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Effect of palmitoylethanolamide on degeneration of a human-derived retinal pigment epithelial cell induced by all-trans retinal

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 191-200页

作者： Yun Han Kun-Huan Yang Dan-Xue He Chao-Feng Yu Lei Tao Chun-Yan Liao bin-xiang cai Zu-Guo Liu Yan Qiu Ya-Lin Wu Eye Institute of Xiamen University Fujian Provincial Key Laboratory of Ophthalmology and Visual ScienceEngineering and Research Center of Eye Regenerative MedicineSchool of MedicineXiamen UniversityXiamen 361102Fujian ProvinceChina Department of Ophthalmology Xiang’an Hospital of Xiamen UniversityXiamen 361102Fujian ProvinceChina Xiamen University Affiliated Xiamen Eye Center Xiamen 361102Fujian ProvinceChina Shenzhen Research Institute of Xiamen University Shenzhen 518000Guangdong ProvinceChina

AIM:To study the effect of palmitoylethanolamide(PEA)on apoptosis of retinal pigment epithelial(RPE)cells induced by all-trans retinal(at RAL)and to explore the possible molecular ***:Cell Titer 96■Aqueous One Solution Cell Proliferation Assay(MTS)was used to detect the effect of PEA on human-derived retinal epithelial cells(ARPE-19)viability induced by at RAL.A Leica DMi8 inverted microscope was used to observe cell *** oxygen species(ROS)production was evaluated with 2’,7’-dichlorodihydrofluorescein diacetate(H2DCFDA)staining and fluorescence *** of c-Jun N-terminal kinase(JNK),phosphorylated JNK(p-JNK),c-Jun,phosphorylated c-Jun(p-c-Jun),Bak,cleaved caspase-3,C/EBP homologous protein(CHOP),and binding(Bip)protein levels were tested by Western ***4-/-Rdh8-/-mice,mouse models of at RAL clearance defects which displays some symbolic characteristics of dry age-related macular degeneration(AMD)and Stargardt disease(STGD1).In the animal models,PEA was injected *** full-field electroretinogram was used to detect visual function under scotopic conditions traced from *** coherence tomography showed reconstitution or thickening of the retinal pigment epithelium *** of PEA on fundus injury induced by light in Abca4-/-Rdh8-/-mice was observed by fundus ***:PEA ameliorated ARPE-19 cells apoptosis and inhibited ROS(including mitochondrial ROS)production induced by at *** improved the retinal functional,prohibited both RPE and photoreceptor from death,ameliorates light-induced fundus impairment in Abca4-/-Rdh8-/-*** vitro and in vivo,PEA inhibited JNK,p-JNK,c-Jun,p-c-Jun,Bak,cleaved caspase-3,CHOP,and Bip protein levels induced by all-trans retinal in ARPE-19 ***:PEA has effect on treating RPE cells apoptosis in retinopathy caused by at RAL *** is a potential treatment strategy for dry AMD and *** molecular mechanism is affecting the

关键词： palmitoethanolamide ARPE-19 fundus all-trans retinal apoptosis

Foliar-applied zinc promotes cadmium allocation from leaf surfaces to grains in rice

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Journal of Environmental Sciences 2025年第5期151卷 582-593页

作者： Ya-Ting Liu Bo-Fang Yan Xuan cai Hong-xiang Zheng Rong-Liang Qiu Ye-Tao Tang School of Environmental Science and Engineering Sun Yat-sen UniversityGuangzhou 510006China Institute of Facility Agriculture Guangdong Academy of Agricultural SciencesGuangzhou 510640China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology Sun Yat-sen UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Agricultural&Rural Pollution Abatement and Environmental Safety College of Natural Resources and EnvironmentSouth China Agricultural UniversityGuangzhou 510642China

The accumulation of Cd by rice poses significant health *** fertilizationwith Zn can reduce grain Cd contents in rice grown in Cd-contaminated ***,atmospheric deposition on leaves is another vector of Cd contamination,and it remains unclear how Zn application affects the allocation of such *** conducted an experiment where the flag leaves of rice plants were treated with solutions with various Zn concentrations and a constant Cd *** 111Cd stable isotope was used to trace the flux of foliarapplied *** levels of foliar-applied Zn enhanced Cd efflux and grain *** is attributed to limited sequestration of foliar-applied Cd in the leaf cell symplasm and increased Cd desorption from leaf cell walls when a high Zn^(2+)concentration occurs in the *** Zn oxide nanoparticlesmitigated these ***,the expressions of OsLCT1 and OsZIP7 in flag leaves and OsHMA2 and OsZIP7 in the uppermost nodes were upregulated under high-Zn^(2+)treatment,which may facilitate Cd phloem loading and grain *** is advised in using foliar Zn in areas with high atmospheric Cd due to potential grain-contamination risks.

