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TLD calibration and absorbed dose measurement in a radiation-induced liver injury model under a linear accelerator

Nuclear Science and Techniques 2023年第4期34卷 69-78页

作者： Hui-Hui Xiao ling-ling liu Wen-Yi li Bing-Bing li xiang-li cui Jie li Tao-Sheng li Zong-Tao Hu School of Basic Medical Sciences Anhui Medical UniversityHefei 230000China Hefei Cancer Hospital Chinese Academy of SciencesHefei 230000China Institute of Health and Medical Technology Hefei Institute of Materials ScienceChinese Academy of SciencesHefei 230000China University of Science and Technology of China Hefei 230000China Hefei Institute of Materials Science Chinese Academy of SciencesHefei 230000China

The application of a thermoluminescent detector(TLD) for dose detection at the liver irradiation site in mice under linear accelerator precision radiotherapy and the use of a single high dose to irradiate the mouse liver to construct a biological model of a radiation-induced liver injury(RILD) in mice were to determine the feasibility of constructing a precision radiotherapy model in small animals under a linear accelerator. A 360° arc volumetric rotational intensity-modulated radiotherapy(VMAT) plan with a prescribed dose of 2 Gy was developed for the planned target volume(PTV) at the location of the TLD within solid water to compare the difference between the measured dose of TLD and the assessed parameters in the TPS system. The TLD was implanted in the livers of mice, and VMAT was planned based on TLD to compare the measured and prescribed doses. C57BL/6 J mice were randomly divided into control and 25-Gy radiation groups and were examined daily for changes in body weight. They were euthanized at 3 and 10 weeks after radiation, and the levels of liver serum enzymes such as alanine aminotransferase(ALT), aspartate aminotransferase(AST), and alkaline phosphatase(ALP) were measured to observe any pathological histological changes in the irradiated areas of the mouse liver. The measured values of solid underwater TLD were within ± 3% of the Dmean value of the evaluation parameter in the TPS system. The mice in the 25-Gy radiation group demonstrated pathological signs of radiation-induced liver injury at the site of liver irradiation. The deviation in the measured and prescribed doses of TLD in the mouse liver ranged from-1.5 to 6%;construction of an accurate model of RILD using the VMAT technique under a linear accelerator is feasible.

关键词： Thermoluminescent detector Radiation-induced liver injury linear accelerator Volumetric rotational intensity-modulated radiotherapy

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Correlation of genes associated with drug response to prognosis of large cell lung carcinoma

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Chinese Journal of Cancer 2011年第7期30卷 497-504页

作者： Cheng Chen xiang-li Jiang cui-cui Zhang Kai li Department of Medical Thoracic Oncology TianjinMedical University Cancer Institute and Hospital Tianjin 300060 P. R.China.

Platinum-based chemotherapy remains the main treatment of advanced lung cancer. However, platinum resistance has become a major treatment obstacle. Novel therapies, particularly tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKI) and agents that target vascular endothelial growth factor (VEGF), have improved the treatment. Both chemotherapy and targeted therapy have their molecular mechanisms. This study aimed to determine the mutation, amplification, or expression status and interrelationships of the epidermal growth factor receptor (EGFR), K-Ras proto-oncogene, excision repair cross-complementation group 1 (ERCC1), and VEGF genes as well as their correlations to prognosis of large cell lung carcinoma (LCLC) after EGFR-targeted therapy, chemotherapy, and anti-VEGF therapy. EGFR and K-Ras mutations in 60 specimens of LCLC were detected by direct DNA sequencing. EGFR, ERCC1, and VEGF protein expression was detected by immunohistochemistry (IHC). EGFR gene copy number was detected by fluorescence in situ hybridization (FISH). One (1.7%) patient had an EGFR L858M point mutation in exon 21, 3 (5.0%) had K-Ras mutations, and 10 (19.6%) had EGFR amplification (FISH positive). Positive rates of EGFR, ERCC1, and VEGF proteins were 38.3%, 56.7%, and 70.0%, respectively. EGFR amplification was positively correlated to EGFR protein expression (r = 0.390, P = 0.005). The positive rate of VEGF protein was significantly higher in patients with lymph node metastasis than in those without (84.6% vs. 58.8%, P = 0.046). No significant correlations were observed among the EGFR, K-Ras, ERCC1, and VEGF genes. EGFR gene amplification and the low rate of EGFR mutation suggest that patients with LCLC are likely to obtain little benefit from anti-EGFR therapies.

