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Ubiquitin ligase DTX3 empowers mutant p53 to promote ovarian cancer development

Genes & Diseases 2022年第3期9卷 705-716页

作者： Shanshan Wang Qian Hao Jiajia Li Yajie Chen hua Lu Xiaohua wu xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032PR China Department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032PR China Department of Gynecological Oncology Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032PR China Department of Radiation Oncology Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032PR China Department of Biochemistry&Molecular Biology and Tulane Cancer Center Tulane University School of MedicineNew OrleansLA 70112USA Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan UniversityShanghai 200032PR China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyInstitutes of Biomedical SciencesFudan UniversityShanghai 200032PR China

The deltex family protein DTX3 is believed to possess E3 ubiquitin ligase activity,as it contains a classic RING finger ***,its biological role and the underlying mechanism in cancer remain largely ***,we identified DTX3 as a novel mutant p53-interacting protein in ovarian ***,DTX3 mediated mutant p53 ubiqui-tination and stabilization by perturbing the MDM2-mutant p53 interaction,consequently leading to activation of *** p53 target ***,a positive correlation between the expression of DTX3 and mutant p53 target genes was further validated in ovarian *** DTX3 promoted,while depletion of DTX3 suppressed,ovarian cancer cell proliferation and ***,the pro-tumorigenic effect of DTX3 is dependent on mutant p53,because ablation of mutant p53 significantly impaired DTX3-induced gene expression and ovarian cancer cell growth and ***,DTX3 elevated the expressi on of muta nt p53 target genes and boosted ovarian tumor growth in *** ally,DTX3 was amplified and overexpressed in ovarian carci no mas,which is sign ificantly associated with unfavorable ***,our findings unveil the oncogenic role of DTX3 in ovarian cancer development by bolstering mutant p53 activity.

关键词： DTX3 E3 ubiquitin ligase Invasion Mutant p53 Ovarian cancer Proliferation

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Seepage Anisotropy of Heterogeneous Body

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Journal of China University of Mining and Technology 2007年第4期17卷 572-577页

作者： WANG Hong-jiang wu Ai-xiang SU Yong-ding YANG bao-hua ZHANG Jie Civil and Environment Engineering School University of Science and Technology Beijing Beijing 100083 China School of Resources and Safety Engineering Central South University Changsha Hunan 410083 China

Ore dumps are heterogeneous bodies with anisotropic seepage characteristics because of the ore segregation. In an indoor experiment,a dump was constructed with three strata,where the horizontal and vertical seepage experi-ments were carried out. Horizontals flow are regarded as phreatic plan flows without penetration. Its seepage law sati-fies the Dupuit equation. With parallel lay seepage model,the equivalent seepage coefficient in the horizontal flow was obtained and was equivalent to the weighted mean of the seepage coefficient of each stratum. An unsaturated flow ap-peared in the vertical experiment,with a hydraulic gradient of 1. The vertical flow was equivalent to the seepage model that moved in vertical bedding; its equivalent seepage coefficient depended on the stratum with the minimum seepage coefficient. That the experiment showed clear anisotropy in a heterogeneous body was obvious with an anisotropic co-efficient between 63 and 155,which is 25 to 100 times larger than that of a homogeneous body.

关键词： heterogeneous body anisotropy equivalent seepage coefficient ore dump

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Cellular and organellar membrane-associated proteins in haloarchaea: Perspectives on the physiological significance and biotechnological applications

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Science China(Life Sciences) 2012年第5期55卷 404-414页

作者： CAI Lei ZHAO DaHe HOU Jing wu Jinhua CAI ShuangFeng DASSARMA Priya xiang hua State Key Laboratory of Microbial Resources Institute of Microbiology Chinese Academy of Sciences Beijing 100101 China Department of Microbiology ＆ Immunology University of Maryland School of Medicine Baltimore MD 21202 USA

Halophilic archaea (haloarchaea) inhabit hypersaline environments,tolerating extreme salinity,low oxygen and nutrient availability,and in some cases,high pH (soda lakes) and irradiation (saltern ponds).Membrane-associated proteins of haloarchaea,such as surface layer (S-layer) proteins,transporters,retinal proteins,and internal organellar membrane proteins including intracellular gas vesicle proteins and those associated with polyhydroxyalkanoate (PHA) granules,contribute greatly to their environmental *** review focuses on these haloarchaeal cellular and organellar membrane-associated proteins,and provides insight into their physiological significance and biotechnological potential.

关键词： halophilic archaea membrane proteins physiology biotechnology

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AN IMPROVED ALGORITHM FOR DPIV CORRELATION ANALYSIS

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Journal of Hydrodynamics 2007年第1期19卷 62-67页

作者： wu Long-hua College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China

In a Digital Particle Image Velocimetry （DPW） system, the correlation of digital images is normally used to acquire the displacement information of particles and give estimates of the flow field. The accuracy and robustness of the correlation algorithm directly affect the validity of the analysis result. In this article, an improved algorithm for the correlation analysis was proposed which could be used to optimize the selection/determination of the correlation window, analysis area and search path. This algorithm not only reduces largely the amount of calculation, but also improves effectively the accuracy and reliability of the correlation analysis. The algorithm was demonstrated to be accurate and efficient in the measurement of the velocity field in a flocculation pool.