关键词： Atmospheric deposition Isotope labelling Metal interaction Phloem Cell wall

A novel method for simultaneous measurement of^(222)Rn and^(220)Rn progeny concentrations measured by an alpha spectrometer

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Nuclear Science and Techniques 2025年第1期36卷 127-139页

作者： Zhong-Kai Fan Jia-Le Sun Hao-Xuan Li xiang-Ming cai Hui Yang Shou-Kang Qiu Yan-Liang Tan Jian Shan School of Nuclear Science and Technology University of South ChinaHengyang 421001China College of Physics and Electronic Engineering Hengyang Normal UniversityHengyang 421008China

The accumulation of^(222)Rn and^(220)Rn progeny in poorly ventilated environments poses the risk of natural radiation exposure to the public.A previous study indicated that satisfactory results in determining the^(222)Rn and^(220)Rn progeny concentrations by measuring the total alpha counts at five time intervals within 560 min should be expected only in the case of high progeny concentrations in *** complete the measurement within a relatively short period and adapt it for simultaneous measurements at comparatively lower^(222)Rn and^(220)Rn progeny concentrations,a novel mathematical model was proposed based on the radioactive decay *** model employs a nonlinear fitting method to distinguish nuclides with overlapping spectra by utilizing the alpha particle counts of non-overlapping spectra within consecutive measurement cycles to obtain the concentrations of^(222)Rn and^(220)Rn progeny in *** verification experiments were conducted using an alpha *** experimental results demonstrate that the concentrations of^(222)Rn and^(220)Rn progeny calculated by the new method align more closely with the actual circumstances than those calculated by the total count method,and their relative uncertainties are all within±16%.Furthermore,the measurement time was reduced to 90 min,representing an acceleration of 84%.The improved capability of the new method in distinguishing alpha particles with similar energies emitted from ^(218)Po and^(212)Bi,both approximately 6 MeV,contributed to realizing more accurate *** proposed method has the potential advantage of measuring relatively low concentrations of^(222)Rn and^(220)Rn progeny in air more quickly via air filtration.

关键词： ^(222)Rn ^(220)Rn Progeny concentration Nonlinear fitting method Alpha spectrometer

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Sedimentary facies analysis,palaeogeography,and reservoir quality of the Middle-Upper Cambrian Xixiangchi Formation in southeast Sichuan Basin, southwest China

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Journal of Palaeogeography 2025年第01期14卷 245-276页

作者： Oumar Ibrahima Kane Ming-Yi Hu Quan-Sheng cai Qing-Jie Deng Ze-bin Tong Institute of Sedimentary Geology Chengdu University of Technology State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation School of Geosciences Yangtze University School of Geosciences China University of Petroleum (East China)

Various data were utilized to analyze the sedimentary facies,completely reconstruct the palaeogeographic maps,and evaluate the reservoir quality of the Middle-Upper Cambrian Xixiangchi Formation in the Sichuan Basin,including evidence from field outcrops,drilling cores,microscopic thin sections,scanning electron microscopy （SEM）,combined with experimental analysis data,such as petrophysical data(porosity （%） and permeability （mD）),and radioactive elements (uranium (238U),thorium (232Th),and potassium (40K)),and isotopic data (δ13C)).In the Sichuan Basin,the Middle-Upper Cambrian Xixiangchi Formation was principally deposited in a restricted platform with a lithology predominantly composed of dolomite,with local occurrences of limestone and other rock types in small *** beddings,cross beddings,horizontal beddings,storm depositions,and mud cracks locally developed in some *** 3rd-order sequences （SQ1-SQ4） were identified within the Xixiangchi Formation in this *** sequence is subdivided into a highstand systems tract （HST） and a transgressive systems tract （TST）.Reservoirs are principally developed in high-energy grain shoal deposits located in SQ2 and SQ3,with a minor occurrence in SQ1 and *** lithology of these shoal deposits is essentially composed of sandy dolomite and crystalline dolomite characterized by relatively low average porosity （2.61%） and permeability （1.0073 mD） *** increase of these values in several studied samples might be related to seepage and connecting dissolution pores and vugs through fractures which have a constructive effect on porosity and *** occurrence of karst caves through superimposed supergene karstification and bedding karstification highly improved the reservoir's physical properties in some *** reservoir space is dominated by intergranular dissolution pores,karst caves,and fractures,and their formation was controlled by sedimentation,diagenesis,penecontemporaneous dissolu

