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Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang Li Tian-Shuo Feng Ji Gao Xin-xiang Yang xiang-Cheng Li Zhen-hua Deng Yong-xiang Xia Zheng-Shan wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of Liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of Living Donor Liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 Liver transplantation

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Fatigue Performance of Microalloyed High-strength Rebar and Analysis of Fracture Mechanism

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Journal of Iron and Steel Research International 2015年第12期22卷 1149-1155页

作者： Peng-yan LU Yu LIU hua-jie wu Gang LIU xiang MENG Yang XU Engineering Research Institute University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing

Fatigue performance of hot-rolled ribbed-steel bar with the yield strength of 500 MPa （HRB500） was stud- ied with bend-rotating fatigue test at a stress ratio of R = -1. It is determined by staircase method that its fatigue strength for 107 cycles is 451 MPa, which is higher than that of common carbon structural steel. This should be at- tributed to the fine-grain strengthening resulting from the high content of alloy element V and Thermo-Mechanical Control Process （TMCP）. The S-N curve function is also obtained by nonlinear regression with three parameters power function. The fatigue fractures of the specimen were further analyzed with Scanning Electron Microscopy （SEM） and Energy Disperse Spectroscopy （EDS） to study the fracture mechanism. Taking into account microstruc- ture, hardness and cleanliness of the material, it implies that the fatigue fractures of HRB500 rebar all arise from surface substrates in which many brittle inclusions are contained, and that the fatigue crack propagation is principally based on the mechanism of quasi-cleavage fracture, because of the intracrystalline hard spots leading to stress con- centration and thus to the cracks. Moreover, the transient breaking area exhibits microvoid coalescence of ductile fracture due to the existing abundant inclusions.

关键词： HRB500 bend-rotating fatigue performance fracture mechanism inclusion

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Synthesis and Characterization of Linked Clusters Capped by Alkylidyne

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Chinese Journal of Structural Chemistry 2002年第1期21卷 17-21页

作者： ZHANG Yu-hua CHI Wei-Guang YIN Yuan-Qi huaNG Zi-xiang wu Qiang-Jin State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China Fujian Institute of Research on the Structure of Matter Chinese Academy of SciencesFuzhou 350002China 不详

The lsolobal displacement reaction between the dianion {M(CO)3[(h5-C5H4) C(O)C6H4C(O)(h5-C5H4)](CO)3M}2- and two molecules of [(m3-C)CO2Et]Co3(CO)9 gave rise to the formation of terephthaloyl(biscyclopentadienyl)-bridged double cluster complexes [(h5-C5H4)C(O)C6H4C(O)(h5-C5H4)]{[(m3-C)CO2Et]Co2M(CO)8}2 (M = Mo 1, M = W, 2). In the reaction, single cluster complexes[(m3-C)CO2Et]-Co2M(CO)8[h5-C5H4C(O)C6H4CO2CH3] ( M = Mo 3, M = W, 4) were yielded as by-products. All the cluster complexes were characterized by C/H analysis, IR and 1H NMR spectroscopy, and the structure of 3 has been determined by single-crystal X-ray diffraction method. Crystal data: Mr = 750.19, monoclinic, space group P21/c, a = 22.652(5), b = 8.954 (2), c = 14.530(3) ? b = 104.00(3), V = 2859.6(10) 懦, Z = 4, Dc = 1.743 mg/m? F(000) = 1488, m = 1.644 mm-1, the final R = 0.0555 and wR = 0.1353 for 5519 observations with I > 2s(I).

关键词： transition metal linked cluster crystal structure cobalt

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Hair regrowth following fecal microbiota transplantation in an elderly patient with alopecia areata: A case report and review of the literature

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World Journal of Clinical Cases 2019年第19期7卷 3074-3081页

作者： Wen-Rui Xie Xiao-Ya Yang Harry hua-xiang Xia Li-Hao wu Xing-xiang He Department of Gastroenterology the First Affiliated Hospital of Guangdong Pharmaceutical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Physiology Guangzhou Health Sciences CollegeGuangzhou 510180Guangdong ProvinceChina

BACKGROUND Alopecia areata is a hair loss disease associated with genetics,autoimmunity,and other *** is an intriguing link between alopecia areata and gut *** microbiota transplantation(FMT)has been recommended to treat Clostridium difficile(previously known as Clostridioides difficile)infection,and has also shown potentials in the treatment of inflammatory bowel disease,irritable bowel syndrome,and non-alcohol fatty liver *** SUMMARY An 86-year-old man,with a history of sigmoid colon carcinoma,suffered from recurrent abdominal pain and distension,and diarrhea for six months,with *** admission,he was also diagnosed with *** physical examination,the patient presented with a 1.5 cm×2.0 cm alopecia areata on his right *** to the negative results of laboratory testing,capsule endoscopy,and colonoscopy,the patient was diagnosed with noninfectious diarrhea,depressive disorder,and patchy alopecia *** that noninfectious diarrhea in the elderly patient was mainly caused by gut dysbiosis,he was given six rounds of *** diarrhea improved remarkably one month after FMT,with improved appetite and disappearance of abdominal pain,distension,and depressive ***,he reported new hair growth on the affected region of his scalp,with some of his white hair gradually turning to black,without taking any other therapies for alopecia areata before and after *** FMT might act as a potential therapy for patients who suffer from alopecia *** and well-designed studies are required to confirm the role of FMT in alopecia areata.

