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Kangfuxin solution alleviates esophageal stenosis after endoscopic submucosal dissection:A natural ingredient strategy

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World Journal of Gastroenterology 2025年第1期31卷 110-125页

作者： Xin Zhou Dan Ma Yi-xiang He Jing Jin Hong-lian Wang Yun-Feng Wang Fan Yang Jian-Qin liu Jie Chen Zhi li Department of Spleen and Stomach Diseases the Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina The Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Digestive System Diseases of Luzhou City The Affiliated Traditional Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina Department of Gastroenterology Changhai HospitalNaval Medical UniversityShanghai 20082China Research Center of Integrated Chinese and Western Medicine The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000Sichuan ProvinceChina School of Integrated Traditional Chinese and Western Clinical Medicine North Sichuan Medical CollegeNanchong637100Sichuan ProvinceChina

BACKGROUND Esophageal stricture ranks among the most significant complications following endoscopic submucosal dissection(ESD).Excessive fibrotic repair is a typical pathological feature leading to stenosis after *** To examine the effectiveness and underlying mechanism of Kangfuxin solution(KFX)in mitigating excessive fibrotic repair of the esophagus *** Pigs received KFX at 0.74 mL/kg/d for 21 days after esophageal full circumferential *** examinations occurred on days 7 and 21 *** vitro,recombinant transforming growth factor(TGF)-β1(5 ng/mL)induced a fibrotic microenvironment in primary esophageal fibroblasts(pEsF).After 24 hours of KFX treatment(at 1.5%,1%,and 0.5%),expression ofα-smooth muscle actin-2(ACTA2),fibronectin(FN),and type collagen I was *** signaling was analyzed,including TGF-β1,Smad2/3,and phosphor-smad2/3(p-Smad2/3).RESULTS Compared to the Control group,the groups treated with KFX and prednisolone exhibited reduced esophageal stenosis,lower weight loss rates,and improved food tolerance 21 d after *** treatment,Masson staining revealed thinner and less dense collagen fibers in the submucosal ***,the expression of fibrotic effector molecules was notably ***,KFX downregulated the transduction levels of fibrotic functional molecules such as TGF-β1,Smad2/3,and p-Smad2/*** vitro,pEsF exposed to TGF-β1-induced fibrotic microenvironment displayed increased fibrotic activity,which was reversed by KFX treatment,leading to reduced activation of ACTA2,FN,and collagen *** 1.5%KFX treatment group showed decreased expression of p-Smad 2/3 in TGF-β1-activated *** KFX showed promise as a therapeutic option for post-full circumferential esophageal ESD strictures,potentially by suppressing fibroblast fibrotic activity through modulation of the TGF-β1/Smads signaling pathway.

关键词： Kangfuxin solution Natural component Endoscopic submucosal dissection Esophagus stricture Fibrosis

Tuning the Stability of the Polyplex Nanovesicles of Oligonucleotides via a Zinc(Ⅱ)-Coordinative Strategy

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Chinese Journal of Polymer Science 2022年第9期40卷 1034-1042页

作者： quan Zhou xiang li Jia-Jia xiang You-Qing Shen Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Department of Cell Biology School of Basic Medical SciencesZhejiang UniversityHangzhou 310058China The Forth Affiliated Hospital Zhejiang University School of MedicineYiwu 322000China Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311215China

Oligonucleotide therapeutics have great potential to target the currently undruggable genes and to generate entirely new therapeutic paradigms in multiple types of disease,thus having attracted much attention in recent ***,their applications are greatly hindered by a lack of safe and efficient oligonucleotide-delivery *** nanovesicles formed from oligonucleotides and the cationic block have shown exceptional features for the delivery of therapeutic oligonucleotides and other ***,these polyplex nanovesicles are deeply fraught with difficulty in tolerating physiological ionic *** by the high binding ability between the dipicolylamine(DPA)/zinc(Ⅱ)complex and the phosphodiester moieties of oligonucleotides,herein,we designed a coordinative cationic block to solve the intrinsic stability ***,we found the stability of the resulted polyplex nanovesicles could be easily tuned by the content of coordinated zinc *** vitro cellular studies implied that the prepared zinc(Ⅱ)-coordinative polyplex nanovesicles preferred to retain in the lysosomes upon internalization,making them ideal delivery candidates for the lysosome-targeting oligonucleotide therapeutics.

