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Promotion and Mechanism of Acupotomy on Chondrocyte Autophagy in Knee Osteoarthritis Rabbits

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Chinese Journal of Integrative Medicine 2024年第9期30卷 809-817页

作者： LU Man MENG De-hong SHE Ze-yu WU xian XIA Shuai YANG Kai-ning LIU Cun-bin LI Tao YANG yong-hui The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei230031China The Second Affiliated Hospital of Anhui University of Chinese Medicine Hefei230038China Department of Acupotomy Rehabilitation Anhui Provincial Hospital of Integrated Traditional Chinese and Western MedicineHefei230031China

Objective:To explore the effect of acupotomy intervention on autophagy of chondrocytes in rabbits with knee osteoarthritis(KOA),and to determine the possible mechanisms of acupotomy to alleviate cartilage ***:The modified Videman method was used to construct a KOA rabbit *** modeling,40 rabbits were randomly divided into 4 groups by a random number table:control;KOA(model);KOA+acupotomy(acupotomy),and KOA+sham acupotomy(sham),10 in each *** a 3-week treatment course,the knee joint activity was determined by the modified Lequesne MG ***-eosin staining staining was used to examine the morphological changes of *** of chondrocytes was observed by transmission electron *** surface morphology of cartilage tissue was observed by scanning electron *** mRNA and protein levels of AMP kinase/mammalian target of rapamycin/Unc-51(AMPK/mTOR/ULK1)signal pathway key proteins,autophagy-related factor Beclin-1 and microtubule-associated protein 1A/1B light chain 3(LC3)in rabbit knee cartilage were assessed by real-time fluorescence quantitative polymerase chain reaction and Western blot,***:The modified Lequesne MG score of acupotomy group was significantly lower than that of model group(Plin-1 and the protein levels of p-AMPK,p-ULK1,Beclin-1,and LC3Ⅱ/LC3Ⅰwere decreased in the model group,while the mRNA and protein expressions of mTOR were increased(Plin1,reduce the expression of mTOR,promote autophagy,and alleviate joint *** is a promising complementary and alternative therapy for KOA.

关键词： acupotomy knee asteoarthritis autophagy AMPK/mTOR/ULK1 signaling pathway rabbit

Exploring the vital role of microglial membrane receptors in Alzheimer’s disease pathogenesis: a comprehensive review

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BIOCELL 2024年第7期48卷 1011-1022页

作者： JUN-FENG ZHAO YI-RAN JIANG TIAN-lin GUO yong-QING JIAO XUN WANG Department of Neurointervention Center Dalian No.3 People’s HospitalDalian Medical UniversityDalianChina Department of Clinical Medicine China Medical UniversityShenyangChina

Neurodegenerative diseases constitute a broad category of diseases caused by the degeneration of the *** are mainly manifested by the gradual loss of neuron structure and function and eventually can cause death or loss of *** the global population ages rapidly,increased people are being diagnosed with neurodegenerative *** has been established that the onset of Alzheimer’s disease(AD)is closely linked with increasing age and its major pathological features include amyloid-beta plaques(Aβ),Tau hyperphosphorylation,Neuroﬁbrillary tangles(NFTs),neuronal death as well as synaptic *** involvement of microglia is crucial in the pathogenesis and progression of AD and exhibits a dual *** instance,in the early stage of AD,microglia surface membrane proteins or receptors can participate in immunophagocytosis,and anti-inﬂammatory functions and act as a physical barrier after recognizing various ligands such as Aβand ***,in the later stage of the disease,membrane receptors on the surface of microglia can cause its activation to release a substantial quantity of pro-inﬂammatory *** can amplify the neuroinﬂammatory *** rapid decline of normal immune phagocytosis can result in the continuous accumulation of abnormal proteins,leading to neuronal dysfunction and destruction of the formed physical barrier as well as the neurovascular *** can also increase the transformation of microglia from anti-inﬂammatory phenotype M2 to pro-inﬂammatory phenotype M1,induce severe neuronal injury or apoptosis,and aggravate the progression of *** to few articles have focused on the AD-related membrane protein receptors on microglia,thus in this paper,we have reviewed several representative microglial membrane proteins or receptors about their speciﬁc roles and functions implicated in AD,and expect that there will be more in-depth research and scientiﬁc research results in the treatment of AD by targeted regulation of mi

