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miR-124 is upregulated in diabetic mice and inhibits proliferation and promotes apoptosis of high-glucose-inducedβ-cells by targeting EZH2

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World Journal of Diabetes 2023年第3期14卷 209-221页

作者： Xiao-Kai Duan yong-xiang sun Hong-Yun Wang Yan-Yan Xu Shi-Zhen Fan Jin-Ya Tian yong Yu Yan-YunZhao Yan-Li Jiang Department of General Practice Zhengzhou First People’s HospitalZhengzhou 450000Henan ProvinceChina

BACKGROUND Diabetes is a chronic metabolic disease,and a variety of miRNA are involved in the occurrence and development of *** clinical studies,miR-124 is highly expressed in the serum of patients with diabetes and in pancreatic isletβ-***,few reports exist concerning the role and mechanism of action of miR-124 in *** To investigate the expression of miR-124 in diabetic mice and the potential mechanism of action in isletβ-*** The expression levels of miR-124 and enhancer of zeste homolog 2(EZH2)in pancreatic tissues of diabetic mice were *** targeted relationship between miR-124 and EZH2 was predicted by Targetscan software and verified by a double luciferase reporter *** isletβ-cells Min6 were grown in a high glucose(HG)medium to mimic a diabetes *** insulin secretion,proliferation,cell cycle and apoptosis of HG-induced Min6 cells were detected after interference of miR-124a and/or *** The expression of miR-124 was upregulated and EZH2 was downregulated in the pancreatic tissue of diabetic mice compared with control mice,and the expression of miR-124 was negatively correlated with that of ***-124 was highly expressed in HG-induced Min6 *** of miR-124 promoted insulin secretion and cell proliferation,induced the transition from the G0/G1 phase to the S phase of the cell cycle,and inhibited cell apoptosis in HG-induced Min6 ***2 was one of the targets of ***-transfection of miR-124 inhibitor and siRNA-EZH2 could reverse the effects of the miR-124 inhibitor in HG-induced Min6 *** miR-124 is highly expressed in diabetic mice and HG-induced Min6 cells and regulates insulin secretion,proliferation and apoptosis of isletβ-cells by targeting EZH2.

关键词： miR-124 Enhancer of zeste homolog 2 Diabetes Insulin secretion Proliferation Apoptosis

Identifying online traffic based on property of TCP flow

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The Journal of China Universities of Posts and Telecommunications 2009年第3期16卷 84-88页

作者： HONG Min-huo,GU Ren-tao,WANG Hong-xiang,sun yong-mei,JI Yue-feng Key Laboratory of Optical Communications and Lightwave Technologies,Beijing University of Posts and Telecommunications,Beijing 100876,China [a]Key Laboratory of Optical Communications and Lightwave Technologies Beijing University of Posts and Telecommunications Beijing 100876 China

Classification of network traffic using port-based or payload-based analysis is becoming increasingly difficult when many applications use dynamic port numbers, masquerading techniques, and encryption to avoid detection. In this article, an approach is presented for online traffic classification relying on the observation of the first n packets of a transmission control protocol （TCP） connection. Its key idea is to utilize the properties of the observed first ten packets of a TCP connection and Bayesian network method to build a classifier. This classifier can classify TCP flows dynamically as packets pass through it by deciding whether a TCP flow belongs to a given application. The experimental results show that the proposed approach performs well in online Internet traffic classification and that it is superior to naive Bayesian method.

关键词： network traffic classification inter-arrival time TCP flow Bayesian network

Ultrafast vibrational dephasing dynamics of 9,10-bis(phenylethynyl)anthracene thin film revealed by femtosecond coherent anti-stokes Raman scattering

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Ultrafast vibrational dephasing dynamics of 9,10-bis(phenyle...

Prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from Nigeria

第十一届新型太阳能材料科学与技术学术研讨会

作者： yong-xiang sun Yun-fei Song Wei-long Liu Hong-lin Wu Qin Chen Li-lin Jiang School of Materials Science and Engineering Guilin University of Electronic Technology Key Laboratory of Shock Wave and Detonation Physics Institute of Fluid PhysicsChina Academy of Engineering Physics School of Physics Harbin Institute of Technology College of Education and Music Hezhou University School of Artificial Intelligence Hezhou University

Ultrafast vibrational dephasing dynamics of 9,10-bis（phenylethynyl）anthracene （BPEA）thin films were revealed by femtosecond coherent anti-stokes Raman scattering spectroscopy （fs-CARS）.Dephasing times （T） of 2.60,2.98,3.72,and 1.64 ps were acquired at 1213,1300,1400,and 1478 cm vibrations,*** steady-state Raman and fast Fourier transform spectra,the dephasing dynamics generated by coherently excited Raman modes 1213 （1478） cm were fitted with 94 （77） cm quantum beat frequencies,with a combination of slow constantsτ=5.92 （2.76） ps and fast constantsτ=1.65 （1.98） *** lifetimes could be ascribed to the time scales associated with the structural changes for the C=C Raman modes in the BPEA thin ***,it is very significant to distinctly understand the underlying ultrafast vibrational dephasing dynamics of the electronic ground state of BPEA caused by vibrational structure changes,which benefits to improve sustainably the molecular device for efficient solar energy conversion.

