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Sea level change under IPCC-A2 scenario in Bohai, Yellow, and East China Seas

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Water Science and Engineering 2014年第4期7卷 446-456页

作者： Chang-lin chen Jun-cheng ZUO mei-xiang chen Zhi-gang GAO C.-K.SHUM State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyState Oceanic Administration College of Harbor Coastal and Offshore EngineeringHohai University National Marine Date and Information Service State Oceanic Administration School of Earth Sciences Ohio State University

Because of the environmental and socioeconomic impacts of anthropogenic sea level rise （SLR）, it is very important to understand the processes leading to past and present SLRs towards more reliable future SLR projections. A regional ocean general circulation model （ROGCM）, with a grid refinement in the Bohai, Yellow, and East China Seas （BYECSs）, was set up to project SLR induced by the ocean dynamic change in the 21st century. The model does not consider the contributions from ice sheets and glacier melting. Data of all forcing terms required in the model came from the simulation of the Community Climate System Model version 3.0 （CCSM3） under the International Panel on Climate Change （IPCC）-A2 scenario. Simulation results show that at the end of the 21st century, the sea level in the BYECSs will rise about 0.12 to 0.20 m. The SLR in the BYECSs during the 21st century is mainly caused by the ocean mass redistribution due to the ocean dynamic change of the Pacific Ocean, which means that water in the Pacific Ocean tends to move to the continental shelves of the BYECSs, although the local steric sea level change is another factor.

关键词： sea level rise steric sea level change IPCC-A2 scenario mass redistribution Bohai, Yellow, and East China Seas

Seasonal and interannual variabilities of mean velocity of Kuroshio based on satellite data

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Water Science and Engineering 2012年第4期5卷 428-439页

作者： Jun-cheng ZUO Min ZHANG Qing XU Lin MU Juan LI mei-xiang chen Key Laboratory of Coastal Disaster and Defence of Ministry of Education Hohai University College of Harbor Coastal and Offshore EngineeringHohai University South China Sea Prediction Center South China Sea BranchState Oceanic Administration National Marine Data and Information Service

Combining sea level anomalies with the mean dynamic topography derived from the geoid of the EGM08 global gravity field model and the CLS01 mean sea surface height, this study examined the characteristics of global geostrophic surface currents and the seasonal and interannual variabilities of the mean velocity of the Kuroshio （the Kuroshio source and Kuroshio extension）. The patterns of global geostrophic surface currents we derived and the actual ocean circulation are basically the same. The mean velocity of the Kuroshio source is high in winter and low in fall, and its seasonal variability accounts for 18% of its total change. The mean velocity of the Kuroshio extension is high in summer and low in winter, and its seasonal variability accounts for 25% of its total change. The interannual variabilities of the mean velocity of the Kuroshio source and Kuroshio extension are significant. The mean velocity of the Kuroshio source and ENSO index are inversely correlated. However, the relationship between the mean velocity of the Kuroshio extension and the ENSO index is not clear. Overall, the velocity of the Kuroshio increases when La Nina occurs and decreases when E1 Nino occurs.

关键词： seasonal and interannual variabilities global gravity field global geostrophicsurface current mean dynamic topography Kuroshio

Integrative analysis of aberrant Wnt signaling in hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第20期21卷 6317-6328页

作者： Shan-Long Ding Zi-Wei Yang Jie Wang Xiao-Lei Zhang xiang-mei chen Feng-Min Lu Department of Microbiology and Infectious Disease Center School of Basic Medical SciencesPeking University Health Science Center

