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GATIS score for predicting the prognosis of rectal neuroendocrine neoplasms:A Chinese multicenter study of 12-year experience

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World Journal of Gastroenterology 2024年第28期30卷 3403-3417页

作者： Xin-Yu zeng Ming zhong Guo-Le Lin Cheng-Guo Li Wei-zhong Jiang Wei Zhang Li-Jian Xia Mao-Jun Di Hong-Xue Wu Xiao-Feng Liao Yue-Ming Sun Min-Hao Yu Kai-Xiong Tao Yong Li Rui Zhang Peng Zhang Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Gastrointestinal Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Colorectal Surgery Fujian Medical UniversityFuzhou 350401Fujian ProvinceChina Department of Colorectal Surgery Changhai HospitalShanghai 200433China Department of Gastrointestinal Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250118Shandong ProvinceChina Department of Gastrointestinal Surgery Taihe HospitalHubei University of MedicineShiyan 442099Hubei ProvinceChina Department of Gastrointestinal Surgery I Section Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of General Surgery Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina Department of Colorectal Surgery Jiangsu Province HospitalNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal Surgery School of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Department of Colorectal Surgery Liaoning Cancer HospitalShenyang 110042Liaoning ProvinceChina

BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)using data from a large *** Data from patients with primary R-NENs were retrospectively collected from 17 large-scale referral medical centers in *** forest and Cox proportional hazard models were used to identify the risk factors for overall survival and progression-free survival,and two nomograms were *** A total of 1408 patients with R-NENs were *** grade,T stage,tumor size,age,and a prognostic nutritional index were important risk factors for *** GATIS score was calculated based on these five *** overall survival prediction,the respective C-indexes in the training set were 0.915(95%confidence interval:0.866-0.964)for overall survival prediction and 0.908(95%confidence interval:0.872-0.944)for progression-free survival *** to decision curve analysis,net benefit of the GATIS score was higher than that of a single *** time-dependent area under the receiver operating characteristic curve showed that the predictive power of the GATIS score was higher than that of the TNM stage and pathological grade at all time *** The GATIS score had a good predictive effect on the prognosis of patients with R-NENs,with efficacy superior to that of the World Health Organization grade and TNM stage.

关键词： Rectal neuroendocrine neoplasm Nomogram Random forest Prognosis Overall survival Progression-free survival

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Research landmarks on the 60th anniversary of Epstein-Barr virus

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Science China Life Sciences 2024年

作者： Lan-Yi zhong Chu Xie Le-Le Zhang Yan-Lin Yang Yuan-Tao Liu Ge-Xin Zhao Guo-Long Bu xian-Shu Tian Zi-Ying Jiang Bo-Yu Yuan Peng-Lin Li Pei-Huang Wu Wei-Hua Jia Christian Münz Benjamin E.Gewurz Qian zhong Cong Sun Mu-Sheng zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangdong Provincial Clinical Research Center for Cancer Sun Yat-sen University Cancer Center Viral Immunobiology Institute of Experimental Immunology University of Zürich Division of Infectious Diseases Department of Medicine Brigham and Women's Hospital Department of Microbiology Harvard Medical School Harvard Program in Virology Broad Institute of Harvard and MIT

Epstein-Barr virus(EBV), the first human oncovirus discovered in 1964, has become a focal point in virology, immunology, and oncology because of its unique biological characteristics and significant role in human diseases. As we commemorate the 60th anniversary of EBV's discovery, it is an opportune moment to reflect on the major advancements in our understanding of this complex virus. In this review, we highlight key milestones in EBV research, including its virion structure and life cycle, interactions with the host immune system, association with EBV-associated diseases, and targeted intervention strategies.

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A simplified noncryogenic strategy to transport mesenchymal stem cells: Potential applications in cell therapy and regenerative medicine

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Genes & Diseases 2024年第3期11卷 26-29页

作者： xiangyu Dong Yannian Gou Meichun Guo Jiamin zhong Aohua Li Ailing Hao Wei zeng Rex C.Haydon Hue H.Luu Russell R.Reid Tongchuan He Yan Xu Jiaming Fan Ministry of Education Key Laboratory of Diagnostic Medicine And Department of Clinical BiochemistryCollege of Laboratory MedicineChongqing Medical UniversityChongqing 400016China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Department of Interventional Neurology The First Dongguan Affiliated HospitalGuangdong Medical UniversityDongguanGuangdong 523475China Laboratory of Craniofacial Suture Biology and Development Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Institute of Sports Medicine Beijing Key Laboratory of Sports InjuriesPeking University Third HospitalBejing 100191China

With the rapid advances in stem cell research and po-tential cell-based therapies,there is an urgent need to develop safe and reliable cell transport *** for autologous stem cell-based therapies,allogeneic stem cell therapies and ex vivo genetically engineered cell therapies would require safe,efficient,and reliable cell preservation and transport methods.

