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Extending the solid solution range of sodium ferric pyrophosphate:Off‐stoichiometric Na_(3)Fe(2.5)(P_(2)O_(7))_(2)as a novel cathode for sodium‐ion batteries

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Carbon Energy 2024年第4期6卷 128-139页

作者： xiang jun pu Kunran Yang Zibing Pan Chunhua Song Yangyang Lai Renjie Li Zheng‐Long Xu Zhongxue Chen Yuliang Cao Hubei Key Laboratory of Electrochemical Power Sources College of Chemistry and Molecular SciencesWuhan UniversityWuhanChina Key Laboratory of Hydraulic Machinery Transients Ministry of EducationSchool of Power and Mechanical EngineeringWuhan UniversityWuhanChina School of Chemistry and Chemical Engineering Jiangsu University of TechnologyChangzhouJiangsuChina Zonergy Corporation ZigongSichuanChina Department of Industrial and Systems Engineering The Hong Kong Polytechnic UniversityHung HomHong Kong SARChina

Iron‐based pyrophosphates are attractive cathodes for sodium‐ion batteries due to their large framework,cost‐effectiveness,and high energy ***,the understanding of the crystal structure is scarce and only a limited candidates have been reported so *** this work,we found for the first time that a continuous solid solution,Na_(4−α)Fe_(2+α)_(2)(P_(2)O_(7))_(2)(0≤α≤1,could be obtained by mutual substitution of cations at center‐symmetric Na3 and Na4 sites while keeping the crystal building blocks of anionic P_(2)O_(7) *** particular,a novel off‐stoichiometric Na_(3)Fe(2.5)(P_(2)O_(7))_(2)is thus proposed,and its structure,energy storage mechanism,and electrochemical performance are extensively investigated to unveil the structure–function *** as‐prepared off‐stoichiometric electrode delivers appealing performance with a reversible discharge capacity of 83 mAh g^(−1),a working voltage of 2.9 V(***^(+)/Na),the retention of 89.2%of the initial capacity after 500 cycles,and enhanced rate capability of 51 mAh g^(−1)at a current density of 1600 mA g^(−1).This research shows that sodium ferric pyrophosphate could form extended solid solution composition and promising phase is concealed in the range of Na_(4−α)Fe_(2+α)_(2)(P_(2)O_(7))_(2),offering more chances for exploration of new cathode materials for the construction of high‐performance SIBs.

关键词： extending solid‐solution range off‐stoichiometric Na_(3)Fe_(2.5)(P_(2)O_(7))_(2) sodium‐ion batteries structure-function relationship

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Study on the Mechanism of Action of Glyasperin A in the Treatment of Atherosclerosis Based on Network Pharmacology and Molecular Docking

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Agricultural Biotechnology 2024年第2期13卷 53-57页

作者： Na LI xiang pu Yihui CHAI Yuqi YANG Lailai LI Guizhou University of Traditional Chinese Medicine Guiyang 550025China

[Objectives] This study was conducted to investigate the mechanism of action of glyasperin A in the treatment of atherosclerosis using a network pharmacology approach. [Methods] Targets related to atherosclerosis were searched in GeneCards database. An active ingredient-disease-target network was constructed by Cytoscape 3.7.1. A target protein interaction network was constructed by String database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed on the DAVID database. [Results] Glyasperin A acted on 36 atherosclerosis-related targets, and the biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, barrier, and lipid oxidation, etc. The results showed that glyasperin A acted on 36 atherosclerosis-related targets. The biofunctional and pathway enrichment analyses showed that it was mainly involved in response to xenobiotic stimulus, drug transport across blood-brain barrier, lipid oxidation, positive regulation of protein localization to nucleus, and hepoxilin biosynthetic process, and it played an anti-fatigue role through signal pathways such as serotonergic synapse, efferocytosis, arachidonic acid metabolism, chemical carcinogenesis-receptor activation and platelet activation. [Conclusions] Glyasperin A has multi-target and multi-pathway effects in the treatment of atherosclerosis. This study provides reference for further research on glyasperin A in the treatment of atherosclerosis.

