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Roles of cancer stem cells in gastrointestinal cancers

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World Journal of Stem Cells 2023年第4期15卷 209-220页

作者： Shi-Hai Xuan meng-Lu Hua Ze xiang xiang-lin He Lan Huang Chun Jiang Peng Dong Jian Wu Department of Laboratory Medicine The People’s Hospital of Dongtai CityDongtai 224299Jiangsu ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of Clinical Laboratory Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina Hangzhou Institute of Cardiovascular Diseases Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

Cancer stem cells(CSCs)are the main cause of tumor growth,invasion,metastasis and ***,CSCs have been extensively studied to identify CSCspecific surface markers as well as signaling pathways that play key roles in CSCs *** involvement of CSCs in the pathogenesis of gastrointestinal(GI)cancers also highlights these cells as a priority target for *** diagnosis,prognosis and treatment of GI cancer have always been a focus of ***,the potential application of CSCs in GI cancers is receiving increasing *** review summarizes the role of CSCs in GI cancers,focusing on esophageal cancer,gastric cancer,liver cancer,colorectal cancer,and pancreatic *** addition,we propose CSCs as potential targets and therapeutic strategies for the effective treatment of GI cancers,which may provide better guidance for clinical treatment of GI cancers.

关键词： Cancer stem cells Gastrointestinal cancers Promotion Inhibition Treatment

Oxidation resistant low-alloyed Ti alloys with good ductility

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Rare Metals 2024年第8期43卷 3921-3936页

作者： meng Li Zhang-Zhi Shi Jun-Yi Xu Fu-Zhi Dai xiang-Min Li Zi-lin Li Lu-Ning Wang Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advance Metals and MaterialsSchool of Materials Science and EngineeringUniversity of Science and Technology BeijingBeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Oxidation resistance enhancement of pure Ti often comes at the cost of reduced ductility,which is frequently the problem through alloying with sole Al,Si,W,Mo and *** overcome the short coming of single element alloying,this paper proposes a multi-element low-alloying strategy to take advantage of synergistic effects and resolve the conflict between oxidation resistance and *** demonstrates that the addition of a small quantity of Ta(0.51wt%)can boost both oxidation resistance and ductility in comparison to pure ***,the combined addition of a small amount(0.54 wt%)of Ta,Nb and Si not only preserves good ductility of pure Ti,but also reduces mass gains to 14%-67%of pure Ti during 100 h oxidation at 650-850℃in *** indicates even better oxidation resistance than that obtained through the use of Ta,Nb,or Nb+Ta *** Ta+Nb+Si alloying creates an oxide layer that is less porous and more resistant to stratification and ***,a 3-μm N-rich layer can form in the Ti substrate beneath the oxide scale,in which phase transformation generates coherent Ti_(2)N with(0001)_(Ti)as the habit plane,with N atoms prefers to diffuse along■than along[0001]_(Ti).The completely transformed Ti_(2)N region or partially transformed Ti+Ti_(2)N region can effectively impede oxygen ***,the multielement low-alloying strategy is promising for enhancing both oxidation resistance and mechanical properties of metallic materials in the future.

关键词： Ti alloys Multi-element Co-alloying Oxidation resistance Mechanical properties

Novel fluorescent chemosensor for Ag^+ based on coumarin fluorophore

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Chinese Chemical Letters 2008年第8期19卷 977-980页

作者： Mao xiang Wang xiang Ming meng Man Zhou Zhu Qing xiang Guo Department of Chemistry University of Science and Technology of China Hefei 230026 China

A novel chemosensor 1 （CS1） bearing one coumarin and two carbodithioate groups was synthesized and its fluorescent sensing behavior toward metal ions was investigated. Ag^＋ addition to a CH3COCH3/H2O （3：7, v：v） solution of CS1 gave a significantly quenched fluorescence. Other ions including Pb^2＋, Zn^2＋, Cu^2＋, Ca^2＋, Cd^2＋, Co^2＋, Mg^2＋, Mn^2＋, Hg^2＋, Ag^＋, Ni^2＋ induced no or much smaller spectral changes. This constitutes an ON-OFF Ag^＋-selective fluorescent chemosensor.