关键词： Ultrafast vibrational dephasing dynamics Coherent anti-stokes Raman scattering

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Infectious Diseases of Poverty 2017年第1期6卷 395-400页

作者： Hong-Wei Zhang San-Jin Li Tao Hu yong-Min Yu Cheng-Yun Yang Rui-Min Zhou Ying Liu Jing Tang Jing-Jing Wang Xiu-Yun Wang yong-xiang sun Zhan-Chun Feng Bian-Li Xu Department of Parasite Disease Control and Prevention Henan Center for Disease Control and PreventionZhengzhouPeople’s Republic of China Department of Infectious Diseases the 6th People’s Hospital of ZhengzhouZhengzhou 450016People’s Republic of China School of Medicine and Health Management Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiPeople’s Republic of China

Background:The spleen plays a pivotal role in the rapid clearance of parasitized red blood cells in patients with falciparum malaria after artemisinin *** parasite clearance can be found in patients who have had a splenectomy,or those with hemoglobin abnormalities and/or reduced immunity,which are all distinguishable from artemisinin *** paper reports on a case of prolonged parasite clearance in a Chinese splenectomized patient with falciparum malaria imported from *** presentation:A 35-year-old Chinese male suffered 2 days of febrile illness after returning to Zhumadian city of Henan province from Nigeria on October 1,*** main symptoms were febrile,including the highest axillary temperature of 40℃,headache,and chills.A peripheral blood smear showed parasitemia(53913 asexual parasites/μl)of Plasmodium *** patient had not used any chemoprophylaxis against malaria in Nigeria when he worked there as a construction worker between 2009 and *** patient had three episodes of malaria in Nigeria and had a splenectomy due to a traffic accident 8 years ago from the time he was admitted to *** patient was orally administrated a total of 320 mg/2.56 g dihydroartemisinin-piperaquine for 2 days and intravenously administrated a total of 3000 mg artesunate for 18 *** axillary temperature of the patient ranged between 37.0 and 37.7℃ from Day 0 to Day 3,and blood microscopy revealed falciparum malaria parasitemia(26674 asexual parasites/μl)on Day *** patient was afebrile on Day 4,falciparum malaria parasitemia was continuously present and then gradually decreased on the next days,and was negative on Day *** patient was cured and left hospital on Day 24 after no plasmodium falciparum was found in the blood on Day 21 to Day *** mutation was found in the K13 propeller gene when compared with the PF3D7_1343700 K13 propeller gene reference ***:This is the first reported case in China of prolong

关键词： Falciparum malaria Artemisinin treatment Prolonged parasite clearance Splenectomy China Nigeria

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艾米丽·卡尔绘画艺术风格的嬗变

艺术与设计（理论版） 2018年第4期 115-117页

作者：聂翔孙勇彬南京财经大学南京210046

艾米丽·卡尔是加拿大现代著名的艺术家,她的艺术创作深受原住民文化的影响。她笔下的图腾柱作品能够体现出独特的原住民风情。尽管卡尔晚年的作品转向加拿大西北海岸自然风光的描绘,但是她仍然没有摒弃原住民主题。相反,她将自然与图... 详细信息

艾米丽·卡尔是加拿大现代著名的艺术家,她的艺术创作深受原住民文化的影响。她笔下的图腾柱作品能够体现出独特的原住民风情。尽管卡尔晚年的作品转向加拿大西北海岸自然风光的描绘,但是她仍然没有摒弃原住民主题。相反,她将自然与图腾柱融为一体,跳出了对原住民文化保守式再现的局囿,从而使得自己的艺术造诣达到巅峰。从物质描绘到诗意表达这一转变是她的心态与原住民文化生态的互动关系的象征,烘托了卡尔独立灵魂的存在,揭示了她的作品与原住民文化的密切关联。

关键词：艾米丽·卡尔绘画风格图腾柱嬗变

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin Zeng Le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su yong Wan xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 335-345页

