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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia Rui Mao xiang cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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Design and numerical analysis of serpentine microchannel integrated with inner-wall ridges for enhanced droplet mixing

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Science China(Technological Sciences) 2023年第2期66卷 560-573页

作者： cao xiang CHEN YongPing Key Laboratory of Energy Thermal Conversion and Control of Ministry of Education School of Energy and EnvironmentSoutheast UniversityNanjing 210096China Jiangsu Key Laboratory of Micro and Nano Heat Fluid Flow Technology and Energy Application School of Environmental Science and EngineeringSuzhou University of Science and TechnologySuzhou 215009China

A numerical model is developed for three-dimensional droplet mixing in serpentine microchannels with inner-wall ridges(referred to as SMR microchannels).The underlying mechanisms of mixing in SMR microchannels are revealed,and the effects of the ridge width and ridge number on mixing inside droplets of different sizes are *** results indicate that SMR microchannels are capable of enhancing the mixing efficiency by 3.6%–12.5%compared with that in smooth serpentine microchannels,particularly when the droplet length is larger than the microchannel width and the width ratio of the ridge to the microchannel is 0.25–*** above mixing enhancement is determined by two main factors:the combined effects of the vortex pair and reverse flow,and non-horizontal ***,when the width ratio is 1,there is a maximum 16.0%increase in mixing efficiency for small droplets with a length equal to the microchannel ***,for small droplets,mixing in an SMR microchannel is worse than in a smooth serpentine microchannel when the width ratio is less than *** increasing the ridge number,when the width ratio is 0.25,the mixing efficiency is reduced for small droplets but increased for larger droplets.

关键词： droplet mixing serpentine microchannel ridge microfluidics

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Admissibility for Linear Estimator of Parameter on Growth Curve Model with Respect to Linear Constraint

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Acta Mathematicae Applicatae Sinica 2009年第1期25卷 171-176页

作者： Ming-xiang cao Fan-chao Kong Department of Mathematics Hefei Teachers College Heifei 230061 China Department of Mathematics Anhui University Hefei 230038 China

By using the vector-method of matrix, we study Growth Curve Model with respect to linear constraint. Under matrix loss function and vector loss function, we obtain necessary and sufficient conditions for admissibility... 详细信息

关键词： Growth curve model linear estimators admissibility

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General Admissibility for Linear Estimators in a General Multivariate Linear Model under Balanced Loss Function

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Acta Mathematica Sinica,English Series 2013年第9期29卷 1823-1832页

作者： Ming xiang cao Fan Chao KONG Department of Mathematics Hefei Normal University School of Mathematics Anhui University

A generalization of Zellner’s balanced loss function is proposed. General admissibility in a general multivariate linear model is investigated under the generalized balanced loss function. And the sufficient and necessary conditions for linear estimators to be generally admissible in classes of homogeneous and nonhomogeneous linear estimators are given, respectively.

关键词： Balanced loss function linear estimators general optimality general admissibility

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Impact of climate change on building heating energy consumption in Tianjin

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Frontiers in Energy 2013年第4期7卷 518-524页

作者： cao xiang Zhe TIAN School of Environmental Science and Engineering Tianjin University Tianjin 300072 China

This paper investigated the variation of build- ing heating energy consumption caused by global warming in Tianjin, China. Based on the hourly historical and monthly projected future （B1/A1B emissions scenarios） meteorological data, the variation of those relevant meteorological parameters was first analyzed. A TRNSYS simulation model for a reference building was introduced to investigate historical variation of office building energy consumption. The results showed that the 10-year-average heating energy consumption of 2001-2010 had reduced by 16.1% compared to that of 1961-1970. By conducting principal component analysis and regression analysis, future variation of building heating load was studied. For B1/A1B emissions scenarios, the multi-year-average heating load was found to decrease by 9.7% （18.1%）/ 10.2% （22.7%） compared to that of 1971-2010 by 2011- 2050 （2051-2100）.

关键词： global warming office building heating energy consumption

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The Characterizations and Constructions of Sprays of Isotropic Curvature

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Acta Mathematica Sinica,English Series 2022年第9期38卷 1612-1620页

作者： Xin Yue CHENG Ke xiang cao Chun Yan QING School of Mathematical Sciences Chongqing Normal UniversityChongqing 401331P.R.China

This paper discusses the sprays of isotropic *** first determine the relationship betweenχ-curvatures of two projectively related *** on this,we find an approach to construct sprays of isotropic curvature and find infinitely many sprays of isotropic curvature via some known sprays of isotropic *** particular,by using famous Funk metricΘ,we can construct infinitely many sprays of isotropic curvature,some of which can be induced by Finsler metrics,but others cannot be induced by any Finsler metric.

