检索结果-南通市图书馆

Journal of Earth Science 2016年第5期27卷 777-785页

作者： Yongge Wan Shuzhong Sheng Jichao Huang xiang li xin Chen Institute of Disaster Prevention Sanhe 065201 China Earthquake Administration of the Guangxi Autonomous Region Nanning 530022 China

Stress field plays a key role in geodynamics. In this study, an algorithm to determine the stress tensor and its confidence range from focal mechanism data by using grid search method was proposed. The experiment uses artificial focal mechanism data which were generated by extensional, compression and strike-slip stress regime and different level of noise, shows that the precision of the estimated stress tensor based on this algorithm is greatly improved compared with traditional algorithms. This algorithm has three advantages：（1） The global optimal solution of the stress tensor is determined by fine grid search of 1o×1o×1o×0.01 and local minimum value is avoided; （2） precision of focal mechanism data can be considered, i.e., different weight of the focal mechanism data contributes differently to the process of determining stress tensor; （3） the confidence range of the determined stress tensor can be obtained by using F-test. We apply this algorithm in the boundary zone of China, Vietnam and Laos, and obtain the stress field with SSE-NNW compressive stress direction and NEE-SWW extensional stress direction. The stress ratio is 0.6, which shows that the eigen values of the stress tensor are nearly in arithmetic sequence. The stress field in this region is consistent with the left-lateral strike slip of the Dienbien-Lauangphrabang arc fault. The result will be helpful in studying the geological dynamic process in this region.

关键词： stress tensor grid search focal mechanism uncertainty.

Identification of cytokines involved in hepatic differentiation of mBM-MSCs under liver-injury conditions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第26期16卷 3267-3278页

作者： Dong, Xue-Jun Zhang, Hui Pan, Ruo-Lang xiang, li-xin Shao, Jian-Zhong Shaoxing Peoples Hosp Mol Med Ctr Shaoxing 312000 Zhejiang Peoples R China Wenzhou Med Coll Sch Lab Med & Life Sci Wenzhou 325035 Zhejiang Peoples R China Zhejiang Univ Coll Life Sci Hangzhou 310058 Zhejiang Peoples R China Key Lab Cell & Gene Engn Zhejiang Prov Hangzhou 310058 Zhejiang Peoples R China

AIM: To identify the key cytokines involved in hepatic differentiation of mouse bone marrow mesenchymal stem cells (mBM-MSCs) under liver-injury conditions. METHODS: Abdominal injection of CCl4 was adopted to duplicate a mouse acute liver injury model. Global gene expression analysis was performed to evaluate the potential genes involved in hepatic commitment under liver-injury conditions. The cytokines involved in hepatic differentiation of mBM-MSCs was function-ally examined by depletion experiment using specifi c antibodies, followed by rescue experiment and direct inducing assay. The hepatic differentiation was characterized by the expression of hepatic lineage genes and proteins, as well as functional features. RESULTS: Cytokines potentially participating in hepatic fate commitment under liver-injury conditions were initially measured by microarray. Among the up-regulated genes determined, 18 cytokines known to closely relate to liver growth, repair and development, were selected for further identif ication. The f ibroblast growth factor-4 (FGF-4), hepatocyte growth factor (HGF) and oncostatin M (OSM) were fi nally found to be involved in hepatic differentiation of mBM-MSCs under liver-injury conditions. Hepatic differentiation could be dramatically decreased after removing FGF-4, HGF and OSM from the liver-injury conditioned medium, and could be rescued by supplementing these cytokines. The FGF-4, HGF and OSM play different roles in the hepatic differentiation of mBM-MSCs, in which FGF-4 and HGF are essential for the initiation of hepatic differentiation, while OSM is critical for the maturation of hepatocytes. CONCLUSION: FGF-4, HGF and OSM are the key cytokines involved in the liver-injury conditioned medium for the hepatic differentiation of mBM-MSCs.

