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Ultrasound-driven self-decomposition porphyrins as metal-free CO precursors for gas and sonodynamic synergistic therapy

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Science China Chemistry 2024年第5期67卷 1624-1635页

作者： Shuxin liu Jinjuan Ma xiang Xu Aiguo Wang nan Zheng School of Chemical Engineering Dalian University of TechnologyDalian 116024China Department of Comparative Medicine Laboratory Animal Center Dalian Medical UniversityDalian 116000China Cancer Hospital of Dalian University of Technology Shenyang 116000China

Carbon monoxide(CO) is an endogenous therapeutic gas with an anti-tumor effect. The precise delivery and controlled release of CO in tumor tissues play crucial roles in anti-cancer treatment. However, efficient in situ generation of CO from metal-free COreleasing molecules(CORMs) remains a formidable challenge. Herein, we develop ultrasound(US)-driven self-decomposition porphyrin as organic and metal-free US-CORMs, which can spatiotemporally control the CO release(347 mmol CO/mol porphyrin) efficiently under physiologically harmless US conditions(1.0 MHz, 1.5 W/cm^(2), 50% duty cycle, 50 min). Moreover,porphyrin as a sonosensitizer can also generate reactive oxygen species(ROS) under US treatment to achieve sonodynamic therapy(SDT). Advanced functions of such porphyrin-based CORMs in CO gas-sonodynamic synergistic treatment have been demonstrated by evaluating the in vitro and in vivo anti-tumor effects.

关键词： porphyrin sonodynamic therapy metal-free CO precursors ultrasound-driven gas therapy

A new species of Discostella guiyangensis ***.(Bacillariophyta,Stephanodiscales)from Guiyang,China:morphology and phylogeny

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Journal of Oceanology and Limnology 2024年第4期42卷 1312-1324页

作者： Yandan xiang Fangru nan Xudong liu Shulian XIE John Patrick KOCIOLEK Qi liu School of Life Science Shanxi UniversityTaiyuan 030006China Department of Ecology and Evolutionary Biology and Museum of Natural History University of ColoradoBoulder CO 80309USA

We describe a new species of Discostella from Guiyang based on light and scanning electron microscopic observations,as well as molecular *** species is morphologically distinguished from other species by a relatively smooth and slightly recessed central area with marginal striae of unequal lengths forked near the *** fultoportulae and a single rimoportula are situated between every two costae or on the *** morphological characters and the concatenated data of rbc L and SSU rDNA indicate that Discostella guiyangensis is a unique and new *** to divergence time estimation analysis,Discostella guiyangensis is the oldest species among the Discostella species sequenced *** addition,we complement molecular data of Discostella asterocostata and Discostella stelligera.

关键词： Discostella morphology molecular analysis divergence time estimation new species

Data driven reduced modeling for fluidized bed with immersed tubes based on PCA and Bi-LSTM neural networksAuthor links open overlay panel

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Particuology 2024年第8期91卷 1-18页

作者： Jiabin Fang Wenkai Cu Huang liu Huixin Zhang Hanqing liu Jinjia Wei xiang Ma nan Zheng School of Chemical Engineering and Technology Xi'an Jiaotong UniversityXi'anShaanxi 710049China

The fast and accurate reduced-order modeling of fluidized beds is a challenging task in the field of fluid dynamics,owing to their high dimensionality and nonlinear dynamic *** this study,a nonintrusive reduced order modeling method,the reduced order model based on principal component analysis and bidirectional long short-term memory networks(PBLSTM ROM),was developed to capture complex spatio-temporal dynamics of fluidized *** combining principal component analysis and Bidirectional long-short-term memory networks,the PBLSTM ROM effectively extracted dynamic evolution information without any prior knowledge of governing equations,enabling reduced-order modeling of unsteady flow *** PBLSTM ROM was validated using the solid volume fraction and gas velocity flow fields of a fluidized bed with immersed tubes,showing superior performance over both the PLSTM and PANN ROMs in accurately capturing temporal changes in the fluidization fields,especially in the region near immersed tubes where severe fluctuations ***,the PBLSTM ROM improved the simulation speed by five orders of magnitude compared to traditional computational fluid dynamics *** findings suggest that the PBLSTM ROM presents a promising approach for analyzing the complex fluid flows in engineering practice.

