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World Journal of Gastroenterology 2016年第9期22卷 2749-2759页

作者： xiang-qian gu Wei-Ping Zheng Da-Hong Teng Ji-San Sun Hong Zheng Organ Transplant Center The First Central Clinical College Tianjin Medical University Organ Transplant Center Tianjin First Central Hospital

Hepatocellular carcinoma (HCC) is the most common primary neoplasm of the liver and is one of the leading causes of cancer-related death worldwide. Liver transplantation (LT) has become one of the best curative therapeutic options for patients with HCC, although tumor recurrence after LT is a major and unaddressed cause of mortality. Furthermore, the factors that are associated with recurrence are not fully understood, and most previous studies have focused on the biological properties of HCC, such as the number and size of the HCC nodules, the degree of differentiation, the presence of hepatic vascular invasion, elevated serum levels of alpha-fetoprotein, and the tumor stage outside of the Milan criteria. Thus, little attention has been given to factors that are not directly related to HCC (i.e., “non-oncological factors”), which have emerged as predictors of tumor recurrence. This review was performed to assess the effects of non-oncological factors on tumor recurrence after LT. The identification of these factors may provide new research directions and clinical strategies for the prophylaxis and surveillance of tumor recurrence after LT, which can help reduce recurrence and improve patient survival.

关键词： Liver transplantation Immunosuppressive agents Hepatocellular carcinoma Recurrence Living donor Deceased donor

Impact of EBV infection and immune function assay for lymphoproliferative disorder in pediatric patients after liver transplantation: A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 3-11页

作者： Tian Qin xiang-qian gu Seog-Song Jeong Yan-Yan Song Jin-Chuan Liu Jian-Xin Zheng Feng Xue qiang Xia Department of Liver Surgery Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Biostatistics Institute of Medical SciencesShanghai Jiaotong University School of MedicineShanghai 200025China

Background:Post-transplant lymphoproliferative disorder(PTLD)is a lethal complication after pediatric liver transplantation,but information regarding risk factors for the development of PTLD remains *** study was to identify characteristics and risk factors of ***:A total of 705 pediatric patients who underwent liver transplantation between January 2017 and October 2018 were *** of clinical characteristics and Epstein-Barr virus(EBV)infection on the development of PTLD was *** addition,ImmuKnow assay was adopted in partial patients to analyze the immune ***:Twenty-five(3.5%)patients suffered from PLTD with a median time of 6 months(3–14 months)after *** high tacrolimus(TAC)level was found in 2 fatal cases at PTLD *** infection was found in 468(66.4%)patients.A higher peak EBV DNA loads(>9590 copies/mL)within 3 months was a significant indicator for the onset of *** addition,the ImmuKnow assay demonstrated that overall immune response was significantly lower in patients with EBV infection and PTLD(Pguidance in reducing immunosuppressive agents in treatment of PTLD.

关键词： Post-transplant lymphoproliferative disor Pediatric liver transplantation Epstein-Barr virus

Direct Photolithography of WO_(x) Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang gu guojian Yang Wenxuan Wang Aiyan Shi Wenjuan Fang Lei qian Xiaofei Hu Ting Zhang Chaoyu xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

Efficacy and Safety of Juan Bi Pill with Add-on Methotrexate in Active Rheumatoid Arthritis:A 48-Week,Multicentre,Randomized,Double-Blind,and Placebo-Controlled Trial

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Chinese Journal of Integrative Medicine 2025年第2期31卷 99-107页

作者： JIA Qing-yun WANG Yi-ru SUN Da-wei MAO Jian-chun XUE Luan gu Xiao-hua YU xiang PIAO Xue-mei XU Hao LIANG qian-qian Spine Institute Longhua Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200032)China Spine Institute Shanghai University of Traditional Chinese MedicineShanghai(200032)China Key Laboratory of Theory and Therapy of Muscles and Bones Ministry of Education(Shanghai University of Traditional Chinese Medicine)Shanghai(201203)China Department of Orthopedics Linyi People's HospitalLinyiShandong Province(273000)China Department of Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai(200437)China Department of Orthopedics the Seventh People's Hospital of Shanghai University of Traditional Chinese MedicineShanghai(200137)China

