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Convenient one-pot synthesis of functionalized (E)-2-arylvinyl bromides from (E)-4-(2-bromovinyl)phenyl acetate

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Chinese Chemical Letters 2009年第5期20卷 545-548页

作者： Yu Bo Jiang Chun xiang kuang Department of Chemistry Tongji University Siping Road 1239 Shanghai 200092 China

A convenient one-pot synthesis of functionalized （E）-2-arylvinyl bromides was achieved by microwave-induced deacetylation and subsequent acylation using dicyclohexyl carbodiimide （DCC） and dimethylamino-pyridine ... 详细信息

关键词： One-pot synthesis (E)-2-Arylvinyl bromide Acylation Deacetylation

One-pot synthesis of(Z)-4-(2-bromovinyl)benezenesulfonamides by microwave-induced simultaneous debrominative decarboxylation and sulfamation of anti-2,3-dibromo-3-(4-chlorosulfonylphenyl)propanoic acid

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Chinese Chemical Letters 2009年第1期20卷 48-51页

作者： Wen Sheng Zhang Chun xiang kuang Qing Yang Department of Chemistry Tongji University Siping Road 1239 Shanghai 200092 China Department of Chemistry Jiaozuo Teachers' College Jiaozuo 454001 China School of Pharmacy Fudan University Yixueyuan Road 138 Shanghai 200032 China

One-pot simultaneous debrominative decarboxylation and sulfamation of anti-2,3-dibromo-3-（4-chlorosulfonylphenyl）propa- noic acid in DMF （for alkyl amines） or DMF-pyridine （for aryl amines） using a diverse range of alkyl and aryl amines under microwave irradiation condition stereoselectively afforded （Z）-4-（2-bromovinyl）benzenesulfonamides in good yields.

关键词： One-pot Arylsulfonamide (Z)-Arylvinyl bromide Amine Microwave irradiation

Iron-catalyzed ketonization of 2-aryl-1,1-dibromoalkenes with KOAc:Synthesis of α-acetoxy aryl ketones via a Michael-like addition process

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Chinese Chemical Letters 2011年第5期22卷 571-574页

作者： Ming Zhao Chun xiang kuang Xue Zhi Cheng Qing Yang Department of Chemistry Tongji University Shanghai 200092 China Department of Biochemistry School of Life Sciences Fudan University Shanghai 200433 China

A novel and convenient iron-catalyzed ketonization of 2-aryl-1,1-dibromoalkenes with KOAc has been achieved.A series ofα-acetoxy aryl ketones were prepared with moderate yields via 2-carbon position functionalization... 详细信息

关键词： Iron catalyst Ketonization Dibromoalkene α-Acetoxy ketone Potassium acetate

Iron-catalyzed bromination of aryl azides by N-bromosuccinimide:Efficient method for the synthesis of brominated aryl azides

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Chinese Chemical Letters 2011年第3期22卷 310-313页

作者： Hui Jin Zhen Dong Huang Chun xiang kuang Xiao Kun Wang Department of Chemistry Tongji University Siping Road 1239 Shanghai 200092 China Zhejiang Citrus Research Institute Taizhou 318020 China

An efficient and mild protocol for bromination of aryl azides with N-bromosuccinimide（NBS） under FeCl_3 catalysis in 1,2- dichloroethane was *** is proved to be an efficient method for obtaining brominated aryl azides.

关键词： Iron-catalyzed Aryl azides N-Bromosuccinimide Bromination

Sodium hydride-mediated synthesis of 1,5-diaryl-1,2,3-triazoles from anti-3-aryl-2,3-dibromopropanoic acids and organic azides

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Chinese Chemical Letters 2013年第8期24卷 764-766页

作者： Xue-Zhi Cheng Wei Liu Zhen-Dong Huang Chun-xiang kuang Department of Chemistry Tongji University Zhejiang Citrus Research Institute Key Laboratory of Yangtze River Water Environment Ministry of Education

A series of 1,5-disubstituted 1,2,3-triazoles are synthesized by a one-pot process from anti-3-aryl-2,3-dibromopropanoic acids and organic azides mediated by sodium hydride in dimethyl *** reaction is mild and simple,... 详细信息

关键词： Cyclizations Heterocycles Sodium hydride Triazoles

Characteristics and sources of WSI in North China Plain:A simultaneous measurement at the summit and foot of Mount Tai

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Journal of Environmental Sciences 2020年第6期32卷 264-277页

作者： Yi Cui Yan Yin Kui Chen Xin Zhang xiang kuang Hui Jiang Honglei Wang Zhongxiu Zhen Chuan He Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044China Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration Nanjing University of Information Science&TechnologyNanjing 210044China

To better understand the characteristics and sources of water soluble ions(WSI) in North China Plain(NCP),fine particles(PM2.5) were simultaneously sampled at the summit(SM)and foot(FT) of Mount Tai during May 12th to June 24th,*** chromato graphy analysis showed that concentration of WSI was lower at SM(22.26±16.53 μg/m3) than that at FT(31.02±21.92 μg/m3).The concentration and proportion of SO4^2- in total WSI were both lower than the values reported in previous *** WSI concentrations were higher than that at nighttime at SM,while the opposite results were obtained at FT,possibly associated with more anthropogenic activities and higher boundary layer height(BLH) during daytimes.A severe pollution event occurred during June 14 th-June 16th was documented at both FT and *** transport and topography-forced vertical transport along the slope of the mountain could explain the higher concentrations of pollutants at *** analyses also indicated that NH4^+ existed mainly in the form of NH4 HSO4 and NH4 NO3,but(NH4)2 SO4 could also exist,especially when emissions of NH4 and NH3 were increased during daytime at *** results of principal component analysis(PCA) illustrated that secondary aerosols,coal/biomass burnings,sea-salts and crustal/soil dusts were the main sources at SM,and secondary aerosols and crustal/soil dusts contributed most at *** air-mass trajectories were classified into four clusters,of which air masses with the highest frequency and WSI concentrations were originated from the southwest with secondary ions(SO4^2-,NO3-and NH4^+) as major pollutants.

