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Journal of Geriatric Cardiology 2022年第8期19卷 565-574页

作者： Qian XIN Chuang ZHANG Yu-Jia WANG Jian LI Tao CHEN shi-Xing LI Wei WANG Yu YANG Wen-Juan SONG Jin ZHOU xiang-min shi Department of Cardiology the Sixth Medical CentreChinese PLA General HospitalBeijingChina Department of Health Service the Eighth Medical CentreChinese PLA General HospitalBeijingChina

BACKGROUND Uninterrupted use of oral anticoagulants before atrial fibrillation(AF)ablation can reduce the incidence of perioperative thromboembolic ***,the effect of new oral anticoagulants on activated clotting time(ACT)in respo-nse to heparin during AF ablation in Chinese populations remains *** aim of the present retrospective study was to investigate the value of ACTs in response to intraoperative heparin administration in patients using dabigatran or *** From January 2018 to December 2021,a total of 173 patients undergoing AF ablation were included in the study,in which 101 patients were treated with dabigatran,72 patients were treated with *** intraoperative ACT values were examined in both *** incidence of periprocedural complications was *** Initial heparin dosage(88±19 U/kg vs.78±27 U/kg,Pministration during catheter ablation in patients with AF.

关键词： patients heparin dosage

Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： xiang-Qun Fu Hong-Wei Li Jian-Hong shi Tan Li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期68卷 300-302页

作者： Ze-min Lin Mai xiang Wen-Hui Wei Shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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Direct Photolithography of WO_(x)Nanoparticles for High‑Resolution Non‑Emissive Displays

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Nano-Micro Letters 2025年第3期17卷 297-309页

作者： Chang Gu Guojian Yang Wenxuan Wang Aiyan shi Wenjuan Fang Lei Qian Xiaofei Hu Ting Zhang Chaoyu xiang Yu‑Mo Zhang Laboratory of Optoelectronic Information Technology and Devices Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201People’s Republic of China Hangzhou Bay Laboratory of Advanced Nano‑Optoelectronic Materials and Devices Qianwan Institute of CNITECHNingbo 315336People’s Republic of China Smart Materials for Architecture Research Lab Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxing 314100People’s Republic of China University of Science and Technology of China Hefei 230026People’s Republic of China State Key Lab of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012People’s Republic of China

High-resolution non-emissive displays based on electrochromic tungsten oxides(WOx)are crucial for future near-eye virtual/augmented reality interactions,given their impressive attributes such as high environmental stability,ideal outdoor readability,and low energy ***,the limited intrinsic structure of inorganic materials has presented a significant challenge in achieving precise patterning/pixelation at the micron ***,we successfully developed the direct photolithography for WOx nanoparticles based on in situ photo-induced ligand *** strategy enabled us to achieve ultra-high resolution efficiently(line width3600 cycles),as well as promising applications in electronic logos,pixelated displays,flexible electronics,*** success and advancements presented here are expected to inspire and accelerate research and development(R&D)in high-resolution non-emissive displays and other ultra-fine micro-electronics.

关键词： Electrochromic Direct photolithography WOx nanoparticles In situ photo-induced ligand exchange High-resolution displays

烘云托月,妙趣天然——文学与绘画审美视觉探析

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贵州大学学报（艺术版） 2009年第2期23卷 75-77页

作者：向士敏贵州大学艺术学院贵州贵阳550003

烘云托月作为国画技法,影响着绘画与文学创作。它使中国画一直坚守和张扬着自身独特的艺术个性,使中国文学始终魅力无穷,匠心独具。文学与绘画在审美感受上,有许多关联性——强调"情"与"意"的结合,物象与心象的共鸣,巧用烘托点染的艺术... 详细信息

烘云托月作为国画技法,影响着绘画与文学创作。它使中国画一直坚守和张扬着自身独特的艺术个性,使中国文学始终魅力无穷,匠心独具。文学与绘画在审美感受上,有许多关联性——强调"情"与"意"的结合,物象与心象的共鸣,巧用烘托点染的艺术手法,对物象、人像、意境大肆渲染、对比、夸张,使物象特点得到鲜明的表现,使艺术家的情感得到淋漓的抒发。艺术作品要做到浑厚华滋,就必须注重个性与精神的写意笔墨,物象美、意境美、形式美,才能给人以审美享受。

关键词：烘云托月物象人像意境

Upcycling of polyethylene terephthalate to1,4-cyclohexanedimethanol in water

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Science China Chemistry 2025年

作者： Shuhui Fang Zhiwen Gao Xinrui shi min Zhang Wei Zhang Yue Liu State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University Engineering Center for Sustainable Carbon Science and Technology East China Normal University Institute of Eco-Chongming