关键词： Glyasperin A Atherosclerosis Network pharmacology Mechanism of action

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Therapeutic Effects and Potential Mechanisms of Glyasperin A against Myocardial Ischemia Based on Network Pharmacology and Molecular Docking

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Asian Agricultural Research 2024年第5期16卷 25-28页

作者： Na LI Shunhuan CHEN xiang pu Yihui CHAI Yuqi YANG Lailai LI Guizhou University of Traditional Chinese Medicine Guiyang 550025China

[Objectives]To explore the therapeutic effects and potential mechanisms of Glyasperin A(GAA)on myocardial ischemia(MI)based on network pharmacology and molecular docking.[Methods]The molecular structure of GAA was downloaded from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),and all targets of GAA were predicted by converting 3D model molecules into SMILES online tool and Swiss target *** database and DisGeNET database were used to find the targets related to MI,and then Venny 2.1.0 was used to generate the corresponding Wayne diagram,and then Cytoscape 3.9.1 software was used to construct the protein-protein interaction(PPI)*** the help of DAVID database and Microbiology,the selected core targets were enriched and analyzed by gene ontology(GO),biological process(BP),and Kyoto Encyclopedia of Genes and Genomes(KEGG),and then the molecular docking between GAA and core targets was verified by AutoDock and Pymol software.[Results]A total of 1883 MI targets were screened,and in the protein-protein interaction network,AKT1,PTGS2,PPARG,ESR1,GSK3B were the proteins with higher *** ontology and KEEG enrichment analysis showed that the biological processes involved mainly included inflammatory response,negative regulation of gene expression,and response to exogenous *** pathways mainly include IL-17 signaling pathway,HIF-1 signaling pathway,and so *** results of molecular docking showed that the binding energy of GAA and core protein was less than-5 Kcal/mol in four *** indicated that GAA with good binding had a certain therapeutic effect on myocardial ischemia.[Conclusions]Based on the systematic network pharmacology method,this study predicts the basic pharmacological effects and potential mechanisms of GAA in the treatment of MI,and reveals that GAA may treat MI through multiple targets and signaling *** is expected to provide a basis for further study of its phar

关键词： Network pharmacology Molecular docking Glyasperin A(GAA) Myocardial ischemia(MI)

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Exploring the Mechanism of Action of Glyasperin A in Intervening Menopause Based on Network Pharmacology and Molecular Docking Technology

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Medicinal Plant 2024年第3期15卷 4-8页

作者： Na LI Shunhuan CHEN xiang pu Yihui CHAI Yuqi YANG Lailai LI Guizhou University of Traditional Chinese Medicine Guiyang 550025China

[Objectives]To investigate the mechanism of action of glyasperin A(GAA)in intervening menopause using network pharmacology and molecular docking technology.[Methods]All target names of the active ingredients were screened using TCMSP,3D model molecules converted into SMILES online tool,Swiss target prediction and literature *** relevant target genes corresponding to menopause were identified using the Genecards *** 2.1.0 was then used to generate the corresponding Venn ***,the protein-protein interaction(PPI)network was constructed using Cytoscape 3.9.1 *** core targets that were screened underwent enrichment and analysis using the Gene Ontology(GO)biological process and KEGG pathways with the assistance of the DAVID database and *** molecular docking was then verified using AutoDock and Pymol software on the core targets.[Results]This study screened 100 target genes of active *** the PPI network,ESR1 and AKT1 were found to have a higher *** GO and KEGG enrichment analyses revealed that the biological processes primarily involved platelet activation,regulation of circadian rhythms,and regulation of mRNA *** signalling pathways included hepatitis B,cytotoxicity,and gastric *** molecular docking results indicated that the key active ingredients and proteins bound well,as evidenced by their small binding energies.[Conclusions]Using a systematic network pharmacology approach,this study predicts the basic pharmacological effects and potential mechanisms of GAA in intervening menopause,which provides a foundation for further research on its pharmacological mechanisms.

关键词： Network pharmacology Molecular docking Menopause Glyasperin A

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基于极限学习机的建筑工程施工成本预测研究

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全面腐蚀控制 2024年第8期38卷 84-86页

作者：李普祥潍坊市三建集团有限公司山东潍坊261100

随着建筑工程行业的发展,施工成本预测越来越受到重视。为了提高预测准确性,我们提出了一种基于极限学习机(ELM)和支持向量机(SVM)的融合预测模型。首先,我们分别构建了基于ELM和SVM的子预测模型,然后通过加权融合策略将两种子模型结合... 详细信息