关键词： Water soluble ions Mount Tai Ionic binding PCA Backward trajectories

A Novel Multichannel Audio Signal Compression Method Based on Tensor Representation and Decomposition

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China Communications 2014年第3期11卷 80-90页

作者： WANG Jing XIE xiang kuang Jingming School of Information Science and Technology Beijing Institute of Technology Beijing 100081 China

Multichannel audio signal is more difficult to be compressed than mono and stereo ones.A novel multichannel audio signal compression method based on tensor representation and decomposition is proposed in this *** multichannel audio is represented with 3-order tensor space and is decomposed into core tensor with three factor matrices in the way of channel,time and *** the truncated core tensor is transmitted which will be multiplied by the pre-trained factor matrices to reconstruct the original tensor *** and subjective experiments have been done to show a very noticeable compression capability with an acceptable output *** novelty of the proposed compression method is that it enables both high compression capability and backward compatibility with limited signal distortion to the hearing.

关键词： multichannel audio signal compression tensor decomposition Tuckermodel core tensor

MCo_12原子簇的电子结构和磁性性质研究

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电子科技大学学报 2005年第3期34卷 336-339页

作者：邝向军西南科技大学理学院四川绵阳621002

利用分离变分局域自旋密度泛函方法,对正二十面体MCo12原子簇的电子结构和磁性性质进行了研究,结果表明:原子簇的中心原子与表面原子之间具有键长收缩效应,其相互作用得到了加强;用Ti、V、Cr、Mn、Fe和Ni原子替代中心Co原子后,原子簇的... 详细信息

利用分离变分局域自旋密度泛函方法,对正二十面体MCo12原子簇的电子结构和磁性性质进行了研究,结果表明:原子簇的中心原子与表面原子之间具有键长收缩效应,其相互作用得到了加强;用Ti、V、Cr、Mn、Fe和Ni原子替代中心Co原子后,原子簇的稳定性得到了一定的提高;均呈现出金属特性和一定的磁性,价带宽度随着M原子原子序数的增加而逐渐变宽。该研究将为探索以过渡金属原子簇为基础合成新的特殊功能材料提供重要的理论依据。

关键词： MCo12原子簇几何结构电子结构磁性性质

The relationship among amyloid-βdeposition,sphingomyelin level,and the expression and function of P-glycoprotein in Alzheimer’s disease pathological process

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Neural Regeneration Research 2023年第6期18卷 1300-1307页

作者： Zi-Kang Xing Li-Sha Du Xin Fang Heng Liang Sheng-Nan Zhang Lei Shi Chun-xiang kuang Tian-Xiong Han Qing Yang State Key Laboratory of Genetic Engineering School of Life SciencesShanghai Engineering Research Center of Industrial MicroorganismsFudan UniversityShanghaiChina Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and EngineeringTongji UniversityShanghaiChina Department of Traditional Chinese Medicine Tenth People’s Hospital of Tongji UniversityShanghaiChina

In Alzheimer’s disease,the transporter P-glycoprotein is responsible for the clearance of amyloid-βin the ***-βcorrelates with the sphingomyelin metabolism,and sphingomyelin participates in the regulation of *** amyloid cascade hypothesis describes amyloid-βas the central cause of Alzheimer’s disease *** understanding of the change of P-glycoprotein and sphingomyelin along with amyloid-βand their potential association in the pathological process of Alzheimer’s disease is ***,we found that the expression of P-glycoprotein in APP/PS1 mice tended to increase with age and was significantly higher at 9 and 12 months of age than that in wild-type mice at comparable *** functionality of P-glycoprotein of APP/PS1 mice did not change with age but was significantly lower than that of wild-type mice at 12 months of *** sphingomyelin levels,increased ceramide levels,and the increased expression and activity of neutral sphingomyelinase 1 were observed in APP/PS1 mice at 9 and 12 months of age compared with the levels in wild-type *** results were observed in the Alzheimer’s disease mouse model induced by intracerebroventricular injection of amyloid-β1-42 and human cerebral microvascular endothelial cells treated with amyloid-β*** human cerebral microvascular endothelial cells,neutral sphingomyelinase 1 inhibitor interfered with the changes of sphingomyelin metabolism and P-glycoprotein expression and functionality caused by amyloid-β1-42 *** sphingomyelinase 1 regulated the expression and functionality of P-glycoprotein and the levels of sphingomyelin and ***,these findings indicate that neutral sphingomyelinase 1 regulates the expression and function of P-glycoprotein via the sphingomyelin/ceramide *** studies may serve as new pursuits for the development of anti-Alzheimer’s disease drugs.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice ceramide ezrin-radixin-moesin human cerebral microvascular endothelial cells neutral sphingomyelinase 1 P-glycoprotein sphingomyelin synthase sphingomyelin