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Development and Evaluation of a Promising Biomarker for Diagnosis of Latent and Active Tuberculosis Infection

Infectious Diseases & Immunity 2024年第1期4卷 10-24页

作者： Cong Peng fan Jiang Yinping Liu Yong Xue Peng Cheng Jie Wang liang Wang Wenping Gong Hebei North University Zhangjiakou 075000Hebei ProvinceChina Beijing Key Laboratory of New Techniques of Tuberculosis Diagnosis and Treatment Senior Department of TuberculosisEighth Medical Center of PLA General HospitalBeijing 100091China Department of Geriatrics Eighth Medical Center of PLA General HospitalBeijing 100091China Section of Health No.94804 Unit of the Chinese People's Liberation ArmyShanghai 200434China

Background:Diagnosing latent tuberculosis(TB)infection(LTBI)and active TB(ATB)is crucial for preventing disease progression and ***,current diagnostic tests have limitations in terms of accuracy and sensitivity,making it challenging to diagnose these different infection ***,this study intends to develop a promising biomarker for LTBI and ATB diagnosis to overcome the limitations of the current diagnostic ***:We developed a novelmultiepitope-based diagnostic biomarker(MEBDB)fromLTBI region of differentiation antigens using bioinformatics and *** responses induced byMEBDM were detected using enzyme-linked immunosorbent spot and cytometric bead *** study was conducted from April 2022 to December 2022 in the SeniorDepartment of Tuberculosis at the 8thMedical Center of PLA General Hospital,*** samples were collected from participants with ATB,individuals with LTBI,and healthy controls(HCs).The diagnostic efficacy of MEBDB was evaluated using receiver operating characteristic ***:A novel MEBDB,designated as CP19128P,was ***19128P comprises 19 helper T lymphocyte epitopes,12 cytotoxic T lymphocyte epitopes,and 8 B-cell *** silico simulations demonstrated that CP19128P possesses strong affinity for Toll-like receptors and elicits robust innate and adaptive immune ***19128P generated significantly higher levels of tumor necrosis factor(TNF-α),interleukin 4(IL-4),and IL-10 in ATB patients(n=7)and LTBI(n=8)individuals compared with HCs(n=62)(P<0.001).Moreover,CP19128P-induced specific cytokines could be used to discriminate LTBI and ATB from healthy subjects with high sensitivity and *** IL-2 with IL-4 or TNF-α could differentiate LTBI from HCs(the area under the receiver operating characteristic curve[AUC],0.976[95% confidence interval[CI],0.934-1.000]or 0.986[0.956-1.000]),whereas combining IL-4 with IL-17A or TNF-α could differentiate ATB from

关键词： Tuberculosis Latent tuberculosis infection Active tuberculosis Multiepitope-based diagnostic biomarker Bioinformatics:Immunoinformatics

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Changes in milk fat globule membrane proteins along lactation stage of Laoshan dairy goat

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Journal of Integrative Agriculture 2024年第5期23卷 1737-1748页

作者： Chuozi liang Zhongna Yu Guangming Zhu Yixuan Li Xueheng Sun Hongning Jiang Qijing Du Rongbo fan Jun Wang Yongxin Yang Rongwei Han College of Food Science and Engineering Qingdao Agricultural UniversityQingdao 266109China Bathurst Future Agri-Tech Institute Qingdao Agricultural UniversityQingdao 266109China Haidu Cllege Qingdao Agricultural UniversityQingdao 266109China

The milk fat globule membrane(MFGM)is a complex structure with numerous functions,and its composition is affected by many *** have been few systematic investigations on goat MFGM proteome profiling during *** milk samples from 15 healthy dairy goats were obtained at six lactation time points for investigation of the MFGM proteome using both data-independent acquisition(DIA)and data-dependent acquisition(DDA)proteomics techniques combined with multivariate statistical *** the DIA method,890 variably abundant MFGM proteins were discovered throughout the lactation *** 1 to 240 d,butyrophilin subfamily 1 member A1,lipoprotein lipase,perilipin-2,and adipose triglyceride lipase were upregulated,while APOE,complement C3,clusterin,and IgG were ***,from 1 to 90 d,annexin A1,annexin A2,and antithrombin-ll were downregulated,then upregulated by d *** had a high degree of connectedness,indicating that it was a key protein,according to protein-protein interaction ***,our findings gave new insights into the biological features of MFGM protein in goat milk throughout lactation,which may aid in the creation of specialized MFGM products and infant formula.