关键词： Neurodegeneration Glial cell Receptor Alzheimer’s disease

Vonoprazan-amoxicillin dual therapy for Helicobacter pylori eradication in Chinese population:A prospective,multicenter,randomized,two-stage study

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World Journal of Gastroenterology 2024年第27期30卷 3304-3313页

作者： Xue-Ping Huang Zhi-Hui lin Yi-Juan Liu Shao-Wei lin Yan-Feng Shao Feng Qiu Qing-Wu Qiu Zhang-Kun Xu Jin-xian Chen Liang-Huo Chen Zhen-Qun lin Wen-Hua Dai Ming-Qing Zhang Qi Jiang Zhong-Qin Xiao xian-Xing Cheng xiang-Fei Zhang Wen-Bin You Wei Chen Long-Qin Li Wei-Xing lin yong-Fu Wang Fu-Jin Lai Long-Qun Chen Zhong-Hua Huang Wen-Qi Zheng Jin-Qi Wei Department of Gastroenterology Shengli Clinical Medical College of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial HospitalFuzhou 350001Fujian ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina School of Public Health Fujian Medical UniversityFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Third People’s Hospital of Fujian ProvinceFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Fujian Provincial Hospital North Brance Fujian Provincial Geriatric HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Xiaoao HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The General Hospital of Fujian Energy GroupFuzhou 350000Fujian ProvinceChina Department of Gastroenterology The Second Hospital of ZhangzhouZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Anxi Country HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Zhangzhou Municipal Hospital of TCMZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology Zhangpu HospitalZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology The Affiliated Dongnan Hospital of Xiamen UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastroenterology First Hospital of Nanping CityNanping 353000Fujian ProvinceChina Department of Gastroenterology Fujian Nanping Second HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Wuyishan Municipal HospitalNanping 353000Fujian ProvinceChina Department of Gastroenterology Fuzhou Changle District HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Changle City Second HospitalFuzhou 350000Fujian ProvinceChina Department of Gastroenterology Jinjiang Municipal HospitalQuanzhou 362000Fujian ProvinceChina Department of Gastroenterology Fuding Hospital Affiliated to Fuj

BACKGROUND The efficacy of Vonoprazan-amoxicillin dual therapy(VAT)in the treatment of Helicobacter pylori(***)is *** To evaluate the efficacy of VAT in the Chinese *** This prospective,multicenter,randomized,open-label,and two-stage study was conducted at 23 centers in Fujian,China(May 2021-April 2022).***-infected patients were randomized to bismuth quadruple therapy(BQT),BQT-Vonoprazan(BQT-V),seven-day VAT(VAT-7),ten-day VAT(VAT-10),and fourteen-day VAT(VAT-14)*** primary endpoint was the *** eradication *** secondary endpoint was the frequency of adverse *** study was registered with the Chinese Clinical Trial Registry,*** In the first stage,VAT-7 and BQT-V groups were selected for early termination because less than 23 among 28 cases were *** the second stage,the eradication rates for BQT,VAT-10,and VA-14 were 80.2%[95%confidence interval(95%CI):71.4%-86.8%],93.2%(86.6%-96.7%),92.2%(85.3%-96.0%)in the intention-to-treat(ITT)analysis,and 80.9%(95%CI:71.7%-87.5%),94.0%(87.5%-97.2%),and 93.9%(87.4%-97.2%)in the per-protocol *** ITT analysis showed a higher eradication rate in the VAT-10 and VAT-14 groups than in the BQT group(P=0.022 and P=0.046,respectively).The incidence of adverse events in the VAT-10 and VAT-14 groups was lower than in the BQT group(25.27%and 13.73%vs 37.62%,respectively;P<0.001).CONCLUSION VAT with a duration of 10 or 14 days achieves a higher eradication rate than the BQT,with a more tolerable safety profile in ***-infected patients in *** XP et *** for *** eradication.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Bismuth quadruple therapy