关键词： Ag^+ chemosensor Fluorescence PET Coumarin

A novel selective fluorescent chemosensor for Cu(Ⅱ)

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Chinese Chemical Letters 2007年第11期18卷 1403-1406页

作者： Mao xiang Wang xiang Ming meng Man Zhou Zhu Qing xiang Guo Department of Chemistry University of Science and Technology of China Hefei 230026 China

A novel fluorescence enhancement Cu^2＋ chemosensor derived from coumarin was prepared. Emission study found that it exhibits evident Cu^2＋-arnplified fluorescence prior to Co^2＋, Pb^2＋, Mg^2＋, Mn^2＋, Ni^2＋, Zn^2＋, Fe^3＋, Ag^＋ and Cd^2＋, and the largest emission enhancement factor is about 9 at a ratio of 2：1 （chemosensor 1/Cu^2＋）.

关键词： Cu^2+ chemosensor Fluorescence 荧光性 Coumarin

Design of coherent wideband radiation process in a Nd3+-doped high entropy glass system

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Light(Science & Applications) 2022年第9期11卷 2065-2076页

作者： linDE ZHANG JINGYUAN ZHANG xiang WANG meng TAO GANGTAO DAI JING WU ZHANGWANG MIAO SHIFEI HAN HAIJUAN YU Xuechun lin Laboratory of All-solid-state Light Sources Beijing Engineering Research CenterInstitute of SemiconductorsChinese Academy of Sciences100083 BeijingChina Synlumin Conuninex(Shanghai)Enterprise Development Co. Ltd.201401 ShanghaiChina Time-wave-space Optical Technology(Xiaogan)Co. Ltd.432012 XiaoganHubeiChina High-dimensional Plasma Sources Technology(Xiaogan)Co. Ltd.432012 XiaoganHubeiChina

We discover that the spatially coherent radiation within a certain frequency range can be obtained without a common nonlinear optical ***,the emission spectra were obtained by de-exciting excited centers from real excited energy levels to the ground *** findings are achieved by deploying a high-entropy glass system(HEGS)doped with neodymium *** HEGS exhibits a much broader infrared absorption than common glass systems,which can be attributed to be high-frequency optical branch phonons or allowable multi-phonon processes caused by phonon broadening in the system.A broadened phonon-assisted wideband radiation(BPAWR)is induced if the pump laser is absorbed by the *** subsequent low-threshold self-absorption coherence modulation(SACM)can be controlled by changing excitation wavelengths,sample size,and doping *** SACM can be red-shifted through the emission of phonons of the excited species and be blue-shifted by absorbing phonons before they are *** is a time delay up to 1.66 ns between the pump pulse and the BPAWR when measured after traveling through a 35 mm long sample,which is much longer than the Raman *** BPAWR-SACM can amplify the centered non-absorption band with a gain up to 26.02 *** results reveal that the shift of the novel radiation is determined by the frequency of the non-absorption band near the absorption region,and therefore the emission shifts can be modulated by changing the absorption *** used in fiber lasers,the BPAWR-SACM process may help to achieve tunability.

关键词： pump wideband excited

The Completeness of Accreting Neutron Star Binary Candidates from the Chinese Space Station Telescope

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Research in Astronomy and Astrophysics 2024年第9期24卷 28-36页

作者： Hao Shen Shun-Yi Lan xiang-Cun meng Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China International Centre of Supernovae Yunnan Key LaboratoryKunming 650216China

A neutron star(NS)has many extreme physical conditions,and one may obtain some important information about an NS via accreting neutron star binary(ANSB)*** upcoming Chinese Space Station Telescope(CSST)provides an opportunity to search for a large sample of ANSB *** goal is to check the completeness of the potential ANSB samples from CSST *** this paper,we generate some ANSBs and normal binaries under the CSST photometric system by binary evolution and binary population synthesis method and use a machine learning method to train a classification *** the Precision(94.56%)of our machine learning model is as high as before study,the Recall is only about 63.29%.The Precision/Recall is mainly determined by the mass transfer rate between the NSs and their *** addition,we also find that the completeness of ANSB samples from CSST photometric data by the machine learning method also depends on the companion mass and the age of the *** candidates with a low initial mass companion star(0.1 M_(⊙)to 1 M_(⊙))have a relatively high Precision(94.94%)and high Recall(86.32%),whereas ANSB candidates with a higher initial mass companion star(1.1 M_(⊙)to 3 M_(⊙))have similar Precision(93.88%)and quite low Recall(42.67%).Our results indicate that although the machine learning method may obtain a relatively pure sample of ANSBs,a completeness correction is necessary for one to obtain a complete sample.