The recycling of waste polyethylene terephthalate（PET）, an extensively used polymer as plastic and fiber materials, has become an urgent topic due to the rapid generation and accumulation of plastic waste into the environment. Current chemical recycling approaches to depolymerize and convert PET into 1,4-cyclohexanedimethanol（CHDM）, an important chemical in the production of advanced polyesters, predominantly use organic solvents, such as alcohols or dioxane. Herein, we developed an environmentally friendly and economically viable pathway for converting PET to CHDM using water as the solvent. In this process, PET is sequentially hydrolyzed in water, hydrogenated to 1,4-cyclohexane dicarboxylic acid（CHDA）, and then reduced to CHDM. The PET conversion rate is self-enhanced in aqueous medium via acid-catalyzed hydrolysis by the generated CHDA intermediate. A Pd-based catalyst（e.g., Pd/C） selectively hydrogenates the arene ring of the PET monomer, terephthalic acid intermediate, and a Ru-Sn/C bimetallic catalyst reduces its COOH to CH2OH group. At optimized reaction conditions, a complete conversion of PET and 80.1% yield of CHDM are obtained. Alternatively, this approach can also efficiently produce CHDA from PET, with a yield up to 86.4%.

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Double [5]carbohelicene: facile synthesis, chiroptical properties,isomerization study, and lasing application

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Science China Chemistry 2025年第1期68卷 233-240页

作者： Peipei Liu Yantong Li Meng-xiang Wu Hao Kang Xiao-Li Zhao Lin Xu Linlin Liu Xiaodong Li Junfeng Fang Zhiwei Fang Ya Cheng Hai-Bo Yang Huakang Yu Xueliang shi State Key Laboratory of Petroleum Molecular & Process Engineering Shanghai Key Laboratory of Green Chemistry and Chemical ProcessesSchool of Chemistry and Molecular Engineering East China Normal University School of Physics and Optoelectronics South China University of Technology Institute of Polymer Optoelectronic Materials & Devices State Key Laboratory of Luminescent Materials & Devices South China University of Technology School of Physics and Electronic Science Engineering Research Center of Nanophotonics & Advanced Instrument Ministry of EducationEast China Normal University State Key Laboratory of Precision Spectroscopy School of Physics and Electronic Science East China Normal University

Double carbohelicenes have attracted considerable attention due to their aesthetic structures, distinct π-conjugation extension, inherent chirality, and intriguing optical and electronic properties. Herein, the concise de novo synthesis of a new double[5]carbohelicene 1 together with its chiroptical properties, isomerization process and lasing application is presented. 1 was synthesized by a simple protocol involving the formation of a 6,6′-bipentacene as the key intermediate. It is worth noting that1 existed as two diastereomers 1-PP/MM and 1-PM, which were successfully isolated and unambiguously confirmed by Xray crystallography. The optical resolution of the racemic 1-PP/MM was successfully achieved by chiral-phase highperformance liquid chromatography（HPLC）, and 1-PP and 1-MM were characterized by circular dichroism. Interestingly, it was found that 1-PP/MM could be completely isomerized to 1-PM upon heating, and the detailed thermodynamics and kinetics of the isomerization process were systematically investigated. 1-PM exhibited deep-red luminescence with emission maximum at 723 nm and fluorescence quantum yield as high as 32.95%. Consequently, we can showcase the lasing application of 1-PM by doping with epoxy resin to assemble a bottle microlaser spontaneously, which the lasing wavelength is 796.6 nm at a threshold of 0.8 m J cm-2. We believe that our studies, including the facile synthesis methodology, detailed isomerization studies, and lasing application, will shed some light on the design and synthesis of novel carbohelical systems with more functions.

关键词： double carbohelicene optical resolution organic laser isomerization X-ray diffraction

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黔南州不同森林类型空气中环境保健因子分析

西部林业科学 2013年第5期42卷 41-46页

作者：田华林李玉敏孟祥江张季向仕敏季梅黔南州林业科学研究所贵州都匀558000 中国林业科学研究院林业科技信息研究所北京100091 重庆市林业科学研究院重庆400036 云南省林业科学院云南昆明650201

2010年在黔南州选择具有代表性的不同森林类型进行实地检测空气负离子、氧气及萜烯类物质含量,采取统计分析、对比分析的方法对森林空气中各项保健因子进行分析。结果表明,黔南州森林环境中空气负离子的平均浓度达2 200个/cm3,明显高于... 详细信息