关键词： Sedimentary facies Palaeogeography Reservoir quality Reservoir prediction Cambrian Xixiangchi Formation Sichuan Basin

Efficient photodegradation of perfluoroalkyl substances under visible light by hexagonal ZnIn_(2)S_(4) nanosheets

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Journal of Environmental Sciences 2025年第2期148卷 116-125页

作者： Fuyu Liu Hui Xue Tingshuo Kang Qiupei Lei Jiazhe Chen Zhihong Zuo bin Han Xize Lu Xiao Yang xiangcheng Shan Xiaoyang Song Qingzhe Zhang Yongguang Yin Yong cai Shandong Key Laboratory of Environmental Processes and Health Qingdao Key Laboratory of Marine Pollutant PreventionSchool of Environmental Science and EngineeringShandong UniversityQingdao 266237China Research Center for Particle Science and Technology Institute of Frontier and Interdisciplinary ScienceShandong UniversityQingdao 266237China Shenzhen Research Institute of Shandong University A301 Virtual University Park in South DistrictShenzhen 518057China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 10085China Department of Chemistry and Biochemistry Florida International UniversityMiamiFlorida 33199USA

Perfluoroalkyl substances(PFASs)are typical persistent organic pollutants,and their removal is urgently required but *** has shown potential in PFASs degradation due to the redox capabilities of photoinduced charge carriers in ***,hexagonal ZnIn_(2)S_(4)(ZIS)nanosheets were synthesized by a one-pot oil bath method and were well characterized by a series of *** the degradation of sodium p-perfluorous nonenoxybenzenesulfonate(OBS),one kind of representative PFASs,the assynthesized ZIS showed activity superior to P25 TiO_(2) under both simulated sunlight and visible-light *** good photocatalytic performance was attributed to the enhanced light absorption and facilitated charge *** pH conditions were found crucial in the photocatalytic process by influencing the OBS adsorption on the ZIS *** e−and h+were the main active species involved in OBS degradation in the ZIS *** work confirmed the feasibility and could provide mechanistic insights into the degradation and defluorination of PFASs by visible-light photocatalysis.

关键词： PFASs Defluorination Photocatalysis Visible light ZnIn_(2)S_(4)

Formation and evolution of supercritical geofluid

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Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei NI Yilin XIAO Xiaolin XIONG Xiandong LIU Chunxiao GAO Yi-xiang CHEN Yunguo LI Wan-cai LI Xuan GUO Yang-Yang WANG Dong-Bo TAN Li ZHANG State Key Laboratory of Lithospheric and Environmental Coevolution University of Science and Technology of ChinaHefei230026China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of ChinaHefei230026China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou510640China School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China State Key Lab of Superhard Materials Jilin UniversityChangchun130012China

In this work,we provide a comprehensive review on the formation,evolution,properties,and effects of supercritical *** Earth's interior,enhanced miscibility between H_(2)O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H_(2)O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems,typified by pegmatite system,is governed by meltfluid critical *** formation of supercritical geofluid in metamorphic systems,typified by subducted slab,is governed by the second critical end *** results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths,but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth.A major presence of both H_(2)O and depolymerized structural units(monomers,dimers,etc.)endows supercritical geofluid with unique physical properties including low density,low elastic moduli,low viscosity,high diffusivity,and high electrical *** geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth *** chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts,and this could give an explanation of the oxidation of arc *** separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt *** fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical *** geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab,and can be linked with intermediate-focus *** geofluid may have played a crucial role in the formation of pegmatites and associ

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

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Value Iteration-Based Distributed Adaptive Dynamic Programming for Multi-Player Differential Game With Incomplete Information

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 436-447页

作者： Yun Zhang Yuqi Wang Yunze cai the Department of Automation Shanghai Jiao Tong University the Key Laboratory of System Control and Information Processing Ministry of Education of China the National Key Laboratory of Air-based Information Perception and Fusion

In this paper, a distributed adaptive dynamic programming(ADP) framework based on value iteration is proposed for multi-player differential games. In the game setting,players have no access to the information of others' system parameters or control laws. Each player adopts an on-policy value iteration algorithm as the basic learning framework. To deal with the incomplete information structure, players collect a period of system trajectory data to compensate for the lack of information. The policy updating step is implemented by a nonlinear optimization problem aiming to search for the proximal admissible policy. Theoretical analysis shows that by adopting proximal policy searching rules, the approximated policies can converge to a neighborhood of equilibrium policies. The efficacy of our method is illustrated by three examples, which also demonstrate that the proposed method can accelerate the learning process compared with the centralized learning framework.

