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胰源性门静脉高压胃静脉破裂出血危险因素分析及列线图预测模型构建

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中国普通外科杂志 2024年第3期33卷 400-407页

作者：刘鹏向兴华李文斌李国光朱朝庚湖南中医药大学第一附属医院肝胆胰与疝外科湖南长沙410007 湖南省人民医院/湖南师范大学第一附属医院胰脾外科湖南长沙410005

背景与目的:由于近年来胰腺相关疾病的发病率和诊断率逐渐增加,胰源性门静脉高压(PPH)及其并发症的发病率及诊断率也随之增加。PPH可出现腹痛、脾功能亢进、消化道出血等临床表现,胃静脉破裂出血是PPH最严重的并发症,可导致失血性休克,... 详细信息

背景与目的:由于近年来胰腺相关疾病的发病率和诊断率逐渐增加,胰源性门静脉高压(PPH)及其并发症的发病率及诊断率也随之增加。PPH可出现腹痛、脾功能亢进、消化道出血等临床表现,胃静脉破裂出血是PPH最严重的并发症,可导致失血性休克,甚至死亡。而目前尚无公认的标准来预测PPH并发胃静脉破裂出血的风险。因此,本研究探讨PPH胃静脉破裂出血的相关危险因素并建立风险预测模型,为临床该病的防治提供参考。方法:以湖南中医药大学第一附属医院和湖南省人民医院自2012年1月—2022年1月收治的176例PPH患者为研究对象,根据是否并发胃静脉破裂出血分为出血组(24例)和未出血组(152例)。收集两组患者的一般资料:性别、年龄、病因、高血压、糖尿病,实验室结果:脾功能亢进、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)、活化部分凝血酶原时间(APTT)与影像学指标:胃左静脉(LGV)内径、胃网膜静脉(GEV)内径、GEV内径/LGV内径比值。采用单因素与多因素Logistic回归分析筛选出PPH并发胃静脉破裂出血的影响因素,建立列线图风险预测模型,并通过受试者工作特征(ROC)曲线、校准曲线和决策曲线评估模型的预测效能、一致性和临床价值。结果:单因素分析显示,糖尿病、脾功能亢进、PT、FIB、LGV内径、GEV内径/LGV内径比值与PPH并发胃静脉破裂出血有关(均P<0.05);多因素Logistic回归显示,糖尿病(OR=0.144,95%CI=0.031~0.675,P=0.014)、LGV内径(OR=3.129,95%CI=1.608~6.090,P=0.001)是PPH并发胃静脉破裂出血的独立危险因素;而FIB(OR=0.580,95%CI=0.348~0.966,P=0.037)、GEV内径/LGV内径比值(OR=0.024,95%CI=0.001~0.696,P=0.030)是PPH并发胃静脉破裂出血的独立保护性因素。纳入以上因素与有临床意义的GEV内径构建PPH胃静脉破裂出血的列线图模型,该模型的ROC曲线下面积为0.954,校准曲线与标准曲线具有很高的拟合度,决策曲线分析显示,当风险阈值在2%~85%之间时,能得到很好的净获益值。结论:糖尿病、LGV内径,FIB、GEV内径/LGV内径比值与PPH并发胃静脉破裂出血密切相关,所建立的列线图风险预测模型可有效识别PPH并发胃静脉破裂出血的高风险患者,可为临床决策提供参考。

关键词：胰腺疾病高血压,门静脉/并发症危险因素列线图

MICROSTRUCTURE　OF　NiCoCrAlY　COMPONENT　IN　PLASMA　SPRAYED　ZrO_2/NiCoCrAlY　GRADED　COATING

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中国有色金属学会会刊：英文版 1997年第1期7卷 107-111页

作者： xiang, xinghua Zhu, Jinchuan Yin, Zhongda Harbin Inst of Technology Harbin China

ＭＩＣＲＯＳＴＲＵＣＴＵＲＥＯＦＮｉＣｏＣｒＡｌＹＣＯＭＰＯＮＥＮＴＩＮＰＬＡＳＭＡＳＰＲＡＹＥＤＺｒＯ２／ＮｉＣｏＣｒＡｌＹＧＲＡＤＥＤＣＯＡＴＩＮＧ①ＸｉａｎｇＸｉｎｇｈｕａ，ＺｈｕＪｉｎｇｃｈｕａｎ，ＹｉｎＺｈ... 详细信息

