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D2 dissection in laparoscopic and open gastrectomy for gastric cancer

World Journal of Gastroenterology 2012年第8期18卷 833-839页

作者： Ming Cui lia-Di Xing Yi-Yuan Ma Zhen-Dan Yao Nan Zhang xiang-qian su Wei Yang Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Minimally Invasive Gastrointestinal Surgery Peking University Cancer Hospital and Institute Beijing 100142 China Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department of Ultrasound Peking University Cancer Hospital and Institute Beijing 100142 China

AIM: To evaluate the radicalness and safety of laparoscopic D2 dissection for gastric cancer. METHODS: Clinicopathological data from 209 patients with gastric cancer, who underwent radical gastrectomy with D2 dissection between January 2007 and February 2011, were analyzed retrospectively. Among these patients, 131 patients underwent laparoscopyassisted gastrectomy (LAG) and 78 underwent open gastrectomy (OG). The parameters analyzed included operative time, blood loss, blood transfusion, morbidity, mortality, the number of harvested lymph nodes (HLNs), and pathological ***: There were no significant differences in sex, age, types of radical resection [radical proximal gastrectomy (PG + D2), radical distal gastrectomy (DG + D2) and radical total gastrectomy (TG + D2)], and stages between the LAG and OG groups (P > 0.05). Among the two groups, 127 cases (96.9%) and 76 cases (97.4%) had 15 or more HLNs, respectively. The average number of HLNs was 26.1 ± 11.4 in the LAG group and 24.2 ± 9.3 in the OG group (P = 0.233). In the same type of radical resection, there were no signifi cant differences in the number of HLNs between the two groups (PG + D2: 21.7 ± 7.5 vs 22.4 ± 9.3; DG + D2: 25.7 ± 11.0 vs 22.3 ± 7.9; TG + D2: 30.9 ± 13.4 vs 29.3 ± 10.4; P > 0.05 for all comparisons). Tumor free margins were obtained in all cases. Compared with OG group, the LAG group had signifi cantly less blood loss, but a longer operation time (P < 0.001). The morbidity of the LAG group was 9.9%, which was not signifi cantly different from the OG group (7.7%) (P = 0.587). The mortality was zero in both groups. CONCLUSION: Laparoscopic D2 dissection is equivalent to OG in the number of HLNs, regardless of tumor location. Thus, this procedure can achieve the same radicalness as OG.

关键词： Gastric cancer Laparoscopy Gastrectomy D2 dissection Lymph node

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Long-Term Outcome of A Large Series of Gastric Cancer Patients in China

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Chinese Journal of Cancer Research 2010年第3期22卷 167-175页

作者： Ai-wen Wu Jia-fu Ji Hong Yang Yan-ning Li Shuang-xi Li Lian-hai Zhang Zi-yu Li Xiao-jiang Wu xiang-long Zong Zhao-de Bu Ji Zhang xiang-qian su Yi Wang Guang-wei Xu Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department ofGastrointestinal Surgery Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing100142 China

Objective：The outcome of gastric cancer treatment in China is relatively poor compared with those in Japan and *** factors are not quite clear till *** aim of this study is to present data on gastric cancer patients from a single high volume cancer center of China and to illuminate relevant factors regarding unsatisfactory ***：A total of 2312 consecutive pathologically proven gastric carcinoma patients were treated in Beijing Cancer Hospital from January 1995 to December *** information including demographic information,tumor characteristics,therapeutic experience and survival was retrieved from the Database specially designed for Gastric Cancer Collaborative Group,Beijing Cancer ***：There were 1633 males and 679 females with a median age of 58.8 years（range 19-89）.Merely 181 patients were in the early stage（7.8%）.Curative resection was performed in less than 72% of the *** number of lymph nodes harvested varied from 0 to 71（average 9） while the median number of positive lymph node was 2（0-37）.Only in 650 patients the number of lymph nodes harvested was more than *** the end of follow-up,874 patients were still alive while 1132 *** 1,2,5,10-year overall survival were 68.50%,51.88%,36.83%,and 30.49%,*** analysis demonstrated that TNM stage,tumor location,tumor size,surgery,and vascular invasion were independent prognostic ***：The outcome of gastric cancer in China is not as good as *** detection and standardized curative resection should be prompted at present to improve the outcome.

关键词： Gastric cancer Management Outcome

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期68卷 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang Xie qian Hao xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University Department of Oncology Shanghai Medical CollegeFudan University Department of Breast surgery Fudan University Shanghai Cancer CenterFudan University Department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

关键词： p53 NRF2 SLC7A11 WEE1 AZD1775 ferroptosis nucleolar stress

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： xiang-Qun Fu Hong-Wei Li Jian-Hong Shi Tan Li Wan-su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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Extralevator abdominoperineal excision versus abdominoperineal excision for low rectal cancer: a meta-analysis

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Chinese Medical Journal 2019年第20期132卷 2446-2456页

作者： Xin-Yu Qi Ming Cui Mao-Xing Liu Kai Xu Fei Tan Zhen-Dan Yao Nan Zhang Hong Yang Cheng-Hai Zhang Jia-Di Xing xiang-qian su Peking University Health Science Center Beijing 100038China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal Surgery IVPeking University Cancer Hospital and InstituteBeijing 100142China