关键词： transport methods simplified

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Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis

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Reproductive and Developmental Medicine 2024年第2期8卷 111-120页

作者： Dan Mo zhong-Hong zeng Xin Sui Rong Li Yi-Hua Yang Guangxi Reproductive Medical Center the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Nanning 530021China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning 530021China Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of Education/Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology/National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital)Beijing 100191China

The female ovaries are critical for follicle growth and development in the process known as"folliculogenesis".This complex process is regulated by various factors,among which the microenvironment around follicles appears to be *** to previous studies,folliculogenesis is an energy-demanding *** fact,well-balanced follicular energy metabolism is associated with ovarian function and female ***,glucose metabolism has been widely described as the main source of energy during ***,the follicular glucose metabolism profiles change dynamically during follicular *** abnormalities during folliculogenesis are associated with aging,primary ovarian insufficiency,and polycystic ovary syndrome,thereby leading to subfertility and infertility in *** signaling pathways in follicles appear to form a link between glucose metabolism and ***,a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental *** review aimed to describe variations in glucose metabolism at different stages of folliculogenesis,provide new insights into glucose metabolic disorder-related diseases,and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis:phosphatidylinositol 3-kinase,protein kinase B(PI3K-PKB/AKT),and AMP-activated protein kinase(AMPK)signaling pathways.

关键词： Folliculogenesis Glucose metabolism Glycolysis Oxidative phosphorylation Signaling pathway

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“大食物观”背景下中国水产养殖业可实现产能测算

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上海海洋大学学报 2024年第3期33卷 811-821页

作者：徐忠曾婷婷上海海洋大学经济管理学院上海201306 中国渔业发展战略研究中心上海201306

测算水产养殖业潜在产能对保障食物安全意义重大,但目前对我国水产养殖业产能的动态变化研究较少。论文基于传统农业产能测算方案,创新性提出了1个综合性的测算方案,按生产方式,分省、分区测算我国水产养殖业可实现产能,并对测算结果进... 详细信息

测算水产养殖业潜在产能对保障食物安全意义重大,但目前对我国水产养殖业产能的动态变化研究较少。论文基于传统农业产能测算方案,创新性提出了1个综合性的测算方案,按生产方式,分省、分区测算我国水产养殖业可实现产能,并对测算结果进行了分析。结果表明:综合性的测算方案切合实际,具有便捷性和科学性。这一方案可在全国推广,运用到省、市、县的水产养殖产能测算工作中。开展大规模本底调查是下一步产能测算的重要工作。我国水产养殖业可实现产能测算为7300万t。养殖面积下降已对水产养殖业产能带来较大负面影响,单产水平的提高对产能贡献巨大。位于西南地区的贵州、云南和东北地区的吉林、黑龙江是未来扩大产能最具潜力地区。稳住养殖面积与提高单产水平是提高渔业产能的两个抓手,提高海水大水面养殖的单产水平对提高我国大水面养殖产能的促进作用更大。

关键词：大食物观水产养殖业可实现产能产能测算

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Regeneration of photovoltaic industry silicon waste toward high-performance lithium-ion battery anode

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Rare Metals 2024年第10期43卷 4948-4960页

作者： Kai Wang Xiao-Bin zhong Yue-xian Song Yao-Hui Zhang Yan-Gang Zhang Xiao-Gang You Pu-Guang Ji Kurbanov Mirtemir Shodievich Umedjon Khalilov Gong-Kai Wang Xin Zhang Xing-Liang Yao Feng Li Jun-Fei Liang Hua Wang School of Energy and Power Engineering North University of China zhongyuan Critical Metals Laboratory Zhengzhou University Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Material Science and EngineeringHebei University of Technology Arifov Institute of Ion-Plasma and Laser Technologies Academy of Sciences of the Republic of Uzbekistan New Uzbekistan University Arifov Institute of Ion-Plasma and Laser Technologies Academy of Sciences of Uzbekistan University of Antwerp School of Chemistry Beihang University

