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A two-stage variable selection strategy for supersaturated designs with multiple responses

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Frontiers of Mathematics in China 2013年第3期8卷 717-730页

作者： Yuhui yin Qiaozhen ZHANG Min-qian LIU Department of Statistics School of Mathematical Sciences and LPMC Nankai University Tianjin 300071 China

A supersaturated design （SSD）, whose run size is not enough for estimating all the main effects, is commonly used in screening experiments. It offers a potential useful tool to investigate a large number of factors with only a few experimental runs. The associated analysis methods have been proposed by many authors to identify active effects in situations where only one response is considered. However, there are often situations where two or more responses are observed simultaneously in one screening experiment, and the analysis of SSDs with multiple responses is thus needed. In this paper, we propose a two-stage variable selection strategy, called the multivariate partial least squares-stepwise regression （MPLS-SR） method, which uses the multivariate partial least squares regression in conjunction with the stepwise regression procedure to select true active effects in SSDs with multiple responses. Simulation studies show that the MPLS-SR method performs pretty good and is easy to understand and implement.

关键词： Multivariate partial least squares (MPLS) supersaturated design(SSD) stepwise regression variable selection variable importance in projection

Blending Basic Shapes By C-Type Splines and Subdivision Scheme

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Computer Modeling in Engineering & Sciences 2019年第7期120卷 45-62页

作者： xiang Li Mei-E Fang qian Qi School of Computer Science and Cyber Engineering Guangzhou UniversityGuangzhouChina School of Computer Hangzhou Dianzi UniversityHangzhouChina

In this article,we adopt the C-type spline of degree 2 to model and blend basic shapes including conics and circle *** C-type spline belongs to theωB-spline category of splines that are capable of blending polynomial,trigonometric and hyperbolic *** used basic shapes can be exactly represented by these types of *** derive explicit formulas for the convenience of modeling the basic *** entire blending curve is C^*** comparison with the existing best blending method by rational G^2 splines,which are rational splines of degree 3,the proposed method allows simpler representation and blending of the basic curves,and it can represent numerous basic shapes including the hyperbolic *** also design a subdivision method to generate blending curves;this method is precise for the basic curves and approximate for the blending *** subdivision process is efficient for modeling and *** has also proven to be C^1-continuous by the asymptotically equivalent theory and the continuity of stationary subdivision *** addition,we extend the proposed methods to cases involving the modeling and blending of basic *** provide many examples that illustrate the merits of our methods.

关键词： Basic shapes blending C-type splines subdivision C^1-continuous

Microstructure and microwave dielectric properties of ZnO-B_2O_3 added (Ca_(0.254)Li_(0.19)Sm_(0.14))TiO_3 ceramics

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Rare Metals 2010年第3期29卷 243-247页

作者： LU yin LI Haitao LI qian ZHANG Boping Department of Mechanical Engineering Henan Polytechnic Institute Nanyang 473009 China School of Materials Science and Engineering Henan University of Science and Technology Luoyang 471003 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

The effects of ZnO-B2O3 （ZB2） on the sintering behavior and microwave dielectric properties of （Ca0.254Li0.19Sm0.14）TiO3 ceramics were investigated. The densities of the specimens reached the maximum value by adding 3 wt.% ZB2 and then decreased. The sintering temperature of the specimens was lowered from 1300 to 1100℃ without degradation of the microwave dielectric properties. The （Ca0.254Li0.19Sm0.14）TiO3＋ 3 wt.% ZB2 sintered at 1100℃ for 3 h showed good microwave dielectric properties, εr= 108.2, Qf= 6545 GHz, and rf= 6.5 ppm/℃, respectively, indicating that ZB2 was an effective sintering aid to improve the densification and microwave dielectric properties of （Ca0.254Li0.19Sm0.14）TiO3 ceramics.

关键词： microwave dielectric properties densification ceramics sintering behavior

Decolorization of reactive brilliant red K-2BP by white rot fungus under sterile and non-sterile conditions

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Journal of Environmental Sciences 2006年第3期18卷 428-432页

作者： GAO Da-wen WEN xiang-hua qian Yi State Key Joint Laboratory of Environmental Simulation and Pollution Control Department of Environment Science and Engineering TsinghuaUniversity Beijing 100084 China.