关键词： Oligonucleotide therapeutics Polyplex nanovesicles Coordinative cationic block Lysosome-targeting

Weak type(1, 1) of the Riesz transform on some direct product manifolds with exponential volume growth

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Science China Mathematics 2024年第7期67卷 1599-1622页

作者： Hong-quan li Jie-xiang Zhu School of Mathematical Sciences Fudan UniversityShanghai200433China Center for Applied Mathematics Tianjin UniversityTianjin300072China

In this paper, we are concerned with the Riesz transform on the direct product manifold H^(n)× M,where H^(n) is the n-dimensional real hyperbolic space, and M is a connected complete non-compact Riemannian manifold satisfying the volume doubling property and generalized Gaussian or sub-Gaussian upper estimates for the heat kernel. We establish its weak type(1, 1) property. In addition, we obtain the weak type(1, 1) of the heat maximal operator in the same setting. Our arguments also work for a large class of direct product manifolds with exponential volume growth. Particularly, we provide a simpler proof of weak type(1, 1) boundedness of some operators considered in the work of li et al.(2016).

关键词： Riesz transform heat kernel direct product real hyperbolic space

Thermal fatigue and wear of compacted graphite iron brake discs with various thermomechanical properties

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China Foundry 2024年第3期21卷 248-256页

作者： Gui-quan Wang Zhuo Xu Zhong-li liu xiang Chen Yan-xiang li School of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China

The increase in payload capacity of trucks has heightened the demand for cost-effective yet high performance brake *** this work,the thermal fatigue and wear of compacted graphite iron brake discs were investigated,aiming to provide an experimental foundation for achieving a balance between their thermal and mechanical *** graphite iron brake discs with different tensile strengths,macrohardnesses,specific heat capacities and thermal diffusion coefficients were produced by changing the proportion and strength of *** peak temperature,pressure load and friction coefficient of compacted graphite iron brake discs were analyzed through inertia friction *** morphology of thermal cracks and 3D profiles of the worn surfaces were also *** is found that the thermal fatigue of compacted graphite iron discs is determined by their thermal properties.A compacted graphite iron with the highest specific heat capacity and thermal diffusion coefficient exhibits optimal thermal fatigue *** of the matrix at low temperatures significantly weakens the function of alloy strengthening in hindering the propagation of thermal *** the reduced hardness,increasing the ferrite proportion can mitigate wear loss resulting from low disc temperatures and the absence of abrasive wear.

关键词： compacted graphite iron brake disc thermomechanical properties thermal fatigue wear

Context-Aware Recommendation System using Graph-based Behaviours Analysis

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Journal of Systems Science and Systems Engineering 2021年第4期30卷 482-494页

作者： Lan Zhang xiang li Weihua li Huali Zhou quan Bai Auckland University of Technology AucklandNew Zealand University of Tasmania HobartAustralia

Recommendation systems have been extensively studied over the last decade in various domains. It has been considered a powerful tool for assisting business owners in promoting sales and helping users with decision-making when given numerous choices. In this paper, we propose a novel Graph-based Context-Aware Recommendation Systems with Knowledge Graph to analyse and predict users’ behaviours, i.e., making recommendations based on historical events and their implicit associations. The model incorporates contextual information extracted from both users’ historical behaviours and events relations, where the contexts have been modelled as knowledge graphs. By leveraging the advantages offered from the knowledge graph, events dependencies and their subtle relations can be established and have been introduced in the recommendation process. Experimental results indicate that the proposed approach can outperform the state-of-the-art algorithms and achieve more accurate recommendations.

关键词： Contextual information extraction knowledge graph context-awareness recommendation system user behaviour analysis

Different thermal fatigue behaviors between gray cast iron and vermicular graphite cast iron

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China Foundry 2022年第3期19卷 245-252页

作者： Gui-quan Wang Zhong-li liu Yan-xiang li xiang Chen School of Nuclear Equipment and Nuclear Engineering Yantai UniversityYantai 264005ShandongChina School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationTsinghua UniversityBeijing 100084China

The initiation and propagation of thermal fatigue cracks in gray cast iron and vemicular graphite cast iron were investigated by Uddeholm method to reveal the complex thermal fatigue behaviors of cast *** of thermal fatigue behaviors of gray cast iron and vemicular graphite cast iron were observed and *** is found that the observed differences are related to the combination of graphite morphology and the oxidization of *** oxidized matrix is observed in gray cast iron due to its large specific surface *** brittle oxidized matrix facilitates the propagation of microcracks along the oxidization *** contrast,the radial microcracks are formed in vermicular graphite at the edge of graphite due to fewer oxidization *** indicates that the thermal fatigue resistance of gray cast iron is dominated by graphite content and morphology while that of vermicular graphite cast iron strongly relates to the strength of the matrix.

