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Selective G6PDH inactivation for Helicobacter pylori eradication with transformed polysulfide

Science China Life Sciences 2025年

作者： Xiaonan wang Ning Zhou Xuejiao J.Gao Zijing Zhu Minmin Sun Qian wang Haolin Cao Xuetong Wu Caiyu Zhou Qingkang Zheng Ye Yuan Yuan Liu Lei Chen jing Jiang Pengcheng Bu Lizeng Gao CAS Engineering Laboratory for Nanozyme Key Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences School of Life Sciences University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering Jiangxi Normal University Key Laboratory of Epigenetic Regulation and Intervention Institute of Biophysics Chinese Academy of Sciences Nanozyme Laboratory in Zhongyuan School of Basic Medical Sciences Zhengzhou University Nanozyme Laboratory in Zhongyuan Henan Academy of Innovations in Medical Science

Alternative treatment for the highly prevalent Helicobacter pylori infection is imperative due to rising antibiotic resistance. We unexpectedly discovered that the anti-H. pylori component in garlic is hydrogen polysulfide（H2S_n, n≥2）, not organic polysulfides. Studies on the mechanism of action（MoA） show that H2S_nspecifically inactivates H. pylori glucose-6-phosphate dehydrogenase（G6PDH） by interfering with electron transfer from glucose-6-phosphate（G6P） to nicotinamide adenine dinucleotide phosphate（NADP+）. However, low H2S_nyield makes garlic derivatives hard to be a reliable donor of H2S_nto treat H. pylori infection. To address this challenge, we established a polysulfide transformation process from garlic organosulfur compounds into Fe3S4that generates H2S_nwith a 25–58 times increase in *** chitosan encapsulation, we designed a gastric-adaptive H2S_nmicroreactor（GAPSR） that eradicates H. pylori with 250 times higher efficiency under gastric conditions. A single GAPSR achieves more rapid H. pylori eradication than combined antibiotics therapy without disturbing the gut microbiota. These findings indicate a distinct MoA transformation mediated by polysulfide as an alternative candidate to treat H. pylori infection.

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掺杂对单层石墨烯纳米梁振动频率的影响

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原子与分子物理学报 2025年第3期42卷 67-71页

作者：王志钦王静新疆大学物理科学与技术学院乌鲁木齐830017

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、... 详细信息

石墨烯优异的力学和电学等性能,使其成为纳米机电谐振器的理想材料.通过分子动力学模拟方法研究了掺杂元素和掺杂浓度对单层石墨烯纳米梁振动特性的影响.研究结果表明,单层石墨烯纳米梁的振动频率随纳米梁长度的增加而减小,硼(B)掺杂、硼-硼(B-B)掺杂、铍(Be)掺杂和铍-铍(Be-Be)掺杂均会导致单层石墨烯纳米梁的振动频率降低.此外,随着硼(B)/铍(Be)掺杂浓度的增加,单层石墨烯纳米梁的振动频率逐渐降低.且随着掺杂浓度的增加,硼(B)掺杂石墨烯纳米梁的振动频率和铍(Be)掺杂石墨烯纳米梁的振动频率的差异逐渐增大.这对石墨烯纳米机械谐振器、振荡器等纳米器件的设计具有一定的理论指导意义.

关键词：石墨烯振动频率分子动力学

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Detached-eddy simulation of turbulent coherent structures around groynes in a trapezoidal open channel

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Journal of Hydrodynamics 2020年第2期32卷 326-336页

作者： jing-xin Zhang Jian wang xiang Fan Dongfang Liang Key Laboratory of Hydrodynamics(Ministry of Education) shanghai Jiao Tong UniversityShanghai200240China School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China