Almost all the studies both domestic and international using white rot fungus for dye wastewater treatment are performed under sterile conditions. However, it is obviously unpractical that wastewater with dyes is treated under sterile conditions. A feasible study was made for using white rot fungus Phanerochaete chrysosporium to degrade reactive brilliant red K-2BP dye under non-sterile conditions. The results showed that there was no decolorizing effect under non-sterile condition if white rot fungus was incubated under non-sterile condition, and the decolorization was always near to 0% during decolorizing test for 3 d; in the meantime, a lot of yeast funguses were found in liquid medium when white rot fungus was incubated under non-sterile conditions; however, if white rot fungus was incubated under sterile condition firstly, its decolorization was above 90% under non-sterile condition, which was similar to that of sterile condition. So we point out that the treating process for wastewater with dyes should be divided into two stages. The first stage is that white rot fungus should be incubated under sterile conditions, and the second stage is that reactive brilliant red K-2BP is decolorized under non-sterile conditions. The method not only save the operation cost which decolorizing reactive brilliant red K-2BP under sterile condition, but also provide the feasibility for using white rot fungus to degrade wastewater with dyes under non-sterile conditions.

关键词： white rot fungus Phanerochaete chrysosporium reactive brilliant red K-2BP decolorization non-sterile condition

Structural and Chemical Characterization of the Ediacaran Embryo-Like Fossils via the Combination of 3D-XRM and FIB-SEM Approaches

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Journal of Earth Science 2024年第4期35卷 1204-1214页

作者： qian Chen Weichen Sun Suping Wu Zongjun yin State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing210008China University of Chinese Academy of Sciences Nanjing211135China

The three-dimensional(3D)morphology,anatomy,and in-situ chemical composition analysis of fossils are crucial for systematic paleontology and determining their phylogenetic *** electron microscopy(SEM)coupled with energy-dispersive X-ray spectroscopy(EDS),offers valuable structural and chemical information for the analysis of ***,its primary limitation is the restriction to two-dimensional surface data,which limits the exploration of fossils’3D ***,3D X-ray microscopy(3D-XRM),also known as a novel form of micro-computed tomography(micro-CT)facilitates the non-destructive 3D reconstruction of fossil ***,it lacks the capability to provide in-situ compositional *** the constraints inherent in these individual techniques,and in response to the evolving requirements of paleontological research,this study introduces an integrated approach that combines 3D-XRM with EDS-coupled focused ion beam scanning electron microscopy(FIB-SEM).This innovative strategy is designed to synergize the advantages of both techniques,thereby addressing challenges that conventional methods *** enables the rapid identification of regions of interest(ROI)within fossil specimens at micrometer ***,this method collects detailed data on both 3D structures and chemical compositions at the nanometer scale for the identified *** integrated approach represents a significant advancement in paleontological and geological research methodologies,promising to meet the increasing demands of these fields.

关键词： Embryo-like microfossils structural and chemical characterization 3D-XRM FIB-SEM 3D reconstruction

Synthesis and Structure of an Octopus-like Octapropargyl Tetra-iso-butyl-resorcin[4]arene

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Chinese Journal of Structural Chemistry 2005年第8期24卷 952-956页

作者： LIU xiang LIU Yu-Jie ZHANG qian-Feng Department of Applied Chemistry School of Chemical Engineering and Chemistry Anhui University of Technology ChinaMaanshan Anhui 243002

Treatment of tetra-iso-butyl-resorcin[4]arene 1 with propargyl bromide in the presence of K2CO3 as base gave an octopus-like octapropargyl tetra-iso-butyl-resorcin[4]arene 2 （C68H72O8, Mr = 1017.26） in a quantitative yield. Single-crystal structure of 2 was determined by X-ray crystallography. 2 crystallizes in the monoclinic system, space group P21/n with a =13.3247（6）, b = 24.7929（11）, c = 19.1810（9）A°, β = 109.272（1）°, V= 5981.5（5） A°^3, Dc = 1.130g/cm^3,μ = 0.073 mm^-1, F（000） = 2176 and Z = 4. Overall structure of 2 reveals an octopus-like resorcinarene with eight propargyl groups in different directions. The resorcinarene adopts the boat conformation where the iso-butyl residues act as four-legged piano stool. The two opposite aryl rings of the macrocyclic framework are almost coplanar, and the two others facing each other are perpendicular to this plane.