关键词： Reduced order modeling Fluidized bed Deep learning Bi-LSTM

Stellate ganglion block reduces inflammation and improves neurological function in diabetic rats during ischemic stroke

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Neural Regeneration Research 2022年第9期17卷 1991-1997页

作者： Ting-Ting Li Qiang Wan Xin Zhang Yuan Xiao Li-Ying Sun Yu-Rong Zhang xiang-nan liu Wan-Chao Yang Department of Anesthesiology the 2nd Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjiang ProvinceChina

Diabetes mellitus is an independent risk factor for ischemic *** diabetes mellitus and stroke are linked to systemic inflammation that aggravates patient *** ganglion block can effectively regulate the inflammatory ***,it is hypothesized that stellate ganglion block could be a potential therapy for ischemic stroke in diabetic *** this study,we induced diabetes mellitus in rats by feeding them a high-fat diet for 4 successive *** left middle cerebral artery was occluded to establish models of ischemic stroke in diabetic ***,we performed left stellate ganglion block with 1%lidocaine using the percutaneous posterior approach 15 minutes before reperfusion and again 20 and 44 hours after *** results showed that stellate ganglion block did not decrease the blood glucose level in diabetic rats with diabetes mellitus but did reduce the cerebral infarct volume and the cerebral water *** also improved the recovery of neurological function,increased 28-day survival rate,inhibited Toll like receptor 4/nuclear factor kappa B signaling pathway and reduced inflammatory response in the plasma of ***,injection of Toll like receptor 4 agonist lipopolysaccharide 5 minutes before stellate ganglion block inhibited the effect of stellate ganglion block,whereas injection of Toll like receptor 4 inhibitor TAK242 had no such *** also found that stellate ganglion block performed at night had no positive effect on diabetic ischemic *** findings suggest that stellate ganglion block is a potential therapy for diabetic ischemic stroke and that it may be mediated through the Toll like receptor 4/nuclear factor kappa B signaling *** also found that the therapeutic effect of stellate ganglion block is affected by circadian rhythm.

关键词： circadian rhythms diabetes mellitus inflammation ischemic stroke long-term prognosis neurological function neuron nuclear factor kappa B stellate ganglion block Toll like receptor 4

A Novel Design of a Pre-separation Panel Structure to Protect Against the Impact of an Explosion in an Aircraft Plenum Chamber

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Acta Mechanica Solida Sinica 2024年第1期37卷 166-180页

作者： Zongxing liu xiang Yang Jun liu School of Aeronautics Northwestern Polytechnical UniversityXi'an 710072China COMAC Shanghai Aircraft Design and Research Institute Shanghai 201210China

To reduce the damage of the pressurizing panel structure of a fuselage caused by an explosion at the“least risk bomb location”in an aircraft structure,a new pre-separation panel structure was designed to resist blast ***,the dynamic strain response and morphology of impact damage of the new pre-separation panel were measured in an impact damage ***,the commercial software LS-DYNA was used to calculate the propagation of the blast shock wave,and the results were compared with empirical equations to verify the rationality of the numerical calculation ***,the fluid–structure coupling method was used to calculate the damage process of the pre-separation panel structure under the impact of an explosion wave and an impact *** calculated results were in good agreement with the test results,which showed the rationality of the calculation method and the *** residual strength of the damaged pre-separation panel was significantly higher than that of the original damaged *** results show that the new pre-separation panel structure is reasonable and has certain significance for guiding the design of plenum chambers with strong resistance to implosion for aircraft fuselages.

关键词： Pre-separation panel structure Explosive response Residual strength Aircraft plenum chamber Least risk bomb location

Review of dynamics and active control of large-scale space membrane antenna

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Astrodynamics 2024年第1期8卷 1-26页

作者： xiang liu Guoping Cai Department of Engineering Mechanics MOE Key Laboratory of HydrodynamicsChongqing Research InstituteShanghai Jiao Tong UniversityShanghai200240China

Large-scale space membrane antennas have significant potential in satellite communication,space-based early warning,and Earth *** of their large size and high flexibility,the dynamic analysis and control of membrane antenna are *** maintain the working performance of the antenna,the pointing and surface accuracies must be strictly ***,the accurate dynamic modeling and effective active control of large-scale space membrane antennas have great theoretical significance and practical value,and have attracted considerable interest in recent *** paper reviews the dynamics and active control of large-scale space membrane ***,the development and status of large-scale space membrane antennas are ***,the key problems in the dynamics and active control of large membrane antennas,including the dynamics of wrinkled membranes,large-amplitude nonlinear vibration,nonlinear model reduction,rigid-flexible-thermal coupling dynamic modeling,on-orbit modal parameter identification,active vibration control,and wave-based vibration control,are discussed in ***,the research outlook and future trends are presented.