AIM: To comprehensively understand the underlying molecular events accounting for aberrant Wnt signaling activation in hepatocellular carcinoma(HCC).METHODS: This study was retrospective. The HCC tissue specimens used in this research were obtained from patients who underwent liver surgery. The Catalogue of Somatic Mutations in Cancer(COSMIC) database was searched for the mutation statuses of CTNNB1, TP53, and protein degradation regulator genes of CTNNB1. Dual-luciferase reporter assay was performed with TOP/FOP reporters to detect whether TP53 gain-of-function(GOF) mutations could enhance the transcriptional activity of Wnt signaling. Methylation sensitive restriction enzyme-quantitative PCR was used to explore the methylation status of Cp G islands located in the promoters of APC, SFRP1, and SFRP5 in HCCs with different risk factors. Finally, nestedreverse transcription PCR was performed to examine the integration of HBx in front of LINE1 element and the existence of HBx-LINE1 chimeric transcript in Hepatitis B virus-related HCC. All results in this article were analyzed with the software SPSS version 19.0 for Windows, and different groups were compared by χ2 test as ***: Based on the data from COSMIC database, compared with other solid tumors, mutation frequency of CTNNB1 was significantly higher in HCC(P < 0.01). The rate of CTNNB1 mutation was significantly less frequent in Hepatitis B virus-related HCC than in other etiologies(P < 0.01). Dual-luciferase reporter system and TOP/FOP reporter assays confirmed that TP53 GOF mutants were able to enhance the transcriptional ability of Wnt signaling. An exclusive relationship between the status of TP53 and CTNNB1 mutations was observed. However, according to the COSMIC database, TP53 GOF mutation is rare in HCC, which indicates that TP53 GOF mutation is not a reason for the aberrant activation of Wnt signaling in HCC. APC and AXIN1 were mutated in HCC. By using methylation sensitive restriction enzym

关键词： β-catenin CTNNB1 Hepatitis B virus Hepatocellular carcinoma TP53 Wnt signaling

Antiviral therapies for hepatitis B virus-related hepatocellular carcinoma

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World Journal of Gastroenterology 2015年第13期21卷 3860-3866页

Chronic hepatitis B virus(HBV) infection is a critical risk factor for the carcinogenesis and progression of hepatocellular carcinoma(HCC). It promotes HCC development by inducing liver fibrogenesis, genetic and epigenetic alterations, and the expression of active viral-coded proteins. Effective antiviral treatments inhibit the replication of HBV, reduce serum viral load and accelerate hepatitis B e antigen serum conversion. Timely initiation of antiviral treatment is not only essential for preventing the incidence of HCC in chronic hepatitis B patients, but also important for reducing HBV reactivation, improving liver function, reducing or delaying HCC recurrence, and prolonging overall survival of HBV-related HCC patients after curative and palliative therapies. The selection of antiviral drugs, monitoring of indicators such as HBV DNA and hepatitis B surface antigen, and timely rescue treatment when necessary, are essential in antiviral therapies for HBVrelated HCC.

关键词： Chronic hepatitis B Hepatocellular carcinoma Antiv

Association between ventricular repolarization variables and cardiac diastolic function: A cross-sectional study of a healthy Chinese population

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World Journal of Clinical Cases 2019年第8期7卷 940-950页

作者： Zhi-Dan Li Xiao-Juan Bai Lu-Lu Han Wen Han Xue-Feng Sun xiang-mei chen Department of Gerontology and Geriatrics Shengjing Hospital of China Medical University Department of Kidney General Hospital of Chinese People's Liberation Army

BACKGROUND Diastolic electromechanical couple, a well-described phenomenon in symptomatic heart failure, has not been well studied in healthy people. We hypothesized that ventricular repolarization variables, such as the QT interval,Tpeak-to-Tend(Tpe) interval and Tpe/QT ratio, are associated with cardiac diastolic function in the healthy Chinese *** To assess the relationship between ventricular repolarization variables and cardiac diastolic function in apparently healthy Chinese *** This was a community-based cross-sectional study conducted in Shenyang,China. A total of 414 healthy subjects aged 35-91 years were enrolled. All subjects underwent standard 12-lead electrocardiography(ECG) and comprehensive echocardiography. ECG enabled the measurement of QT and Tpe intervals and Tpe/QT ratio. echocardiographic parameters, such as the ratio of mitral early diastolic inflow velocity(E) and late diastolic inflow velocity(A), E-wave deceleration time, left atrial volume(LAV) and LAV index, were measured to assess diastolic function. E/A < 0.75 was considered to indicate reduced diastolic function. ECG and echocardiography results were analyzed separately and in a blinded fashion. Correlation and regression analyses were applied to determine *** Ventricular repolarization variables, such as the QTc interval(393.59 ± 26.74 vs403.86 ± 33.56; P < 0.001), Tpe interval(72.68 ± 12.41 vs 77.26 ± 17.86; P < 0.01),Tpec interval(76.36 ± 13.53 vs 83.32 ± 21.25; P < 0.001) and Tpe/QT ratio(0.19 ±0.03 vs 0.20 ± 0.04; P < 0.01), were significantly different between the normal diastolic function group and the reduced diastolic function group. Significant associations were found between repolarization variables and diastolic *** adjusting for all other possible confounders, the QTc and Tpe_c intervals were significantly associated with the E/A ratio(P = 0.008; P = 0.010). In men, the QTc interval was associated with abnormal diastoli