关键词： Hepatic differentiation Mouse bone marrow mesenchymal stem cells Inducing cytokines Fibroblast growth factor-4 Hepatocyte growth factor Oncostatin M

Transition metal clusters with precise numbers of atoms anchored on graphdiyne as multifunctional electrocatalysts for OER/ORR/HER:a computational study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 3107-3117页

作者： xin-Yang liu Jing-Wei liu Gang li Jing-xiang Zhao College of Chemistry and Chemical Engineering Harbin Normal UniversityHarbin 150025China

Subnanometer metal clusters play an increasingly important role in heterogeneous catalysis due to their high catalytic activity and *** this work,by means of the density functional theory(DFT) calculations,the catalytic activities of transition metal clusters with precise numbers of atoms supported on graphdiyne(TM_(1-4)@GDY,TM=V,Cr,Mn,Fe,Co,Ni,Cu,Ru,Rh,Pd,Ir,Pt) were investigated for oxygen evolution reactions(OER),oxygen reduction reactions(ORR) and hydrogen evolution reactions(HER).The computed results reveal that the Pd_(2),Pd_(4) and Pt_(1) anchored graphdiyne can serve as trifunctional catalysts for OER/ORR/HER with the overpotentials of 0.49/0.37/0.06,0.45/0.33/0.12 and 0.37/0.43/0.01 V,respectively,while Pd_(1) and Pt_(2)@graphdiyne can exhibit excellent catalytic performance for water splitting(OER/HER) with the overpotentials of 0.55/0.17 and 0.43/0.03 *** addition,Ni_(1) and Pd_(3) anchored GDY can perform as bifunctional catalysts for metal-air cells(OER/ORR) and fuels cells(ORR/HER) with the overpotentials of 0.34/0.32 and 0.42/0.04 V,***,by precisely controlling the numbers of atoms in clusters,the TM_(1-4) anchored graphdiyne can serve as promising multifunctional electrocatalysts for OER/ORR/HER,which may provide an instructive strategy to design catalysts for the energy conversation and storage devices.

关键词： Density functional theory Graphdiyne Single-cluster catalysts Multifunctional electrocatalysts Overpotential

Sandwich structures with tapered tubes as core:A quasi-static investigation

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 447-462页

作者： xinmei xiang Dehua Shao xin Zhang Umer Sharif Ngoc San Ha li xiang Jing Zhang Jiang Yi School of Civil Engineering Guangzhou UniversityGuangzhouChina Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhenGuangdongChina School of Engineering Centre for Innovative Structures and MaterialsRMIT UniversityMelbourneAustralia China Southern Airlines Co. LtdShenzhen BranchShenzhen518000China

In this article,the experimental and finite element analysis is utilized to investigate the quasi-static compression features of sandwich constructions built with tapered tubes.3D printing technology was utilized to create the hollow centers of the tapering tubes,with and without *** results demonstrate that the energy absorption(EA)and specific energy absorption(SEA)of the single corrugated tapered tube sandwich are 51.6% and 19.8% higher,respectively,than those of the conical tube ***,the results demonstrate that energy absorbers can benefit from corrugation in order to increase their ***,the tapered corrugated tubes'resistance to oblique impacts was *** to a straight tube,the tapered tube is more resistant to oblique loads and has a lower initial peak crushing force(PCF),according to numerical *** conducting a parametric study,it was discovered that the energy absorption performance of the sandwich construction is significantly affected by the amplitude,number of corrugations,and wall *** and SEA of DTS with corrugation number of 8 increased by 17.4%and 29.6%,respectively,while PCF decreased by 9.2% compared to DTS with corrugation number of 10.

关键词： Sandwich structure Corrugated tube Tapered tube Quasi-static Energy absorption

Effect of tungsten carbide particles on microstructure and mechanical properties of Cu alloy composite bit matrix

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第2期31卷 519-530页

作者： Ding-qian Dong Feng-yuan He xin-hui Chen Hui li Kai-hua Shi Hui-wen Xiong xin xiang li Zhang College of Mechanical Engineering Sichuan University of Science and EngineeringZigong643000SichuanChina State Key Laboratory of Powder Metallurgy Central South UniversityChangsha410083HunanChina Zigong Cemented Carbide Co. Ltd.Zigong643011SichuanChina Material Corrosion and Protection Key Laboratory of Sichuan Province Sichuan University of Science and EngineeringZigong643000SichuanChina

Copper alloy composite bit matrix was prepared by pressureless vacuum infiltration,using at least one of the three kinds of tungsten carbide particles,for example,irregular cast tungsten carbide,monocrystalline tungsten carbide and sintered reduced tungsten carbide *** effects of powder particle morphology,particle size and mass fraction of tungsten carbide on the microstructure and mechanical properties of copper alloy composite were investigated by means of scanning electron microscopy,X-ray diffraction and abrasive wear test in *** results show that tungsten carbide morphology and particle size have obvious effects on the mechanical properties of copper alloy *** tungsten carbide partially dissolved in the copper alloy binding phase,and layers of Cu_(0.3)W_(0.5)Ni_(0.1)Mn_(0.1)C phase with a thickness of around 8–15μm were formed on the edge of the cast tungsten *** 45%irregular crushed fine cast tungsten carbide and 15%monocrystalline cast tungsten carbide were used as the skeleton,satisfactory comprehensive performance of the reinforced copper alloy composite bit matrix was obtained,with the bending strength,impact toughness and hardness reaching 1048 MPa,4.95 J/cm^(2) and 43.6 HRC,*** main wear mechanism was that the tungsten carbide particles firstly protruded from the friction surface after the copper alloy matrix was worn,and then peeled off from the matrix when further wear occurred.