关键词： large-scale space membrane antenna dynamicmodeling active control

Comparative study of the effects of Tartary buckwheat seed and sprout consumption on the physiological indices and gut microbiota of C57BL/6J mice

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Food Science and Human Wellness 2024年第2期13卷 791-800页

作者： Guohui nan Haixia Zhao Qiong Wu Lisong liu Zichao Guan Chenglei Li Huala Wu Dabing xiang Qi Wu College of Life Science Sichuan Agricultural UniversityYa'an 625014China Faculty of Quality Management and Inspection&Quarantine Yibin UniversityYibin 644000China College of Pharmacy and Biological Engineering Chengdu UniversityChengdu 610106China

Tartary buckwheat(Fagopyrum tataricum)is a well-known pseudocereal for its health and economic ***,abundant antinutritional factors(ANFs)reduces its health *** reported,germination can improve the nutritional profile of *** this study,we systematically evaluate the safety of Tartary buckwheat seeds(TB)and Tartary buckwheat sprouts(TBS)used as high active *** evaluating nutrition levels,bioactive compounds and ANFs in TBS during germinating,5^(th)-day TBS were selected as the raw material.C57BL/6J mice were gavaged daily with distilled water,TB,or TBS for 6 *** physiological indices related to ANFs were *** showed that the TB intake tends to generate negative effects on the gut microbiota,and ***,upon TB intake,the Fe^(3+)content in serum,trypsin activity in pancreas and jejunum decreased,while the cytokine,IgE,and histamine levels in serum,water content in faeces,cytokine levels in liver and jejunum ***,TBS did not induce any obvious negative effects on the above relevant indices and showed better lipid-lowering ***,TBS are safer and more effective as a raw material to produce the functional food for long-term consumption with the intention of preventing and treating hyperlipidaemia.

关键词： Tartary buckwheat Tartary buckwheat sprouts Antinutritional factors Gut microbiota Health effect

Removal of Cr(Ⅵ)by glutaraldehyde-crosslinked chitosan encapsulating microscale zero-valent iron:Synthesis,mechanism,and longevity

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Journal of Environmental Sciences 2024年第8期142卷 115-128页

作者： Yijun Duan Fang liu xiang liu Miao Li School of Environment Tsinghua UniversityBeijing 100084China Transportation Institute of Inner Mongolia University Hohhot 010070China

Microscale zero-valent iron(mZVI)has shown great potential for groundwater Cr(Ⅵ)***,low Cr(Ⅵ)removal capacity caused by passivation restricted the wide use of *** prepared mZVI/GCS by encapsulating mZVI in a porous glutaraldehydecrosslinked chitosan matrix,and the formation of the passivation layer was alleviated by reducing the contact between zero-valent iron *** average pore diameter of mZVI/GCS was 8.775 nm,which confirmed the mesoporous characteristic of this *** of batch experiments demonstrated that mZVI/GCS exhibited high Cr(Ⅵ)removal efficiency in a wide range of pH(2-10)and temperature(5-35℃).Common groundwater coexisting ions slightly affected m ZVI/*** material showed great reusability,and the average Cr(Ⅵ)removal efficiency was 90.41%during eight *** this study,we also conducted kinetics and isotherms ***-second-order model was the most matched kinetics *** Cr(Ⅵ)adsorption process was fitted by both Langmuir and Freundlich isotherms models,and the maximum Langmuir adsorption capacity of m ZVI/GCS reached243.63 mg/g,which is higher than the adsorption capacities of materials reported in most of the previous ***,the column capacity for Cr(Ⅵ)removal of a mZVI/GCS-packed column was 6.4 times higher than that of a mZVI-packed column in a 50-day ***,mZVI/GCS with a porous structure effectively relieved passivation problems of mZVI and showed practical application prospects as groundwater Cr(Ⅵ)remediation material with practical application prospects.

关键词： Chitosan Glutaraldehyde mZVI Cr(Ⅵ) Groundwater

Localization−delocalization transitions in non-Hermitian Aharonov−Bohm cages

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Frontiers of physics 2024年第3期19卷 39-50页

作者： xiang Li Jin liu Tao liu School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640China

A unique feature of non-Hermitian systems is the extreme sensitivity of the eigenspectrum to boundary conditions with the emergence of the non-Hermitian skin effect (NHSE). A NHSE originates from the point-gap topology of complex eigenspectrum, where an extensive number of eigenstates are anomalously localized at the boundary driven by nonreciprocal dissipation. Two different approaches to create localization are disorder and flat-band spectrum, and their interplay can lead to the anomalous inverse Anderson localization, where the Bernoulli anti-symmetric disorder induces mobility in a full-flat band system in the presence of Aharonov−Bohm (AB) Cage. In this work, we study the localization−delocalization transitions due to the interplay of the point-gap topology, flat band and correlated disorder in the one-dimensional rhombic lattice, where both its Hermitian and non-Hermitian structures show AB cage in the presence of magnetic flux. Although it remains the coexistence of localization and delocalization for the Hermitian rhombic lattice in the presence of the random anti-symmetric disorder, it surprisingly becomes complete delocalization, accompanied by the emergence of NHSE. To further study the effects from the Bernoulli anti-symmetric disorder, we found the similar NHSE due to the interplay of the point-gap topology, correlated disorder and flat bands. Our anomalous localization−delocalization property can be experimentally tested in the classical physical platform, such as electrical circuit.

关键词： non-Hermitian skin effects disorder flat band localization−delocalization transition