2010年在黔南州选择具有代表性的不同森林类型进行实地检测空气负离子、氧气及萜烯类物质含量,采取统计分析、对比分析的方法对森林空气中各项保健因子进行分析。结果表明,黔南州森林环境中空气负离子的平均浓度达2 200个/cm3,明显高于非林区;平均氧浓度超出正常空气氧浓度的0.26%,其中针阔混交林中氧气浓度要高于其他类型的林分;萜烯类物质近20种,主要包括α-蒎烯、β-蒎烯和蒈烯等单萜烯以及环戊二烯、异戊三烯、长叶烯等多萜烯,平均浓度为0.012 8μg/m3;针叶林释放的萜烯类物质浓度高于其他类型林分,其中针叶林释放的多为单萜烯物质,阔叶林释放的多为多萜烯物质。大部分森林环境中空气质量为A级,即达到最清洁的水平,其中森林公园明显高于其他森林环境。因此,黔南州整体空气质量极佳,适于开展休养保健游。

关键词：森林环境保健因子评价黔南州

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寻找地外生命的进展与前景

地质科技情报 2009年第6期28卷 128-135页

作者：向世民黄定华高举林鑫波中国地质大学研究生院中国地质大学地球科学学院中国地质大学空间科学技术研究中心武汉430074

介绍并探讨了人类运用天文学、深空探测及计算机模拟与统计等多种方法和手段在太阳系内的地外天体及太阳系外的类地行星上寻找地外生命的进展,如:美国航空航天局及欧空局的一系列探测器都发现火星土壤略呈碱性可能适宜生命的存在,火星... 详细信息

介绍并探讨了人类运用天文学、深空探测及计算机模拟与统计等多种方法和手段在太阳系内的地外天体及太阳系外的类地行星上寻找地外生命的进展,如:美国航空航天局及欧空局的一系列探测器都发现火星土壤略呈碱性可能适宜生命的存在,火星大气正在不断释放可能由火星地质或生物作用产生的甲烷;表面为巨厚的水冰覆盖的木卫二如果内部炽热,则极有可能存在生命;而土卫六则非常类似现代生命起源理论中生命起源时的原始地球。对彗星的撞击探测结果表明,其内部存在着有机物和黏土矿物,可能给早期原始地球带来了有机物甚至生命;对太阳系外的射电天文观测则发现了仅银河系中就有无数的类地行星。不仅如此,"寻找地外智慧生命"计划还试图通过倾听地外智慧生命的通讯信号和主动发射地球人类的通讯信号以和地外智慧生命取得联系。美国航空航天局发射了带有地球位置及生命信息的太阳系外探测器,也做出了类似的努力。从取得的探测结果和重要发现来看,地外可能存在着适宜生命产生及演化的条件,这使我们看到了寻找地外生命的新曙光。但囿于对地外生命形式认识的缺乏和深空探测技术的限制,目前想要找到它们还是个极其艰巨的任务。

关键词：地外生命深空探测火星木卫二木卫六彗星类地行星

哺乳仔猪中伪狂犬病病毒鄂A株对细胞凋亡的诱导或抑制

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生物化学与生物物理学报 2003年第4期35卷 325-330页

作者：李祥敏钱平石德时金梅林蓝盛银陈焕春华中农业大学动物医学院动物病毒室华中农业大学生命科学技术学院分子细胞生物学研究室华中农业大学动物医学院动物病毒室武汉430070

通过人工感染伪狂犬病病毒阴性的健康仔猪 ,取实验组和阴性对照组仔猪的咽部扁桃体、胸腺、颈部淋巴结、腹股沟淋巴结、大脑、小脑、嗅球、三叉神经节等组织作样本。通过电子显微镜观察、DNA梯谱和原位末端脱氧核苷酸标记等试验进行细... 详细信息

通过人工感染伪狂犬病病毒阴性的健康仔猪 ,取实验组和阴性对照组仔猪的咽部扁桃体、胸腺、颈部淋巴结、腹股沟淋巴结、大脑、小脑、嗅球、三叉神经节等组织作样本。通过电子显微镜观察、DNA梯谱和原位末端脱氧核苷酸标记等试验进行细胞凋亡分析 ,结果发现实验组仔猪的淋巴组织细胞呈现典型的细胞凋亡的特征 ,而神经组织中无。这一结果表明 :伪狂犬病病毒感染诱导大量淋巴细胞凋亡 ,造成仔猪免疫功能低下 ,导致大量死亡 ,这可能是伪狂犬病病毒急性感染致病机制之一 ;同时也证实伪狂犬病病毒通过抑制神经细胞的凋亡 ,在神经组织中建立潜伏感染并终生带毒。

关键词：伪狂犬病病毒淋巴组织细胞神经组织细胞细胞凋亡