Pedestrian trajectory prediction method based on the Social-LSTM model for vehicle collision

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Transportation Safety and Environment 2024年第3期6卷 140-151页

作者： yong Han Xujie lin Di Pan Yanting Li Liang Su Robert Thomson Koji Mizuno School of Mechanical and Automotive Engineering Xiamen University of TechnologyXiamen 361024China Fujian Province Key Laboratory of Advanced Design and Manufacturing of Buses Xiamen 361024China Engineering Research Institute of Xiamen Kinglong United Automobile Industry Co. Ltd.Xiamen 361000China Chalmers University of Technology Gothenburg 41296Sweden Department of Mechanical Systems Engineering Nagoya UniversityNagoya 464-8603Japan

Techniques for predicting the trajectory of vulnerable road users are important to the development of perception systems for autonomous vehicles to avoid *** most effective trajectory prediction methods,such as Social-LSTM,are often used to predict pedestrian trajectories in normal passage ***,they can produce unsatisfactory prediction results and data redundancy,as well as difficulties in predicting trajectories using pixel-based coordinate systems in collision avoidance *** is also a lack of validations using real vehicle-to-pedestrian *** address these issues,some insightful approaches to improve the trajectory prediction scheme of Social-LSTM were proposed,such methods included transforming pedestrian trajectory coordinates and converting image coordinates to world *** YOLOv5 detection model was introduced to reduce target loss and improve prediction *** DeepSORT algorithm was employed to reduce the number of target transformations in the tracking *** Perspective Transformation(IPT)and Direct linear Transformation(DLT)theories were combined to transform the coordinates to world coordinates,identifying the collision location where the accident could *** performance of the proposed method was validated by training tests using MS COCO(Microsoft Common Objects in Context)and ETH/UCY *** results showed that the target detection accuracy was more than 90%and the prediction loss tends to decrease with increasing training steps,with the final loss value less than 1%.The reliability and effectiveness of the improved method were demonstrated by benchmarking system performance to two video recordings of real pedestrian accidents with different lighting conditions.

关键词： vehicle-to-pedestrian collisions pedestrian trajectory prediction YOLOvB DeepSORT Social-LSTM

A mixed-valence polyoxometalate-based 3D inorganic framework cathode material for high-efficiency rechargeable AZIBs

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Rare Metals 2024年第8期43卷 3677-3691页

作者： Qing Han Hao-Ran Xiao Tao Zhou Bing-Chuan Li Liu Yang ling-ling Xie Xue-Jing Qiu xian-yong Wu Li-Min Zhu Xiao-Yu Cao School of Chemistry and Chemical Engineering Henan University of TechnologyZhengzhou 450001China Key Laboratory of High Specific Energy Materials for Electrochemical Power Sources of Zhengzhou City Zhengzhou 450001China College of Materials Engineering Henan University of EngineeringZhengzhou450007China School of Environmental Engineering Henan University of TechnologyZhengzhou 450001China Department of Chemistry University of Puerto Rico-Rio Piedras CampusSan JuanPR 00925USA

The global trend towards new energy storage systems has stimulated the development of electrochemical energy storage *** these technologies,rechargeable aqueous zinc-ion batteries(AZIBs)have attracted considerable interest as a potential alternative to lithium-ion batteries(LIBs)due to their affordable cost,environmental compatibility and high safety *** this study,a high-quality electrode for AZIBs has been successfully developed using a dehydrated mixed-valence polyoxometalate-based three-dimensional(3D)inorganic framework material known as[H_6Mn_(3)V^Ⅳ_(15)V-^Ⅴ_(4O)_(46)(H_2O)_(12)](3D-MnVO).This innovative 3D-MnVO material is built from the alternate connections of{V_(19)O_(46)}"sphere-shaped"clusters andμ_(2)-{Mn(H_(2)O)_(4)}bridges,where each{V_(19)O_(46)}cluster is surrounded by three pairs of vertically distributed{Mn(H_(2)O)_(4)}units,thus resulting in the 3D interpenetrating grid-like network from the infinite[-{V_(19)O_(46)}-μ_(2)-Mn(H_(2)O)_(4)-{V_(19)O_(46)}]_∞chains in three mutually perpendicular *** 3D framework structure of 3D-MnVO possesses abundant oxygen vacancies,spacious and multi-level interconnected channels for ion transport,which facilitates the efficient intercalation/deintercalation of hydrated Zn^(2+)into the pores of the primary structure via the intercalation capacitance *** a result,the 3D-MnVO electrode exhibits excellent diffusion rates and minimal interfacial *** a current density of 0.1 A·g^(-1),the 3D-MnVO cathode delivers a commendable discharge capacity of170.5 mAh·g^(-1)with 81.6%capacity retention after100 charge/discharge ***,even at a high current density of 1.0 A·g^(-1),the 3D-MnVO electrode delivers a remarkable reversible capacity of198.9 mAh·g^(-1).Our research results provide valuable insights into the development of advanced polyoxometalate-based 3D inorganic framework electrode materials for high-performance rechargeable AZIBs.

