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Adrenal pheochromocytoma impacts three main pathways: cysteine-methionine, pyrimidine, and tyrosine metabolism

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 410-421页

作者： Chong LAI Qingling YANG Yunuo ZHANG Renjie gong Majie WANG Jiankang LI Maode LAI Qingrong SUN Department of Urology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China School of Basic Medical Sciences and Clinical Pharmacy China Pharmaceutical UniversityNanjing 210009China Department of Laboratory Medicine the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Laboratory of Behavioral Neuroscience Ningbo Kangning HospitalNingbo Institute of Microcirculation and HenbaneSchool of MedicineNingbo UniversityNingbo 315201China Xi'an Key Laboratory of Stem Celland Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXi'an 710072China Department of Pathology Research Unit of Intelligence Classification of Tumor Pathology and Precision TherapyChinese Academy of Medical Sciences Key Laboratory of Disease Proteomics of Zhejiang ProvinceZhejiang University School of MedicineHangzhou 310058China

Pheochromocytomas and paragangliomas(PPGLs)cause symptoms by altering the circulation levels of catecholamines and peptide ***,the diagnosis of PPGLs relies on diagnostic imaging and the detection of *** this study,we used ultra-performance liquid chromatography(UPLC)/quadrupole time-of-flight mass spectrometry(Q-TOF MS)analysis to identify and measure the perioperative differential metabolites in the plasma of adrenal pheochromocytoma *** identified differentially expressed genes by comparing the transcriptomic data of pheochromocytoma with the normal adrenal *** conducting two steps of metabolomics analysis,we identified 111 differential metabolites between the healthy group and the patient group,among which 53 metabolites were *** integrating the information of differential metabolites and differentially expressed genes,we inferred that the cysteine-methionine,pyrimidine,and tyrosine metabolism pathways were the three main metabolic pathways altered by the *** analysis of transcription levels revealed that the tyrosine and cysteine-methionine metabolism pathways were downregulated in pheochromocytoma,whereas the pyrimidine pathway showed no significant ***,we developed an optimized diagnostic model of two metabolites,L-dihydroorotic acid and *** results for these metabolites suggest that they may serve as potential clinical biomarkers and can be used to supplement and improve the diagnosis of pheochromocytoma.

关键词： Pheochromocytoma and paraganglioma(PPGL) Metabolomics Gene set variation analysis L-Dihydroorotic acid Vanylglycol

Optimizing magnetoelastic properties by machine learning and high-throughput micromagnetic simulation

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Rare Metals 2024年第5期43卷 2251-2262页

作者： Jian-Hu gong Zheng-Ming Zhang Cheng-Liang Zhang Peng-Qiang Hu Chao Zhou Dun-Hui Wang Sen Yang Division of Microelectronic Materials and Devices Hangzhou Dianzi UniversityHangzhou 310018China School of Physics MOEKey Laboratory forNonequilibrium Synthesis and Modulation of Condensed Matter and State Key Laboratory for Mechanical Behavior of MaterialsXi'an Jiaotong UniversityXi'an 710049China National Laboratory of Solid State Microstructures Nanjing UniversityNanjing210093China

Magnetoelastic couplings in giant magnetostrictive materials(GMMs)attract significant interests due to their extensive applications in the fields of spintronics and energy harvesting *** the role of the selection of materials and the response to external fields is essential for attaining desired functionality of a ***,machine learning(ML)models are conducted to predict saturation magnetostrictions(λ_(s))in RFe_(2)-type(R=rare earth)GMMs with different *** to ML-predicted composition–λsrelations,it is discovered that the values ofλshigher than1100×10^(-6)are almost situated in the composition space surrounded by 0.26≤x≤0.60 and 1.90≤y≤2.00 for the ternary compounds of Tb_(x)Dy_(1-x)Fe_(y).Assisted by ML predictions,the compositions are further narrowed down to the space surrounded by 0.26≤x≤0.32 and 1.92≤y≤1.97 for the excellent piezomagnetic(PM)performance in the Tb_(x)Dy_(1-x)Fe_(y)based PM device through our developed high-throughput(HTP)micromagnetic simulation(MMS)***,high sensitivities up to10.22-13.61 m T·MPa^(-1)are observed in the optimized range within which the available experimental data fall *** work not only provides valuable insights toward understanding the mechanism of magnetoelastic couplings,but also paves the way for designing and optimizing highperformance magnetostrictive materials and PM sensing devices.

