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Clinical effects of antidiabetic drugs on psoriasis:The perspective of evidence-based medicine

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World Journal of Diabetes 2021年第8期12卷 1141-1145页

作者： mei-xian zhang Bo-Yuan Zheng Hai-Xiao Chen Ching-Wen Chien Evidence-based Medicine Center Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Public Laboratory Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina Institute for Hospital Management Tsing Hua UniversityShenzhen CampusShenzhen 518055Guangdong ProvinceChina Department of Orthopedics Taizhou Hospital of Zhejiang ProvinceWenzhou Medical UniversityLinhai 317000Zhejiang ProvinceChina

Psoriasis and diabetes shared common underlying pathophysiological *** data suggested that antidiabetic medications may improve the psoriasis severity in patients with diabetes *** hypoglycemic agents including thiazolidinediones,glucagon-like peptide-1 receptor agonists,dipeptidyl peptidase-4 inhibitors,and biguanides have been reported to make a remarkable reduction in the Psoriasis Area and Severity Index score from *** antipsoriatic effect could be mediated not only by the glucoselowering action of these agents but also via inhibition of keratinocyte over proliferation,increase expression of differentiation markers,suppression the immune inflammatory pathway,and blocking the calcium channels and mitogen-activated protein kinase signaling *** the other hand,there was no significant increase in adverse reactions associated with the treatment of pioglitazone or ***,previous studies often had the relatively short duration of the trials,and did not have enough power to assess recurrence of *** bias in the study and missing data could undermine the reliability of the ***,the appropriately randomized controlled studies with large sample sizes and long-term durations in various psoriasis patients are warranted for further support.

关键词： Psoriasis Hypoglycemic agents Thiazolidinediones Glucagon-like peptide-1 receptor agonists Dipeptidyl peptidase-4 inhibitors Biguanides Antipsoriatic effect Evidence-based medicine

OXIDATIVE COUPLING OF METHANE IN EMPTY REACTORS

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Journal of Energy Chemistry 1994年第2期 156-162页

作者： QIU xian-Qing zhang mei-Zhen ZHU Qi-Ming department of Chemistry, Tsinghua University Beijing 100084

Gas-phase OCM was investigated with various empty tubular reac-tors（quartz,ceranic and stainless steel tubes）.When temperature is higherthan 680℃,the CHconversions in three kinds of empty reactors are measur-able,and the gas-phase OCM becomes noticeable at 750℃ or higher *** temperature is beneficial to the activation of CHand the dehydro-genation of CNto *** time of reactants in the heated volumeplays an important role in the ags-phase *** indicated that thegas-phase OCM can be minimized by increasing reactant gas velocity or fillingthe free volume of the reactor with inert *** surface has effecton the *** may participate in some surface *** on the ki-netic results and the SEM investigation on the surfaces of reactors,a gas-phasereaction scheme of OCM is assumed.

关键词：山田 CO OXIDATIVE COUPLING OF METHANE IN EMPTY REACTORS

OXIDATIVE COUPLING OF METHANE OVER Na2O-La2O3/BaCO3 CATALYSTS

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Journal of Energy Chemistry 1994年第2期 150-155页

作者： Q1U xian-Qing zhang mei-Zhen ZHU Qi-Ming Department of Chemistry, Tsinghua University Beijing 100084

The oxidative coupling of methane over various alkali metal oxidespromoted LaOO/BaCOcatalysts and the effects of NaO content on the performance of NaO-LaO/BaCOcatalyst have been *** was found thatNaO promoted LaCO/BaCOcatalyst showed advantages of high CHconver-sion,Cselectivity and CH/CHratio,NaO might affect the properties ofcatalyst through elctronic and geometric *** highest Cyield（19.0一20.6%）over Na-9wt%LaO/BaCOcatalysts was obtained in the NaOcontent range of 1.0—3.0%.Effects of reaction conditions on OCM over3wt% NaO-9wt%LaCO/BaCOcatalyst were also *** catalystswere characterized by BET,TPD,and *** studies on 3wt% NaO-9wt%LaO/BaCOcatalyst demonstrated that CO,*** bestrongly on the *** might be related to the activation of CHand theformation and reseneration of active oxygen soecies.

关键词： Na La OXIDATIVE COUPLING OF METHANE OVER Na2O-La2O3/BaCO3 CATALYSTS

Bubble nucleation in spherical liquid cavity wrapped by elastic medium

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Chinese Physics B 2023年第6期32卷 323-332页

作者：张先梅李凡王成会胡静莫润阳沈壮志郭建中林书玉 Institute of Shaanxi Key Laboratory of Ultrasonics Shaanxi Normal UniversityXi'an 710119China

According to classical nucleation theory, gas nuclei can generate and grow into a cavitation bubble when the liquid pressure exceeds a threshold. However, classical nucleation theory does not include boundary effects. An enclosed spherical liquid cavity surrounded by elastic medium is introduced to model the nucleation process in tissue. Based on the equilibrium pressure relationship of a quasi-static process, the expressions of the threshold and the modified nucleation rate are derived by considering the tissue elasticity. It is shown that the constraint plays an important role in the nucleation process. There is a positive correlation between nucleation threshold pressure and constraint, which can be enhanced by an increasing tissue elasticity and reducing the size of the cavity. Meanwhile, temperature is found to be a key parameter of nucleation process, and cavitation is more likely to occur in confined liquids at temperature T > 100℃. In contrast, less influences are induced by these factors, such as bulk modulus, liquid cavity size, and acoustic frequency. Although these theoretical predictions of the thresholds have been demonstrated by many previous researches, much lower thresholds can be obtained in liquids containing dissolved gases, e.g., the nucleation threshold is about-21 MPa in a liquid of 0.8-nm gas nuclei at room temperature. Moreover, when there is a gas nucleus of 20 nm, the theoretical threshold pressure might be less than1 MPa.