The diamond-wire sawing silicon waste（DWSSW） from the photovoltaic industry has been widely considered as a low-cost raw material for lithium-ion battery silicon-based electrode,but the effect mechanism of impurities presents in DWSSW on lithium storage performance is still not well understood;meanwhile,it is urgent to develop a strategy for changing DWSSW particles into high-performance electrode *** this work,the occurrence state of impurities presents in DWSSW was carefully analyzed using in situ Ar ion etching technology Then,the novel Si@C@SiOx@PAl-NDC composite was designed through in situ encapsulation *** obtained Si@C@SiOx@PAl-NDC electrode shows a high first capacity of 2343.4 mAh·g-1with an initial Coulombic efficiency （ICE） of 84.4%under current density of 1.0 A·g-1,and can deliver an impressive capacity of 984.9 mAh·g-1after 200 *** numerical simulation modeling calculations,the increase in proportion of Si4+/Si0and Si3+/Si0valence states in SiOxlayer leads to a decrease in von Mises stress,which ultimately improves the cycling structural ***,the porous 2D-3D aluminum/nitrogen （Al/N） co-doped carbon layer and nanowires on SiOxlayer can provide abundant active sites for lithium storage due to its developed hierarchical pores structure,which facilitates ion transport What is more,the performance of Si@C@SiOx@PAl-NDC//LiFePO4full cell shows its great potential in practical application.

关键词： Aluminum/nitrogen co-doped In situ encapsulation Lithium-ion batteries Porous carbon nanowires Sawing silicon waste

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Review of 2D Bi_(2)X_(3)(X=S,Se,Te):from preparation to photodetector

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Rare Metals 2024年第6期43卷 2349-2370页

作者： Zhi zeng Dong-Bo Wang Xuan Fang Jia-Mu Cao Bing-Ke Zhang Jing-Wen Pan Dong-Hao Liu Si-Hang Liu Shu-Jie Jiao Tian-Yuan Chen Gang Liu Lian-Cheng Zhao Jin-zhong Wang Department of Optoelectronic Information Science School of Materials Science and EngineeringHarbin Institute of TechnologyHarbin 150001China Changchun University Science and Technology School of PhysicsThe State Key Laboratory of High Power Semiconductor LasersChangchun 130022China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Detector has become an indispensable part of human *** increasing demand for photodetectors with high performance has promoted the research of novel *** the same time,with the development of rising material system,two-dimensional(2D)materials attract a lot of attention,while the suitable option for fabricating photodetector is still *** prospering of bismuth chalcogenides injected new vitality for material field,thereinto,the unique topological insulator characteristics make the research on bismuth selenide(Bi_(2)X_(3))and bismuth telluride(Bi_(2)X_(3)) intriguing.2D Bi_(2)X_(3) also exhibits unique features among various 2D materials,of which,the adjustable narrow energy band gap and polarization-sensitive photocurrent contribute to the promising application of high performance and broadband *** this review,from a bottom-up perspective,we summarize fundamental properties,synthesis method,photodetector performance of 2D Bi_(2)X_(3) based on the previous study,which provide an overall perspective of 2D Bi_(2)X_(3).Wherein,the section of the photodetector is specifically discu ssed with regard to pure Bi_(2)X_(3) photodetector and heterojunction photodetector.A brief summary and outlook were also explored in the end.

关键词： Bi_(2)X_(3) Preparation 2D Photodetector

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Design and implementation of low-cost geomagnetic field monitoring equipment for high-density deployment

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Applied Geophysics 2024年第3期21卷 505-512,618页

作者： Sun Lu-Qiang Bai xian-Fu Kang Jian zeng Ning Zhu Hong Zhang Ming-Dong Tianjin Earthquake Agency Tianjin 300201China Yunnan Earthquake Agency Kunming 650224China