关键词： Digital Particle Image Velocimetry (DPIV),correlation analysis improved algorithm

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Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease via the modulation of the gut microbiota in rabbits

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World Journal of Gastroenterology 2019年第8期25卷 955-966页

作者： Ya-Wei Xing Guang-Tao Lei Qing-hua wu Yu Jiang Man-xiang huang Department of Gastroenterology The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Procyanidins have beneficial effects on metabolic syndrome and antimicrobial activity,but the mechanisms underlying these effects are *** To investigate the effects of procyanidin B2(PB2)on non-alcoholic fatty liver disease and to explore the possible *** Thirty male New Zealand white rabbits were randomized into three *** of them were fed either a high-fat-cholesterol diet(HCD)or chow ***-fed rabbits were treated with vehicle or PB2 daily for 12 *** weight and food intake were evaluated once a *** biomarkers,such as total cholesterols,triglycerides,and aspartate transaminase,were *** rabbits were sacrificed and histological parameters of liver were assessed by hematoxylin and eosin-stained ***,several lipogenic genes and gut microbiota(by 16S rRNA sequencing)were investigated to explore the possible *** The HCD group had higher body weight,liver index,serum lipid profile,insulin resistance,serum glucose,and hepatic steatosis compared to the CHOW ***2 treatment prevented HCD-induced increases in body weight and hypertriglyceridemia in association with triglyceride accumulation in the ***2 also ameliorated low-grade inflammation,which was reflected by serum lipopolysaccharides and improved insulin *** rabbit liver,PB2 prevented the upregulation of steroid response element binding protein 1c and fatty acid synthase and the downregulation of carnitine palmitoyltransferase,compared to the HCD ***,HCD led to a decrease of Bacteroidetes in gut ***2 significantly improved the proportions of Bacteroidetes at the phylum level and Akkermansia at the genus *** Our results indicate the possible mechanism of PB2 to improve HCD-induced features of metabolic syndrome and provide a new dietary supplement.

关键词： Procyanidin Rabbit Non-alcoholic fatty liver disease Gut microbiota 16S rRNA

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Selection diagram of design algorithms for neutron-focusing supermirrors

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Nuclear Science and Techniques 2022年第8期33卷 106-117页

作者： Wen-Bo Mo hua-Rui wu Xue-wu Wang Department of Engineering Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Particle Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

The neutron supermirror is an important neutron optical device that can significantly improve the efficiency of neutron transport in neutron guides and has been widely used in research neutron *** types of algorithms,including approximately ten algorithms,have been developed for designing high-efficiency supermirror *** addition to its applications in neutron guides,in recent years,the use of neutron supermirrors in neutronfocusing mirrors has been proposed to advance the development of neutron scattering and neutron imaging instruments,especially those at compact neutron *** this new application scenario,the performance of supermirrors strongly affects the instrument performance;therefore,a careful evaluation of the design algorithms is *** this study,we examine two issues:the effect of nonuniform film thickness distribution on a curved substrate and the effect of the specific neutron intensity distribution on the performance of neutron supermirrors designed using existing *** effect of film thickness nonuniformity is found to be relatively insignificant,whereas the effect of the neutron intensity distribution over Q(where Q is the magnitude of the scattering vector of incident neutrons)is *** diagrams that show the best design algorithm under different conditions are obtained from these *** the intensity distribution is not considered,empirical algorithms can obtain the highest average reflectivity,whereas discrete algorithms perform best when the intensity distribution is taken into *** reasons for the differences in performance between algorithms are also *** findings provide a reference for selecting design algorithms for supermirrors for use in neutron optical devices with unique geometries and can be very helpful for improving the performance of focusing supermirror-based instruments.

关键词： Neutron-focusing supermirror Design algorithm Thickness nonuniformity Intensity distribution over Q Selection diagram

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Effects of cytoreductive surgery combined with hyperthermic perfusion chemotherapy on prognosis of patients with advanced gallbladder cancer

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2413-2422页

作者： Jin-Xiu wu Rong hua xiang-Ji Luo Feng Xie Li Yao Department of Hepatobiliary-Pancreatic Surgery Punan Branch of Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200125China Department of Biliary-Pancreatic Surgery Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Biliary Tract Surgery Eastern Hepatobiliary Surgery HospitalSecondary Military Medical UniversityShanghai 200438China