ＭＩＣＲＯＳＴＲＵＣＴＵＲＥＯＦＮｉＣｏＣｒＡｌＹＣＯＭＰＯＮＥＮＴＩＮＰＬＡＳＭＡＳＰＲＡＹＥＤＺｒＯ２／ＮｉＣｏＣｒＡｌＹＧＲＡＤＥＤＣＯＡＴＩＮＧ①ＸｉａｎｇＸｉｎｇｈｕａ，ＺｈｕＪｉｎｇｃｈｕａｎ，ＹｉｎＺｈｏｎｇｄａＳｃｈｏｏｌｏｆＭａｔｅ...

关键词： plasma spraying graded coating NiCoCrAlY microstructure

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局域共振声学超材料耦合效应研究

压电与声光 2024年第4期46卷 586-590页

作者：项兴华雷怡俊胡志明刘金涛国网浙江省电力有限公司紧水滩水力发电厂浙江丽水323000 浙江工业大学土木工程学院浙江杭州310000

针对传统的声学超材料存在降噪频率窄、造价成本过高、实现难度大等诸多问题,提出一种带柔性薄膜结构的Helmholtz共振腔声学超材料结构,以局域共振耦合效应现象为出发点,推导出Helmholtz共振腔和柔性薄膜的数学模型。运用COMSOL Multiph... 详细信息

针对传统的声学超材料存在降噪频率窄、造价成本过高、实现难度大等诸多问题,提出一种带柔性薄膜结构的Helmholtz共振腔声学超材料结构,以局域共振耦合效应现象为出发点,推导出Helmholtz共振腔和柔性薄膜的数学模型。运用COMSOL Multiphysics软件对模型进行仿真分析,研究表明,该结构产生了2个局域共振峰值。为了实现对声学超材料消声频带的控制,向薄膜内注入液体。实验测试表明,当注液量从0增至35 mL时,薄膜峰值处的共振频率从612 Hz偏移到446 Hz,偏移量为166 Hz。所设计的局域共振声学超材料在频带范围内对低频噪声具有良好的控制效果,为声学超材料的设计提供了一种方法。

关键词：局域共振声学超材料噪声 Helmholtz共振腔

基于文献数据的知识图谱构建——以中医药治疗糖尿病周围神经病变为例

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中国实验方剂学杂志 2024年第6期30卷 144-150页

作者：柴嘉琪谈钰濛向兴华李苗苗文天才赵晖中国中医科学院中医临床基础医学研究所北京100700 中国中医药循证医学中心北京100700 中国中医科学院中医基础理论研究所北京100700 中国中医科学院中医药数据中心北京100700 中国中医科学院中医药信息研究所北京100700

目的:系统梳理现有文献中关于中医药治疗糖尿病周围神经病变(DPN)的“病-证-治-方-药”知识框架和概念逻辑关系,构建中医药治疗DPN的知识图谱,促进中医药治疗DPN的文献中隐性知识显性化。方法:以中国知网中有关中医药治疗DPN的文献为主... 详细信息

目的:系统梳理现有文献中关于中医药治疗糖尿病周围神经病变(DPN)的“病-证-治-方-药”知识框架和概念逻辑关系,构建中医药治疗DPN的知识图谱,促进中医药治疗DPN的文献中隐性知识显性化。方法:以中国知网中有关中医药治疗DPN的文献为主要数据来源,通过人工标引构建中医相关概念和实体,并建立实体之间的对应关系;利用Python 3.7处理形成结构化数据,并基于Neo4j 3.5.34图数据库构建知识图谱。结果:该知识图谱在模式层定义了方剂、中药、证型等12种节点标签,以及包含、对应、选择、组成这4种关系类型,形成了具备中医诊疗逻辑的知识图谱,可支持中医药治疗DPN证候要素、证候类型、治法等节点及各节点之间关系的查询与发现。结论:该研究基于文献数据探索性构建了中医药治疗DPN的知识图谱,汇聚了中医药治疗DPN的多种方式,包括内治法及外治法等,并从证素分析、证型组成至治法选择形成了辨证分型治疗DPN的全链条知识结构,可为文献数据服务于临床、科研工作提供新思路和新方法,并可为中医文献知识可视化、中医药知识服务智能化、中医标准化和规范化诊疗提供参考。