关键词： Fecal microbiota transplantation Alopecia areata Gut microbiota Autoimmune disease Psychopathogenesis Case report

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Modeling the carbon dynamics of alpine grassland in the Qinghai-TibetanPlateau under scenarios of 1.5 and 2 ℃ global warming

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Advances in Climate Change Research 2019年第2期10卷 80-91页

作者： YI Shu-hua xiang Bo MENG Bao-Ping wu Xiao-Dong DING Yong-Jian Instiute o f Fragile Ecosystem and Environment Nantong University Nantong 226007 China of Geographic Sciences Nantong University Nantong 226007 China State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Lanzhou 730000 China Chongqing Climate Center Chongqing 401147 China Cryosphere Research Station on the Qinghai-Tibetan Plateau Lanzhou 730000 China Key Laboratory of Ecohydrology of Inland River Basin Chinese Academy of Sciences Lanzhou 730000 China University of Chinese Academy Sciences Beijing 100049 China

Alpine grassland occupies two-thirds of the Qinghai-Tibetan Plateau (QTP). It is vital to project changes of this vulnerable ecosystem under different climate change scenarios before taking any mitigation or adaptation measures. In this study, we used a process-based ecosystem model, driven with output from global circulation models under different Representative Concentration Pathways (RCPs), to project the carbon dynamics of alpine grassland. The results showed the following: 1) Vegetation carbon (C) on the QTP increased by 22—38 gC m^-2 during periods of 1.5 and 2 ℃ warming under different RCPs when compared to the baseline period (1981—2006), while soil C increased by 85—122 gC m^-2. 2) The increases of vegetation C and soil C at the period of 1.5 ℃ warming were about 15 gC m^-2 and 40 gC m^-2 smaller than those at the period of 2 ℃ warming, respectively;increase of C was greater for alpine meadow than for alpine steppe. 3) Precipitation, radiation, and permafrost changed significantly and showed heterogeneous spatial patterns, and caused heterogeneous response of C dynamics. For alpine meadow in regions transformed from permafrost to seasonally frozen soil with medium annual precipitation (200—400 mm), vegetation C and net primary production decreased by 18.7 gC m-2 and 3.1 gC m^-2 per year during 2 °C warming under RCP 4.5, respectively. This decrease can be attributed to the disappearing impermeable permafrost. Different from previous studies that indicated an unfavorable response of alpine grassland to climate warming, this study showed a relatively favorable response, which is mainly attributed to C 0 2 fertilization.

关键词： Permafrost Terrestrial ecosystem model Vegetation Soil Net primary production

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Extrapancreatic solid pseudopapillary neoplasm followed by multiple metastases:Case report

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 497-501页

作者： Hao wu Yan-Fen huang xiang-Hong Liu Mei-hua Xu Department of Gastroenterology Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina

Solid pseudopapillary neoplasm(SPN), also known as Gruber-Frantz tumor, is a rare form of neoplasm that almost exclusively occurs in the pancreas and in young females. While the potential of malignancy is low for SPN, these tumors can mimic other diseases and require a meticulous investigation and a standard treatment by total surgical resection. We present an unusual case of SPN arising in the mesentery of a 40-year-old man with subsequent multiple metastases. Histopathological examination showed similar properties of the mesenteric neoplasm to those of SPN in pancreas. Although the mass was surgically removed, the patient died of recurrent disease 4 years after the initial presentation. We speculate that SPN originates from pancreatic progenitor cells. Further histopathological analyses are required for the prediction of SPN recurrence after resection.

关键词： Solid pseudopapillary neoplasm Mesentery Metastasis

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Gelation of polymeric nanoparticles

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Particuology 2014年第3期12卷 1-11页

作者： hua wu Massimo Morbidelli Institute for Chemical and Bioengineering.Department of Chemistry and Applied Biosciences ETH Zurich8093 ZurichSwitzerland

We review how, starting from polymeric nanoparticles, to generate clusters of fractal morphology and to expand the entire space and interconnect to form gels, through either Brownian motion or intense shear-induced aggregation. In the case of Brownian motion-induced gelation, specific techniques developed to obtain uniform structure of gels under both reaction-limited and diffusion-limited cluster aggregation conditions have been described. In the case of intense shear-induced gelation as a newly developed technique, our focus is on its principle, theoretical development and advantages with respect to Brownian motion-induced gelation in practical applications. We consider gelation of both rigid and soft particles. As a physical process, the bonding between the particles within gels is owed to van der Waals attractions, thus being easily broken. However, in the case of soft particles that can coalesce upon contact, the coalescence can allow the particles to stick together forming permanent gels. In this case, the gel structure can be controlled by controlling the degree of coalescence. Techniques used to control the degree of coalescence have also been described.

