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Safety and efficacy of a programmed cell death 1 inhibitor combined with oxaliplatin plus S-1 in patients with Borrmann large type III and IV gastric cancers

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1281-1295页

作者： Zhe-Han Bao Can Hu Yan-Qiang Zhang Peng-cheng Yu Yi Wang Zhi-Yuan Xu Huan-Ying Fu xiang-dong cheng Department of Interventional Radiology Zhejiang Cancer HospitalHangzhou 310004Zhejiang ProvinceChina Department of Gastric Surgery Zhejiang Cancer HospitalHangzhou 310022Zhejiang ProvinceChina Department of Colonic Surgery Jinhua Central HospitalJinhua 321000Zhejiang ProvinceChina Department of Breast Surgery Lin’an People’s HospitalHangzhou 311300Zhejiang ProvinceChina

BACKGROUND Gastric cancer(GC)is the fifth most common and the fourth most lethal malignant tumour in the *** patients are already in the advanced stage when they are diagnosed,which also leads to poor overall *** effect of posto-perative adjuvant chemotherapy for advanced GC is unsatisfactory with a high rate of distant metastasis and local *** To investigate the safety and efficacy of a programmed cell death 1(PD-1)inhibitor combined with oxaliplatin and S-1(SOX)in the treatment of Borrmann large type III and IV *** A retrospective analysis(IRB-2022-371)was performed on 89 patients with Borrmann large type III and IV GCs who received neoadjuvant therapy(NAT)from January 2020 to December *** to the different neoadjuvant treatment regimens,the patients were divided into the SOX group(61 patients)and the PD-1+SOX(P-SOX)group(28 patients).RESULTS The pathological response(tumor regression grade 0/1)in the P-SOX group was significantly higher than that in the SOX group(42.86%vs 18.03%,P=0.013).The incidence of ypN0 in the P-SOX group was higher than that in the SOX group(39.29%vs 19.67%,P=0.05).The use of PD-1 inhibitors was an independent factor affecting tumor regression ***,the use of PD-1 did not increase postoperative complications or the adverse effects of *** A PD-1 inhibitor combined with SOX could significantly improve the rate of tumour regression during NAT for patients with Borrmann large type III and IV GCs.

关键词： Neoadjuvant therapy Immunotherapy Gastric cancer Borrmann type Tumor regression grade

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Synergistic effects of multiscale TiC and dual-phase structure on tensile properties of particle-reinforced steel

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Journal of Iron and Steel Research(International) 2024年第5期31卷 1232-1245页

作者： Ye Jia xiang-tao Deng Qi Wang cheng-ru Li Hao Wu Zhao-dong Wang State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819LiaoningChina

The conventional melting methods were used to obtain in situ TiC particle-reinforced dual-phase steel,followed by hot rolling and heat treatment *** aim was to investigate the effect of TiC particles on the fracture behavior of dual-phase steel at different annealing temperatures,by analyzing the microstructure and tensile behavior of the multiscale TiC particle-reinforced dual-phase *** results showed that TiC particles precipitated in the as-cast microstructure of dual-phase steel were distributed along the grain *** hot rolling,the grain boundary-like morphology of the micron-sized TiC particles was disrupted,and the particles became more refined and evenly distributed in the *** tensile tests revealed that the strength of the TiC particle-reinforced dual-phase steel increased with increasing martensite content,while the elongation *** results were similar to those of conventional *** addition of 1 vol.%multiscale TiC particles improved the strength of the dual-phase steel but did not affect elongation of the *** and holes were primarily concentrated around the TiC particles rather than at the interface of martensite and *** main causes of crack sprouting were TiC particle interface cracking and TiC particle internal ***,the study demonstrated the potential of multiscale TiC particle-reinforced dual-phase steel as a strong and tough *** refined distribution of TiC particles in the matrix improved the strength of the material without compromising its *** results also highlighted the importance of careful selection of reinforcement particles to avoid detrimental effects on the fracture behavior of the material.

关键词： TiC particle Dual-phase structure TiC-reinforced dual-phase steel Tension Fracture behavior

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Applying dynamic light scattering to investigate the self-assembly process of DNA nanostructures

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Chinese Chemical Letters 2024年第3期35卷 316-320页

作者： Wei Yuan Gui-Zhi dong Hui Ning xiang-xiang Guan Jia-Feng cheng Zi-Wei Shi Xiu-Ji Du Si-Wen Meng dong-Sheng Liu Yuan-Chen dong CAS Key Laboratory of Colloid Interface and Chemical ThermodynamicsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Dandong Bettersize Instruments Ltd. Dandong 118000China Key Laboratory of Organic Optoelectronics&Molecular Engineering of the Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Department of Chemistry Renmin University of ChinaBeijing 100872China

Understanding the dynamic assembly process of DNA nanostructures is important for developing novel strategy to design and construct functional *** this work,temperature-controlled dynamic light scattering(DLS)strategy has been applied to study the global assembly process of DNA origami and DNA *** the temperature dependent size and intensity profiles,the self-assembly process of various DNA nanostructures with different morphologies have been well-studied and the temperature transition ranges could be *** advantage of the DLS information,rapid preparation of the DNA origami and the brick assembly has been realized through a constant temperature *** results demonstrate that the DLS-based strategy provides a convenient and robust tool to study the dynamic process of forming hieratical DNA structures,which will benefit understanding the mechanism of self-assembly of DNA nanostructures.