关键词： Spray spray of isotropic curvature χ-curvature S-curvature Funk metric

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First Total Synthesis of Hyacinthacine A_6 from the Protected Derivative of Polyhydroxylated Pyrrolidine

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Chemical Research in Chinese Universities 2008年第4期24卷 469-472页

作者： ZHANG Tao-xiang ZHOU Ling cao Xiao-ping State Key Laboratory of Applied Organic Chemistry College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 P. R. China

（1S、2R、3R、5R、7aR）-1,2-Dihydroxy-3-hydroxy methyl-5-methylpyrrolizidine（hyacinthacine A6, I） was synthesized by Wittig＇s methodology via the reaction of aldehyde 6, prepared from the partially protected derivative of polyhydroxylated pyrrolidine, with appropriated ylides, followed by cyclization through the intemal reductive amination process of the resulting a,B-unsaturated ketone 7, and total deprotection.

关键词： Hyacinthacine A6 Pyrrolidines Wittig reaction Cyclization

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Pulmonary cryptococcosis after immunomodulator treatment in patients with Crohn’s disease:Three case reports

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World Journal of Gastroenterology 2023年第4期29卷 758-765页

作者： Yan-Fei Fang xiang-Han cao Ling-Ya Yao Qian cao Department of Gastroenterology Inflammatory Bowel Disease CenterSir Run Shaw HospitalCollege of Medicine Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Corticosteroids and anti-tumor necrosis factorαmAbs are widely used to treat Crohn's disease(CD).However,one disadvantage of this treatment is impairment of normal immune function,leading to an increased risk of *** infection is an opportunistic infection that occurs mainly in immunocompromised patients and poses a significant diagnostic challenge in patients with *** SUMMARY Here,we report three cases of pulmonary cryptococcosis in patients with CD after receiving immunomodulatory *** patients presented with no or mild respiratory *** computed tomography scans revealed pulmonary nodules in the unilateral or bilateral *** were made using pathological examination and metagenomic *** patients were treated with fluconazole 400 mg once daily for 1 to 6 mo,and symptoms were *** searches were conducted in PubMed,Web of Science,and Embase to retrieve previously reported cases and summarize patient *** The incidence of cryptococcus infection has increased along with immunomodulator *** vigilance is required for early identification and standardized treatment.

关键词： Crohn’s disease Immunomodulator Infliximab Opportunistic infections Pulmonary cryptococcosis Case report

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A neurodynamics control strategy for real-time tracking control of autonomous underwater vehicle

A neurodynamics control strategy for real-time tracking cont...

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第25届中国控制与决策会议

作者： Xun Hua Daqi Zhu xiang cao Laboratory Of Underwater Vehicles and Intelligent Systems Shanghai Maritime University

ISBN: (纸本)9781467355322

How to control an AUV accurately to complete an underwater path-following task is still an open challenging problem. A biological inspired neurodynamics based tracking controller of underactuated autonomous underwater vehicle （AUV） is proposed in this paper. The proposed control strategy includes a velocity controller with the biological neurons and an adaptive sliding mode controller. The biological neurons are embedded into the backstepping velocity controller to eliminate the sharp speed jumps commonly existing in vehicle due to tracking errors changing suddenly. The outputs of the velocity controller are used as the command inputs of the sliding mode controller, and the thrusters control constraints problem which are commonly seen in the backstepping control of AUV are overcomed by the proposed controller. Simulation results show that the control strategy achieved success in the position and velocity smoothly tracking of AUV.

关键词： Autonomous underwater vehicle Tracking control Biological inspired neurodynamics Backstepping control Sliding mode control.

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Effects of surface tension on bubble growth in an extensive uniformly superheated liquid

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Chinese Science Bulletin 2011年第30期56卷 3191-3198页

作者： ZHANG XiaoBin xiang ShiJun cao XiaoLi QIU LiMin Institute of Refrigeration and Cryogenics Zhejiang University Hangzhou 310027 China

The study of bubble growth in an extensive pool of liquid provides considerable insight into the mechanisms that play a role in bubble growth near a heated surface and in the cavitation phenomenon. This work focuses on analyzing the effects of surface tension on the growth rate for the thermally controlled stage of a single bubble in such a liquid. The conservation of energy equations, including the internal energy term for the bubble and that within boundary layer around it, are numerically solved. The complete temporal variations of the bubble in water and liquid nitrogen are investigated based on the assumption that the bubble growth is controlled only in sequence by inertia and heat. Thus, the two stages are subject to the continuity of the bubble growth, while the inertia-controlled stage is only formulated by the well-known Rayleigh solution. The thickness of the boundary layer around the bubble is also determined. The results are comparable with the Plesset-Zwick models and Forster-Zuber models, as well as available experimental data. It is found that the influence of internal energy on the rate of bubble growth is small enough to be ignored; however, the accumulative effects of the surface tension are significant and increase with a decrease in the degree of superheat.

关键词：表面张力气泡生长过热度液体均匀能量方程惯性控制泡沫层

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