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The role of low-density lipoprotein （LDL） and high-density lipoprotein （HDL） in comparison with whole egg yolk for sperm cryopreservation in rhesus monkeys

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Asian Journal of Andrology 2011年第3期13卷 459-464,513页

作者： qiao-xiang Dong Sarah E Rodenburg Dana Hill Catherine A VandeVoort School of Environmental Science and Public Health Wenzhou Medical College Wenzhou 325035 China California National Primate Research Center University of California Davis CA 95616 USA Department of Obstetrics and Gynecology School of Medicine University of California Davis CA 95616 USA

Low-density lipoprotein （LDL） extracted from hen egg yolk has recently been considered to be superior to whole egg yolk in sperm cryopreservation of various animal species. Meanwhile, there was a notion that high-density lipoprotein （HDL） in egg yolk may have a negative effect on post-thaw survival. The role of LDL and HDL in sperm cryopreservation of rhesus monkeys has not been explored. The present study evaluates their effect in comparison with egg yolk with or without the addition of permeable cryoprotectant （glycerol） on sperm cryopreservation of rhesus macaques. In addition, various additives intended to change the lipid composition of LDL-sperm membrane complex have also been tested for their effectiveness in preserving post-thaw viability. Our findings indicated that LDL is the main component in egg yolk that is responsible for its protective role for sperm cryopreservation in rhesus monkeys. Regardless of the presence or absence of glycerol, the protective role of LDL is similar to that of egg yolk and we did not observe any superiority in post-thaw survival with LDL when compared to egg yolk. Modifying the lipid composition of LDL-sperm membrane complex with the addition of cholesterol, cholesterol loaded cyclodextrin and phosphatidylcholine also did not yield any improvements in pest-thaw survival; while addition of methyl-β-cyclodextrin reduced post-thaw motility. HDL plays a neutral role in sperm cryopreservation of rhesus monkeys. The present study suggests that egg yolk may still hold advantages when compared with LDL as effective components in extenders for sperm cryopreservation in rhesus monkeys.

关键词： non-human primates sperm cryopreservation low-density lipoprotein high-density lipoprotein egg yolk

A facile approach to construct hybrid multi-shell calcium phosphate gene particles

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第4期11卷 292-297页

作者： Zhi-xue XU Ran ZHANG You-xiang WANG qiao-ling HU MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 31002 7 China

The calcium phosphate (CaP) particles have attracted much attention in gene therapy. How to construct stable gene particles was the determining factor. In this study,hybrid multi-shell CaP gene particles were successfully constructed. First,CaP nanoparticles served as a core and were coated with DNA for colloidal stabilization. The ξ-potential of DNA-coated CaP nanoparticles was -15 mV. Then polyethylenimine (PEI) was added and adsorbed outside of the DNA layer due to the electrostatic attraction. The ξ-potential of hybrid multi-shell CaP particles was slightly positive. With addition of PEI,the hybrid multi-shell particles could condense DNA effectively,which was de-termined by ethidium bromide (EtBr) exclusion assay. The hybrid particles were spherical and uniform with diameters of about 150 nm at proper conditions. By simple modification of PEI,the hybrid multi-shell CaP gene particles were successfully constructed. They may have great potential in gene therapy.

关键词： Calcium phosphate Polyethylenimine (PEI) Hybrid Gene

Preoperative detecting metastases of cervical cancer in pelvic and para-aortic lymph nodes:comparison of integrated ^(18)F-FDG PET/CT with or without contrast enhancement

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Nuclear Science and Techniques 2012年第5期23卷 305-311页

作者： XING Yan ZHAO Jinhua SONG Jianhua CHEN xiang qiao Wenli Department of Nuclear Medicine Shanghai First People 's Hospital Shanghai Jiao Tong University Shanghai 200080 China