关键词： Structured material Fractal Gelation Gel Polymer

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Homocysteine, hypertension, and risks of cardiovascular events and all-cause death in the Chinese elderly population: a prospective study

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Journal of Geriatric Cardiology 2021年第10期18卷 796-808页

作者： Zhong-Ying ZHANG xiang GU Zhe TANG Shao-Chen GUAN Hong-Jun LIU Xiao-Guang wu Yan ZHAO xiang-hua FANG Geriatric Department Xuanwu HospitalCapital Medical UniversityBeijingChina Evidence-based Medical Center Xuanwu HospitalCapital Medical UniversityBeijingChina Medical Affair Department Beijing Friendship HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Healthcare Center Xuanwu HospitalCapital Medical UniversityBeijingChina Education Department Xuanwu HospitalCapital Medical UniversityBeijingChina

BACKGROUND Increased homocysteine levels are associated with the risk of cardiovascular disease(CVD)and ***,their prevention has not been effective in decreasing CVD *** study investigated the individual and combined associations of hyperhomocysteinemia and hypertension with incident CVD events and all-cause death in the Chinese elderly population without a history of *** This prospective study was conducted among 1,257 elderly participants(mean age:69 years).A questionnaire survey,physical examinations,and laboratory tests were conducted to collect baseline *** was defined as homocysteine level≥15μmol/L.H-type hypertension was defined as concomitant hypertension and *** Cox regression analysis was used to evaluate individual and combined associations of hyperhomocysteinemia and hypertension with the risks of incident CVD events and all-cause *** Over a median of 4.84-year follow-up,hyperhomocysteinemia was independently associated with incident CVD events and all-cause *** hazard ratios(HRs)were 1.45(95%CI:1.01−2.08)for incident CVD events and 1.55(95%CI:1.04−2.30)for all-cause *** adjustment for confounding factors,H-type hypertension had the highest HRs for incident CVD events and all-cause *** fully adjusted HRs were 2.44 for incident CVD events(95%CI:1.28−4.65),2.07 for stroke events(95%CI:1.01−4.29),8.33 for coronary events(95%CI:1.10−63.11),and 2.31 for all-cause death(95%CI:1.15−4.62).CONCLUSIONS Hyperhomocysteinemia was an independent risk factor,and when accompanied by hypertension,it contrib-uted to incident CVD events and all-cause death in the Chinese elderly population without a history of CVD.

关键词： hypertension prospective prevention

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改善H型钢断面性能均匀性的研究

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塑性工程学报 2003年第5期10卷 82-85页

作者：徐旭东刘相华吴迪王国栋东北大学轧制技术及连轧自动化国家重点实验室沈阳110004

针对H型钢的断面性能特点,对最终产品的材料组织形态和夹杂物含量进行研究,从温度和变形两个方面阐述了造成H型钢断面性能不均的原因。轧件断面的组织形态和空冷温度场计算结果表明,为了改善轧件的断面性能,应在轧件的不同部位选择不同... 详细信息

针对H型钢的断面性能特点,对最终产品的材料组织形态和夹杂物含量进行研究,从温度和变形两个方面阐述了造成H型钢断面性能不均的原因。轧件断面的组织形态和空冷温度场计算结果表明,为了改善轧件的断面性能,应在轧件的不同部位选择不同的冷却强度对其进行轧后的控制冷却。

关键词： H型钢断面性能夹杂物

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Journal of Clinical and Translational Hepatology Has Been Indexed in SCIE: A Milestone towards a Greater Academic Goal

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Journal of Clinical and Translational Hepatology 2020年第4期8卷 357-358页

作者： Harry hua-xiang Xia George Y.wu Hong Ren Department of Gastroenterology First Affiliated HospitalGuangdong Pharmaceutical UniversityGuangzhouGuangdongChina Department of Medicine Division of Gastroenterology-HepatologyUniversity of Connecticut Health CenterFarmingtonCTUSA Institute for Viral Hepatitis Department of Infectious DiseasesThe Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina

On November 10, 2020, the Editorial Office received a no-tification letter from Clarivate Analytics stating that Journal of Clinical and Translational Hepatology (JCTH) had been selected to be included in citation indexes in the Web of Science, and that articles published in JCTH after December 30, 2017 will be listed in some of the most influential and widely used databases in the world, including Current Con-tents/Clinical Medicine, Science Citation Index Expanded (SCIE), Essential Science Indicators, and Journal Citation Reports Science.

关键词： SCIE Academic Miles

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