关键词： Polycrystalline diamond compact Pressureless vacuum infiltration Copper alloy composite bit matrix Microstructure characterization Abrasive wear behavior

银质针配合温控银针治疗仪治疗腰背肌筋膜炎临床研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

风湿病与关节炎 2024年第1期13卷 36-39页

作者：郑宇辰李向欣李跃飞周国徽郝小刚长春中医药大学吉林长春130117 长春中医药大学附属医院吉林长春130021

目的:研究银质针配合温控银针治疗仪治疗腰背肌筋膜炎患者的疗效。方法:将60例腰背肌筋膜炎患者随机分为治疗组和对照组,每组30例。对照组给予常规针刺治疗,治疗组给予银质针配合温控银针治疗仪治疗。2组疗程均为3周。观察2组临床疗效,... 详细信息

目的:研究银质针配合温控银针治疗仪治疗腰背肌筋膜炎患者的疗效。方法:将60例腰背肌筋膜炎患者随机分为治疗组和对照组,每组30例。对照组给予常规针刺治疗,治疗组给予银质针配合温控银针治疗仪治疗。2组疗程均为3周。观察2组临床疗效,以及治疗前,治疗后第1,2,3周视觉模拟评分法(VAS)评分。结果:治疗组显效18例,有效10例,无效2例,总有效率为93.33%;对照组显效10例,有效12例,无效8例,总有效率为73.33%。2组比较,差异有统计学意义(P<0.05)。治疗后第1,2,3周,2组VAS评分均较治疗前改善(P<0.05),且治疗组优于对照组(P<0.05)。结论:银质针配合温控银针治疗仪治疗腰背肌筋膜炎,可有效减轻患者的疼痛症状,提高疗效。

关键词：腰背肌筋膜炎银质针电针临床研究

在线全文

学校读者我要写书评

暂无评论

自平衡法抗拔与传统法抗拔试验的对比分析

广州建筑 2024年第7期52卷 109-115页

作者：王晓伟李祥新许宇星巫卓伦广州建设工程质量安全检测中心有限公司广州510440

本文结合工程实际,以分别采用自平衡法和传统法测试的抗拔桩为研究对象,通过沿桩身布置的钢筋计测试不同荷载下对应的桩身应力,揭示自平衡法和传统法抗拔试验中桩体内力分布存在的异同。通过分析得出:自平衡法抗拔测试中桩身轴力沿着深... 详细信息

本文结合工程实际,以分别采用自平衡法和传统法测试的抗拔桩为研究对象,通过沿桩身布置的钢筋计测试不同荷载下对应的桩身应力,揭示自平衡法和传统法抗拔试验中桩体内力分布存在的异同。通过分析得出:自平衡法抗拔测试中桩身轴力沿着深度由下向上逐渐减少,传统法抗拔则是由上向下逐渐减小;自平衡法抗拔测试中侧摩阻力由下往上发挥,传统法抗拔测试中则是由上往下发挥。

关键词：抗拔桩自平衡法传统法桩身轴力桩侧摩阻力

BIO-inspired intelligent navigation: from methodology, system theory, to behavioural science

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第9期67卷 333-335页

作者： Wenshuo li xin liU Pengwei HU Jian YANG xiang YU Lei GUO Hangzhou Innovation Institute of Beihang University School of Automation Science and Electrical Engineering Beihang University School of Instrumentation and Optoelectronic Engineering Beihang University

It is crucial for unmanned systems to determine their motion information accurately, reliably, and in real time. This function is accomplished by the autonomous navigation module of the unmanned systems. By analogy to the animals,the autonomous navigation module can be regarded as the“sensory nerve center” of an unmanned system.

