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Syndecan 4-c-ros oncogene 1 fusion as a mechanism of acquired resistance in epidermal growth factor receptor mutant lung adenocarcinoma

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Chinese Medical Journal 2019年第24期132卷 3015-3017页

作者： You-Cai Zhu Chun-Wei Xu Qu-Xia zhang Wen-xian Wang Lei Lei Wu Zhuang Department of Thoracic Disease Center Zhejiang Rongjun HospitalJiaxingZhejiang 314000China Department of Pathology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujian 350014China Department of Chemotherapy Zhejiang Cancer HospitalHangzhouZhejiang 310022China Department of Medical Thoracic Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhouFujian 350014China.

To the Editor:A 37-year-old Chinese woman,a nonsmoker,presented with adenocarcinoma of the left lung(stage IV)[Figure 1A],malignant pleural effusion,and multiple bone metastases in December *** acid sequencing of the tumor biopsy revealed an epidermal growth factor receptor(EGFR)exon 19 deletion,and treatment with gefitinib was consequently initiated in December *** were no treatmentrelated side effects except for a grade 1 rash,and stable disease was ***,the patient did not experience long-term benefits and developed disease progression after only two months.A follow-up examination showed that extracranial disease and a small intracranial lesion had developed *** patient then received whole-brain radiotherapy(30 Gy in ten fractions)and four cycles of single-agent pemetrexed in April *** disease was achieved,which coincided with an improvement in the patient’s cough,shortness of breath,and general *** chemotherapy course was changed to two cycles of pemetrexed combined with cisplatin.A partial response(PR)was achieved,and the patient was treated with 14 cycles of pemetrexed alone as maintenance *** follow-up evaluations showed the patient’s condition to be stable;however,the patient’s disease progressed after 23 months.A computed tomography(CT)scan in March 2017 revealed that both the lung lesion and the malignant pleural effusion had increased in size[Figure 1B].The subsequent biopsy specimen was subjected to next-generation sequencing(NGS)and a Syndecan 4-c-ros oncogene 1(SDC4-ROS1)rearrangement was detected[Figure 1C].The patient then received crizotinib in April 2017,and a PR was achieved[Figure 1D].A CT scan done in August 2018 indicated the progression of the primary lesion in the left lung and malignant pleural ***,the growth of the remaining lesions remained stable.

关键词： adenocarcinoma Figure smoke

Relevance of SYNTAX score for assessment of saphenous vein graft failure after coronary artery bypass grafting

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Chronic Diseases and Translational Medicine 2020年第1期6卷 55-61页

作者： Li Jia-Hui Song xian-Tao Yang Xue-Yao zhang Wen-Yi Xing Hao-Ran Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseaseBeijing 100029China

Objective::To identify risk factors of saphenous vein graft (SVG) failure and to investigate the utility of anatomical SYNTAX score (SS) and SYNTAX score II (SS-II) in predicting SVG ***::A total of 598 patients who underwent angiography for clinical reasons after coronary artery bypass grafting (CABG) were included. Baseline data and factors related to SVG failure were analyzed at the patient and graft levels. Patients were divided in tertiles by anatomical SS and in three groups by SS-II revascularization recommendation, and SVG patency was analyzed across these ***::Patency rates were similar in all SS-stratified and SS-II recommendation groups within 1, 5, and 10 years after CABG. At the patient level, fasting blood glucose (FBG) level <7.0 mmol/L was less common in SVG failure (68.0% vs. 76.2%). At the graft level, patients with SVG failure tended to have angiography later (4.0 years vs. 3.0 years), poorer FBG control (FBG <7.0 mmol/L: 68.2% vs. 74.7%), and more grafts anastomosed to the right coronary system (59.2% vs. 47.4%). Longer time interval after CABG was related to SVG failure both at the patient and graft levels, and odds ratio ( OR)/ P values ( OR/ P) were 1.282/0.029 and 1.384/0.016, respectively. Using independent graft and grafting to the right artery system as risk factors at the graft level, OR/ Ps were 3.094/0.000 and 2.524/0.000, respectively. Conclusions::Longer time interval after CABG, independent grafts, and grafting to the right artery system are associated with SVG failure. Anatomical SS or SS-II may not be reasonable tools for predicting SVG failure.