关键词： resorcinarene propargyl crystal structure supramolecular chemistry

Cancer metabolism and dietary interventions

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Cancer Biology & Medicine 2022年第2期19卷 163-174页

作者： Lin qian Fan Zhang Miao yin Qunying Lei Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences Cancer InstitutesKey Laboratory of Breast Cancer in ShanghaiShanghai Key Laboratory of Radiation OncologyShanghai Key Laboratory of Medical EpigeneticsShanghai Medical CollegeFudan UniversityShanghai 200030China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200030China State Key Laboratory of Medical Neurobiology Fudan UniversityShanghai 200030China Lead Contact Shanghai 200030China

Metabolic remodeling is a key feature of cancer *** of cancer metabolism has greatly expanded since the first observation of abnormal metabolism in cancer cells,the so-called Warburg *** cells tend to modify cellular metabolism to favor specialized fermentation over the aerobic respiration usually used by most normal ***,targeted cancer therapies based on reprogramming nutrient or metabolite metabolism have received substantial attention both conceptually and in clinical *** particular,the management of nutrient availability is becoming more attractive in cancer *** this review,we discuss recent findings on tumor metabolism and potential dietary interventions based on the specific characteristics of tumor ***,we present a comprehensive overview of changes in macronutrient ***,amino acids,and lipids,are rewired in the cancer microenvironment individually or ***,we summarize recent progress in cancer interventions applying different types of diets and specific nutrient restrictions in pre-clinical research or clinical trials.

关键词： Cancer metabolism diet intervention carbohydrate amino acid lipid

Parasitism of Pieris rapae （Lepidoptera： Pieridae） by the endoparasitic wasp Pteromalus puparum （Hymenoptera： Pteromalidae）： Effects of parasitism on differential hemocyte counts, micro- and ultra-structures of host hemocytes

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Insect Science 2012年第4期19卷 485-497页

作者： qian-qian Zhang Jia Huang Jia-ying Zhu Gong-yin Ye State Key Laboratory of Rice Biology&Key laboratory of Molecular Biology of Crop Pathology and Insects of Ministry of Agriculture Institute of Insect SciencesZhejiang UniversityHangzhouChina

Parasitism by the endoparasitic wasp Pteromalus puparum （Hymenoptera： Pteromalidae） by using only its associated venom, can suppress the immunal responses of Pieris rapae （Lepidoptera： Pieridae）. However, up to now, current knowledge of the mech- anisms has been limited. The response of host hemocytes to parasitism was investigated using a combination of light and transmission electron microscopy （TEM）. Five hemocyte types, prohemocytes （PRs）, granulocytes （GRs）, plasmatocytes （PLs）, oenocytoids （OEs） and coagulocytes （COs）, were observed and characterized from both unparasitized and parasitized Pieris rapae pupae. Light microscopy showed that both GRs and PLs became more round and spread abnormally after parasitism, whereas the shape of other types of hemocytes remained unaffected. In addition, the size of PRs and PLs became larger while OEs became smaller. The proportion of PRs significantly increased after parasitism and that of PLs decreased by 43.9%, but there was no significant increase of GRs and OEs. TEM showed that all types of hemocytes except COs were damaged to various degrees after parasitism, especially resulting in electron opaque cytoplasm and nucleus, fewer cell organelles of rough endoplasmic reticulum, mitochondria and vesicles. Our results indicate that parasitism by P. puparum affects differential hemocyte counts and structures of host hemocytes, particularly for GRs and PLs, which may be the main cause of the parasitoid suppressing host cellular immune responses.

关键词： Key words hemocytes light microscopy parasitism Pieris rapae Pteromaluspuparum,transmission electron microscopy ultrastructure

Deviation Property of Periodic Measures in C^1 Non-uniformly Hyperbolic Systems with Limit Domination

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Acta Mathematica Sinica,English Series 2012年第9期28卷 1727-1740页

作者： Sheng qian Wen xiang SUN Xue Ting TIAN Department of Mathematics Peking University Academy of Mathematics and Systems Science Chinese Academy of Sciences

In a C1 non-uniformly hyperbolic systems with limit domination, we consider the periodic measures that supported on the Pesin set and keep a distance at least 6 to a hyperbolic ergodic measure μ given before. And then, we bound from top the exponential growth rate of such periodic measures by the supremum of measure theoretic entropy on a closed set.

关键词： Exponential growth rate generalized entropy large deviation limit domination Pesin set