检索结果-南通市图书馆

The gut-eye axis:from brain neurodegenerative diseases to age-related macular degeneration

Neural Regeneration Research 2025年第10期20卷 2741-2757页

作者： Qianzi Jin Suyu Wang Yujia Yao Qin jiang Keran Li Department of Ophthalmology The Affiliated Eye Hospital of Nanjing Medical UniversityNanjingJiangsu ProvinceChina The Fourth School of Clinical Medicine Nanjing Medical UniversityNanjingJiangsu ProvinceChina

Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts ***,the specific pathogenesis remains unclear,and effective early treatment options are consequently *** microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a *** intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other *** dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many *** recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the ***,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s ***,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular ***,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable *** such,the intestinal flora may play an important role in age-related macular *** the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic ***,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular ***-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the inte

关键词： age-related macular degeneration biological agents blinding eye disease dietary nutrition fecal microbial transplantation gut-eye axis intestinal flora metabolite microecology neurodegenerative disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Glycolytic dysregulation in Alzheimer's disease:unveiling new avenues for understanding pathogenesis and improving therapy

引用

Neural Regeneration Research 2025年第8期20卷 2264-2278页

作者： You Wu Lijie Yang Wanrong jiang Xinyuan Zhang Zhaohui Yao Department of Geriatrics Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Alzheimer's disease poses a significant global health challenge owing to the progressive cognitive decline of patients and absence of curative *** current therapeutic strategies,primarily based on cholinesterase inhibitors and N-methyl-Daspartate receptor antagonists,offer limited symptomatic relief without halting disease progression,highlighting an urgent need for novel research directions that address the key mechanisms underlying Alzheimer's *** studies have provided insights into the critical role of glycolysis,a fundamental energy metabolism pathway in the brain,in the pathogenesis of Alzheimer's *** in glycolytic processes within neurons and glial cells,including microglia,astrocytes,and oligodendrocytes,have been identified as significant contributors to the pathological landscape of Alzheimer's *** changes impact neuronal health and function,thus offering promising targets for therapeutic *** purpose of this review is to consolidate current knowledge on the modifications in glycolysis associated with Alzheimer's disease and explore the mechanisms by which these abnormalities contribute to disease onset and *** focus on the pathways through which glycolytic dysfunction influences Alzheimer's disease pathology should provide insights into potential therapeutic targets and strategies that pave the way for groundbreaking treatments,emphasizing the importance of understanding metabolic processes in the quest for clarification and management of Alzheimer's disease.

关键词： Alzheimer’s disease glial cells glycolysis neuronal metabolism pathogenesis therapeutic targets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Characterization of Tomato Transcription Factor WUSCHEL and Functional Study in Arabidopsis

引用

Journal of Integrative Agriculture 2012年第8期11卷 1257-1265页

作者： WANG xiang WANG Xin-guo REN jiang-ping MA Ying YIN Jun National Center for Wheat Research Henan Agricultural University Zhengzhou 450002 P.R.China Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China

The homeobox transcription factor WUSCHEL （WUS） plays a critical role in keeping the balance between the maintenance and differentiation of stem cell population in shoot and floral meristems of Arabidopsis thaliana. The corresponding gene SlWUS is yet to be characterized in tomato. In order to characterize SlWUS gene and its biological function, we cloned it from tomato and analyzed its structure. Tissue expression showed that the SlWUS highly expressed in tomato flower abscission zone. The overexpression of SlWUS in Arabidopsis could trigger undifferentiation of plant flower organ and indeterminacy of flower identity, suggesting that SlWUS maybe involved in flower structure development as well as flower organ identity. Taken together, our results indicated that the SlWUS plays an important role in flower abscission zone and plant organ shedding.

关键词： SlWUS tomato meristem determination Arabidopsis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Robust Adaptive Dynamic Programming Principle for Sensorimotor Control with Signal-Dependent Noise

引用

Journal of Systems Science & Complexity 2015年第2期28卷 261-288页

作者： jiang Yu jiang Zhong-ping Department of Electrical and Computer Engineering Polytechnic School of EngineeringNew York University6 Metrotech Center

As human beings,people coordinate movements and interact with the environment through sensory information and motor adaptation in the daily *** characteristics of these interactions can be studied using optimization-based models,which assume that the precise knowledge of both the sensorimotor system and its interactive environment is available for the central nervous system(CNS).However,both static and dynamic uncertainties occur inevitably in the daily *** these uncertainties are taken into consideration,the previously developed models based on optimization theory may fail to explain how the CNS can still coordinate human movements which are also robust with respect to the *** order to address this problem,this paper presents a novel computational mechanism for sensorimotor control from a perspective of robust adaptive dynamic programming(RADP).Sharing some essential features of reinforcement learning,which was originally observed from mammals,the RADP model for sensorimotor control suggests that,instead of identifying the system dynamics of both the motor system and the environment,the CNS computes iteratively a robust optimal control policy using the real-time sensory *** online learning algorithm is provided in this paper,with rigorous convergence and stability ***,it is applied to simulate several experiments reported from the past *** comparing the proposed numerical results with these experimentally observed data,the authors show that the proposed model can reproduce movement trajectories which are consistent with experimental *** addition,the RADP theory provides a unified framework that connects optimality and robustness properties in the sensorimotor system.