Purpose: Compared the performance of contrast-enhanced PET/CT and non-enhanced PET/CT for preoperatively detecting pelvic and para-aortic lymph node metastases in patients with cervical cancer. Methods: This prospective study included 72 patients with clinically M0 cervical cancer. They underwent surgery within two weeks of PET/CT imaging. Imaging consisted of a whole-body PET/CT protocol without intravenous contrast, followed by abdominal and pelvic PET/CT protocol including contrast-enhanced CT. We compared the diagnostic efficiency between the methods on per-patient and per-lesion basis. Results: Patient-based analysis showed that the sensitivity, specificity, and accuracy of contrast-enhanced PET/CT were 63.6% (14/22), 94.0% (47/50), and 84.7%(61/72), respectively, whereas those of non-enhanced PET/CT were 54.5% (12/22), 88.0% (44/50), and 77.8% (56/72), respectively, and those of enhanced CT alone were 36.4% (8/22), 80.0% (40/50), and 66.7% (48/72), respectively. Lesion-based analysis showed that the sensitivity, specificity, and accuracy of contrast-enhanced PET/CT were 77.7% (87/112), 98.7%(938/950), and 96.5% (1025/1062), respectively, whereas those of non-enhanced PET/CT were 69.6% (78/112), 97.5% (926/950), and 94.5% (1004/1062), respectively, and those of enhanced CT were 54.4% (61/112), 96.1% (913/950), and 91.7% (974/1062), respectively. Contrast-enhanced PET/CT had the best sensitivity, specificity and accuracy. Although patient-based analysis showed no significant difference between contrast-enhanced PET/CT and non-enhanced PET/CT (p =0.540, 0.295 and 0.286), the specificity and accuracy of these two methods were significantly different on lesion-based analysis (p =0.043 and 0.027).

关键词： CT成像子宫颈癌 PET 腹主动脉淋巴结对比度增强盆腔检测

Blockzone: A Decentralized and Trustworthy Data Plane for DNS

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Computers, Materials & Continua 2020年第11期65卷 1531-1557页

作者： Ning Hu Shi Yin Shen Su Xudong Jia qiao xiang Hao Liu Cyberspace Institute of Advanced Technology Guangzhou UniversityGuangzhouChina Department of Computer Science Yale UniversityNew Haven06520-8241USA Qianxin Technology Group Co. Ltd.BeijingChina

The domain name system(DNS)provides a mapping service between memorable names and numerical internet protocol addresses,and it is a critical infrastructure of the *** authenticity of DNS resolution results is crucial for ensuring the accessibility of Internet *** of supplementary specifications of protocols have been proposed to compensate for the security flaws of ***,DNS security incidents still occur *** DNS is a distributed system,for a specified domain name,only authorized authoritative servers can resolve *** servers must obtain the resolution result through a recursive or iterative resolving procedure,which renders DNS vulnerable to various attacks,such as DNS cache poisoning and distributed denial of service(DDoS)*** paper proposes a novel decentralized architecture for a DNS data plane,which is called ***,Blockzone utilizes novel mechanisms,which include on-chain authorization and off-chain storage,to implement a decentralized and trustworthy DNS data ***,in contrast to the hierarchical authentication and recursive query of traditional DNS,Blockzone implements a decentralized operation *** model significantly increases the efficiency of domain name resolution and verification and enhances the security of DNS against DDoS and cache poisoning *** addition,Blockzone is fully compatible with the traditional DNS implementation and can be incrementally deployed as a plug-in service of DNS without changing the DNS protocol or system *** Blockzone scheme can also be generalized to address security issues in other areas,such as the Internet of things and edge computing.

关键词： Network security DNS security DNS decentralization blockchain

Effect of platelet-rich plasma in the treatment of periodonta intrabony defects in humans

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Chinese Medical Journal 2006年第18期 1511-1521页

作者： OUYANG xiang-ying qiao Jing Department of Periodontology School and Hospital of Stomatology Peking University Beijing 100081 China

Background Platelet-rich plasma （PRP） is a kind of natural source of autologous growth factors, and has been used successfully in medical community. However, the effect of PRP in periodontal regeneration is not clear yet. This study was designed to evaluate the effectiveness of PRP as an adjunct to bovine porous bone mineral （BPBM） graft in the treatment of human intrabony defects. Methods Seventeen intrabony defects in 10 periodontitis patients were randomly treated either with PRP and BPBM （test group, n=9） or with BPBM alone （control group, n=8）. Clinical parameters were evaluated including changes in probing depth, relative attachment level （measured by Florida Probe and a stent）, and bone probing level between baseline and 1 year postoperatively. Standardized periapical radiographs of each defect were taken at baseline, 2 weeks, and 1 year postoperatively, and analyzed by digital subtraction radiography （DSR）. Results Both treatment modalities resulted in significant attachment gain, reduction of probing depth, and bone probing level at 1-year post-surgery compared to baseline. The test group exhibited statistically significant improvement compared to the control sites in probing depth reduction：（4.78± 0.95） mm versus （3.48 ± 0.41） mm （P〈0.01）; clinical attachment gain：（4.52± 1.14） mm versus （2.85 ± 0.80） mm （P〈0.01）; bone probing reduction：（4.56±1.04） mm versus （2.88±0.79） turn （P〈0.01）; and defect bone fill：（73.41± 14.78）% versus （47.32± 11.47）% （P〈0.01）. DSR analysis of baseline and 1 year postoperatively also showed greater radiographic gains in alveolar bone mass in the test group than in the control group： gray increase （580±50） grays versus （220± 32） grays （P=0.0001）; area with increased gray were （5.21± 1.25） mm^2 versus （3.02± 1.22） mm^2 （P=0.0001）.Conclusions The treatment with a combination of PRP and BPBM led to a significantly favorable clinical improvement in periodontal intrabony defects compared to using BPBM alone. Further studies are

