,and discusses the new direction of therapeutic strategies targeting mitophagy for intracerebral hemorrhage,aiming to determine the close connection between mitophagy and intracerebral hemorrhage and identify new therapies to modulate mitophagy after intracerebral *** conclusion,although only a small number of drugs modulating mitophagy in intracerebral hemorrhage have been found thus far,most of which are in the preclinical stage and require further investigation,mitophagy is still a very valid and promising therapeutic target for intracerebral hemorrhage in the long run.

关键词： intracerebral hemorrhage mitochondrial dysfunction mitophagy neuroinflammation neuroprotection reactive oxygen species secondary brain injury therapeutic target

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Design of weak current measurement system and research on temperature impact

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Nuclear Science and Techniques 2024年第4期35卷 46-56页

作者： Chu-xiang Zhao San-Gang Li Rong-Rong Su Li Yang Ming-Zhe Liu Qing-Yue Xue shan Liao Zhi Zhou Qing-shan Tan Xian-Guo Tuo Yi Cheng College of Nuclear Technology and Automation Engineering Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China Applied Nuclear Technology in Geosciences Key Laboratory of Sichuan Province Chengdu University of Technology1#DongsanluErxianqiaoChengdu 610059China University of Science and Technology of China Hefei 230026China School of Physics and Electronic Engineering Sichuan University of Science and EngineeringZigong 643000China

A dedicated weak current measurement system was designed to measure the weak currents generated by the neutron ionization *** system incorporates a second-order low-pass filter circuit and the Kalman filtering algorithm to effectively filter out noise and minimize interference in the measurement *** conducted under normal temperature conditions has demonstrated the system's high precision ***,it was observed that temperature variations can affect the measurement *** were collected across temperatures ranging from -20 to 70℃,and a temperature correction model was established through linear regression fitting to address this *** feasibility of the temperature correction model was confirmed at temperatures of -5 and 40℃,where relative errors remained below 0.1% after applying the temperature *** research indicates that the designed measurement system exhibits excellent temperature adaptability and high precision,making it particularly suitable for measuring weak currents.

关键词： Weak current measurement system Neutron ionization chamber Kalman filter algorithm Temperature correction model

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Spatial-and spin-resolution ARPES and magnetism beamline at SSRF

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Nuclear Science and Techniques 2024年第8期35卷 23-37页

作者： Fang‑yuan Zhu Jie‑Feng Cao xiang‑Yu Meng Jun‑Qin Li Rui Yu Ya‑Mei Wang shan Qiao Bo Zhao Ming‑Zhu Zhang Zhong‑Kai Liu Mei‑Xiao Wang Yong Wang Ren‑Zhong Tai shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China shanghaiTech Laboratory for Topological Physics School of Physical Science and TechnologyShanghai Tech UniversityShanghai 201210China University of Chinese Academy of Sciences Beijing 100049China

The BL07U beamline is a new extreme ultraviolet and soft X-ray beamline housed in the shanghai Synchrotron Radiation Facility. Beamlines are used in nano-resolved angle-resolved photoemission spectroscopy(nano-ARPES), spin-resolved angle-resolved photoemission spectroscopy(spin-ARPES), X-ray magnetic circular dichroism spectroscopy, and X-ray magnetic linear dichroism spectroscopy for certain scientific research. The BL07U beamline, which is based on a pair of elliptical polarized undulators and a variable-included-angle plane-grating monochromator, delivers circularly or linear polarized X-rays within the energy range of 50–2000 eV. The beamline features two branches: One dedicated to nano-ARPES,which has a minimum spot size of only ~ 200 nm, and another branch comprising spin-ARPES, a vector magnetic field, and superconductive magnetic end-station.

关键词： Soft X-ray beamline Nano-ARPES Spin-ARPES XMCD/XMLD

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Remaining useful life prediction for train bearing based on an ILSTM network with adaptive hyperparameter optimization

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Transportation Safety and Environment 2024年第2期6卷 75-86页

作者： Deqiang He Jingren Yan Zhenzhen Jin Xueyan Zou Sheng shan Zaiyu xiang Jian Miao State Key Laboratory of Featured Metal Materials and Life-cycle Safety for Composite Structures Guangxi Key Laboratory of Manufacturing System&Advanced Manufacturing Tec hnologySc hool of Mec hanical EngineeringGuangxi Univ ersityNanning 530004GuangxiChina Zhuzhou CRRC Times Electric Co. Ltd.Zhuzhou 412001HunanChina

Remaining useful life(RUL)prediction for bearing is a significant part of the maintenance of urban rail transit *** RUL is closely linked to the reliability and safety of train running,but the current prediction accuracy makes it difficult to meet the re-quirements of high reliability *** at the problem,a prediction model based on an improved long short-term memory(ILSTM)network is ***,the variational mode decomposition is used to process the signal,the intrinsic mode function with stronger representation ability is determined according to energy entropy and the degradation feature data is constructed com-bined with the time domain ***,to improve learning ability,a rectified linear unit(ReLU)is applied to activate a fully connected layer lying after the long short-term memory(LSTM)network,and the hidden state outputs of the layer are weighted by attention *** Harris Hawks optimization algorithm is introduced to adaptively set the hyperparameters to improve the performance of the ***,the ILSTM is applied to predict bearing *** experimental cases,the better perfor-mance in bearing RUL prediction and the effectiveness of each improving measures of the model are validated,and its superiority of hyperparameters setting is demonstrated.

关键词： train bearing remaining useful life prediction long short-term memory(LSTM) attention mechanism Harris Hawks op-timization(HHO)

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