关键词： Dynamic light scattering Self-assembly process DNA nanostructures Temperature transition ranges Rapid preparation

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Transition-Metal-Free Allylic Defluorination Cross-Electrophile Coupling Employing Rongalite

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Chinese Journal of Chemistry 2024年第12期42卷 1360-1366页

作者： xiang-Long Chen Chun-Yan Wu dong-Sheng Yang Bo-cheng Tang Huai-Yu Wang Zhi-cheng Yu Anling Li Yan-dong Wu An-Xin Wu National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhanHubei 430079China state Key Laboratory of Chemical Biology and Drug Discovery Department of Applied Biology and Chemical Technology The HongKong Polytechnic UniversityKowloonHong Kong SARChina Department of Clinical Laboratory Center for Gene Diagnosisand Program of Clinical Laboratory MedicineZhongnan Hospital of Wuhan UniversityWuhanHubei 430062China

Comprehensive Summary The conversion of CF3-alkenes to gem-difluoroalkenes using reductive cross-coupling strategy has received much attention in recent years,however,the use of green and readily available reducing salt to mediate these reactions remains to be *** this work,a concise construction of gem-difluoroalkenes,which requires neither a catalyst nor a metal reducing agent,was ***,a safe and inexpensive industrial product,was employed as both a radical initiator and *** procedure was compatible with both linear and cyclic diaryliodonium salts,enabling a wide variety of substrates(>70 examples).The utility of this approach was demonstrated through gram-scale synthesis and efficient late-stage functionalizations of anti-inflammatory drugs.

关键词： Defluoroarylation Transition metal free gem-Difluoroalkenes Rongalite Single electron transfer C-C coupling Redox reactions Cross-coupling

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Effect of slow shot speed on externally solidified crystal,porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy

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China Foundry 2024年第1期21卷 11-19页

作者： Wen-ning Liu Wei Zhang Peng-yue Wang Yi-xian Liu xiang-yi Jiao Ao-xiang Wan cheng-gang Wang Guo-dong Tong Shou-mei Xiong School of Materials Science and Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Tsinghua UniversityBeijing 100084Beijing China FAW Group Co. Ltd.Changchun 130013China China FAW Foundry Co. Ltd.Changchun 130013China

The effect of slow shot speed on externally solidified crystal(ESC),porosity and tensile property in a newly developed high-pressure die-cast Al-Si alloy was investigated by optical microscopy(OM),scanning electron microscopy(SEM)and laboratory computed tomography(CT).Results showed that the newly developed AlSi9MnMoV alloy exhibited improved mechanical properties when compared to the AlSi10MnMg *** AlSi9MnMoV alloy,which was designed with trace multicomponent additions,displays a notable grain refining effect in comparison to the AlSi10MnMg *** elements Ti,Zr,V,Nb,B promote heterogeneous nucleation and reduce the grain size of primaryα-*** a lower slow shot speed,the large ESCs are easier to form and gather,developing into the dendrite net and *** an increase in slow shot speed,the size and number of ESCs and porosities significantly *** addition,the distribution of ESCs is more dispersed and the net-shrinkage *** tensile property is greatly improved by adopting a higher slow shot *** ultimate tensile strength is enhanced from 260.31 MPa to 290.31 MPa(increased by 11.52%),and the elongation is enhanced from 3.72%to 6.34%(increased by 70.52%).

关键词： hypoeutectic Al-Si alloy high pressure die casting porosity externally solidified crystal tensile property

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Continuous Orbit Equivalence of Semigroup Actions

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1581-1598页

作者： xiang Qi QIANG cheng Jun HOU School of Mathematical Science Yangzhou UniversityYangzhou 225002P.R.China

We introduce notions of continuous orbit equivalence and its one-sided version for countable left Ore semigroup actions on compact spaces by surjective local homeomorphisms,and characterize them in terms of the corresponding transformation groupoids and their operator *** particular,we show that two essentially free semigroup actions on totally disconnected compact spaces are continuously orbit equivalent if and only if there is a canonical abelian subalgebra preserving C^(∗)-isomorphism between the associated transformation groupoid C^(∗)-*** also give some examples of orbit equivalence,consider the special case of semigroup actions by homeomorphisms and relate continuous orbit equivalence of semigroup actions to that of the associated group actions.