关键词：中医药糖尿病周围神经病变(DPN) 知识图谱 Neo4j 证候要素证候类型治法治则

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中医教材在变应性鼻炎中医诊疗指南制定中的证据价值探讨

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中医杂志 2024年第4期65卷 368-375页

作者：刘翠芳卫东锋杨伟谢飞彪郑丹平向兴华刘孟宇中国中医科学院中医临床基础医学研究所北京市100700 湖南科技大学数学与计算科学学院中国中医科学院中医药信息研究所

目的以变应性鼻炎为例,探讨中医类教材相关诊疗方案作为中医诊疗指南中证据应用的可行性与合理性。方法检索1949年10月至2022年12月出版的教材,检索截至2022年12月发表的变应性鼻炎中医诊疗指南,提取教材中变应性鼻炎相关章节诊疗内容,... 详细信息

目的以变应性鼻炎为例,探讨中医类教材相关诊疗方案作为中医诊疗指南中证据应用的可行性与合理性。方法检索1949年10月至2022年12月出版的教材,检索截至2022年12月发表的变应性鼻炎中医诊疗指南,提取教材中变应性鼻炎相关章节诊疗内容,比较分析不同时期的教材之间、现行不同版本教材之间、现行教材与指南之间的异同点。结果共纳入1975年至2021年中医耳鼻喉科的国家规划教材12本及变应性鼻炎中医诊疗指南4份。不同时期教材显示了诊疗方案的演变过程,从2003年出版的教材开始增加了肺经伏热证,并丰富了涂鼻法、滴鼻法等特色疗法,以及预防调摄、预后转归的内容,主要证型为肺气虚寒证、脾气虚弱证、肾阳不足证及肺经伏热证,常见推荐方剂分别为温肺止流丹、玉屏风散合苍耳子散,补中益气汤、参苓白术散,肾气丸或真武汤,辛夷清肺饮。现行不同版本教材之间比较显示其证型一致,方药略有差异。现行不同版本教材与指南的比较显示,教材推荐方剂增加了苍耳子散、小青龙汤、真武汤等,丰富了特色疗法如吹鼻、嗅法、塞鼻、洗鼻等,并增加了用药加减、预防调摄、预后转归等信息,可为指南补充相应证据。结论教材可以作为中医诊疗指南制定证据的有力补充,但仍需进一步研究教材证据的质量评价体系,以提高其应用于指南证据的可信度。

关键词：变应性鼻炎中医诊疗指南教材证据

Geochemical fractionation and potential release behaviour of heavy metals in lead–zinc smelting soils

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Journal of Environmental Sciences 2024年第5期139卷 1-11页

作者： xinghua Luo Chao xiang Chuan Wu Wenyan Gao Wenshun Ke Jiaqing Zeng Waichin Li Shengguo Xue School of Metallurgy and Environment Central South UniversityChangsha 410083China Chinese National Engineering Research Center for Control and Treatment of Heavy Metal Pollution Central South UniversityChangsha 410083China Department of Science and Environmental Studies The Education University of Hong KongHong Kong 999077China

The lack of understanding of heavy metal speciation and solubility control mechanisms in smelting soils limits the effective pollution *** this study smelting soils were investigated by an advanced mineralogical analysis(AMICS),leaching tests and thermodynamic *** aims were to identify the partitioning and release behaviour of Pb,Zn,Cd and *** integration of multiple techniques was necessary and displayed coherent *** addition to the residual fraction,Pb and Zn were predominantly associated with reducible fractions,and As primarily existed as the crystalline iron oxide-bound *** quantitative analysis further confirmed that Fe oxyhydroxides were the common dominant phase for As,Cd,Pb and *** addition,a metal arsenate(paulmooreite)was an important mineral host for Pb and *** pH-stat leaching indicted that the release of Pb,Zn and Cd increased towards low pH values while release of As increased towards high p H *** separate leaching schemes were associated with the geochemical behaviour under the control of minerals and were confirmed by thermodynamic *** calculations suggested that the formation of arsenate minerals(schultenite,mimetite and koritnigite)and the binding to Fe oxyhydroxides synchronously controlled the release of Pb,Zn,Cd and *** results emphasized the governing role of Fe oxyhydroxides and secondary insoluble minerals in natural attenuation of heavy metals,which provides a novelty strategy for the stabilization of multi-metals in smelting sites.