随着建筑工程行业的发展,施工成本预测越来越受到重视。为了提高预测准确性,我们提出了一种基于极限学习机(ELM)和支持向量机(SVM)的融合预测模型。首先,我们分别构建了基于ELM和SVM的子预测模型,然后通过加权融合策略将两种子模型结合在一起。实验结果表明,所提出的融合预测模型在建筑工程施工成本预测方面表现优越,具有较高的预测精度和稳定性。我们对比了ELM、SVM和多层感知机(MLP)等方法的性能,并对融合预测模型进行了详细的分析。此外,我们还讨论了未来研究方向,以期推动建筑工程施工成本预测领域的发展。

关键词：建筑工程施工成本预测极限学习机支持向量机融合预测模型

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Precipitated phases of superaustenitic stainless steel 654SMO

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Journal of Iron and Steel Research International 2017年第7期24卷 743-749页

作者： Zhi-gang Song En-xiang pu Special Steel Institute Central Iron & Steel Research Institute School of Materials Science and Engineering Tsinghua University

The phase diagram of superaustenitic stainless steel 654SMO was calculated by thermodynamic software and the precipitated phases in the specimens aged at 800-1100°C for 1hwere studied by methods of physicochemical phase analysis,scanning electron microscopy and transmission electron *** results showed that the size of precipitated particles increased with increasing the *** amount of second phases reached the maximum value at 900°C,but decreased above 900°*** were about eight kinds of precipitated phases in 654SMO includingσphase,Cr_2N,μphase,χphase,Laves phase,M_（23）C_6,M_6C and M_3C,in which theσphase and Cr_2N were the dominant precipitated phases.

关键词： 654SMO Precipitation Superaustenitic stainless steel Precipitated phase Second phase

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陇南诗碑题壁诗与陇蜀“诗教”类文献的流传

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齐齐哈尔大学学报（哲学社会科学版） 2024年第5期 13-17页

作者：焦福维蒲向明陇南师范高等专科学校陇蜀道文学与文化研究中心文学与传媒学院甘肃成县742500

散见于陇南各地诗碑与题壁中的诗作,数量较多,诸体兼备,作者属于官员、本地乡贤或游陇者群体。就其题材内容而言,除游宴抒怀、题咏陇南人文景观的篇什外,颂扬历代先贤乡哲、教化人心是其重要的方面。这些作品绝大多数不见于史传,但体现... 详细信息

散见于陇南各地诗碑与题壁中的诗作,数量较多,诸体兼备,作者属于官员、本地乡贤或游陇者群体。就其题材内容而言,除游宴抒怀、题咏陇南人文景观的篇什外,颂扬历代先贤乡哲、教化人心是其重要的方面。这些作品绝大多数不见于史传,但体现了陇蜀地域“诗教”类文献流传的重要文学文化价值,在赓续地方文脉、承载诗教化育、补史存诗文献、资于地方文旅等方面价值突出。对继承和弘扬中华优秀传统文化,坚定历史自信、文化自信具有重要现实意义。

关键词：陇南诗碑题壁诗陇蜀 “诗教”类文献

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头花蓼黄酮类化合物O-甲基转移酶基因家族的鉴定及表达分析

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药学学报 2024年第5期59卷 1467-1477页

作者：骆江利刘畅曾宪法吴娜娜王小雪唐英蒲翔贵州中医药大学药学院贵州贵阳550025 贵州中医药大学基础医学院贵州贵阳550025

头花蓼Polygonum capitatum为贵州特色苗药,临床常用于治疗胃肠道和泌尿系统感染,研究发现其具有较好的抑菌抗炎作用,其主要活性成分为黄酮类化合物。黄酮O-甲基转移酶(flavonoid O-methyltransferase,FOMT)是黄酮类化合物氧甲基化修饰... 详细信息