关键词： QT interval Tpeak-to-Tend interval Diastolic dysfunction Ventricular repolarization Electrocardiography

The Prokaryotic Expression and Bioactivity of the Recombinant Red Fire Ant Venom Allergen Sol i 4

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Agricultural Sciences in China 2009年第2期8卷 182-187页

作者： HAN Xue-qing LIN xiang-mei chen Hong-jun ZHANG Yong-guo YE Gui-sheng WU Shao-qiang LI Jian chen Nai-zhong chen Yan ZHU Shui-fang Chinese Academy of Inspection and Quarantine Beijing 100029 P.R.China

The sting of red imported fire ant （RIFA） could cause serious allergic response in fraction of people. These allergic reactions are mainly caused by its venom, especially venom allergen Sol i 1-4. To produce large amount of RIFA venom allergen Sol i 4 for diagnosis of RIFA allergy and allergen-specific immunotherapy, the gene encoding this protein was amplified and cloned into the prokaryotic expression vector pET43, la. The recombinant plasmid was used to transform competent cells and the recombinant proteins were expressed in E. coll. SDS-PAGE and Western blotting analysis indicated that high-level expression of Sol i 4 protein was successfully achieved. Allergenic activity analysis of the recombinant allergen Sol i 4 was then performed on rabbit. The result showed that the recombinant protein obtained had significant allergenic activity. It indicated that the recombinant allergen Sol i 4 of RIFA venom was successfully expressed in E. coli, which provided foundation for further developing therapeutic and diagnosis reagents of RIFA allergy.

关键词： red imported fire ant recombinant allergen Sol i 4 expression activity

Glycogen Synthase Kinase 3β Inhibitor (2'Z,3'E)-6-Bromo-indirubin-3'-Oxime Enhances Drug Resistance to 5-Fluorouracil Chemotherapy in Colon Cancer Cells

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Chinese Journal of Cancer Research 2012年第2期24卷 116-123页

作者： Kun-ping Liu Feng Luo Si-ming Xie Li-juan Tang mei-xiang chen Xue-fang Wu Xue-yun Zhong Tong Zhao Department of Pathology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Pathology Qingyuan HospitalMedical CollegeJinan UniversityQingyuan 511518China Department of Pathology Medical CollegeJinan UniversityGuangzhou 510632China Department of Pathology School of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510515China

Objective： To explore the effects and mechanism of glycogen synthase kinase 3β （GSK-313） inhibitor （2＇Z,3＇E）-6-bromo-indirubin-3＇-oxime （BIO） on drug resistance in colon cancer cells. Methods： The colon cancer SW480 and SW620 cells were treated with BIO, 5-fluorouracil （5-FU） and BIO/5-FU, separately. Cell cycle distribution, apoptosis level and efflux ability of rhodamine 123 （Rh123） were detected by flow cytometry. The protein expressions of P-glycoprotein （P-gp）, multidrug resistance protein 2 （MRP2）, thymidylate synthase （TS）, β-catenin, E2F-1 and βcl-2 were detected by Western blot. β-catenin and P-gp were stained with double immunofluorescence and observed under a confocal microscope. Results： BIO up-regulated β-catenin, P-gp, MRP2 and TS, enhanced the efflux ability of Rh123, decreased Bcl-2 protein and gave the opposite effect to E2F-1 protein in SW480 and SW620 ceils. Furthermore, BIO significantly inhibited cell apoptosis, increased S and G2/M phase cells, and reduced the cell apoptosis induced by 5-FU in SW480 cells, whereas the effects were slight or not obvious in SW620 cells. Conclusion： GSK-3β was involved in drug resistance regulation, and activation of β-catenin and inhibition of E2F-1 may be the most responsible for the enhancement of 5-FU chemotherapy resistance induced by GSK-β inhibitor β10 in colon cancer.