关键词： Cathode Polyoxometalate 3D inorganic framework Zinc-ion batteries Energy storage mechanism

Evaluation of the clinical effects of atropine in combination with remifentanil in children undergoing surgery for acute appendicitis

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2065-2072页

作者： Yu-Juan Li yong-Yan Chen Xia-Lan lin Wei-Zhi Zhang Department of Anesthesiology Shanxi Provincial Children’s HospitalTaiyuan 030013Shanxi ProvinceChina

BACKGROUND Acute appendicitis(AA)is the most common cause of acute abdomen in *** significantly influences the surgical treatment of AA in children,making the scientific and effective selection of anesthetics *** To assess the clinical effect of atropine(ATR)in combination with remifentanil(REMI)in children undergoing surgery for *** In total,108 cases of pediatric AA treated between May 2020 and May 2023 were selected,58 of which received ATR+REMI[research group(RG)]and 50 who received REMI[control group(CG)].Comparative analyses were conducted on the time to loss of eyelash reflex,pain resolution time,recovery time from anesthesia,incidence of adverse events(AEs;respiratory depression,hypoxemia,bradycardia,nausea and vomiting,and hypotension),intraoperative responses(head shaking,limb activity,orientation recovery,safe departure time from the operating room),hemodynamic parameters[oxygen saturation(SPO2),mean arterial pressure,heart rate,and respiratory rate],postoperative sedation score(Ramsay score),and pain level[the Face,Legs,Activity,Cry,Consolability(FLACC)Behavioral Scale].RESULTS Compared with the CG,the RG showed significantly shorter time to loss of eyelash reflex,pain resolution,recovery from anesthesia,and safe departure from the operating ***,the incidence rates of overall AEs(head shaking,limb activity,etc.)were lower,and influences on intraoperative hemodynamic parameters and stress response indexes were *** Ramsay score at 30 min after extubation and the FLACC score at 60 min after extubation were significantly lower in the RG than in the *** ATR+REMI is superior to REMI alone in children undergoing AA surgery,with a lower incidence of AEs,fewer influences on hemodynamics and stress responses,and better post-anesthesia recovery.

关键词： Atropine Remifentanil Pediatric acute appendicitis Surgery Clinical efficacy

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减阻增程弹道的射程估算与特性分析

宇航学报 2017年第10期38卷 1048-1056页

作者：凌王辉鲜勇郭玮林李杰张大巧火箭军工程大学七系西安710025

为实现弹道导弹射程的快速估算和减阻设计后弹道增程的定量分析,提出一种基于导弹基本参数的射程快速精确估算方法。通过建立减阻模型,仿真计算得到气动阻力系数表,并对速度计算公式进行逐项积分,利用高度近似值和气动系数拟合结果得到... 详细信息

为实现弹道导弹射程的快速估算和减阻设计后弹道增程的定量分析,提出一种基于导弹基本参数的射程快速精确估算方法。通过建立减阻模型,仿真计算得到气动阻力系数表,并对速度计算公式进行逐项积分,利用高度近似值和气动系数拟合结果得到关机点状态量和射程的初步值,最终通过迭代计算得到满足精度要求的射程结果。仿真结果表明,经过高度和气动系数的迭代计算能有效快速得到满足精度的计算结果,通过减阻设计,导弹射程提高了162.36 km,增程的效果明显。