关键词： stars:neutron X-rays:binaries methods:analytical

Interfacial Structures Governed Plastic Deformation Behaviors in Metallic Multilayers

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Acta Metallurgica Sinica(English Letters) 2016年第2期29卷 199-204页

作者： Ming-Zhen Wei Zhen-Hua Cao xiang-Kang meng Institute of Materials Engineering National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Nanjing University Department of Physics School of Science Linyi University

In this work, we have investigated the mechanical properties of Cu/Ta, Ag/Cu and Ag/Nb multilayers with different heterogeneous interfaces. The results suggest that when individual layer thickness （h） is larger than 5-10 nm, the hardness/strength of three different multilayer systems has the similar length scale effect with decreasing layer thickness, while when h ≤ 5 nm, the three multilayer systems show remarkably different plastic deformation behaviors. The strength curves exhibit the variation trends of unchanging, softening and increasing corresponding to Cu/Ta, Ag/Cu and Ag/Nb multilayers, respectively. The microstructure analysis shows that three kinds of multilayers have totally different interfacial structures, which lead to the different strengthening or softening mechanisms.

关键词： Metallic multilayers Plastic deformation Interfacial structures Strengthening mechanism

Homogeneous CO_(3)O_(4) film electrode with enhanced oxygen evolution electrocatalysis via surface reduction

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Chinese Journal of Chemical Engineering 2021年第1期34卷 221-227页

作者： xiang Li Bo Yang Yaqin Wu Saisai lin lin Zhang Key laboratory of Biomass Chemical Engineering Ministry of EducationCollege of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Research and Development Center of Water Treatment Technology Co. Ltd.Hangzhou 310012China

Homogeneous NaBH_(4)-reduced Co_(O)_(4) thin film electrodes with enhanced oxygen evolution electrocatalysis were obtained via a controlled-synthesis *** CoOx colloids were synthesized via ethylene glycol solvothermal method and cast on conductive glass *** oxygen evolution reaction(OER) electrocatalysis of these asprepared CO_(3)O_(4) thin films were then significantly enhanced via a simple surface reduction by NaBH_(4) *** OER catalytic performance of the NaBH_(4)-reduced thin films was strongly dependent on the NaBH_(4) *** use of NaBH_(4)-reduced thin film electrodes for OER in alkaline solution supported higher current density and consequently negative shifts of the onset potential compared to that of the *** optimal B_(12.5,20)-CO_(3)O_(4) thin films exhibited excellent OER catalytic performances:At the current density of 10 mA·cm^(-2),a low overpotential of 365 mV and a small Tafel slope of 59.0 mV·dec^(-1) were *** addition,these B_(12.5,20)-CO_(3)O_(4) thin film electrodes possessed good stability that can well recover its OER performance in a 24-h chronoamperometric stability test.

关键词： CO_(3)O_(4)thin film NaBH_(4)reduction Electrolysis Oxygen evolution reaction Stability

Non-coding RNAs in acute ischemic stroke:from brain to periphery

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Neural Regeneration Research 2025年第1期20卷 116-129页

作者： Shuo Li Zhaohan Xu Shiyao Zhang Huiling Sun Xiaodan Qin lin Zhu Teng Jiang Junshan Zhou Fuling Yan Qiwen Deng Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu ProvinceChina General Clinical Research Center Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina

Acute ischemic stroke is a clinical emergency and a condition with high morbidity,mortality,and *** predictive,diagnostic,and prognostic biomarkers and effective therapeutic targets for acute ischemic stroke remain *** innovations in high-throughput gene sequencing analysis,many aberrantly expressed non-coding RNAs(ncRNAs)in the brain and peripheral blood after acute ischemic stroke have been found in clinical samples and experimental *** expressed ncRNAs in the post-stroke brain were demonstrated to play vital roles in pathological processes,leading to neuroprotection or deterioration,thus ncRNAs can serve as therapeutic targets in acute ischemic ***,distinctly expressed ncRNAs in the peripheral blood can be used as biomarkers for acute ischemic stroke prediction,diagnosis,and *** particular,ncRNAs in peripheral immune cells were recently shown to be involved in the peripheral and brain immune response after acute ischemic *** this review,we consolidate the latest progress of research into the roles of ncRNAs(microRNAs,long ncRNAs,and circular RNAs)in the pathological processes of acute ischemic stroke–induced brain damage,as well as the potential of these ncRNAs to act as biomarkers for acute ischemic stroke prediction,diagnosis,and *** from this review will provide novel ideas for the clinical application of ncRNAs in acute ischemic stroke.

关键词： acute ischemic stroke apoptosis blood–brain barrier damage circular RNAs excitatory toxicity long non-coding RNAs microRNAs neuroinflammation non-coding RNAs oxidative stress