关键词： goat milk fat globule membrane protein data-independent acquisition(DIA) data-dependent acquisition(DDA) lactation proteomics

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Staging liver fibrosis with various diffusion-weighted magnetic resonance imaging models

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World Journal of Gastroenterology 2024年第9期30卷 1164-1176页

作者： Yan-Li Jiang Juan Li Peng-Fei Zhang Feng-xian fan Jie Zou Pin Yang Peng-Fei Wang Shao-Yu Wang Jing Zhang Department of Magnetic Resonance Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Second Clinical School Lanzhou UniversityLanzhou 730030Gansu ProvinceChina Gansu Province Clinical Research Center for Functional and Molecular Imaging The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina Department of Hepatology The Second Hospital&Clinical Medical SchoolLanzhou UniversityLanzhou 730030Gansu ProvinceChina MR Scientific Marketing Siemens HealthineersXi’an 710065Shaanxi ProvinceChina

BACKGROUND Diffusion-weighted imaging(DWI)has been developed to stage liver ***,its diagnostic performance is inconsistent among ***,it is worth studying the diagnostic value of various diffusion models for liver fibrosis in one *** To evaluate the clinical potential of six diffusion-weighted models in liver fibrosis staging and compare their diagnostic *** This prospective study enrolled 59 patients suspected of liver disease and scheduled for liver biopsy and 17 healthy *** participants underwent multi-b value *** main DWI-derived parameters included Mono-apparent diffusion coefficient(ADC)from mono-exponential DWI,intravoxel incoherent motion model-derived true diffusion coefficient(IVIM-D),diffusion kurtosis imaging-derived apparent diffusivity(DKI-MD),stretched exponential model-derived distributed diffusion coefficient(SEM-DDC),fractional order calculus(FROC)model-derived diffusion coefficient(FROC-D)and FROC model-derived microstructural quantity(FROC-μ),and continuous-time random-walk(CTRW)model-derived anomalous diffusion coefficient(CTRW-D)and CTRW model-derived temporal diffusion heterogeneity index(CTRW-α).The correlations between DWI-derived parameters and fibrosis stages and the parameters’diagnostic efficacy in detecting significant fibrosis(SF)were assessed and *** CTRW-D(r=-0.356),CTRW-α(r=-0.297),DKI-MD(r=-0.297),FROC-D(r=-0.350),FROC-μ(r=-0.321),IVIM-D(r=-0.251),Mono-ADC(r=-0.362),and SEM-DDC(r=-0.263)were significantly correlated with fibrosis *** areas under the ROC curves(AUCs)of the combined index of the six models for distinguishing SF(0.697-0.747)were higher than each of the parameters alone(0.524-0.719).The DWI models’ability to detect SF was *** combined index of CTRW model parameters had the highest AUC(0.747).CONCLUSION The DWI models were similarly valuable in distinguishing SF in patients with liver *** combined index of CTRW paramet

关键词： Liver fibrosis Magnetic resonance imaging Diffusion-weighted magnetic resonance Liver biopsy Significant fibrosis

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Preparation and properties of ZrO_(2)-strengthened porous mullite insulation materials using Y_(2)O_(3) additive

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Journal of Iron and Steel Research International 2024年第6期31卷 1514-1521页

作者： Wang-zhi Yu Yi-hong Shi Ping Liu Yong-wan Wu Cheng-hao Song xian-gong Deng xiang Ding Song-lin Ran Yi Zhang Hai-jun Zhang Hai-liang Deng Advanced Ceramics Research Center School of Materials Science and EngineeringAnhui University of TechnologyMa'anshan 243002AnhuiChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina

ZrO_(2)-strengthened porous mullite insulation materials were prepared by foaming technology utilizing ZrSiO_(4) and Al_(2)O_(3) as primary materials and Y_(2)O_(3) as an *** effects of Y_(2)O_(3) contents on the phase composition,microstructure,mechanical properties,and heat conductivity of the porous mullite insulation materials were investigated.A suitable Y_(2)O_(3) content could promote phase transition of monoclinic ZrO_(2)(m-ZrO_(2))to tetragonal ZrO_(2)(t-ZrO_(2)),reduce pore size,and improve the strengths of as-prepared *** cold crushing strength and bending strength of as-prepared specimens with a 119µm spherical pore size using 6 wt.%Y_(2)O_(3) were 35.2 and 13.0 MPa,respectively,with a heat conductivity being only 0.248 W/(m K).

关键词： Porous mullite insulation material Zirconium oxide Y_(2)O_(3) Mechanical property Heat conductivity

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Microstructures and mechanical properties of laser-directed energy deposited CrCoNi medium-entropy alloy

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Rare Metals 2024年第7期43卷 3286-3300页

作者： Wen-Jie Zhao Chang-Yu Liu Peng-Cheng Che Zhi-liang Ning Hong-Bo fan Jian-Fei Sun Yong-Jiang Huang Alfonso H.W.Ngan National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China Space Environment Simulation Research Infrastructure Harbin Institute of TechnologyHarbin 150001China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China

The distinctive intrinsic heat treatment(IHT)originating from cyclic reheating in the laser-directed energy deposition(LDED) has attracted growing attention in recent *** this investigation,simulations and experimental characterizations were performed to examine the impact of IHT on the micros true ture and mechanical properties of LDED-fabricated CrCoNi medium-entropy alloy(MEA).The results show that the intensity of the IHT is proportional to the utilized laser energy density(LED).As the LED increased,significant dynamic recrystallization and grain refinement occurred within the alloy due to the enhanced intensity of ***,the high LED leads to severe hot cracking within the as-built MEA,resulting in inferior *** decreasing LED,the hot cracking was effectively ***,low LED weakened the intensity of IHT and consequently inhibited kinetic conditions of dynamic recrystallization,resulting in a heterogeneous grain structure characterized by multi-scale-sized *** structure provides significant hetero-deformation-induced hardening during plastic deformation,enabling the alloy to have a sustainable work-hardening *** expect that this work will have implications in taking full advantage of the unique IHT of the LDED process to fabricate ME As with excellent metallurgical quality and mechanical performance.

关键词： Intrinsic heat treatment Laser-directed energy deposition CrCoNi MEA Dynamic recrystallization Heterogeneous grain structure

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Selective Hydrodeoxygenation of Lignin-Derived Vanillin via Hetero-Structured High-Entropy Alloy/Oxide Catalysts

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Energy & Environmental Materials 2024年第3期7卷 206-214页

作者： Yan Sun Kaili liang Ren Tu Xudong fan Charles Q.Jia Zhiwen Jia Yingnan Li Hui Yang Enchen Jiang Hanwen Liu Yonggang Yao Xiwei Xu Key Laboratory for Biobased Materials and Energy of Ministry of Education College of Materials and EnergySouth China Agricultural University Department of Chemical Engineering and Applied Chemistry University of Toronto State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and EngineeringHuazhong University of Science and Technology

The chemoselective hydrodeoxygenation of natural lignocellulosic materials plays a crucial role in converting biomass into value-added *** their complex molecular structures often require multiple active sites synergy for effective activation and achieving high ***,it is reported that a high-entropy alloy (HEA) on high-entropy oxide (HEO)hetero-structured catalyst for highly active,chemoselective,and robust vanillin *** heterogenous HEA/HEO catalysts were prepared by thermal reduction of senary HEOs (NiZnCuFeAIZrOx),where exsolvable metals (e.g.,Ni,Zn,Cu) in situ emerged and formed randomly dispersed HEA nanoparticles anchoring on the HEO *** catalyst exhibits excellent catalytic performance:100%conversion of vanillin and 95%selectivity toward high-value 2-methyl-4 methoxy phenol at low temperature of 120℃,which were attributed to the synergistic effect among HEO matrix(with abundant oxygen vacancies),anchored HEA nanoparticles (having excellent hydrogenolysis capability),and their intimate hetero-interfaces(showing strong electron transferring effect).Therefore,our work reported the successful construction of HEA/HEO heterogeneous catalysts and their superior multifunctionality in biomass conversion,which could shed light on catalyst design for many important reactions that are complex and require multifunctional active sites.