关键词： Magnetostriction Piezomagnetic effect Machine learning Micromagnetic simulation

Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries

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Current Medical Science 2024年第3期44卷 642-647页

作者： Wan-rong LU Ping WU gong SONG Mei-qi GU Zhe XU Li HE National Clinical Research Center for Gynecology and Obstetrics Cancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Traumatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective After traumatic injury in pregnant women,providing timely and appropriate management for high-risk patients is crucial for both pregnant women and *** study aimed to identify risk factors that predict adverse pregnancy outcomes after traumatic *** A retrospective cohort study including 317 pregnant patients who experienced trauma was *** collected data included general demographics,injury mechanisms and adverse pregnancy *** were divided into two subgroups based on the absence or presence of trauma-related adverse pregnancy *** and multivariate logistic regressions were conducted to estimate the associations between clinical variables and adverse pregnancy *** A total of 41(12.93%)patients experienced adverse pregnancy outcomes within the first 24 h *** study revealed that age>35 years(OR=14.995,95%CI:5.024–44.755,P<0.001),third trimester trauma(OR=3.878,95%CI:1.343–11.204,P=0.012),abdominal pain(OR=3.032,95%CI:1.221–7.527,P=0.017),vaginal bleeding(OR=3.226,95%CI:1.093–9.523,P=0.034),positive scan in focused assessment with sonography for trauma(FAST)positive(OR=8.496,95%CI:2.825–25.555,P<0.001),9≤injury severity score(ISS)<16(OR=3.039,95%CI:1.046–8.835,P=0.041)and ISS≥16(OR=5.553,95%CI:1.387–22.225,P=0.015)increased the probability of posttraumatic adverse pregnancy *** age,gestational age at delivery,vaginal bleeding and positive FAST results were risk factors for abnormal *** Advanced maternal age,third trimester,and positive FAST results should alert multidisciplinary trauma teams to closely monitor patients to prevent adverse pregnancy outcomes.

关键词： adverse pregnancy outcomes predictive factors abnormal delivery trauma

Palladium single atoms from melting nanoparticles on WO_(3-x) for boosted hydrogen evolution reaction

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Journal of Energy Chemistry 2024年第4期91卷 637-644页

作者： Zhongmiao gong Zhigang Chen Hao Li Guang Yang Min Yuan Zhiyun Li Xueying Wan Yi Cui School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026AnhuiChina i-lab Vacuum Interconnected Nanotech WorkstationSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123JiangsuChina School of Materials Science and Engineering Chongqing University of TechnologyChongqing 400054China Key Laboratory of Precision and Intelligent Chemistry School of Chemistry and Materials ScienceHefei National Research Center for Physical Sciences at the MicroscaleNational Synchrotron Radiation LaboratorySchool of Nuclear Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026AnhuiChina

Surface-supported isolated atoms in single-atom catalysts(SACs)grant maximum utilization of metals in heterogeneous ***,we report a feasible pyrolysis strategy to synthesize Pd single atoms by thermally melting Pd nanoparticles on an oxygen-vacancy-rich tungsten-oxide matrix at reduction *** ambient pressure X-ray photoelectron spectroscopy was used to monitor the formation of zero-valence Pd single atoms and the increased metallic feature of WO_(3-x)***,the as-obtained zero-valence Pd single-atom catalyst exhibits a markedly boosted HER activity with a low overpotential(η_(10)=70 mV)at the current density of 10 mA/cm2and a small Tafel slope(b=68 mV/dec),nearly 150 mV and a 3,0-fold enhancement than those of Pd nanoparticles(η_(10)=220 mV,b=133 mV/dec)under the same *** addition,quasi in situ XPS results suggest the hydrogen spillover effect is more likely to occur on Pd single atoms during the electrochemical *** work may pave an interesting route for the rational design of highly-efficient single-atom catalysts,and the elucidation of corresponding enhanced reaction mechanisms by the utilization of advanced characterization techniques.

关键词： Pd WO_(3-x) Single-atom catalysts NAP-XPS HER

Anti-vascular endothelial growth factor drugs combined with laser photocoagulation maintain retinal ganglion cell integrity in patients with diabetic macular edema: study protocol for a prospective, non-randomized, controlled clinical trial

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Neural Regeneration Research 2024年第4期19卷 923-928页

作者： xiangjun Li Chunyan Li Hai Huang Dan Bai Jingyi Wang Anqi Chen Yu gong Ying Leng Department of Ophthalmology Affiliated Hospital of Beihua University Department of Endocrinology Affiliated Hospital of Beihua University