关键词： Colorectal neoplasms Drug resistance Glycogen synthase kinase 313 Fluorouracil 13-catenin E2F-1

Effect of probucol on insulin resistance in patients with non-diabetic chronic kidney disease

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Journal of Geriatric Cardiology 2015年第5期12卷 521-527页

作者： Rui WANG Ri-Bao WEI Yue YANG Na WANG Meng-Jie HUANG Cui-Ming CAO Zi-cheng WANG Guang-Yan CAI xiang-mei chen Department of Nephrology Chinese PL4 General Hospital Beijing China

Background Insulin resistance （IR） is present at all stages of chronic kidney disease （CKD） and is associated with CKD progression. Probueol can improve the prognosis of IR in diabetes mellitus （DM） patients. This study aimed to observe the effect of probucol on IR and kidney protection in non-diabetic CKD patients. Methods This was an open-label, non-placebo-controlled, randomized study. A total of 59 patients were randomized to the probucol group （0.5 g, twice daily） or the control group using a 1： 1 treatment ratio. IR was determined using a homeostatic model assessment-IR （HOMA-IR） index. An Excel database was established to analyze foUow-up data at weeks 0, 12, and 24. The primary outcome of interest was changes in the HOMA-IR, and the secondary outcomes of interest were changes in the estimated glomerular filtration rate （eGFR）, body mass index （BMI）, cholesterol, triglycerides, high-density lipoprotein （HDL）, low-density lipoprotein （LDL）, and 24-h urinary protein. Results The HOMA-IR index of the probucol group after 24 weeks was significantly decreased （P 〈 0.001） compared to the value before treatment （average decrease： 1.45; range： -2.90 to -0.43）. The HOMA-IR index in the control group increased （average increase： 0.54; range： -0.38 to 1.87）. For the secondary outcomes of interest, the changes between these two groups also exhibited significant differences in eGFR （P = 0.041）, cholesterol （P = 0.001）, fasting insulin （P 〈 0.001）, and fasting C-peptide （P = 0.001）. Conclusions Compared to angiotensin receptor blockers alone, the combination with probucol ameliorates IR in non-diabetic CKD patients and delays disease progression.

关键词： Chronic kidney disease Insulin resistance Probucol

Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3×Tg-AD mice

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Neural Regeneration Research 2023年第1期18卷 183-188页

作者： Fei Yan Ju Liu mei-xiang chen Ying Zhang Sheng-Jiao Wei Hai Jin Jing Nie Xiao-Long Fu Jing-Shan Shi Shao-Yu Zhou Feng Jin Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education Zunyi Medical UniversityZunyiGuizhou ProvinceChina Institute of Digestive Diseases Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Icariin,a major prenylated flavonoid found in Epimedium spp.,is a bioactive constituent of Herba Epimedii and has been shown to exert neuroprotective effects in experimental models of Alzheimer’s *** this study,we investigated the neuroprotective mechanism of icariin in an APP/PS1/Tau triple-transgenic mouse model of Alzheimer’s *** performed behavioral tests,pathological examination,and western blot assay,and found that memory deficits of the model mice were obviously improved,neuronal and synaptic damage in the cerebral cortex was substantially mitigated,and amyloid-βaccumulation and tau hyperphosphorylation were considerably reduced after 5 months of intragastric administration of icariin at a dose of 60 mg/kg body weight per ***,deficits of proteins in the insulin signaling pathway and their phosphorylation levels were significantly reversed,including the insulin receptor,insulin receptor substrate 1,phosphatidylinositol-3-kinase,protein kinase B,and glycogen synthase kinase 3β,and the levels of glucose transporter 1 and 3 were markedly *** findings suggest that icariin can improve learning and memory impairments in the mouse model of Alzheimer’s disease by regulating brain insulin signaling and glucose transporters,which lays the foundation for potential clinical application of icariin in the prevention and treatment of Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-beta brain insulin signaling glucose transporter glucose uptake icariin memory neurodegenerative disease tau hyperphosphorylation triple-transgenic Alzheimer’s disease mice