关键词：相关基因表皮生长因子受体血管内皮生长因子药物反应肺癌预后细胞基因突变检测

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THE QIONGHAI CRUSTAL TILT OBSERVATION SYSTEM AND THE SEISMIC ACTIVITY IN WESTERN SICHUAN PROVINCE, CHINA

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地震地质 1990年第2期 115-120页

作者： Zhang Chong-li, Zhang Cun-de xiang Jia-cui, li Tie-ming and Zhang Da-wei(Institute of Geology, State Seismological Bureau)

In this paper, we introduce the measurements of crustal tilt using the Qionghai Observation System and a preliminary approach to the relation between the crustal plane tilt observed by the System and seismic activity in the region around the Qionghai Lake, at *** results show that the observed accuracy may reach the magnitude of 10-7-10-8 radian. The processes of the crustal stress accumulation and release are characterized by the activity of moderate earthquakes (M≥5.0) whose epicenters are located within a range away from the Qionghai Lake, and are reflected to a certain extent by time dependent processes of the crustal tilt observed by the *** short- term and impending precursors of moderate earthquakes are similar to those of the great ones, featuring of trending and abrupt anomalies.

关键词： Crustal deformation Xichang Qionghai Seismic activity

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue li cui Chang xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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壳聚糖复合膜的制备及其界面的生物功能化

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功能材料 2012年第B08期43卷 125-128页

作者：向翠丽邱树君孙立贤徐芬周怀营桂林电子科技大学广西信息材料重点实验室广西桂林541004 中国科学院大连化学物理研究所辽宁大连116023 辽宁师范大学化学化工学院辽宁大连116029

采用电沉积方法在电极上沉积了壳聚糖-琼脂糖复合膜,考察了复合膜的组成对生物分子特异性吸附的影响。采用电化学方法对生物复合膜进行了活化,并共价组装了免疫生物分子,构建了免疫分析体系,通过电场的作用排除了非特异性吸附。研究结... 详细信息

采用电沉积方法在电极上沉积了壳聚糖-琼脂糖复合膜,考察了复合膜的组成对生物分子特异性吸附的影响。采用电化学方法对生物复合膜进行了活化,并共价组装了免疫生物分子,构建了免疫分析体系,通过电场的作用排除了非特异性吸附。研究结果表明,在电场的作用下,所沉积的生物复合膜有效地排除了生物分子非特异性吸附,提高了免疫检测的准确性。

关键词：壳聚糖生物相容膜免疫分析

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电沉积锡-铟合金电极在氢氧化钾溶液中的电化学性能

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材料保护 2005年第12期38卷 8-10页

作者：李俊华费锡明向翠丽华中师范大学化学学院湖北武汉430079

在电池集流体铜表面电沉积锡,锡溶解后易使其析氢量增加,电沉积铟在碱性溶液中抑氢效果好,但成本高,目前对锡-铟合金共沉积的效果研究甚少。用电化学方法在高能碱性锌锰电池集流体铜电极表面沉积Sn,In和Sn-In合金。研究了Sn,In和Sn-In... 详细信息

在电池集流体铜表面电沉积锡,锡溶解后易使其析氢量增加,电沉积铟在碱性溶液中抑氢效果好,但成本高,目前对锡-铟合金共沉积的效果研究甚少。用电化学方法在高能碱性锌锰电池集流体铜电极表面沉积Sn,In和Sn-In合金。研究了Sn,In和Sn-In合金电极在1 mol/L KOH溶液中的析氢电化学性能和电化学稳定性,测定了其在相同溶液中的循环伏安曲线和交流阻抗图谱。结果表明:沉积In和Sn-In合金的电极比铜电极的析氢过电位分别提高了569 mV和488 mV,有效地抑制了氢气析出;在无汞化电池工业中,用价格低廉且稳定性较好的Sn-In合金共沉积电极代替In沉积电极具有广阔的应用前景。