Background:Extralevator abdominoperineal excision (ELAPE) has become a popular procedure for low rectal cancer as compared with abdominoperineal excision (APE). No definitive answer has been achieved whether one is superior to the other. This study aimed to evaluate the safety and efficacy of ELAPE for low rectal cancer with ***:The Web of Science, Cochrane Library, Embase, and PubMed databases before September 2019 were comprehensively searched to retrieve comparative trials of ELAPE and APE for low rectal cancer. Pooled analyses of the perioperative variables, surgical complications, and oncological variables were performed. Odds ratio (OR) and mean differences (MD) from each trial were pooled using random or fixed effects model depending on the heterogeneity of the included studies. A subgroup analysis or a sensitivity analysis was conducted to explore the potential source of heterogeneity when ***:This meta-analysis included 17 studies with 4049 patients, of whom 2248 (55.5%) underwent ELAPE and 1801 (44.5%) underwent APE. There were no statistical differences regarding the circumferential resection margin positivity (13.0% vs. 16.2%, OR = 0.69, 95% CI = 0.42-1.14, P = 0.15) and post-operative perineal wound complication rate (28.9% vs. 24.1%, OR = 1.21, 95% CI = 0.75-1.94, P= 0.43). The ELAPE was associated with lower rate of intraoperative perforation (6.6% vs. 11.3%, OR = 0.50, 95% CI = 0.39-0.64, P surgical treatment of low rectal cancer.

关键词： Extralevator abdominoperineal excision Abdominoperineal excision Low rectal cancer surgical complications

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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang su Yong Wan xiang Li Department of Spine surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

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Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei qian Xiaofei Hu Ting Zhang Chaoyu xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line widthsulting device exhibited impressive electrochromic performance,such as fast response(3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

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Comparison of neoadjuvant chemotherapy followed by surgery *** alone for locally advanced gastric cancer:a meta-analysis

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Chinese Medical Journal 2021年第14期134卷 1669-1680页

作者： Jian-Hong Yu Zao-Zao Wang Ying-Chong Fan Mao-Xing Liu Kai Xu Nan Zhang Zhen-Dan Yao Hong Yang Cheng-Hai Zhang Jia-Di Xing Ming Cui xiang-qian su Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Gastrointestinal Surgery IVPeking University Cancer Hospital&InstituteBeijing 100142China Department of Minimally Invasive Gastrointestinal surgery Beijing Institute for Cancer ResearchBeijing 100142China

Background:The neoadjuvant chemotherapy is increasingly used in advanced gastric cancer,but the effects on safety and survival are still *** objective of this meta-analysis was to compare the overall survival and short-term surgical outcomes between neoadjuvant chemotherapy followed by surgery(NACS)and surgery alone(SA)for locally advanced gastric ***:Databases(PubMed,Embase,Web of Science,Cochrane Library,and Google Scholar)were explored for relative studies from January 2000 to January *** quality of randomized controlled trials and cohort studies was evaluated using the modified Jadad scoring system and the Newcastle-Ottawa scale,*** Review Manager software(version 5.3)was used to perform this *** overall survival was evaluated as the primary outcome,while perioperative indicators and post-operative complications were evaluated as the secondary ***:Twenty studies,including 1420 NACS cases and 1942 SA cases,were *** results showed that there were no significant differences in overall survival(P=0.240),harvested lymph nodes(P=0.200),total complications(P=0.080),and 30-day post-operative mortality(P=0.490)between the NACS and SA ***,the NACS group was associated with a longer operation time(Psurvival indicated a less important effect of NACS on long-term oncological outcomes.

关键词： Neoadjuvant chemotherapy followed by surgery surgery alone Advanced gastric cancer Gastrectomy Overall survival Meta-analysis

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Effect of pouring time on microstructure and mechanical properties of centrifugal cast Ti-46Al alloy tubes

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China Foundry 2025年

作者： Gang Huang qian Dang Cong-cong su Jing Zhao Chi Zhang Guo-huai Liu Zhao-dong Wang The State Key Laboratory of Rolling and Automation Northeastern University School of Materials Science and Engineering Shenyang University of Technology

The grain size of TiAl alloy castings prepared by traditional casting process is coarse, thus showing poor mechanical properties. In this study, a new type of high performance Ti-46Al alloy tube prepared by vacuum centrifugal casting technology was introduced. This research comprehensively examined the influence of pouring time on the microstructure and mechanical performance of the castings, employing both experimental approaches and ProCast simulation methodologies. The findings indicate that prolonging the pouring time facilitates a microstructural evolution from coarse columnar grains to refined equiaxed grains. Under the condition of pouring temperature of 1,600 °C, rotation speed of 800 r·min-1and pouring time of 6 s, the tensile strength of Ti-46Al alloy at room temperature reaches 650 MPa, and the tensile strength at 800 °C reaches 705 MPa, which is significantly higher than that of traditional as-cast Ti-Al alloy.

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Insight into the particle shape on the impact of dry granular flow against a rigid barrier: A DEM study

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Journal of Earth Science 2025年

作者： Rui-Xiao Zhan Dong su xiang-Sheng Chen Yuan-Jun Jiang Guo-Ping Lei Jing-Jing Yu Key Laboratory for Resilient Infrastructures of Coastal Cities (MOE)， Shenzhen University College of Civil and Transportation Engineering， Shenzhen University School of Architecture and Urban Planning， Shenzhen University Shenzhen Key Laboratory of Green， Efficient and Intelligent Construction of Underground Metro Station， Shenzhen University Institute of Mountain Hazards and Environment， Chinese Academy of Sciences School of Transportation， Civil Engineering & Architecture， Foshan University

The effect of particle shape on the impact of dry granular flow remains an open area for further investigation. Five distinct particle shapes were examined in this study using discrete element simulations after calibrating the numerical model using a published work. The findings indicated that the particle shape had a significant influence on granular mobility. With negligible variations in normalized kinetic energy between particles of different shapes， the effect of particle shape on the increasing rate of kinetic energy became more obvious. All irregular particle scenarios had longer accumulated particle lengths down the channel than spherical particles. Variations in particle shape led to adjustments in the distribution of impact forces on the barrier. These findings substantially enhance our understanding of the distinctive effects of particle shapes on the impact mechanism of dry granular flow.

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