The observation of geomagnetic field variations is an important approach to studying earthquake *** 1987,the China Earthquake Administration has explored this seismomagnetic *** particular,they studied local magnetic field anomalies over the Chinese mainland for earthquake *** to the years of research on the seismomagnetic relationship,earthquake prediction experts have concluded that the compressive magnetic effect,tectonic magnetic effect,electric magnetic fluid effect,and other factors contribute to preearthquake magnetic ***,this involves a small magnitude of magnetic field *** is difficult to relate them to the abnormal changes of the extremely large magnetic field in regions with extreme earthquakes owing to the high cost of professional geomagnetic equipment,thereby limiting large-scale ***,it is difficult to obtain strong magnetic field changes before an *** Tianjin Earthquake Agency has developed low-cost geomagnetic field observation equipment through the Beijing–Tianjin–Hebei geomagnetic equipment test *** new system was used to test the availability of equipment and determine the findings based on big data..

关键词： geomagnetic field earthquake prediction low cost high density big data

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季节性生态旅游地的旅游化过程与机制及其启示——基于新疆赛里木湖案例

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自然资源学报 2024年第7期39卷 1626-1642页

作者：梁增贤李新静中山大学旅游学院珠海519082 新疆历史文化旅游可持续发展重点实验室乌鲁木齐830046

如何平衡保护与开发、淡季与旺季问题是促进生态旅游地高质量发展的关键,而旅游化是生态地区常用的平衡途径。然而,现有旅游化研究缺乏有效的分析工具和解释机制,难以厘清旅游地历时态的阶段性特征、因果机制及其时空影响。拓展旅游化... 详细信息

如何平衡保护与开发、淡季与旺季问题是促进生态旅游地高质量发展的关键,而旅游化是生态地区常用的平衡途径。然而,现有旅游化研究缺乏有效的分析工具和解释机制,难以厘清旅游地历时态的阶段性特征、因果机制及其时空影响。拓展旅游化理论的应用情境,构建包含时空维度的旅游化模型,并开展案例研究,采用观察法、访谈法和收集二手数据等方式获得多源数据,解释与厘清新疆赛里木湖景区由生态牧场到成熟生态旅游地20多年的旅游化过程及其内在机制。研究表明:赛里木湖的旅游化经历政府主导的内部空间旅游化、政府主导的外部空间旅游化、企业主导的深度时空旅游化、政企主导的淡季时间旅游化四个阶段,总体上呈现先内部旅游化、再外部旅游化及先旺季和白天的旅游化、再夜间和淡季旅游化等特征。赛里木湖旅游化的各阶段互有交叉,解决的关键问题和旅游化的驱动力均不同。其中,内部旅游化是构建吸引力的重点,外部旅游化是发挥吸引力的关键,二者应相互协调。本文提出的旅游化模型为理解旅游化的演进规律和各阶段的因果关系及其影响提供了分析工具,为生态旅游地平衡保护与开发、破解淡旺季供需矛盾、促进高质量发展提供路径指引和案例借鉴。

关键词：生态旅游旅游化季节性旅游目的地赛里木湖

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一种可重构微波光子混频器的设计与研究

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激光与光电子学进展 2024年第5期61卷 459-465页

作者：韩一石李贤钟永明曾昶盛广东工业大学信息工程学院广东广州510006

提出一种可重构微波光子混频器的设计与研究方案,该方案仅通过改变驱动信号和直流偏置电压,即可重构生成线性调频信号、变频信号或移相信号。其中,生成的线性调频信号具有三个波段,带宽最高可提高四倍;上、下变频信号可同时生成;获得的... 详细信息

提出一种可重构微波光子混频器的设计与研究方案,该方案仅通过改变驱动信号和直流偏置电压,即可重构生成线性调频信号、变频信号或移相信号。其中,生成的线性调频信号具有三个波段,带宽最高可提高四倍;上、下变频信号可同时生成;获得的移相信号相位可在0~360°连续调谐。仿真结果表明,该方案可生成频率11 GHz和带宽2 GHz、频率18 GH和带宽4 GHz,以及频率29 GHz和带宽2 GHz的线性调频信号,脉冲压缩性能良好;可同时生成频率32 GHz的上变频信号以及8 GHz的下变频信号,电杂散抑制比高于30 dB;亦可生成0~360°相位连续可调的移相信号,且功率波动在0.1 dB以内,系统的无杂散动态范围达到114.1 dB·Hz^(2/3)。

关键词：光通信微波光子混频线性调频移相

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