关键词：电沉积锡-铟合金铜电极析氢电化学稳定性

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Ni-W-TiO_2复合电极在碱性介质中的析氢电催化性能

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化学研究与应用 2005年第5期17卷 664-666页

作者：向翠丽费锡明李俊华华中师范大学化学学院湖北武汉430079

Composite electrode Ni-W-TiO2 was prepared by *** behaviors of hydrogen evolution reaction on the obtained electrode was studied by steady-state polarization and AC impedance techniques in 7mol/L KOH *** apparent activation energy of hydrogen evolution reaction and stability of the elctrode were also *** results showed that the introduction of TiO2 to the Ni-W layer lead to an improvement of Electrocatalytic and stability of the *** improvemment was due to the increase of the surface area and the decrease of the apparent activation energy.

关键词：电沉积 Ni-W-TiO2 电催化析氢

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硫酸型镀铟电极过程动力学初探

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材料保护 2006年第6期39卷 12-14页

作者：李俊华费锡明向翠丽华中师范大学化学学院湖北武汉430079

过去用电化学方法对硫酸型镀铟工艺、作用机理研究较少。采用循环伏安、线性电位扫描和交流阻抗等电化学方法,研究了硫酸型镀铟中的阴极反应机理。结果表明:该体系内铟电沉积的最佳pH值为2~3,最佳温度为35~45℃;该阴极过程中存在前置化... 详细信息

过去用电化学方法对硫酸型镀铟工艺、作用机理研究较少。采用循环伏安、线性电位扫描和交流阻抗等电化学方法,研究了硫酸型镀铟中的阴极反应机理。结果表明:该体系内铟电沉积的最佳pH值为2~3,最佳温度为35~45℃;该阴极过程中存在前置化学反应和随后两个不可逆电化学反应,其中第一个电化学反应是控制步骤,其阴极过程电极反应标准常数为8.188×10-10cm/s。

关键词：硫酸型镀铟阴极反应机理动力学

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人际和语篇功能对中英新闻语篇的跨文化研究

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齐齐哈尔大学学报（哲学社会科学版） 2016年第9期 135-137页

作者：栗香翠长治学院外语系山西长治046011

研究从跨文化视角下对中英政治新闻进行人际功能和语篇功能语篇分析,旨在探索中英政治新闻语言特征及其隐含的文化因素。研究的创新之处在于其研究方法是从跨文化视角下结合系统功能理论进行中英语篇分析。研究发现,人际功能方面中文语... 详细信息

研究从跨文化视角下对中英政治新闻进行人际功能和语篇功能语篇分析,旨在探索中英政治新闻语言特征及其隐含的文化因素。研究的创新之处在于其研究方法是从跨文化视角下结合系统功能理论进行中英语篇分析。研究发现,人际功能方面中文语篇倾向高值情态词,而英文语篇则多用低值情态词;语篇功能里英文语篇以主动语态和被动语态结合为主,中文语篇则主要使用主动语态结构小句。

关键词：人际功能语篇功能新闻语篇跨文化分析

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概念功能理论对中英新闻语篇的跨文化研究

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长治学院学报 2017年第1期34卷 59-62页

作者：栗香翠长治学院外语系山西长治046011

研究以韩礼德系统功能语法中概念元功能为理论依据,从元功能中的及物性过程方面对抗战胜利70周年阅兵式的中英两种新闻报道进行对比分析。研究以中西文化基本差异为切入点,通过对及物性过程在不同新闻语篇的分布异同分析,对其语篇结构... 详细信息

研究以韩礼德系统功能语法中概念元功能为理论依据,从元功能中的及物性过程方面对抗战胜利70周年阅兵式的中英两种新闻报道进行对比分析。研究以中西文化基本差异为切入点,通过对及物性过程在不同新闻语篇的分布异同分析,对其语篇结构进行文化阐述,力求探索出语言差异背后的文化因素。

关键词：概念功能及物性过程新闻语篇跨文化分析

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