关键词： thermal fatigue gray cast iron vermicular graphite cast iron oxidization cracking propagation

INTRINSIC FEATURES OF TURBULENT FLOW IN STRONGLY 3-D SKEW BLADE PASSAGE OF A FRANCIS TURBINE

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Journal of Hydrodynamics 2007年第1期19卷 92-99页

作者： ZHANG li-xiang WANG Wen-quan GUO Yakun Department of Engineering Mechanics Kunming University of Science and Technology Kunming 650051 China GUO Yakun Department of Engineering University of Aberdeen Aberdeen AB24 3UE UK.

The turbulent flow, with the Reynolds number of 5.9×10^5, in the strongly 3-D skew blade passage of a true Francis hydro turbine was simulated by the Large Eddy Simulation （LES） approach to investigate the spatial and temporal distributions of the fully developed turbulence in the passage with strongly 3-D complex geometry. The simulations show that the strong three-dimensionality of the passage has a great amplification effect on the turbulence in the passage, and the distributions of the turbulence are diversely nonuniform, for instance, the rise of turbulent kinetic energy in the lower 1/3 region of the passage is more than 45%, whereas its rise in the upper 1/3 region is less than 1%. With the LES approach, the details of the flow structures at the near-wall surfaces of the blades could be obtained. Several turbulent spots were captured.

关键词： turbulent flow Large Eddy Simulation (LES),hydro turbine

重型机械变速箱锁销式同步器常见故障模式的原因分析及解决方法

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企业技术开发 2012年第10期31卷 32-33页

作者：向权力杨子轩刘晓雷陕西法士特齿轮有限责任公司陕西西安710077

目前,国内中、重卡多采用主副箱结合的机械式变速箱,副箱使用锁销式同步器。用于高低档转换的锁销式同步器,适合于空间较大、需要传递大扭矩的副箱,其性能直接影响变速器能否顺利实现换档。通过理论分析、故障件拆解、实车跟踪等方法,... 详细信息

目前,国内中、重卡多采用主副箱结合的机械式变速箱,副箱使用锁销式同步器。用于高低档转换的锁销式同步器,适合于空间较大、需要传递大扭矩的副箱,其性能直接影响变速器能否顺利实现换档。通过理论分析、故障件拆解、实车跟踪等方法,文章分析了重型变速器锁销式同步器在使用过程中常见的故障模式,产生故障的原因,并提出了相应的解决办法。

关键词：锁销式同步器故障模式锁止销锥环

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Effect of Potassium Addition on Coprecipitated Iron Catalysts for Fischer-Tropsch Synthesis Using Bio-oil-syngas

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Chinese Journal of Chemical Physics 2008年第2期21卷 141-150页

作者： Zhao-xiang Wang Ting Dong Tao Kan quan-xin li Department of Chemical Physics Lab of Biomass Clean Energy University of Science and Technology of China Hefei 230026 China

The effects of potassium addition and the potassium content on the activity and selectivity of coprecipitated iron catalyst for Fischer-Tropsch synthesis （FTS） were studied in a fixed bed reactor at 1.5 MPa, 300 ℃, and contact time （W/F） of 12.5 gcath/mol using the model bio-oil-syngas of H2/CO/CO2/N2 （62/8/25/5, vol%）. It was found that potassium addition increases the catalyst activity for FTS and the reverse water gas shift reaction. Moreover, potassium increases the average molecular weight （chain length） of the hydrocarbon products. With the increase of potassium content, it was found that CH4 selectivity decreases and the selectivity of liquid phase products （C5＋） increases. The characteristics of FTS catalysts with different potassium content were also investigated by various characterization measurements including X-ray diffraction, X-ray photoelectron spectroscopy and Brunauer-Emmett-Teller surface area. Based on experimental results, 100Fe/6Cu/16Al/6K （weight ratio） was selected as the optimal catalyst for FTS from bio-oil-syngas. The results indicate that the 100Fe/6Cu/16Al/6K catalyst is one of the most promising candidates to directly synthesize liquid bio-fuel using bio-oil-syngas.

关键词： Bio-oil-syngas Fischer-Tropsch synthesis Potassium Coprecipitated iron