The hydrodynamics in a straight open channel with a multiple-embayment groyne field was investigated using the detached-eddy simulation(DES).A series of short groynes were included on a 1:3 side slope of the *** work focuses on the turbulent coherent structures around groynes on an uneven *** around groyne fields are characterized by massive separation and highly unsteady *** can capture a wide spectrum of eddies at a lower computational cost than the large eddy simulation(LES)or direct numerical simulation(DNS).In the present work,a zonal DES model(ZDES)was used to simulate the flow around *** ZDES model is a modified version of the DES designed to overcome the model-stress depletion(MSD)of the RANS/LES hybrid *** vortex system consists of the horseshoe vortex(HV)formed at the base of the obstructions,the necklace vortex(NV)that wrapped the groyne tips near the free surface,and the shedding vortex(SV)underneath the free *** effects of the incident flow and local topography on the vortex evolution were investigated by analyzing the mean flow structures and the instantaneous turbulent flow *** important vortices cannot be captured because of the averaging process,while some flow structures cannot be observed in the instantaneous *** mean flow is only a reflection of the averaging process when complex vortices are present.

关键词： Open channel flow groyne free surface detached eddy simulation turbulent coherent structure

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火电站烟气脱硝大流量高速混合过程仿真研究

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系统仿真学报 2009年第23期21卷 7652-7654页

作者：张圣杰孙翔王景成金强李雨上海交通大学自动化系上海200240 上海电气石川岛电站环保工程有限公司上海201108

介绍了冷态模型与实物的比例为1:15冷模实验装置(FMT)的设计和应用过程,使之能与高速氨-烟气混合过程流态数值仿真相验证、指导脱硝反应器设计。应用相似模化原理,确立了FMT各参数和实际脱硝反应器各参数的对应关系,阐述了气体混合管道... 详细信息

介绍了冷态模型与实物的比例为1:15冷模实验装置(FMT)的设计和应用过程,使之能与高速氨-烟气混合过程流态数值仿真相验证、指导脱硝反应器设计。应用相似模化原理,确立了FMT各参数和实际脱硝反应器各参数的对应关系,阐述了气体混合管道以及第一层模拟催化剂上表面速度分布测量和还原剂模拟气体混合气浓度分布测量的方案和结果,使混合效果得到了较大的提高,实验结果的速度分布、浓度分布和压力损失均达到目前的工艺要求。

关键词：冷模实验脱硝火电站气体混合

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Soluble and Degradable Polyimides with Phenyl-2-pyridyl Ether Structure:Synthesis and Characterization

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Chinese Journal of Polymer Science 2015年第3期33卷 481-489页

作者：杨逢春 jing wang Lin Chen Xin wang xiang-yu Chen 张欣 Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials ScienceNorthwest University Samsung China Semiconductor Company Limited. Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry Institute of Analytical ScienceNorthwest University

A diamine monomer o-phenylenedioxybis（5-amino-2-pyridine） was synthesized via reduction of a dinitro compound o-phenylenedioxybis（5-nitro-2-pyridine）, producing a series of new polyimides from this diamine and various commercially available aromatic dianhydrides via conventional two-stage processes. The resulting polyimides are able to form tough and transparent films, with decomposition temperatures in the range of 529-551 ℃, and can be dissolved in organic polar solvents. Meanwhile, these polyimides can be degraded in a hydrazine hydrate medium, a degradation mechanism proposed by analyzing the degradation products suggests that the degradable properties could be attributed to the phenyl-2-pyridyl ether structure in the polymer. In addition, the transformation of the compound structure from dinitro compound to damine monomer in the synthetic process is discussed in respect to X-ray structure.

关键词： Monomer structure Polymer solubility Degradable polyimide.

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Solvent Reorganization Energy and Electronic Coupling for Intramolecular Electron Transfer in BiphenyI-Acceptor Anion Radicals

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Chinese Journal of Chemical Physics 2008年第1期21卷 45-54页

作者： jing-bo wang Jian-yi Ma xiang-yuan Li Fu-cheng He Ke-xiang Fu College of Chemical Engineering Sichuan University Chengdu 610065 China Institute for Nanobiomedical Technology and Membrane Biology 5ichuan University Chengdu510055 China

A novel algorithm was designed and implemented to realize the numerical calculation of the solvent reorganization energy for electron transfer reactions, on the basis of nonequilibrium solvation theory and the dielectric polarizable continuum model. Applying the procedure to the well-investigated intramoleeular electron transfer in biphenyl-androstane-naphthyl and biphenyl-androstane-phenanthryl systems, the numerical results of solvent reorganization energy were determined to be around 60 k J/mol, in good agreement with experimental data. Koopman＇s theorem was adopted for the calculation of the electron transfer coupling element, associated with the linear reaction coordinate approximation. The values for this quantity obtained are acceptable when compared with experimental results.