关键词： Coronary artery bypass grafting Graft patency Saphenous vein graft SYNTAX score Predictor

Be(0001)薄膜中的量子尺寸效应与吸附氢的第一性原理计算

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物理学报 2007年第1期56卷 465-473页

作者：宋红州张平赵宪庚北京应用物理与计算数学研究所北京100088

通过基于密度泛函理论的第一性原理方法对铍自由表面的电子结构及表面原子氢的吸附能作了详细计算,给出Be(0001)薄膜的电子结构、表面能、电子功函数、层间弛豫等物理量随厚度变化关系,同时讨论了原子氢在Be(0001)表面的吸附性质,给出... 详细信息

通过基于密度泛函理论的第一性原理方法对铍自由表面的电子结构及表面原子氢的吸附能作了详细计算,给出Be(0001)薄膜的电子结构、表面能、电子功函数、层间弛豫等物理量随厚度变化关系,同时讨论了原子氢在Be(0001)表面的吸附性质,给出了吸附能及局域电子态密度随铍薄膜层厚的变化关系,体现了铍薄膜的量子尺寸效应.

关键词：表面能功函数量子尺度效应

基于露天煤矿边坡渐进破坏法分析排土场稳定性

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煤炭技术 2011年第6期30卷 134-136页

作者：张先良湖南工学院机械系湖南衡阳421002

在露天煤矿边坡问题的分析中,其稳定分析是一个十分重要的问题,它对工程的安全性和经济性有着重要的影响,边坡破坏不是瞬时发生的整体破坏,而是从坡体局部出现裂缝,并一步步"生长",形成滑动面的渐进破坏过程。

关键词：渐进破坏稳定性系数传递

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民族地区精准扶贫工作的哲学化考量

贵州民族研究 2019年第4期40卷 55-58页

作者：张景先内蒙古民族大学经济管理学院内蒙古通辽028043

民族地区精准扶贫工作的开展关系国家整体布局,在历史和现实的双重制约中民族地区精准扶贫逐渐成为社会发展的"短板",特别是民族地区独特的民俗文化和原生态工艺技术并未发挥应有效应,民族地区扶贫工作在创新与求变中忽略民族哲学文化... 详细信息

民族地区精准扶贫工作的开展关系国家整体布局,在历史和现实的双重制约中民族地区精准扶贫逐渐成为社会发展的"短板",特别是民族地区独特的民俗文化和原生态工艺技术并未发挥应有效应,民族地区扶贫工作在创新与求变中忽略民族哲学文化的本土化推进与马克思主义哲学辩证法实践性指导,导致民族地区精准扶贫工作在另辟蹊径的创新中步履维艰。因此,立足民族地区精准扶贫工作困境与双重哲学属性,成为优化民族地区精准扶贫工作的重要思想指导和实践举措。

关键词：民族地区精准扶贫民族哲学马克思主义

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玉米叶部形态指标与抗旱性的关系研究

玉米科学 2009年第3期17卷 68-70页

作者：张振平孙世贤张悦白向历齐华沈阳农业大学沈阳110161 沈阳市农业科学院沈阳110034 全国农业技术推广服务中心北京100026

研究了中度水分胁迫下不同抗旱型品种的叶部形态特征及其与抗旱性的关系。结果表明:叶片衰老指数、叶片卷曲指数与抗旱性呈显著负相关;叶形值、叶向值与抗旱性呈显著正相关。灰色关联度分析结果表明,叶向值、叶形值与抗旱性的关系较叶... 详细信息

研究了中度水分胁迫下不同抗旱型品种的叶部形态特征及其与抗旱性的关系。结果表明:叶片衰老指数、叶片卷曲指数与抗旱性呈显著负相关;叶形值、叶向值与抗旱性呈显著正相关。灰色关联度分析结果表明,叶向值、叶形值与抗旱性的关系较叶片卷曲指数、叶片衰老指数更为重要,以上叶部形态指标是抗旱性鉴定的重要指标之一。