关键词： biomass conversion heterogeneous catalysts high-entropy oxide high-entropy alloys lignin pyrolysis

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The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation

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Journal of Genetics and Genomics 2024年第8期51卷 877-879页

作者： Yuxin Kang Yilin liang Fengting fan Hojjat Asadollahpour Nanaei Chunna Cao Yu Jiang xianyong Lan Chuanying Pan Ran Li College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Livestock Biology Northwest A&F UniversityYanglingShaanxi 712100China Department of Animal Science Fars Agricultural and Natural Resources Research and Education CenterAgricultural ResearchEducation&Extension Organization(AREEO)FarsIran Author links open overlay panel

Hemoglobin is responsible for transporting oxygen from the lungs to body ***,this protein is a tetramer composed of two a-globin chains and twoβ-globin *** sheep,the β-globin locus is of particular interest because it contains two different haplotypes,namely haplotype A(hap A)and hap B,which differ in length by more than 30 kb and do not undergo recombination with each other due to low sequence similarity(Bauer and Jung,1975;Jiang et al.,2015).The two haplotypes also differ in gene content with hap A possessing two clusters of hemoglobin gene families and hap B possessing only one(Aguiletam et al.,2004),which implies differentiation in their functional *** A was speculated to be associated with high-altitude adaptation in sheep(Hu et al.,2019).

关键词： chains altitude similarity

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Enhancing hydrogen evolution and oxidation kinetics through oxygen insertion into nickel lattice

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Journal of Energy Chemistry 2024年第8期95卷 529-539,I0012页

作者： Wanli liang Xiyu Gong Jinchang Xu Zixuan Dan fanyan Xie Hulei Yu Hao-fan Wang Yanshuo Jin Hongjuan Wang Yonghai Cao Hui Meng Hao Yu School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510641GuangdongChina Siyuan Laboratory Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Key Laboratory of Optical Fiber Sensing and CommunicationsDepartment of PhysicsJinan UniversityGuangzhou 510632GuangdongChina GBA Branch of Aerospace Information Research Institute Chinese Academy of SciencesGuangzhou 510700GuangdongChina Instrumental Analysis&Research Center Sun Yat-sen UniversityGuangzhou 510275GuangdongChina School of Materials Science and Engineering South China University of TechnologyGuangzhou 510641GuangdongChina

Nickel-based materials,including metallic Ni and Ni oxide,have been widely studied in the exploration of non-precious-metal hydrogen electrocatalysts,but neither pure Ni nor NiO is ideal for the hydrogen evolution reaction(HER)and hydrogen oxidation reaction(HOR).In this paper,an oxygen insertion strategy was applied on nickel to regulate its hydrogen electrocatalytic performance,and the oxygen-inserted nickel catalyst was successfully obtained with the assistance of tungsten dioxide support(denoted as O-Ni/WO_(2)).The partial insertion of oxygen in Ni maintains the face-centered cubic arrangement of Ni atoms,simultaneously expanding the lattice and increasing the lattice ***,the adsorption strength of^(*)H and^(*)OH on Ni is optimized,thus resulting in superior electrocatalytic performance of0-Ni/WO_(2)in alkaline HER/*** Tafel slope of O-Ni/WO_(2)@NF for HER is 56 mV dec^(-1),and the kinetic current density of O-Ni/WO_(2)for HOR reaches 4.85 mA cm^(-2),which is ahead of most currently reported *** proposed strategy of inserting an appropriate amount of anions into the metal lattice could provide more possibilities for the design of high-performance catalysts.