The integrity of retinal ganglion cells is tightly associated with diabetic macular degeneration that leads to damage and death of retinal ganglion cells,affecting *** major clinical treatments for diabetic macular edema are anti-vascular endothelial growth factor drugs and laser ***,although the macular thickness can be normalized with each of these two therapies used alone,the vision does not improve in many *** might result from the incomplete recovery of retinal ganglion cell ***,a prospective,non-randomized,controlled clinical trial was designed to investigate the effect of anti-vascular endothelial growth factor drugs combined with laser photocoagulation on the integrity of retinal ganglion cells in patients with diabetic macular edema and its relationship with vision *** this trial,150 patients with diabetic macular edema will be equally divided into three groups according to therapeutic methods,followed by treatment with anti-vascular endothelial growth factor drugs,laser photocoagulation therapy,and their *** patients will be followed up for 12 *** primary outcome measure is retinal ganglion cell-inner plexiform layer thickness at 12 months after *** secondary outcome measures include retinal ganglion cell-inner plexiform layer thickness before and 1,3,6,and 9 months after treatment,retinal nerve fiber layer thickness,best-corrected visual acuity,macular area thickness,and choroidal thickness before and 1,3,6,9,and 12 months after *** measure is the incidence of adverse events at 1,3,6,9,and 12 months after *** study protocol hopes to validate the better efficacy and safety of the combined treatment in patients with diabetic macula compared with the other two monotherapies alone during the 12-month follow-up *** trial is designed to focus on clarifying the time-effect relationship between imaging measures related to the integrity of retinal

关键词： choroidal thickness diabetic macular edema laser photocoagulation retinal ganglion cell-inner plexiform layer thickness retinal ganglion cells retinal nerve fiber layer thickness thickness of the macular area vascular endothelial growth factor visual acuity

Light-field modulation and optimization near metal nanostructures utilizing spatial light modulators

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Chinese Physics B 2024年第10期33卷 1-14页

作者： Zini Cao Hai Lin Yuqing Cheng Yixuan Xu Qihuang gong Guowei Lü State Key Laboratory for Mesoscopic Physics Collaborative Innovation Center of Quantum MatterFrontiers Science Center for Nano-OptoelectronicsSchool of PhysicsPeking UniversityBeijing 100871China School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China Peking University Yangtze Delta Institute of Optoelectronics Nantong 226010China

Plasmonic modes within metal nanostructures play a pivotal role in various nanophotonic ***,a significant challenge arises from the fixed shapes of nanostructures post-fabrication,resulting in limited modes under ordinary illumination.A promising solution lies in far-field control facilitated by spatial light modulators(SLMs),which enable on-site,real-time,and non-destructive manipulation of plasmon *** the robust modulation of the incident light using SLMs,this approach enables the generation,optimization,and dynamic control of surface plasmon polariton(SPP)and localized surface plasmon(LSP)*** versatility of this technique introduces a rich array of tunable degrees of freedom to plasmon-enhanced spectroscopy,offering novel approaches for signal optimization and functional expansion in this *** paper provides a comprehensive review of the generation and modulation of SPP and LSP modes through far-field control with SLMs and highlights the diverse applications of this optical technology in plasmon-enhanced spectroscopy.

关键词： surface plasmon spatial light modulator dynamic control plasmon-enhanced spectroscopy

Femtosecond laser-induced periodic surface structures on hard and brittle materials

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Science China(Technological Sciences) 2024年第1期67卷 19-36页

作者： ZHAO GuoXu WANG gong LI YunFei WANG Lei LIAN YuDong YU Yu ZHAO Hui WANG YuLei LU ZhiWei Center for Advanced Laser Technology Hebei University of TechnologyTianjin 300401China Hebei Key Laboratory of Advanced Laser Technology and Equipment Tianjin 300401China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China School of Information and Electrical Engineering Hebei University of EngineeringHandan 056038China

Hard and brittle materials have high hardness,excellent optical stability,chemical stability,and high thermal ***,they have huge application potential in various fields,such as optical components,substrate materials,and quantum information,especially under harsh conditions,such as high temperatures and high *** laser direct writing technology has greatly promoted the development of femtosecond laser-induced periodic surface structure(Fs-LIPSS or LIPSS by a femtosecond laser)applications of hard and brittle materials due to its high precision,controllability,and three-dimensional processing *** far,LIPSSs have been widely used in material surface treatment,optoelectronic devices,and ***,a consensus has not been reached regarding the formation mechanism of LIPSSs on hard and brittle *** this paper,three widely accepted LIPSS formation mechanisms are introduced,and the characteristics and applications of LIPSSs on diamonds,silicon,silicon carbide,and fused silica surfaces in recent years are *** addition,the application prospects and challenges of LIPSSs on hard and brittle materials by a femtosecond laser are discussed.