关键词：减阻设计弹道增程射程快速估算气动拟合迭代计算

Intermediate-mass black holes in Green pea galaxies(IMBH-GP)I:A candidate sample from LAMOST and SDSS

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 147-161页

作者： Ruqiu lin Zhen-Ya Zheng Fang-Ting Yuan Jun-xian Wang Chunyan Jiang Ning Jiang lingzhi Wang linhua Jiang xiang Ji Shuairu Zhu Xiaodan Fu Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of SciencesShanghai 200030China School of Astronomy and Space Sciences University of Chinese Academy of SciencesBeijing 100049China CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of ChinaHefei 230026China Chinese Academy of Sciences South America Center for Astronomy(CASSACA) National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China

The scaling relation of central massive black holes(M_(BH)s)and their host galaxies is well-studied for supermassive BHs(SM_(BH)s,M_(BH)≥10^(6)M_(⊙)).However,this relation has large uncertainties in the mass range of the intermediate-mass BHs(IM_(BH)s,M_(BH)~10^(3)-10^(6)M_(⊙)).Since Green pea(GP)galaxies are luminous compact dwarf galaxies,which may be likely to host less massive SM_(BH)s or even IM_(BH)s,we systematically search for M_(BH)s in a large sample of 2190 GP galaxies at zline width,BPT diagram,mid-infrared color,X-ray luminosity,and radio *** studies show that it is very promising to find IM_(BH)s in GP galaxies,and the BH sample so obtained enables us to probe the connection between the M_(BH)s and compact dwarf galaxies in the low-redshift Universe.

关键词： SMBHs IMBHs Green pea galaxies compact dwarf galaxies

A Generic Strategy to Create Mechanically Interlocked Nanocomposite/Hydrogel Hybrid Electrodes for Epidermal Electronics

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Nano-Micro Letters 2024年第5期16卷 120-133页

作者： Qian Wang Yanyan Li yong lin Yuping Sun Chong Bai Haorun Guo Ting Fang Gaohua Hu Yanqing Lu Desheng Kong College of Engineering and Applied Sciences National Laboratory of Solid State Microstructureand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210023People’s Republic of China State Key Laboratory of Analytical Chemistry for Life Science and Jiangsu Key Laboratory of Artificial Functional MaterialsNanjing UniversityNanjing 210023People’s Republic of China College of Chemical Engineering and Technology Engineering Research Center of Seawater Utilization Technology of Ministry of EducationState Key Laboratory of Reliability and Intelligence of Electrical EquipmentHebei University of TechnologyTianjin 300130People’s Republic of China Key Laboratory of Intelligent Optical Sensing and Manipulation Nanjing UniversityNanjing 210093People’s Republic of China

Stretchable electronics are crucial enablers for next-generation wearables intimately integrated into the human *** the primary compliant conductors used in these devices,metallic nanostructure/elastomer composites often struggle to form conformal contact with the textured *** electrodes have been consequently developed based on conductive nanocomposite and soft hydrogels to establish seamless skin-device ***,chemical modifications are typically needed for reliable bonding,which can alter their original *** overcome this limitation,this study presents a facile fabrication approach for mechanically interlocked nanocomposite/hydrogel hybrid *** this physical process,soft microfoams are thermally laminated on silver nanowire nanocomposites as a porous interface,which forms an interpenetrating network with the *** microfoam-enabled bonding strategy is generally compatible with various *** resulting interlocked hybrids have a 28-fold improved interfacial toughness compared to directly stacked *** electrodes achieve firm attachment to the skin and low contact impedance using tissue-adhesive *** have been successfully integrated into an epidermal sleeve to distinguish hand gestures by sensing mus-cle *** nanocomposite/hydrogel hybrids reported here offer a promising platform to combine the benefits of both materials for epidermal devices and systems.

关键词： Stretchable electronics Epidermal electronics Silver nanowire Conductive nanocomposites Hydrogel