关键词： Hydrogen evolution Hydrogen oxidation Nickel Oxygen insertion Adsorption free energy

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Role of gut microbiota in Crohn’s disease pathogenesis:Insights from fecal microbiota transplantation in mouse model

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World Journal of Gastroenterology 2024年第31期30卷 3689-3704页

作者： Qiang Wu Lian-Wen Yuan Li-Chao Yang Ya-Wei Zhang Heng-Chang Yao liang-Xin Peng Bao-Jia Yao Zhi-xian Jiang Geriatric Surgery of Department of General Surgery The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND Inflammatory bowel disease,particularly Crohn’s disease(CD),has been associated with alterations in mesenteric adipose tissue(MAT)and the phenomenon termed“creeping fat”.Histopathological evaluations showed that MAT and intestinal tissues were significantly altered in patients with CD,with these tissues characterized by inflammation and *** To evaluate the complex interplay among MAT,creeping fat,inflammation,and gut microbiota in *** Intestinal tissue and MAT were collected from 12 patients with *** manifestations and protein expression levels were analyzed to determine lesion *** samples were collected from five recently treated CD patients and five control subjects and transplanted into *** intestinal and mesenteric lesions in these mice,as well as their systemic inflammatory status,were assessed and compared in mice transplanted with fecal samples from CD patients and control *** Pathological examination of MAT showed significant differences between CDaffected and unaffected colons,including significant differences in gut microbiota *** microbiota transplantation(FMT)from clinically healthy donors into mice with 2,4,6-trinitrobenzene sulfonic acid(TNBS)-induced CD ameliorated CD symptoms,whereas FMT from CD patients into these mice exacerbated CD ***,FMT influenced intestinal permeability,barrier function,and levels of proinflammatory factors and ***,FMT from CD patients intensified fibrotic changes in the colon tissues of mice with TNBS-induced *** Gut microbiota play a critical role in the histopathology of *** MAT and creeping fat may therefore have potential in the treatment of patients with CD.

关键词： Mesenteric adipose tissue Crohn’s disease Fecal microbiota transplantation Intestinal fibrosis Intestinal barrier

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Activation of the PGC-1α-mediated mitochondrial glutamine metabolism pathway attenuates female offspring osteoarthritis induced by prenatal excessive prednisone

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Science China Life Sciences 2024年

作者： Qingxian Li fan Zhang Yongguo Dai liang Liu Liaobin Chen Hui Wang Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Department of Pharmacology School of Basic Medical Sciences Wuhan University Joint Disease Research Center of Wuhan University Division of Joint Surgery and Sports Medicine Hubei Provincial Key Laboratory of Developmentally Originated Disease

Osteoarthritis is a chronic, age-related joint disease. Previous studies have shown that osteoarthritis develops during intrauterine development. Prednisone is frequently used to treat pregnancies complicated by autoimmune diseases. However, limited research has been conducted on the enduring effects of prednisone use during pregnancy on the offspring. In this study, we investigated the effect of excessive prednisone exposure on cartilage development and susceptibility to osteoarthritis in the offspring. We found that prenatal prednisone exposure(PPE) impaired cartilage extracellular matrix(ECM) synthesis, resulting in poor cartilage pathology in female offspring during the adult period, which was further exacerbated after long-distance running stimulation. Additionally, PPE suppressed cartilage development during the intrauterine period. Tracing back to the intrauterine period, we found that Pred, rather than prednisone, decreased glutamine metabolic flux, which resulted in increased oxidative stress, and decreased histone acetylation, and expression of cartilage phenotypic genes. Further, PGC-1α-mediated mitochondrial biogenesis, while PPE caused hypermethylation in the promoter region of PGC-1α and decreased its expression in fetal cartilage by activating the glucocorticoid receptor, resulting in a reduction of glutamine flux controlled by mitochondrial biogenesis. Additionally, overexpression of PGC-1α(either pharmacological or through lentiviral transfection) reversed PPEand Pred-induced cartilage ECM synthesis impairment. In summary, this study demonstrated that PPE causes chondrodysplasia in female offspring and increases their susceptibility to postnatal osteoarthritis. Hence, targeting PGC-1α early on could be a potential intervention strategy for PPE-induced osteoarthritis susceptibility.

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