头花蓼Polygonum capitatum为贵州特色苗药,临床常用于治疗胃肠道和泌尿系统感染,研究发现其具有较好的抑菌抗炎作用,其主要活性成分为黄酮类化合物。黄酮O-甲基转移酶(flavonoid O-methyltransferase,FOMT)是黄酮类化合物氧甲基化修饰的关键酶,为了解头花蓼FOMT蛋白功能及特性,本研究以头花蓼根、茎、叶、花为材料,采用Illumina HiSeq 4000高通量测序技术进行转录组测序,对获得的转录本进行注释分析,并对头花蓼中FOMT基因家族进行全基因组的挖掘和鉴定。共获得99 298条Unigenes,其中71 514条被公共数据库成功注释。头花蓼的基因组中,共鉴定得到50个FOMT基因,系统发育树显示FOMT基因分为咖啡酰辅酶A O-甲基转移酶(caffeoyl CoA O-methyltransferase,CCoAOMT)亚家族和咖啡酸O-甲基转移酶(caffeic acid O-methyltransferase,COMT)亚家族两个亚类。基因序列特征分析显示FOMT编码氨基酸的数目介于99~1053aa,分子质量为11 224.91~86 687.42 Da,等电点为4.79~9.45,50个FOMT家族成员均为疏水性蛋白,亚细胞定位结果显示54%的FOMT亚家族CCoAOMT及COMT成员定位于细胞质,28%定位于叶绿体。FOMT基因具有组织特异性,在头花蓼花中高表达,其次是茎,在根中表达最低。本研究对头花蓼FOMT基因家族进行鉴定与分析,为进一步深入研究FOMT功能和甲基化黄酮类化合物的生物合成提供理论依据。

关键词：头花蓼转录组黄酮类化合物O-甲基转移酶生物信息学表达分析

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冷却塔热羽对核电厂周围流动与扩散影响的数值模拟研究

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辐射防护 2024年第4期44卷 383-390页

作者：裴娟李若洁张俊芳赵丹王雪浦祥上海核工程研究设计院股份有限公司上海200030 中国辐射防护研究院太原030006

以某核电厂为研究对象,利用计算流体力学(CFD)方法研究了自然通风冷却塔对核电厂周围气流流动与污染物扩散的影响,并与风洞实验结果进行了比对,以验证模式有效性。结果表明:冷却塔背风侧,在近尾流区风速显著减小,湍流强度显著增大。冷... 详细信息

以某核电厂为研究对象,利用计算流体力学(CFD)方法研究了自然通风冷却塔对核电厂周围气流流动与污染物扩散的影响,并与风洞实验结果进行了比对,以验证模式有效性。结果表明:冷却塔背风侧,在近尾流区风速显著减小,湍流强度显著增大。冷却塔位于烟囱下风向时热羽排放对烟囱污染物扩散的影响较大,污染物通过冷却塔自然卷吸,出现二次排放现象,有热羽排放时的地面轴线扩散因子在1000 m前小于无热羽排放的。

关键词：冷却塔热羽流场浓度场数值模拟

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市售药食同源保健花茶物种鉴定研究

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药学学报 2024年第9期59卷 2612-2624页

作者：孙靖黄子怡李思齐李余芳胡艳郭世文胡格申传璞杨芙蓉林余霖辛天怡浦香东安徽医科大学药学院安徽合肥230032 中国医学科学院、北京协和医学院药用植物研究所国家中医药管理局中药资源保护重点研究室北京100193

掺伪混伪严重影响药材质量,进而危及人类健康。药食同源保健食品属于中药衍生物,相比于药物而言,其更易获取且贴近消费者生活。然而,市售药食同源保健食品中的中药组分真伪鉴定尚未引起重视,且无明确标准可依,急需开展系统性研究。本研... 详细信息

掺伪混伪严重影响药材质量,进而危及人类健康。药食同源保健食品属于中药衍生物,相比于药物而言,其更易获取且贴近消费者生活。然而,市售药食同源保健食品中的中药组分真伪鉴定尚未引起重视,且无明确标准可依,急需开展系统性研究。本研究基于DNA条形码分子鉴定技术,结合ITS2、psbA-trnH、matK通用条形码序列及DX、HH、JYH特异性条形码序列对市售药食两用保健花茶真伪进行鉴定,旨在对市场上流通的药食同源保健花茶产品真伪情况进行调查。研究结果显示:180份市售产品中共有164份样品成功获得DNA条形码序列,其余样品因无目标组分或DNA存在降解,无法获得扩增产物。结合性状鉴定研究发现180份样品中共有141份为正品,占总样品量的78.33%;31份样品存在掺伪现象,8份样品无目标组分,共占总样品量的21.67%。此外,水试研究发现,5份红花花茶样品存在红花掺重现象。本研究揭示药食同源保健花茶产品质量存在掺伪及掺重情况,提示监管部门应该加速药食同源保健食品领域质量标准的建立,为药食同源保健食品产业的快速发展提供参考。

关键词：药食同源中药花茶分子鉴定 DNA条形码真伪

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