关键词： Nonequilibrium salvation Electron transfer Solvent reorganization energy Continuum model

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Effect of rare earth on primary carbides in H13 die steel and their addition method:a review

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Journal of Iron and Steel Research International 2024年第3期31卷 531-551页

作者： jing-feng wang Lin-zhu wang Chao-yi Chen xiang wang Fei Zhao School of Materials and Metallurgy Guizhou UniversityGuiyang 550025GuizhouChina Zhengzhou Railway Vocational and Technical College Zhengzhou 450000HenanChina Guizhou Provincial University Key Laboratory of High Performance Battery Materials Guizhou UniversityGuiyang 550025GuizhouChina Shougang Guiyang Special Steel Co. Guiyang 550005GuizhouChina

Larger-sized primary carbides lead to stress concentration during the application of H13 hot-work die steel,resulting in microcracks and fatigue *** earth was usually added to modify the carbides and *** existing literature is reviewed on the effect of rare earth on primary carbides in H13 steel.A comprehensive review on the effect of rare earth on the characteristics of primary carbides,i.e.,number,size,morphology,and thermal stability in H13 steel,was *** precipitation mechanism and nucleation of primary carbides with rare earth were *** position and form of rare earth in steel and their effects on alloying elements segregation were *** addition techniques of rare earth in H13 steel were compared,and the prospects for other uncommon rare earth and emerging technology were *** on the current references,it can be known that adding rare earth facilitated refined and dispersed primary *** size of primary carbides would be reduced,and their morphology would be improved because the rare earth inclusions formed in H13 steel can act as nucleation cores forγ-Fe orδ-Fe,refining the dendritic ***,the number of primary carbides at grain boundaries would be significantly ***,rare earth had little impact on thermal *** nucleation of primary carbides tended to be inhibited due to the modification of inclusions by rare earth which were likely to be nucleation cores for primary *** earth had been reported to affect the mechanism and process of primary carbide ***,the addition of rare earth can inhibit the segregation of alloying elements and carbon diffusion by ***,laboratory experiments and theoretical calcu-lations need to be conducted to study the states and evolution of rare earth steels.

关键词： Rare earth H13 die steel Primary carbide Nucleation Dendritic structure

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Parallel Factories for Smart Industrial Operations:From Big AI Models to Field Foundational Models and Scenarios Engineering

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IEEE/CAA Journal of Automatica Sinica 2022年第12期9卷 2079-2086页

作者： jingwei Lu Xingxia wang xiang Cheng jing Yang Oliver Kwan Xiao wang Qingdao Academy of Intelligent Industries Qingdao 266114 The State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100190 Motion G Inc.Singapore 068898Singapore IEEE School of Artificial Intelligence Anhui UniversityHefei 230031

The rapid advancement of fundamental theories and computing capacity has brought artificial intelligence,internet of things, extended reality, and many other new intelligent technologies into our daily lives. Due to the lack of interpretability and reliability guarantees, it is extremely challenging to apply these technologies directly to real-world industrial systems. Here we present a new paradigm for establishing parallel factories in metaverses to accelerate the deployment of intelligent technologies in real-world industrial systems: QAII-1.0. Based on cyber-physical-social systems,QAII-1.0 incorporates complex social and human factors into the design and analysis of industrial operations and is capable of handling industrial operations involving complex social and human behaviors. In QAII-1.0, a field foundational model called Eu Artisan combined with scenarios engineering is developed to improve the intelligence of industrial systems while ensuring industrial interpretability and reliability. Finally, parallel oil fields in metaverses are established to demonstrate the operating procedure of QAII-1.0.