关键词： elastic confinement liquid cavities cavitation nucleation

Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： mei zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

基于准三维冰形算法的结冰预测技术及应用研究

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飞行力学 2017年第2期35卷 76-79页

作者：赵宾宾黎先平张美红张淼周峰上海飞机设计研究院总体气动部上海201210 上海飞机设计研究院科学技术委员会上海201210

机翼结冰是威胁民用飞机飞行安全的主要因素之一,准确预测机翼的结冰过程和特点,可为防除冰设计提供依据和支撑。提出了利用二维模拟三维的准三维冰形算法,该算法在保证结冰预测精度的同时,极大地降低了型号结冰计算成本;给出了顺气流... 详细信息

机翼结冰是威胁民用飞机飞行安全的主要因素之一,准确预测机翼的结冰过程和特点,可为防除冰设计提供依据和支撑。提出了利用二维模拟三维的准三维冰形算法,该算法在保证结冰预测精度的同时,极大地降低了型号结冰计算成本;给出了顺气流和垂直于前缘两种典型民用飞机后掠翼机翼的二维剖面截取方法,并将采用该方法的计算结果与三维后掠机翼的结冰预测结果进行了对比分析。结果表明,相对于顺气流方式,垂直于前缘方式的准三维冰形算法与三维后掠机翼的结果更为接近。

关键词：机翼结冰准三维冰形算法结冰预测后掠翼机翼

The Computer Game Model of Contract Bridge

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The Computer Game Model of Contract Bridge

Insights into spinal muscular atrophy from molecular biomarkers

第24届中国控制与决策会议

作者： mei xian 1 , zhang Dianlong 1 , LIAO Qijun 1 , JIANG Yanxin 2 , LI Zhiguang 1 1. Harbin University of Science and Technology, Harbin 1500802. Heilongjiang University, Harbin 150080

Computer game is an important field of artificial intelligence. Contract bridge is a kind of athletics project backlash using cards. It is an incomplete information game. We analyzed the contract bridge game process and described a computer game model in this paper in the following six respects, ranging from the participant, historical collection, participant function, information space, natural probability distribution function and the participant preferences six respects. This model will be used for studying the contract bridge computer game theory or program algorithm.

关键词： Contract Bridge Computer Game Game Model

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

青藏高原亚高寒草甸封育区鼢鼠扰动对植物群落物种多样性和生产力的影响

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兰州大学学报（自然科学版） 2017年第5期53卷 652-658页

作者：杨莹博曹铨杨倩来兴发钱雅丽张学梅王先之张美艳沈禹颖甘肃农业大学资源与环境学院兰州730070 兰州大学草地农业科技学院草地农业生态系统国家重点实验室兰州730020 云南省草地动物科学研究院昆明650212

从群落和功能群两个水平出发,通过对比分析不同恢复年限的鼢鼠土丘植物群落的物种多样性和生产力特征差异,了解小尺度斑块扰动对草地植物群落组成结构及功能特征的影响,探讨相应尺度上植物群落的物种多样性和群落生产力的关系.结果表明... 详细信息

从群落和功能群两个水平出发,通过对比分析不同恢复年限的鼢鼠土丘植物群落的物种多样性和生产力特征差异,了解小尺度斑块扰动对草地植物群落组成结构及功能特征的影响,探讨相应尺度上植物群落的物种多样性和群落生产力的关系.结果表明:亚高寒草甸围栏封育区内鼢鼠土丘植被的演替过程中,群落水平的物种丰富度和多样性指数均呈对数增长模式,群落内物种均匀性指数亦逐渐增加,群落生产力线性显著增加;功能群水平上,短命类杂草的物种丰富度的变化趋势不显著,但其在群落中的相对盖度逐渐降低,地上生物量先增加后降低;多年生杂类草的物种丰富度、相对盖度和地上生物量均呈极显著的增加模式;豆科植物的物种丰富度和地上生物量均呈显著增加模式,而其相对盖度逐渐增加,但拟合结果不显著;禾本科植物的物种丰富度、相对盖度和地上生物量均呈显著增加模式;群落物种多样性与生产力均呈极显著正相关关系;功能群水平上,4种类群植物的物种丰富度与群落生产力呈显著正相关关系,多年生杂类草和豆科植物的香浓威纳指数与其相应类群生产力呈显著正相关关系,而短命杂类草和禾本科植物的香浓威纳指数却与其相应类群的生产力呈正相关关系但不显著.围封条件下,随鼢鼠土丘植物群落的演替,群落物种丰富度的增加对生产力的促进作用,可能是由不同功能群间生态位的差异、物种间对资源的互补性利用能力和扩散限制引起的.

关键词：扰动鼢鼠土丘恢复演替物种多样性群落生产力功能群