关键词： Adaptive dynamic programming human motor adaptation robust optimal control.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Reliability evaluation for Weibull distribution under multiply type-? censoring

引用

Journal of Central South University 2015年第9期22卷 3506-3511页

作者：贾祥蒋平郭波 College of Information Systems and Management National University of Defense Technology

The multiply type-I censoring represented that all units in life test were terminated at different times. For estimations of Weibull parameters, it was easy to compute the maximum likelihood estimation （MLE） and least-squares estimation （LSE） while it was hard to build confidence intervals （CI）. The concept of generalized confidence interval （GCI） was introduced to build CIs of parameters under multiply type-I censoring. Further, GCI based on LSE and GCI based on MLE were proposed. It is mathematically proved that the former is exact and the latter is approximate. Besides, a Monte Carlo simulation study and an illustrative example also Ran out that the GCI method based on LSE yields rather satisfactory results by comparison with the ones based on MLE. It should be clear that the GCI method is a sensible choice to evaluate reliability under multiply type-I censoring.

关键词： multiply type-I censoring generalized confidence interval maximum likelihood estimation least-squares estimation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cascade degradation and electrocatalytic upcycling of waste poly(ethylene terephthalate)to valued products

引用

Nano Research 2025年第1期18卷 76-93页

作者： Xin Li Zirui jiang Zongkui Kou John Wang Shiyou Zheng School of Materials and Chemistry University of Shanghai for Science and TechnologyShanghai 200093China School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore

The global annual production of poly(ethylene terephthalate)(PET)has reached 82 million tons,yet only a small fraction(less than 20%)is *** ultra-slow degradation rate of PET results in the accumulation of PET waste in the environment,causing serious plastic pollution and posing severe challenges to *** response,great efforts have been directed toward developing a cascade degradation and electrocatalytic upcycling strategy,which serves as a“waste-towealth”*** strategy involves electro-reforming PEThydrolyzed intermediates or using PET pyrolyzed products as electrocatalysts to generate high-value *** review provides an overview of the state-of-the-art strategies for the“degradation-electrocatalytic upcycling(De-eUp)”of PET ***,an introduction to the strategy is provided,categorizing it into two main frameworks:“pyrolysis-electrocatalytic upcycling”and“hydrolysis-electrocatalytic upcycling”.The section on“pyrolysis-electrocatalytic upcycling”delves into the degradation methods for designing derived carbon nanomaterials and their utilization as high-performance ***“hydrolysis-electrocatalytic upcycling”section discusses recent advancements in electro-reforming of PET hydrolyzed intermediates for the production of C_(1) and C_(2) *** review concludes by examining the challenges and future prospects in developing an efficient and economical PET upcycling *** is anticipated that this review will stimulate further progress in plastic waste valorization.

关键词： poly(ethylene terephthalate)waste electrocatalytic upcycling pyrolysis hydrolysis ethylene glycol oxidation reaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Role of the globus pallidus in motor and non-motor symptoms of Parkinson's disease

引用

Neural Regeneration Research 2025年第6期20卷 1628-1643页

作者： Yimiao jiang Zengxin Qi Huixian Zhu Kangli Shen Ruiqi Liu Chenxin Fang Weiwei Lou Yifan jiang Wangrui Yuan Xin Cao Liang Chen Qianxing Zhuang Department of Physiology School of MedicineNantong UniversityNantongJiangsu ProvinceChina Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiChina National Center for Neurological Disorders ShanghaiChina Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration ShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain ScienceFudan UniversityShanghaiChina