Objective:To explore the efficacy and safety of Juan Bi Pill(JBP)in treatment of active rheumatoid arthritis(RA).Methods:From February 2017 to May 2018,115 participants from 4 centers were randomly divided into JBP group(57 cases)and placebo group(58 cases)in a 1:1 ratio using a random number table *** received a dose of JBP(4 g,twice a day,orally)combined with methotrexate(MTX,10 mg per week)or placebo(4 g,twice a day,orally)combined with MTX for 12 *** were required with follow-up visits at 24 and 48 weeks,attending 7 assessment *** were undergo disease activity assessment 7 times(at baseline and 2,4,8,12,24,48 weeks)and safety assessments 6 times(at baseline and 4,8,12,24,48 weeks).The primary endpoint was 28-joint Disease Activity Score(DAS28-ESR and DAS28-CRP).The secondary endpoints included American College of Rheumatology(ACR)criteria for 20%and 50%improvement(ACR20/50),Health Assessment Questionnaire Disability Index(HAQ-DI),clinical disease activity index(CDAI),visual analog scale(VAS),Short Form-36(SF-36)score,Medial Outcomes Study(MOS)sleep scale score,serum erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),tender joint count,swollen joint count,and morning *** adverse reactions were observed during the ***:After 12 weeks of treatment,DAS28-ESR and DAS28-CRP scores in both groups were lower than before treatment(both P<0.01),while the remission rate of DAS28-ESR and DAS28-CRP and low disease activity of JBP group were higher than those in the placebo group(both P<0.01).JBP demonstrated better efficacy on ACR20 and ACR50 compliance rate at 12 and 48 weeks comparing to placebo(all P<0.05).The CDAI and HAQ-DI score,pain VAS and global VAS change of RA patients and physicians,the serum ESR and CRP levels,and the number of tenderness and swelling joints were lower than before treatment at 4,8,12,24,48 weeks in both groups(P<0.05 or P<0.01),while the reduction of above indices in

关键词： Chinese medicine Juan Bi Pill methotrexate active rheumatoid arthritis randomized controlled trial

Molecular Mechanism Behind the Capture of Fluorinated Gases by Metal–Organic Frameworks

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Nano-Micro Letters 2025年第5期17卷 407-462页

作者： qian Wang Yong Hu Yifan gu College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji UniversitySiping Rd 1239Shanghai 200092People’s Republic of China Department of Polymeric Materials School of Materials Science and EngineeringTongji UniversityCaoan Road 4800Shanghai 201804People’s Republic of China Shanghai Institute of Pollution Control and Ecological Security Shanghai 200092People’s Republic of China Key Laboratory of Cities’Mitigation and Adaptation to Climate Change China Meteorological Administration(CMA)Tongji UniversityShanghai 200092People’s Republic of China

Fluorinated gases(F-gases)play a vital role in the chemical industry and in the fields of air conditioning,refrigeration,health care,and organic ***,the direct emission of waste gases containing F-gases into the atmosphere contributes to greenhouse effects and generates toxic *** porous materials for the energy-efficient capture,separation,and recovery of F-gases is highly ***,as a highly designable porous adsorbents,metal–organic frameworks(MOFs)exhibit excellent selective sorption performance toward F-gases,especially for the recognition and separation of different F-gases with highly similar properties,showing their great potential in F-gases control and *** this review,we discuss the capture and separation of F-gases and their azeotropic,near-azeotropic,and isomeric mixtures in various application scenarios by MOFs,specifically classify and analyze molecular interaction between F-gases and MOFs,and interpret the mechanisms underlying their high performance regarding both adsorption capacity and selectivity,providing a repertoire for future materials *** faced in the transformation research roadmap of MOFs adsorbent separation technologies toward F-gases are also discussed,and areas for future research endeavors are highlighted.

关键词： Fluorinated gas Metal–organic framework Adsorption Separation Molecular interaction

A single-pixel elemental imaging method using neutron-induced gamma-ray activation

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Nuclear Science and Techniques 2025年第1期36卷 1-12页

作者： Can Cheng Yong-Ji Xie Xun-Rong Xia Jia-Yu gu Dong Zhao Yi-Ze Chen Ai-Yun Sun Xu-Wen Liang Wen-Bao Jia Da-qian Hei Department of Ionizing Radiation and Medical Engineering Jiangsu Institute of MetrologyNanjing 210023China Institute of Nuclear Analytical Technology Nanjing University of Aeronautics and AstronauticsNanjing 211106China China Nuclear Power Engineering Co. LtdBeijing 100840China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China

Neutron-induced gamma-ray imaging is a spectroscopic technique that uses characteristic gamma rays to infer the elemental distribution of an ***,this technique requires the use of large facilities to supply a high neutron flux and a time-consuming detection procedure involving direct collimating *** this study,a new method based on low neutron flux was proposed.A single-pixel gamma-ray detector combined with random pattern gamma-ray masks was used to measure the characteristic gamma rays emitted from the *** of the elemental distribution in the sample,comprising 30×30 pixels,were reconstructed using the maximum-likelihood expectation-maximization *** results demonstrate that the elemental imaging of the sample can be accurately determined using this *** proposed approach,which eliminates the need for high neutron flux and scanning measurements,can be used for in-field imaging applications.