关键词： Smelting soils Heavy metal Fractionation AMICS Geochemical modelling

Distributed Least Squares Algorithm of Continuous-Time Stochastic Regression Model Based on Sampled Data

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Journal of Systems Science & Complexity 2024年第2期37卷 609-628页

作者： ZHU xinghua GAN Die LIU Zhixin The Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of Sciencesand School of Mathematical SciencesUniversity of Chinese Academy of SciencesBeijing 100190China Zhongguancun Laboratory Beijing 100094China

In this paper,the authors consider the distributed adaptive identification problem over sensor networks using sampled data,where the dynamics of each sensor is described by a stochastic differential *** minimizing a local objective function at sampling time instants,the authors propose an online distributed least squares algorithm based on sampled data.A cooperative non-persistent excitation condition is introduced,under which the convergence results of the proposed algorithm are established by properly choosing the sampling time *** upper bound on the accumulative regret of the adaptive predictor can also be ***,the authors demonstrate the cooperative effect of multiple sensors in the estimation of unknown parameters by computer simulations.

关键词： Cooperative excitation condition distributed least squares regret sampled data stochastic differential equation

Distributed order estimation for continuous-time stochastic systems

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Control Theory and Technology 2024年第3期22卷 406-418页

作者： xinghua Zhu Zhixin Liu Xiaoming Hu Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China Department of Mathematics KTH Royal Institute of TechnologyStockholm 10044Sweden

In this paper,we investigate the distributed estimation problem of continuous-time stochastic dynamic systems over sensor networks when both the system order and parameters are *** propose a local information criterion(LIC)based on the L_(0)penalty *** minimizing LIC at the diffusion time instant and utilizing the continuous-time diffusion least squares algorithm,we obtain a distributed estimation algorithm to simultaneously estimate the unknown order and the parameters of the *** dealing with the effect of the system noises and the coupling relationship between estimation of system orders and parameters,we establish the almost sure convergence results of the proposed distributed estimation ***,we give a simulation example to verify the effectiveness of the distributed algorithm in estimating the system order and parameters.

关键词： Stochastic differential equations Sensor networks Distributed order estimation Cooperative excitation condition.Convergence

Collision-free parking recommendation based on multi-agent reinforcement learning in vehicular crowdsensing

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Digital Communications and Networks 2024年第3期10卷 609-619页

作者： Xin Li xinghua Lei Xiuwen Liu Hang Xiao College of Computer Science and Technology China University of Petroleum(East China)QingDao266580China

The recent proliferation of Fifth-Generation(5G)networks and Sixth-Generation(6G)networks has given rise to Vehicular Crowd Sensing(VCS)systems which solve parking collisions by effectively incentivizing vehicle ***,instead of being an isolated module,the incentive mechanism usually interacts with other *** on this,we capture this synergy and propose a Collision-free Parking Recommendation(CPR),a novel VCS system framework that integrates an incentive mechanism,a non-cooperative VCS game,and a multi-agent reinforcement learning algorithm,to derive an optimal parking strategy in real ***,we utilize an LSTM method to predict parking areas roughly for recommendations *** incentive mechanism is designed to motivate vehicle participation by considering dynamically priced parking tasks and social network *** order to cope with stochastic parking collisions,its non-cooperative VCS game further analyzes the uncertain interactions between vehicles in parking *** its multi-agent reinforcement learning algorithm models the VCS campaign as a multi-agent Markov decision process that not only derives the optimal collision-free parking strategy for each vehicle independently,but also proves that the optimal parking strategy for each vehicle is ***,numerical results demonstrate that CPR can accomplish parking tasks at a 99.7%accuracy compared with other baselines,efficiently recommending parking spaces.

关键词： Incentive mechanism Non-cooperative VCS game Multi-agent reinforcement learning Collision-free parking strategy Vehicular crowdsensing