关键词： Semigroup action continuous one-sided orbit equivalence continuous orbit equivalence groupoid C^(∗)-algebras

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Editorial Commentary:Top Five Stories of the Cellular Landscape and Therapies of Atherosclerosis:Current Knowledge and Future Perspectives

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Current Medical Science 2024年第1期44卷 241-243页

作者： Miao YU xiang cheng Department of Cardiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Provincial Engineering Research Center of Immunological Diagnosis and Therapy for Cardiovascular Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Atherosclerosis(AS)is the main underlyingpathology of atherosclerotic cardiovascular disease(ASCVD),which is the leading cause of mortality inthe worldwide[1,2].Since the 19th century,Virchowhas already stated that AS is a chronic inflammatorystate induced by *** that,it took at leastthree decades’worth of study to establish the multipleinflammatory pathways related to AS.

关键词： Virchow mortality cardiovascular

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Spacelike Framed Curves with Lightlike Components and Singularities of Their Evolutes and Focal Surfaces in Minkowski 3-space

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1521-1532页

作者： Peng cheng LI dong He PEI Xin ZHAO School of Mathematics and Statistics Northeast Normal UniversityChangchun 130024P.R.China Department of Mathematics Harbin Institute of TechnologyWeihai 264209P.R.China School of Mathematics and Statistics Qingdao UniversityQingdao 266071P.R.China

In this paper,we define the evolute and focal surface of a spacelike framed curve with lightlike components in Minkowski *** is a generalization of the previous results of regular spacelike curves,since singularities are allowed in the original spacelike curves studied by spacelike framed curves with lightlike ***,we show a new geometric invariant to characterise singularities of the focal ***,the classification theorem and recognition theorem for the singularities of the focal surface in generic are also given.

关键词： Evolutes focal surfaces spacelike framed curves singularities

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Nuclearity and Finite-Representability in the System of Completely Integral Mapping Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1197-1214页

作者： Zhe dong Ji cheng TAO Ya Fei ZHAO Department of Mathematics Zhejiang UniversityHangzhou 310027P.R.China Department of Mathematics China Jiliang UniversityHangzhou 310018P.R.China Department of Mathematics Zhejiang International Studies UniversityHangzhou 310023P.R.China

In this paper,we investigate local properties in the system of completely integral mapping *** introduce notions of injectivity,local reflexivity,exactness,nuclearity,finite-represent ability and WEP in the system of completely integral mapping *** we obtain that any finite-dimensional operator space is injective in the system of completely integral mapping *** we prove that C is the unique nuclear operator space and the unique exact operator space in this *** also show that C is the unique operator space which is finitely representable in{T_(n)}n∈Nin this *** corollaries,Kirchberg’s conjecture and QWEP conjecture in the system of completely integral mapping spaces are false.

关键词： Completely integral mapping space injectivity exactness nuclearity finite-representability WEP

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Persistent radical anion of perylene dianhydride:an emerging metal-free photocatalyst for near-infrared photocontrolled RAFT polymerization

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Science China Chemistry 2024年第2期67卷 677-686页

作者： Haitao Zhao Guoqing Bian xiang Xu Weiwei He Lifen Zhang Zhenping cheng State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials Jiangsu Key Laboratory of Advanced Functional Polymer Design and ApplicationSuzhou Key Laboratory of Macromolecular Design and Precision SynthesisCollege of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou215123China

Developing a new type of photocatalyst(PC) and catalytic mechanism for near-infrared(NIR) photocontrolled reversibledeactivation radical polymerization(RDRP) system is charming but ***,a novel PC of the persistent radical anion(PRA)(possessing the properties of both radical and anion) was developed for NIR photocontrolled reversible additionfragmentation chain transfer(RAFT) polymerization,enabling successful polymerization while gaining a deep insight into the mechanism of photo-induced electron transfer RAFT(PET-RAFT) *** from the conventional and wellaccepted reductive quenching(RQ) pathway,in which the radical anion intermediates of PCs(PCs^(·-)) must be generated in an excited state(ES),here,the PRA(3,4,9,10-perylenetetracarboxylic dianhydride radical anion(PTCDA^(·-))) could generate conveniently in situ in the ground state(GS) and subsequently serve as highly efficient PC in the NIR region(740–850 nm).The successful implementation of this strategy elucidates the peculiar role played by light and the real way of electron transfer *** fact,the transfer of a single electron from PRA to chain transfer agent(CTA) and cleavage of the C–S bonds is a process from ES to GS,rather than always from GS(PCs^(·-)) to GS(CTA) in the RQ pathway as is well known to *** addition,the excellent spatial-temporal control and powerful penetration ability of the NIR light were also confirmed by this PRAcatalyzed polymerization system.

关键词： photocatalyst persistent radical anion(PRA) near-infrared(NIR)light reversible-deactivation radical polymerization(RDRP) photo-induced electron transfer RAFT(PET-RAFT)polymerization

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