BACKGROUND Gallbladder cancer(GC)is a common malignant tumor and one of the leading causes of cancer-related death *** is typically highly invasive,difficult to detect in the early stages,and has poor treatment outcomes,resulting in high mortality *** available treatment options for GC are relatively *** emerging treatment modality is hyperthermic intraperitoneal chemotherapy(HIPEC).HIPEC involves delivering heated chemotherapy directly into the abdominal *** combines the strategies of surgical tumor resection and localized chemotherapy administration under hyperthermic conditions,aiming to enhance the concentration and effectiveness of drugs within the local tumor site while minimizing systemic *** To determine the effects of cytoreductive surgery(CRS)combined with HIPEC on the short-term prognosis of patients with advanced *** Data from 80 patients treated at the Punan Branch of Renji Hospital,Shanghai Jiao Tong University School of Medicine between January 2018 and January 2020 were retrospectively *** control group comprised 44 patients treated with CRS,and the research group comprised 36 patients treated with CRS combined RESULTS The baseline data of the research and control groups were similar(P>0.05).Six days after surgery,the alanine aminotransferase,aspartate aminotransferase,total bilirubin,and direct bilirubin levels significantly decreased compared to the preoperative levels in both groups(P0.05).Similarly,the postoperative creatinine and blood urea nitrogen levels were significantly lower than the preoperative levels in both groups(P0.05).Furthermore,the research group had fewer postoperative adverse reactions than the control group(P=0.027).Finally,a multivariate Cox analysis identified the tumor stage,distant metastasis,and the treat

关键词： Gallbladder diseases Chemotherapy,Cancer,Regional Perfusion Gallbladder neoplasms Prognosis Regression analysis Survival rate

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Roles of cancer stem cells in gastrointestinal cancers

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World Journal of Stem Cells 2023年第4期15卷 209-220页

作者： Shi-Hai Xuan Meng-Lu hua Ze xiang xiang-Lin He Lan huang Chun Jiang Peng Dong Jian wu Department of Laboratory Medicine The People’s Hospital of Dongtai CityDongtai 224299Jiangsu ProvinceChina School of Medicine Zhejiang UniversityHangzhou 310009Zhejiang ProvinceChina Department of Clinical Laboratory Suzhou Municipal HospitalSuzhou 215008Jiangsu ProvinceChina Hangzhou Institute of Cardiovascular Diseases Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

Cancer stem cells(CSCs)are the main cause of tumor growth,invasion,metastasis and ***,CSCs have been extensively studied to identify CSCspecific surface markers as well as signaling pathways that play key roles in CSCs *** involvement of CSCs in the pathogenesis of gastrointestinal(GI)cancers also highlights these cells as a priority target for *** diagnosis,prognosis and treatment of GI cancer have always been a focus of ***,the potential application of CSCs in GI cancers is receiving increasing *** review summarizes the role of CSCs in GI cancers,focusing on esophageal cancer,gastric cancer,liver cancer,colorectal cancer,and pancreatic *** addition,we propose CSCs as potential targets and therapeutic strategies for the effective treatment of GI cancers,which may provide better guidance for clinical treatment of GI cancers.

关键词： Cancer stem cells Gastrointestinal cancers Promotion Inhibition Treatment

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FLOW REGIMES BELOW AERATORS FOR DISCHARGE TUNNELS

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Journal of Hydrodynamics 2012年第3期24卷 378-382页

作者： MA Fei wu Jian-hua College of Water Conservancy and Hydropower Engineering Hohai University Nanjing 210098 China

The flow regimes below an aerator influence directly the air entrainment and the cavitation damage control. Based on the theoretical considerations, the experiments of the aerator for a discharge tunnel were conducted, and the relationships between the flow regime and hydraulic and geometric parameters were investigated. The results showed that, there are two kinds of threshold values for the flow regime conversions. One is Fr1-2 standing for the conversion from the fully filled cavity to the partially filled cavity, and the other is Fr2-3 which shows the change from the partially filled cavity to the net air cavity. Two empirical expressions were obtained for the conversions of the flow regimes, which can be used in the designs of the aerators.

关键词： aerator discharge tunnel flow regime filling water jet length

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A K-Means Clustering-Based Multiple Importance Sampling Algorithm for Integral Global Optimization

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Journal of the Operations Research Society of China 2023年第1期11卷 157-175页

作者： Chen Wang Dong-hua wu Department of Mathematics Shanghai UniversityShanghai200444China

In this paper, we propose a K-means clustering-based integral level-value estimation algorithm to solve a kind of box-constrained global optimization problem. For this purpose, we introduce the generalized variance function associated with the level-value of the objective function to be minimized. The variance function has a good property when Newton’s method is used to solve a variance equation resulting by setting the variance function to zero. We prove that the largest root of the variance equation is equal to the global minimum value of the corresponding optimization problem. Based on the K-means clustering algorithm, the multiple importance sampling technique is proposed in the implementable algorithm. The main idea of the cross-entropy method is used to update the parameters of sampling density function. The asymptotic convergence of the algorithm is proved, and the validity of the algorithm is verified by numerical experiments.

关键词： Global optimization Generalized variance function Multiple importance sampling K-means clustering algorithm

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