关键词： Cyber-physical-social system(CPSS) Industry5.0 Metaverses Parallel factories Parallel intelligence

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CCaP1/CCaP2/CCaP3 interact with plasma membrane H^(+)-ATPases and promote thermoresponsive growth by regulating cell wall modification in Arabidopsis

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Plant Communications 2024年第7期5卷 90-105页

作者： jing-jing wang Juan Gao Wei Li Jian-xiang Liu State Key Laboratory of Plant Environmental Resilience College of Life SciencesZhejiang UniversityHangzhou 310027China College of Environmental and Resource Sciences Zhejiang UniversityHangzhou 310027China

Arabidopsis plants adapt to warm temperatures by promoting hypocotyl growth primarily through the basic helix-loop-helix transcription factor PIF4 and its downstream genes involved in auxin responses,which enhance cell *** the current study,we discovered that cell wall-related calcium-binding protein 2(CCaP2)and its paralogs CCaP1 and CCaP3 function as positive regulators of thermo-responsive hypocotyl growth by promoting cell elongation in ***,mutations in CCaP1/CCaP2/CCaP3 do not affect the expression of PIF4-regulated classic downstream ***,they do noticeably reduce the expression of xyloglucan endotransglucosylase/hydrolase genes,which are involved in cell wall *** also found that CCaP1/CCaP2/CCaP3 are predominantly localized to the plasma membrane,where they interact with the plasma membrane H^(+)-ATPases AHA1/***,we observed that vanadate-sensitive H^(+)-ATPase activity and cell wall pectin and hemicellulose contents are significantly increased in wild-type plants grown at warm temperatures compared with those grown at normal growth temperatures,but these changes are not evident in the ccap1-1 ccap2-1 ccap3-1 triple ***,our findings demonstrate that CCaP1/CCaP2/CCaP3 play an important role in controlling thermo-responsive hypocotyl growth and provide new insights into the alternative pathway regulating hypocotyl growth at warm temperatures through cell wall modification mediated by CCaP1/CCaP2/CCaP3.

关键词： AHA1/AHA2 CCaP1/CCaP2/CCaP3 cell wall modification hypocotyl growth thermomorphogenesis warm temperature

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Nature of spin-lattice coupling in two-dimensional CrI_(3) and CrGeTe_(3)

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Science China(Physics,Mechanics & Astronomy) 2021年第8期64卷 63-71页

作者： jing Li JunSheng Feng PanShuo wang ErJun Kan HongJun xiang Key Laboratory of Computational Physical Sciences(Ministry of Education) State Key Laboratory of Surface Physicsand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Qi Zhi Institute Shanghai 200232China School of Physics and Materials Engineering Hefei Normal UniversityHefei 230601China Department of Applied Physics and Institution of Energy and Microstructure Nanjing University of Science and TechnologyNanjing 210094China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

Spin-lattice (SL) coupling plays an important role in spintronic applications given its effects on magnetic,ferroelectric,optical,and thermodynamic *** and theoretical calculations have revealed a large SL coupling effect in CrGeTe_(3) and CrI_(3) ***,the microscopic origin of SL coupling in these systems is still *** this work,we develop a systematic method to explore the atomistic mechanism of SL coupling based on the density functional *** find that the first-and second-order SL couplings in ternary system CrGeTe_(3) are considerably stronger than those in binary system CrI_(3).For the first-order SL coupling,the Cr ions of the magnetic pair and Ge ions positively contribute to the strain enhancement of ferromagnetism in CrGeTe_(3).However,the Cr ions provide a negative contribution in CrI_(3).Furthermore,our tight-binding analysis suggests that the p-d hopping in CrGeTe_(3) gradually decreases with the tensile strain,rapidly enhancing the ferromagnetism under the tensile *** large frequency shifts in CrGeTe_(3) are caused by the large second-order exchange derivatives (one type of second-order SL coupling) of the Cr ions of the magnetic pair.

关键词： spin-lattice effect two-dimensional magnetic materials first-principle calculation

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