关键词： laser-induced periodic surface structures hard and brittle materials femtosecond laser

Nano-Au-decorated hierarchical porous cobalt sulfide derived from ZIF-67 toward optimized oxygen evolution catalysis:Important roles of microstructures and electronic modulation

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Carbon Energy 2024年第5期6卷 1-14页

作者： Hongyu gong Guanliang Sun Wenhua Shi Dongwei Li xiangjun Zheng Huan Shi Xiu Liang Ruizhi Yang Changzhou Yuan Department of New Energy Materials School of Environmental and Chemical EngineeringJiangsu University of Science and TechnologyZhenjiangJiangsuChina Advanced Materials Institute Qilu University of Technology(Shandong Academy of Sciences)JinanShandongChina Shandong Saikesaisi Hydrogen Energy Co. Ltd.JinanShandongChina Department of Materials Science and Engineering School of Materials Science&EngineeringUniversity of JinanJinanShandongChina Department of New Energy Science and Engineering College of EnergySoochow Institute for Energy and Materials InnovationsSoochow UniversitySuzhouJiangsuChina

Enhancing both the number of active sites available and the intrinsic activity of Co-based electrocatalysts simultaneously is a desirable ***,a ZIF-67-derived hierarchical porous cobalt sulfide decorated by Au nanoparticles(NPs)(denoted as HP-Au@CoxSy@ZIF-67)hybrid is synthesized by low-temperature sulfuration *** well-defined macroporous-mesoporous-microporous structure is obtained based on the combination of polystyrene spheres,as-formed CoxSy nanosheets,and ZIF-67 *** novel three-dimensional hierarchical structure significantly enlarges the three-phase interfaces,accelerating the mass transfer and exposing the active centers for oxygen evolution *** electronic structure of Co is modulated by Au through charge transfer,and a series of experiments,together with theoretical analysis,is performed to ascertain the electronic modulation of Co by ***,HP-Au@CoxSy@ZIF-67 catalysts with different amounts of Au were synthesized,wherein Au and NaBH4 reductant result in an interesting“competition effect”to regulate the relative ratio of Co^(2+)/Co^(3+),and moderate Au assists the electrochemical performance to reach the highest ***,the optimized HP-Au@CoxSy@ZIF-67 exhibits a low overpotential of 340 mV at 10 mA cm^(-2)and a Tafel slope of 42 mV dec-1 for OER in 0.1 M aqueous KOH,enabling efficient water splitting and Zn-air battery *** work here highlights the pivotal roles of both microstructural and electronic modulation in enhancing electrocatalytic activity and presents a feasible strategy for designing and optimizing advanced electrocatalysts.

关键词： Au nanoparticles cobalt sulfide electronic modulation hierarchical porous structure oxygen evolution reaction

Efficient Electromagnetic Wave Absorption and Thermal Infrared Stealth in PVTMS@MWCNT Nano‑Aerogel via Abundant Nano‑Sized Cavities and Attenuation Interfaces

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Nano-Micro Letters 2024年第1期16卷 370-383页

作者： Haoyu Ma Maryam Fashandi Zeineb Ben Rejeb Xin Ming Yingjun Liu Pengjian gong Guangxian Li Chul B.Park College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University24 Yihuan RoadNanyiduanChengdu 610065SichuanPeople’s Republic of China Microcellular Plastics Manufacturing Laboratory Department of Mechanical and Industrial EngineeringUniversity of Toronto5 King’s College RoadTorontoON M5S 3G8Canada Jiangsu JITRI Advanced Polymer Materials Research Institute Tengfei Building88 Jiangmiao RoadJiangbei New DistrictNanjing 211800JiangsuPeople’s Republic of China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringInternational Research Center for X PolymersZhejiang University38 Zheda RoadHangzhou 310027People’s Republic of China

Pre-polymerized vinyl trimethoxy silane(PVTMS)@MWCNT nano-aerogel system was constructed via radical polymerization,sol-gel transition and supercritical CO_(2)*** fabricated organic-inorganic hybrid PVTMS@MWCNT aerogel structure shows nano-pore size(30-40 nm),high specific surface area(559 m^(2)g^(−1)),high void fraction(91.7%)and enhanced mechanical property:(1)the nano-pore size is beneficial for efficiently blocking thermal conduction and thermal convection via Knudsen effect(beneficial for infrared(IR)stealth);(2)the heterogeneous interface was beneficial for IR reflection(beneficial for IR stealth)and MWCNT polarization loss(beneficial for electromagnetic wave(EMW)attenuation);(3)the high void fraction was beneficial for enhancing thermal insulation(beneficial for IR stealth)and EMW impedance match(beneficial for EMW attenuation).Guided by the above theoretical design strategy,PVTMS@MWCNT nano-aerogel shows superior EMW absorption property(cover all Ku-band)and thermal IR stealth property(ΔT reached 60.7℃).Followed by a facial combination of the above nano-aerogel with graphene film of high electrical conductivity,an extremely high electromagnetic interference shielding material(66.5 dB,2.06 mm thickness)with superior absorption performance of an average absorption-to-reflection(A/R)coefficient ratio of 25.4 and a low reflection bandwidth of 4.1 GHz(A/R ratio more than 10)was experimentally obtained in this work.

关键词： Nano-pore size Heterogeneous interface Electromagnetic wave absorption Thermal infrared stealth Nano-aerogel