The globus pallidus plays a pivotal role in the basal ganglia circuit. Parkinson's disease is characterized by degeneration of dopamine-producing cells in the substantia nigra, which leads to dopamine deficiency in the brain that subsequently manifests as various motor and non-motor symptoms. This review aims to summarize the involvement of the globus pallidus in both motor and non-motor manifestations of Parkinson's disease. The firing activities of parvalbumin neurons in the medial globus pallidus, including both the firing rate and pattern, exhibit strong correlations with the bradykinesia and rigidity associated with Parkinson's disease. Increased beta oscillations, which are highly correlated with bradykinesia and rigidity, are regulated by the lateral globus pallidus. Furthermore,bradykinesia and rigidity are strongly linked to the loss of dopaminergic projections within the cortical-basal ganglia-thalamocortical loop. Resting tremors are attributed to the transmission of pathological signals from the basal ganglia through the motor cortex to the cerebellum-ventral intermediate nucleus circuit. The cortico–striato–pallidal loop is responsible for mediating pallidi-associated sleep disorders. Medication and deep brain stimulation are the primary therapeutic strategies addressing the globus pallidus in Parkinson's disease. Medication is the primary treatment for motor symptoms in the early stages of Parkinson's disease, while deep brain stimulation has been clinically proven to be effective in alleviating symptoms in patients with advanced Parkinson's disease,particularly for the movement disorders caused by levodopa. Deep brain stimulation targeting the globus pallidus internus can improve motor function in patients with tremordominant and non-tremor-dominant Parkinson's disease, while deep brain stimulation targeting the globus pallidus externus can alter the temporal pattern of neural activity throughout the basal ganglia–thalamus network. Therefore, the comp

关键词： anxiety basal ganglia bradykinesia deep brain stimulation depression globus pallidus externus globus pallidus internus lateral globus pallidus medial globus pallidus neural circuit Parkinson's disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Kobayashi’s and Teichmuller’s Metrics and Bers Complex Manifold Structure on Circle Diffeomorphisms

引用

Acta Mathematica Sinica,English Series 2020年第3期36卷 245-272页

作者： Yun ping jiang Department of Mathematics Queens College of the City University of New York FlushingNY 11367-1597USA Department of Mathematics Graduate School of the City University of New York365 Fifth A venueNew YorkNY 10016USA

Given a modulus of continuity ω,we consider the Teichmuller space TC1+ω as the space of all orientation-preserving circle diffeomorphisms whose derivatives are ω-continuous functions modulo the space of Mobius transformations preserving the unit *** study several distortion properties for diffeomorphisms and quasisymmetric *** these distortion properties,we give the Bers complex manifold structure on the Teichm(u| ")ller space TC^1+H as the union of over all0 <α≤1,which turns out to be the largest space in the Teichmuller space of C1 orientation-preserving circle diffeomorphisms on which we can assign such a ***,we prove that with the Bers complex manifold structure on TC^1+H ,Kobayashi’s metric and Teichmuller’s metric coincide.

关键词： Bers complex manifold structure circle diffeomorphism modulus of continuity quasisymmetric circle homeomorphism Teichmuller space Kobayashi's metric Teichmuller's metric

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simultaneous desulfurization and denitrogen of liquid fuels using two functionalized group ionic liquids

引用

Science China Chemistry 2014年第12期57卷 1766-1773页

作者： NIE Yi GONG Xue GAO Hong Shuai ZHANG xiang ping ZHANG Suo jiang Beijing Key Laboratory of Ionic Liquids Clean Process Key Laboratory of Green Process and Engineering State Key Laboratory of Multiphase Complex Systems Institute of Process Engineering Chinese Academy of Sciences College of Chemistry and Chemical Engineering Qufu Normal University

Deep desulfurization of liquid fuels is an important and challenging issue in worldwide petroleum refining *** and catalytic oxidative desulfurization(ECODS)of liquid fuels using a series of ionic liquids(ILs)with two functionalized groups,such as[(CH2)2COOHmim]Cl/n Fe Cl3,[(CH2)2COOHmim]Cl/n Zn Cl2,and[Amim]Cl/n Fe Cl3,was *** the ECODS,the ILs were used as both extractant and catalyst and 30 wt%hydrogen peroxide(H2O2)solution as *** effects of molar ratios of[(CH2)2COOHmim]Cl(or[Amim]Cl)to Fe Cl3(or Zn Cl2)in ILs,H2O2/sulfur(O/S)molar ratio,reaction temperature,and the nature of sulfur compounds on sulfur removal were *** natures of the functional groups(–COOH,–CH2–CH=CH2)in cations and the acid strength of anions play important roles in the ECODS and affect the reaction time,temperature,and desulfurization efficiency of different ***,nitrogen-containing compounds(pyridine,pyrrole,and quinoline)could be removed simultaneously in the ECODS and had different effects on dibenzothiophene removal.

关键词： ionic liquids desulfurization denitrogen fuel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Highly homogeneous zero-index metamaterials make devices more compact and perform better

引用

Light(Science & Applications) 2024年第5期13卷 806-807页

作者： Wei-xiang jiang State Key Laboratory of Millimeter Waves School of Information Science and EngineeringSoutheast University210096 NanjingChina

A highly homogeneous microwave zero-index metamaterial based on high-permittivity SrTiO3 ceramics is demonstrated to realize the small-aperture high-directivity *** a novel technique is a remarkable step forward to de... 详细信息

关键词： ceramics SrTiO3 Highly

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：