关键词： Elemental imaging Neutron-induced gamma-ray activation Single-pixel imaging

A stretchable, ionic conductive, and adhesive patch electrode with ultra-low on-skin impedance for electrophysiological signal recording

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Science China(Information Sciences) 2025年第2期68卷 391-392页

作者： Yang LI Yuzhe gu Sheng qian Yuncong PANG Aoxi YU Shuwen ZHENG Wenjie XIA Yuan LIAO Baoguang LIU Shujuan LIU qiang ZHAO College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology) Nanjing University of Posts & Telecommunications (NJUPT) State Key Laboratory of Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials (IAM)Nanjing University of Posts&Telecommunications (NJUPT)

Flexible electrodes have significant potential in fields such as healthcare and neuroscience, as they enable comprehensive recording and analysis of human electrical signals, providing deeper insights into physiological conditions and the state of internal organs and tissues [1, 2]. However, commercial Ag/AgCl wet electrodes face issues such as dehydration,poor comfort, and insufficient mechanical strength, while other types of electrodes, like dry and semi-dry electrodes,also have their own limitations, including the higher contact impedance.

关键词： Lithium Chloride

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Molecular Mechanism Behind the Capture of Fluorinated Gases by Metal–Organic Frameworks

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Nano-Micro Letters 2025年第05期 415-470页

作者： qian Wang Yong Hu Yifan gu College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji University Department of Polymeric Materials School of Materials Science and EngineeringTongji University Shanghai Institute of Pollution Control and Ecological Security Key Laboratory of Cities' Mitigation and Adaptation to Climate Change China Meteorological Administration (CMA)Tongji University

Fluorinated gases(F-gases) play a vital role in the chemical industry and in the fields of air conditioning, refrigeration, health care, and organic ***, the direct emission of waste gases containing F-gases into the atmosphere contributes to greenhouse effects and generates toxic substances. Developing porous materials for the energy-efficient capture, separation, and recovery of F-gases is highly desired. Recently, as a highly designable porous adsorbents, metal–organic frameworks(MOFs) exhibit excellent selective sorption performance toward F-gases,especially for the recognition and separation of different F-gases with highly similar properties, showing their great potential in F-gases control and recovery. In this review, we discuss the capture and separation of F-gases and their azeotropic,near-azeotropic, and isomeric mixtures in various application scenarios by MOFs,specifically classify and analyze molecular interaction between F-gases and MOFs,and interpret the mechanisms underlying their high performance regarding both adsorption capacity and selectivity, providing a repertoire for future materials *** faced in the transformation research roadmap of MOFs adsorbent separation technologies toward F-gases are also discussed,and areas for future research endeavors are highlighted.

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持续性视觉注意对视觉工作记忆项目优先加工的影响

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心理学报 2025年第2期57卷 191-206页

作者：连浩敏张倩谷雪敏李寿欣山东师范大学心理学院济南250358

采用行为实验、事件相关电位和事件相关光信号联合采集技术,通过操纵视觉工作记忆(VWM)项目的检测概率变化VWM项目加工的优先性,探讨持续性视觉注意对VWM项目优先加工的影响是否受到工作记忆资源的调节,以及VWM项目优先加工的神经基础... 详细信息

采用行为实验、事件相关电位和事件相关光信号联合采集技术,通过操纵视觉工作记忆(VWM)项目的检测概率变化VWM项目加工的优先性,探讨持续性视觉注意对VWM项目优先加工的影响是否受到工作记忆资源的调节,以及VWM项目优先加工的神经基础。行为结果显示,在VWM保持阶段插入消耗视觉注意的任务,当优先加工1个项目时,非优先项目受到干扰,而优先项目不受影响;当优先加工2个项目时,优先与非优先项目均受到干扰。事件相关电位和事件相关光信号结果显示,在VWM保持阶段,与无项目优先加工相比,存在项目优先加工时诱发更大的晚期正成分和负慢波,更高激活额叶和枕叶。这表明,持续性视觉注意对VWM项目优先加工的作用受到工作记忆资源的调节,VWM项目优先加工的潜在机制是在保持阶段激活额叶和枕叶,并投入更多的工作记忆资源,增强优先项目的表征稳定性。

关键词：视觉工作记忆视觉注意优先加工事件相关光信号联合采集

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CFRP对砖墙抗震加固对比试验研究与计算分析

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世界地震工程 2003年第1期19卷 77-82页

作者：张祥顺谷倩彭少民武汉理工大学土木工程与建筑学院湖北武汉430070

结合一工程实践的需要,通过5片碳纤维布加固的新建墙体在周期反复荷载作用下的试验,研究了碳纤维布加固对砌体结构抗震性能的影响,以及砖砌体在碳纤维布加固后的受力特性,比较了不同加固方案对砖砌体加固效果的影响,在此基础上讨论了对... 详细信息

结合一工程实践的需要,通过5片碳纤维布加固的新建墙体在周期反复荷载作用下的试验,研究了碳纤维布加固对砌体结构抗震性能的影响,以及砖砌体在碳纤维布加固后的受力特性,比较了不同加固方案对砖砌体加固效果的影响,在此基础上讨论了对碳纤维布加固砖墙抗剪承载力计算模型,并提出了简化计算公式。

关键词：碳纤维布砌体结构加固技术振震性能抗剪承载力