关键词： Distributed adaptive dynamic programming incomplete information multi-player differential game (MPDG) value iteration

An ionic liquid functionalized sericin hydrogel for drug-resistant bacteria-infected diabetic wound healing

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Chinese Chemical Letters 2025年第2期36卷 307-313页

作者： Jiajia Wang XinXin Ge Yajing xiang Xiaoliang Qi Ying Li Hangbin Xu Erya cai Chaofan Zhang Yulong Lan Xiaojing Chen Yizuo Shi Zhangping Li Jianliang Shen National Engineering Research Center of Ophthalmology and Optometry Eye HospitalWenzhou Medical University School of Chemical Engineering Nanjing University of Science&Technology School&Hospital of Stomatology Wenzhou Medical University Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of Sciences The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital

Diabetic wound healing is often complicated due to bacterial infections that intensify inflammation. Employing hydrogel dressings with inherent antibacterial properties can significantly reduce reliance on antibiotics for treating infected wounds in diabetics. Traditional hydrogels typically rely on the infiltration of bacteria into their porous structure to manifest antibacterial effects. However, this infiltration process is not only prolonged but can also exacerbate inflammation, further delaying the healing of the ***, promptly capturing and eliminating bacteria is crucial for enhancing the antibacterial efficiency of the hydrogel. In this context, we present a multifunctional hydrogel dressing, termed SIP, designed to tackle drug-resistant bacterial infections in diabetic wounds. This dressing integrates ionic liquid functional groups into a sericin-based matrix: phenylboronic acid for the immobilization of bacteria and imidazole for their subsequent annihilation. Expectedly, the SIP system demonstrates potent antibacterial activity against methicillin-resistant Staphylococcus aureus, verified through in vitro and in vivo experiments. As a result, SIP emerges as a promising candidate in the realm of hydrogel dressings with innate antibacterial properties, showcasing considerable potential for addressing diabetic wounds plagued by drug-resistant bacterial infections.

关键词： Diabetic wound healing Hydrogels Ionic liquids Methicillin-resistant Staphylococcus aureus infection Sericin

Profiles,exposure assessment and expanded screening of PAHs and their derivatives in one petroleum refinery facility of China

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Journal of Environmental Sciences 2025年第1期147卷 550-560页

作者： Ning Wang Fengjiao Jiang Lin Xu Yaqi cai School of Municipal and Environmental Engineering Shandong Jianzhu UniversityJinan 250101China Resource and Environmental Innovation Institute Shandong Jianzhu UniversityJinan 250101China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 330106China Hubei Key Laboratory of Environmental and Health Effects of Persistence Toxic Substances Institute of Environment and HealthJianghan UniversityWuhan 430056China

This study investigated environmental distribution and human exposure of polycyclic aromatic hydrocarbons(PAHs)and their derivatives in one Chinese petroleum refinery *** was found that,following with high concentrations of 16 EPA PAHs(∑Parent-PAHs)in smelting subarea of studied petroleum refinery facility,total derivatives of PAHs[named as XPAHs,including nitro PAHs(NPAHs),chlorinated PAHs(Cl-PAHs),and brominated PAHs(Br-PAHs)]in gas(mean=1.57×10^(4)ng/m^(3)),total suspended particulate(TSP)(mean=4.33×10^(3) ng/m^(3))and soil(mean=4.37×10^(3) ng/g)in this subarea had 1.76-6.19 times higher levels than those from other subareas of this facility,surrounding residential areas and reference areas,indicating that petroleum refining processes would lead apparent derivation of ***,compared with those in residential and reference areas,gas samples in the petrochemical areas had higher∑NPAH/∑PAHs(mean=2.18),but lower∑Cl-PAH/∑PAHs(mean=1.43×10^(-1))and∑Br-PAH/∑PAHs ratios(mean=7.49×10^(-2)),indicating the richer nitrification of PAHs than chlorination during petrochemical *** occupational exposure to PAHs and XPAHs in this petroleum refinery facility were 24-343 times higher than non-occupational exposure,and the ILCR(1.04×10^(-4))for petrochemical workers was considered to be potential high ***,one expanded high-resolution screening through GC Orbitrap/MS was performed for soils from petrochemical area,and another 35 PAHs were found,including alkyl-PAHs,phenyl-PAHs and other species,indicat-ing that profiles and risks of PAHs analogs in petrochemical areas deserve further expanded investigation.

关键词： Polycyclic aromatic hydrocarbons(PAHs) Derivatives Petroleum refinery Human exposure Non-targeted screening