关键词： platelet-rich plasma periodontal regeneration intrabony defect bone graft

Construction of digital 3D magic-cube organization structure for innovation-driven manufacturing

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Frontiers of Engineering Management 2023年第3期10卷 373-390页

作者： qiao xiang You ZHANG Jie ZHONG Guoxuan WANG Lirong LONG Aero Engine Corporation of China(AECC) Beijing 100097China Chengdu Holy Industry&Commerce Corp. Ltd.(Group)Pengzhou 611936China School of Management Huazhong University of Science and TechnologyWuhan 430074China

Owing to the heterogeneity between functional units and resource scarcity,manufacturing firms have been struggling with intra-organizational coordination for productivity and *** organizational structures,such as linear-functional and matrix,may cause responsibility division and independent goals(Shahani,2020),and are more difficult to be adopted by large-sized innovative manufacturing firms for quantity *** is based on a review of several new forms of organization(i.e.,network organization,multiteam system,and platform organization)compared with the traditional forms of organization(i.e.,linear,matrix,and business unit organization,among others).This study proposes a three-dimensional(3D)magic-cube organizational structure,considering the product dimensions,business,and ***,the characteristics,propositions of system operation,system dynamic model,and working model of the 3D magic-cube organization are ***,the 3D model is applied in a Chinese manufacturing firm to test its *** redesigning the post and pay system,the pilot organization establishes a project-driven and cross-functional coordination mechanism,positively affecting the firm’s financial profit,output value,labor productivity,and income of per *** proposed 3D model can be adopted by large-or medium-sized manufacturing firms for product development and *** implications of both practice and theory are also discussed in this study.

关键词： innovation manufacturing 3D magic-cube organization structure coordination

Atomic multicast protocol for intrusion-tolerance based on trusted timely computing base

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The Journal of China Universities of Posts and Telecommunications 2009年第6期16卷 97-102页

作者： ZHOU Hua,MENG xiang-ru,ZHANG Li,qiao xiang-dong Telecommunication Engineering Institute,Air Force Engineering University,Xi’an 710077,China [a] Telecommunication Engineering Institute Air Force Engineering University Xi'an 710077 China

Distributed architecture is often adopted for the intrusion-tolerance system ***,this distributed intrusiontolerance system has a consensus *** solve this problem,this article explores a distributed intrusion-tolerance system of hybrid time model based on trusted timely computing base（TTCB） and implement an atomic multicast protocol using TTCB *** TTCB is a trust secure real-time component inside the server,with a well defined interface and separated from the operation *** is in the synchronous communication environment,while the application layer in the server works *** the atomic multicast protocol,it can be achieved that when the servers are over twice the number of faulty servers,the consensus can be *** performance evaluations show that the proposed protocol can yield larger good throughput with a lower unavailability.

关键词： Intrusion-tolerance atomic multicast protocol consensus TTCB network security

Discussion on Problem-Based Engineering Management System

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Frontiers of Engineering Management 2015年第3期2卷 249-260页

作者： qiao xiang Chengdu Holy Industry & Commerce Corp. Ltd. (Group)

The paper puts forward the idea of problembased engineering management, expounds its connotation and guiding ideology and moreover, substantially demonstrates its practical significance in the engineering management s... 详细信息

关键词： problem engineering management system

Innovation on Remanufacturing Engineering Management——Striving for Sustainable Development

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Frontiers of Engineering Management 2016年第2期3卷 101-101,185页

作者： qiao xiang Chengdu Holy Industry & Commerce Corp. Ltd. (Group)

The historic Treaty of Paris passed at the 21st UN Climate Change Conference on 12 December,2015 makes a commitment to control global warming within 2℃.Data released by the Global Carbon Project showed that the goal of controlling global warming within 2℃ may be achieved only if CO2 emissions controlled must be less than 3.2 trillion *** entering the era of industrialization,around 2 trillion tons of CO2 have been emitted

关键词： Striving for Sustainable Development Innovation on Remanufacturing Engineering Management