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Science china(Life sciences) 2010年第3期53卷 330-337页

作者： DUAN ShuMin institute of neuroscience,state key laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai china,200031 institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Glial cells in the central nervous system(CNS) consist of a heterogeneous population of cell types,each characterized by distinct morphological features,physiological properties,and specific *** contrast to the previous view that glial cells were passive elements in the brain,accumulating evidence suggests that glial cells are active participants in various brain functions and brain *** review summarizes recent progress of glial cell studies from several groups in china,ranging from studies about the mechanisms of neuron-glia crosstalking to investigations on the roles of glial cells in various CNS disorders.

关键词： neuron-glia interaction ATP plasticity pain ischemia neural injury and repair

Synapse formation and remodeling

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Science china(Life sciences) 2010年第3期53卷 315-321页

作者： LUO ZhenGe institute of neuroscience and state key laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china institute of neuroscience and state key laboratory of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Synapses are specialized structures that mediate information flow between neurons and target cells,and thus are the basis for neuronal system to execute various functions,including learning and *** are around 1011 neurons in the human brain,with each neuron receiving thousands of synaptic inputs,either excitatory or inhibitory.A synapse is an asymmetric structure that is composed of pre-synaptic axon terminals,synaptic cleft,and postsynaptic *** formation involves a number of cell adhesion molecules,extracellular factors,and intracellular signaling or structural *** the establishment of synaptic connections,synapses undergo structural or functional changes,known as synaptic plasticity which is believed to be regulated by neuronal activity and a variety of secreted *** review summarizes recent progress in the field of synapse development,with particular emphasis on the work carried out in china during the past 10 years(1999-2009).

关键词： synapse development neuronal activity synaptic plasticity

Pain research in china

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Science china(Life sciences) 2010年第3期53卷 356-362页

作者： ZHANG xu institute of neuroscience,state key laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

In addition to investigating the anatomy,neurochemistry and neurophysiology of pain pathways,chinese researchers have extended their work into the molecular and cellular mechanisms of sensory afferent transmission at the spinal cord level as well as cognitive processing in the *** mechanism underlying acupuncture analgesia remains a subject of special interest for chinese pain researchers,with the aim of combining clinical practice with the understanding of pain transmission and analgesic mechanism.

关键词： dorsal root ganglion spinal cord nociception receptors ion channels gene expression

Ion channels in neuronal survival

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Science china(Life sciences) 2010年第3期53卷 342-347页

作者： wang YiZheng & xu tianle institute of neuroscience and state key laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china institute of neuroscience and state key laboratory of neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

The study of ion channels represents one of the most active fields in neuroscience research in *** the last 10 years,active research in various chinese neuroscience institutions has sought to understand the mechanisms responsible for sensory processing,neural development and neurogenesis,neural plasticity,as well as *** addition,extensive studies have been directed to measure ion channel activity,structure-function relationships,as well as many other biophysical and biochemical *** review focuses on the progress achieved in the investigation of ion channels in neuronal survival during the past 10 years in china.

关键词： ion channels neuronal survival and ischemia.

Visual neuroscience research in china

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Science china(Life sciences) 2010年第3期53卷 363-373页

作者： YAO HaiShan,LU HaiDong & wang Wei institute of neuroscience,state key laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences

Historically,vision research in china was one of a few distinct research programs within the chinese academy of sciences(CAS).With improved funding opportunities and research environment in neuroscience,vision research at several research institutes within the academy has made significant progress not only in the quantity of publications,but also in the quality of the *** on our own expertise,this review is mainly focused on the findings that have advanced the understanding of visual processing in the central visual pathway,visual perceptual learning,visual development and eye diseases.