关键词：

Clinical application of eight-zone laparoscopic dissection strategy for rectal cancer:Experience and discussion

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第30期30卷 3574-3583页

作者： Chang Chen xiang Zhang xin li Yan-Lei Wang Department of General Surgery Rongchang People's HospitalChongqing 250012China Department of Colorectal Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of General Surgery Huantai Branch of Qilu Hospital of Shandong UniversityZibo 255000Shandong ProvinceChina

BACKGROUND The incidence of rectal cancer is increasing worldwide,and surgery remains the primary treatment *** the advent of total mesorectal excision(TME)technique,the probability of tumor recurrence post-surgery has significantly ***'focus has gradually shifted towards minimizing the impact of surgery on urinary and sexual *** these concerns,the optimal dissection of the rectal lateral ligaments and preservation of the pelvic floor neuro-vascular bundle have become *** explore the optimal surgical technique for TME and establish a standardized surgical protocol to minimize the impact on urinary and sexual functions,we propose the eight-zone dissection strategy for pelvic floor *** To compare the differences in surgical specimen integrity and postoperative quality of life satisfaction between the traditional pelvic floor dissection strategy and the innovative eight-zone dissection *** We analyzed the perioperative data of patients who underwent laparoscopic radical resection of rectal cancer at Qilu Hospital of Shandong University between January 1,2021 and December 1,*** study included a total of 218 patients undergoing laparoscopic radical surgery for rectal cancer,among whom 109 patients underwent traditional pelvic floor dissection strategy,and 109 patients received the eight-zone dissection *** There were no significant differences in general characteristics between the two *** in the eight-zone dissection group had higher postoperative specimen integrity(88.1%vs 78.0%,P=0.047).At the 3-month followup,patients in the eight-zone surgery group had better scores in urinary issues(6.8±3.3 vs 5.3±2.5,P=0.045)and male sexual desire(2.2±0.6 vs 2.5±0.5,P=0.047)compared to the traditional surgery strategy *** This study demonstrates that the eight-zone dissection strategy for laparoscopic lateral ligament dissection of rectal cancer is safe and ***

关键词： Eight-zone dissection strategy Rectal cancer Lateral ligament dissection Nerve injury Total mesorectal excision surgery

Differentiation and immunosuppressive function of CD19^(+)CD24^(hi)CD27^(+) regulatory B cells are regulated through the miR-29a-3p/NFAT5 pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 472-480页

作者： Jin-Yang li Tian-Shuo Feng Ji Gao xin-xiang Yang xiang-Cheng li Zhen-Hua Deng Yong-xiang Xia Zheng-Shan Wu Hepatobiliary Center the First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Key Laboratory of liver Transplantation Chinese Academy of Medical SciencesNanjing 210029China NHC Key Laboratory of living Donor liver Transplantation Nanjing Medical UniversityNanjing 210029China

Background: Regulatory B cells(Bregs) is an indispensable element in inducing immune tolerance after liver transplantation. As one of the microRNAs(miRNAs), mi R-29a-3p also inhibits translation by degrading the target mRNA, and yet the relationship between Bregs and mi R-29a-3p has not yet been fully explored. This study aimed to investigate the impact of miR-29a-3p on the regulation of differentiation and immunosuppressive functions of memory Bregs(m Bregs) and ultimately provide potentially effective therapies in inducing immune tolerance after liver transplantation. Methods: Flow cytometry was employed to determine the levels of Bregs in peripheral blood mononuclear cells. TaqMan low-density array miRNA assays were used to identify the expression of different miRNAs, electroporation transfection was used to induce mi R-29a-3p overexpression and knockdown, and dual luciferase reporter assay was used to verify the target gene of miR-29a-3p. Results: In patients experiencing acute rejection after liver transplantation, the proportions and immunosuppressive function of m Bregs in the circulating blood were significantly impaired. mi R-29a-3p was found to be a regulator of m Bregs differentiation. Inhibition of miR-29a-3p, which targeted nuclear factor of activated T cells 5(NFAT5), resulted in a conspicuous boost in the differentiation and immunosuppressive function of m Bregs. The inhibition of mi R-29a-3p in CD19~+ B cells was capable of raising the expression levels of NFAT5, thereby promoting B cells to differentiate into m Bregs. In addition, the observed enhancement of differentiation and immunosuppressive function of m Bregs upon mi R-29a-3p inhibition was abolished by the knockdown of NFAT5 in B cells. Conclusions: mi R-29a-3p was found to be a crucial regulator for m Bregs differentiation and immunosuppressive function. Silencing mi R-29a-3p could be a potentially effective therapeutic strategy for inducing immune tolerance after liver transplantation.

关键词： Regulatory B cells miR-29a-3p NFAT5 liver transplantation