作者： Feng Zhang Chenyang Zhang Linlin Wu Wei sun Hongliang Zhang Jianhua Chen yong Pei Songjiang Li Engineering Research Center of Ministry of Education for Carbon Emission Reduction in Metal Resource Exploitation and Utilization Hunan International Joint Research Center for Efficient and Clean Utilization of Critical Metal Mineral ResourcesSchool of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China State Key Laboratory of Mineral Processing Beijing General Research Institute of Mining&MetallurgyBeijing 100160China Hunan Provincial Key Laboratory of Micro&Nano Materials Interfaces Science College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China School of Resources Environment and MaterialsGuangxi UniversityNanning 530004China Department of Chemistry Xiangtan UniversityXiangtan 411105China China Railway Resource Group Co.Ltd Beijing 102300China

The depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite still lacked in-depth ***,the depression mechanism of sulfite ions on sphalerite and Pb^(2+)activated sphalerite in the flotation separation of galena from sphalerite was further systematically investigated with experiments and density functional theory(DFT)*** X-ray photoelectric spectroscopy(XPS)results,DFT calculation results,and frontier molecular orbital analysis indicated that sulfite ions were difficult to be adsorbed on sphalerite surface,suggesting that sulfite ions achieved depression effects on sphalerite through other non-adsorption ***,the oxygen content in the surface of sphalerite treated with sulfite ions in creased,which enhanced the hydrophilicity of the sphalerite and further increased the difference in hydrophilicity between sphalerite and ***,sulfite ions were chelated with lead ions to form PbSO_(3)in *** hydrophilic PbSO_(3)was more easily adsorbed on sphalerite than *** interaction between sulfite ions and lead ions could effectively inhibit the activation of *** addition the UV spectrum showed that after adding sulfite ions,the peak of perxanthate in the sphalerite treated xanthate solution was significantly stronger than that in the galena with xanthate solution,indicating that xanthate interacted more readily with sulfite ions and oxygen mo lecules within the sphalerite system,leading to the formation of ***,sulfite ions hardly depressed the flotation of ga lena and could promote the flotation of galena to some *** study deepened the understanding of the depression mechanism o sulfite ions on sphalerite and Pb^(2+)activated sphalerite.

关键词： sphalerite galena sulfite ion density functional theory depression mechanism

Visualization of the protective role of estrogen against female liver fibrosis via an ER viscosity NIR fluorescent probe

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Science China Chemistry 2025年第1期 360-368页

作者： Zheng Liu Changyu Zhang Zipeng Li Wanying Ma Jia Liu xiang Xia Ning Xu Wen sun Jianjun Du Jiangli Fan Xiaojun Peng State Key Laboratory of Fine Chemicals Dalian University of Technology Ningbo Institute of Dalian University of Technology

Endoplasmic reticulum(ER) viscosity has emerged as a new potential biomarker for hepatic fibrosis(HF). Herein, we report the first ER-targeting viscosity-responsive near-infrared(NIR) fluorescent probe HBT-PP for investigations of HF *** twisted intramolecular charge transfer(TICT) and the excited state intramolecular proton transfer(ESIPT) are combined to endow HBT-PP with the selective response towards viscosity(～62-fold) and a super large stokes shift(～320 nm). HBT-PP mainly targets organelle ER and is able to image the drug-or alcohol-induced viscosity elevation in living cells. Significantly,HBT-PP was successfully applied to visualize the gender difference in HF and the protective role of estrogen in restraining HF progression. Of note, after 10 min of stain with HBT-PP, HF lesions showed a stage-based response, indicating the potential of this probe in fast and early diagnosis of HF. These results clearly demonstrated the promising application of HBT-PP as a new tool for exploring ER viscosity-involved physiological and pathological processes.

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多编队对地攻击协同目标分配方法研究

系统仿真学报 2009年第8期21卷 2148-2151,2173页

作者：代进进李相民孙永芹杜艳强海军航空工程学院烟台264001

首先介绍了协同目标分配在多编队对地攻击中的重要性,然后提出了一种初始分配与全面分配相结合的目标分配方案,建立了目标分配模型,设计了分群算法实现目标的初始分配,采用遗传算法完成目标的全面分配。最后在态势威胁评估的基础上给出... 详细信息

首先介绍了协同目标分配在多编队对地攻击中的重要性,然后提出了一种初始分配与全面分配相结合的目标分配方案,建立了目标分配模型,设计了分群算法实现目标的初始分配,采用遗传算法完成目标的全面分配。最后在态势威胁评估的基础上给出了具体仿真算例,计算结果表明,介绍的方法可以全面、有效地解决编队对地攻击中的目标优化分配问题,从而提高了多编队对地攻击的整体作战效能。

关键词：编队对地攻击目标分配威胁评估:遗传算法