关键词： visual cortices contextual modulation feedback feature binding motion processing perceptual learning functional brain imaging eye movement visual development and senescence

Computational neuroscience in china

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Science china(Life sciences) 2010年第3期53卷 385-397页

作者： WU Si1 & LIANG PeiJi2 1institute of neuroscience,shanghai institutes for biological sciences,state key laboratory of Neurobiology,chinese academy of sciences,shanghai 200031,china 2Department of Biomedical Engineering,shanghai Jiaotong University,shanghai 200240,china institute of neuroscience Shanghai Institutes for Biological Sciences State Key Laboratory of Neurobiology Chinese Academy of Sciences Department of Biomedical Engineering Shanghai Jiaotong University

The ultimate goal of Computational neuroscience(CNS) is to use and develop mathematical models and approaches to elucidate brain *** is a young and highly multidisciplinary *** heavily interacts with experimental neuroscience and such other research areas as artificial intelligence,robotics,computer vision,information science and machine *** paper reviews the history of CNS in china,its current status and the prospects for its future *** of CNS research in china are also presented.

关键词： computational neuroscience experimental neuroscience artificial intelligence

Research progress on Drosophila visual cognition in china

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Science china(Life sciences) 2010年第3期53卷 374-384页

作者： GUO AiKe1,2,ZHANG Ke1,PENG YueQin1 & XI wang1 1 institute of neuroscience,state key laboratory of neuroscience,shanghai institutes for biological sciences,chinese academy of sciences,shanghai 200031,china 2 state key laboratory of Brain and Cognitive Science,institute of Biophysics,chinese academy of sciences,Beijing 100101,china institute of neuroscience State Key Laboratory of Neuroscience Shanghai Institutes for Biological Sciences Chinese Academy of Sciences state key laboratory of Brain and Cognitive Science Institute of Biophysics Chinese Academy of Sciences

Visual cognition,as one of the fundamental aspects of cognitive neuroscience,is generally associated with high-order brain functions in animals and ***,as a model organism,shares certain features of visual cognition in common with mammals at the genetic,molecular,cellular,and even higher behavioral *** learning and memory to decision making,Drosophila covers a broad spectrum of higher cognitive behaviors beyond what we had *** with powerful tools of genetic manipulation in Drosophila,an increasing number of studies have been conducted in order to elucidate the neural circuit mechanisms underlying these cognitive behaviors from a genes-brain-behavior *** goal of this review is to integrate the most important studies on visual cognition in Drosophila carried out in china's Mainland during the last decade into a body of knowledge encompassing both the basic neural operations and circuitry of higher brain function in ***,we consider a series of the higher cognitive behaviors beyond learning and memory,such as visual pattern recognition,feature and context generalization,different feature memory traces,salience-based decision,attention-like behavior,and cross-modal leaning and *** discuss the possible general gain-gating mechanism implementing by dopamine-mushroom body circuit in fly's visual *** hope that our brief review on this aspect will inspire further study on visual cognition in flies,or even beyond.

关键词： Visual invariance recognition visual memory traces feature and context generalization selective attention cross-modality memory integration salience-based decision making

Physiological and pathological roles of glia-released ATP

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Physiological and pathological roles of glia-released ATP

The upregulation of TRPA1 following the development of diabetic peripheral neuropathy

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Shu-Min DUAN institute of neuroscience and state key laboratory of neuroscience,shanghai institutes for biological sciences, chinese academy of sciences,shanghai 200031,china

Astrocytes can release signal molecules that mediate intercellular *** particular,ATP release from astrocytes is required for Ca wave propagation among *** found that repetitive neuronal activity induces extensive release of ATP/adenosine from astrocytes,which in turn causes both short-term and long-term hetero-synaptic *** studies showed that lysosomes in astrocytes contained abundant ATP and their partial exocytosis resulted in a low-level ATP release,whereas full exocytosis led to the release of a larger amount of ATP,together with lysosomal *** intracellular lysis of lysosomes abolished both ATP release and Ca wave propagation among *** physiological and pathological relevance of the regulated lysosome exocytosis from other types of glial cells will be also discussed.

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来源： cnki会议评论

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The upregulation of TRPA1 following the development of diabe...