关键词：玉米水分胁迫抗旱性形态指标

热浸镀稀土铝合金层的生长动力学及其计算机拟合

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金属热处理 2006年第1期31卷 49-52页

作者：张伟郭献军李海涛洛阳工业高等专科学校材料系河南洛阳471003

分别在710℃、740℃和770℃对工业纯铁热浸镀纯铝和稀土铝,考察了稀土在各温度下对合金层生长动力学的影响。根据试验结果,通过计算机拟合给出了合金层生长动力学曲线,并建立了方程。结果表明,热浸镀稀土铝时,稀土渗入了合金层,增加了... 详细信息

分别在710℃、740℃和770℃对工业纯铁热浸镀纯铝和稀土铝,考察了稀土在各温度下对合金层生长动力学的影响。根据试验结果,通过计算机拟合给出了合金层生长动力学曲线,并建立了方程。结果表明,热浸镀稀土铝时,稀土渗入了合金层,增加了合金层厚度,且在710℃和740℃作用较明显。对动力学曲线拟合后,拟合度达99.0%以上,可用于合金层的预报和控制。

关键词：动力学稀土元素计算机拟合工业纯铁热浸镀铝

The Assessment of the Clinical Effect of the Drug Compatibility and Course of Treatment to the Brucellar Spondylitis

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Surgical Science 2013年第1期4卷 92-99页

作者： Xin-Ming Yang Wei Shi xian-Yong Meng Ying zhang Ya-Kun Du Lei zhang Yao-Yi Wang Department of Neurology The Children’s Hospital of Hebei Province Shijiazhuang China Department of Neurosurgery The Fourth Affiliated Hospital of Hebei Medical University Shijiazhuang China Department of Orthopaedics The First Affiliated Hospital of Hebei North University Zhangjiakou China Department of Paediatrics The First Affiliated Hospital of Hebei North University Zhangjiakou China

Objective: To evaluate five drug treatment regimens in the treatment of Brucella spondylitis. Methods: Patients with clinical symptoms compatible and diagnostic test consistent with Brucella spondylitis were randomly assigned to five drug treatment regimens. Results: Combination therapy with doxycycline, rifampin and sulfamethoxazole for 56 consecutive days showed the highest cure rate of 20% after a single course and of 85% after a double course with affectivity rates of 55% and 95%. Cure rate and affectivity rate was significant better (P 0.05) than for patients receiving doxycycline, rifampin and streptomycin for the same period and regimens containing doxycycline were significant better than regimens without this drug. Conclusion: Combination therapy of doxycycline, rifampin and sulfamethoxazole for 8 weeks using one or two full courses should be recommended for Brucella spondylitis.

关键词： Brucellosis Spondylitis Clinic Effect Course of Treatment Drug Compatibility

纳米铂-纤维配合物(Pt(0)/AOCF)的制备及表征

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无机化学学报 2009年第7期25卷 1299-1303页

作者：张勇吴之传陶庭先童伟安徽工程科技学院生化工程系芜湖241000

金属Pt具有很高的催化活性．在催化工业上有着广泛的用途．尤其在石油化工方面是一种重要的催化剂。传统的Pt催化剂基本都是以炭、空心SiO2、Al2O3等粉体颗粒或固体物质为载体,通过模板法、液相合成法、电化学法、辐射法、溶胶-凝胶法... 详细信息

金属Pt具有很高的催化活性．在催化工业上有着广泛的用途．尤其在石油化工方面是一种重要的催化剂。传统的Pt催化剂基本都是以炭、空心SiO2、Al2O3等粉体颗粒或固体物质为载体,通过模板法、液相合成法、电化学法、辐射法、溶胶-凝胶法以及溅射法等将金属Pt负载上去．对于以纤维为载体的金属Pt配合物的制备尚未见报道。

关键词： Pt 偕胺肟纤维配位表征