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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-bo Feng Hai-Hui Jiang Hui-Li Kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze Li Wen-Li huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Sliding mode tracking control for miniature unmanned helicopters

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Chinese Journal of Aeronautics 2015年第1期28卷 277-284页

作者： xian Bin Guo Jianchuan Zhang Yao Zhao bo The Institute of Robotics and Autonomous System Tianjin Key Laboratory of Process Measurement and ControlSchool of Electrical Engineering and Automation Tianjin University

A sliding mode control design for a miniature unmanned helicopter is presented. The control objective is to let the helicopter track some predefined velocity and yaw trajectories. A new sliding mode control design method is developed based on a linearized dynamic model. In order to facilitate the control design, the helicopter＇s dynamic model is divided into two subsystems,such as the longitudinal-lateral and the heading-heave subsystem. The proposed controller employs sliding mode control technique to compensate for the immeasurable flapping angles＇ dynamic effects and external disturbances. The global asymptotic stability（GAS） of the closed-loop system is proved by the Lyapunov based stability analysis. Numerical simulations demonstrate that the proposed controller can achieve superior tracking performance compared with the proportionalintegral-derivative（PID） and linear-quadratic regulator（LQR） cascaded controller in the presence of wind gust disturbances.

关键词： unmanned sliding miniature compensate quadratic cascaded subsystem disturbance facilitate linearized

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Solving X-ray protein structures without a crystal: using X-ray Free Electron Laser, the fourth generation synchrotron light sources

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Protein & Cell 2010年第11期1卷 965-966页

作者： bo huang Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

A synchrotron light source is a source of electromagnetic radiation artificially produced by specialized electron *** to the commonly used in-house X-ray sources,it is wavelength adjustable,much stronger and more *** the last two decades,synchrotron usage has become the mainstream for X-ray protein structure *** the advantage of micro-focus light beams of the third generation synchrotron,the size of a usable protein crystal for data collection decreases to micron level,which increases the rate of macromolecular structure determination to about 10 new protein data bank entries per *** fourth generation synchrotron light sources not only inherit the above advantages of traditional synchrotron but also develop them to a higher level:you do not even need a protein crystal for atomic resolution X-ray structure determination by using the nano-focus beam line at the fourth generation synchrotron!This is obviously exciting news for those structural biologists working on membrane proteins and large macromolecular complexes which are notorious for crystallization.X-ray Free Electron Laser(XFEL),provided by the fourth generation synchrotron light sources,has femtosecond pulse length and both peak and average brightness largely exceeding the beam of 3rd generation sources.

关键词： sources crystal Electron

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Tumor microenvironment:a mechanical force link

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Science China(Life Sciences) 2015年第2期58卷 202-204页

作者： huang bo State Key Laboratory of Medical Molecular Biology & Department of Immunology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences & Peking Union Medical College

The tumor microenvironment is created by tumor cells and molded by infiltrating immune cells. both adaptive immune cells like T cells and B cells and innate immune cells such as macrophages, dendritic cells （DC）, NK cells, granulo- cytes, mast cells and immature myeloid cells are brought together to form a tumor immune microenvironment [1]. Although it is virtually taken for granted that the entry of immune cells to tumor microenvironment is a mechanistic process involving chemotaxis and extravasation, blood vessels are indeed a matter. And their real role in this pro- cess is much complex than what we generally think at pre- sent [2].

关键词：肿瘤细胞微环境机械力免疫细胞链接树突状细胞巨噬细胞 NK细胞

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Premature deposition of lithium polysulfide in lithium-sulfur batteries

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Journal of Energy Chemistry 2023年第7期82卷 507-512,I0011页

作者： Zi-xian Chen Yu-Tong Zhang Chen-Xi Bi Meng Zhao Rui Zhang bo-Quan Li Jia-Qi huang School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081China

Lithium-sulfur(Li-S)batteries have attracted extensive attention due to ultrahigh theoretical energy density of 2600 Wh kg^(-1).Liquid-solid deposition from dissolved lithium polysulfides(LiPSs)to solid lithium sulfide(Li_(2)S)largely determines the actual battery ***,a premature liquidsolid deposition process of LiPSs is revealed at higher thermodynamic potential than Li_(2)S deposition in Li-S *** premature solid deposit exhibits higher chemical state and hemispherical morphology in comparison with Li_(2)S,and the premature deposition process is slower in kinetics and higher in deposition ***,a supersaturation deposition mechanism is proposed to rationalize the above findings based on thermodynamic *** work demonstrates a unique premature liquid-solid deposition process of Li-S batteries.

关键词： Lithium-sulfur batteries Lithium polysulfides Liquid-solid deposition Supersaturation

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Reaction characteristics and kinetics of gallium in chlorination roasting of copper tailings using calcium chloride

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Rare Metals 2022年第3期41卷 1063-1070页

作者： Chang Lei Tao Chen bo Yan xian-Ming Xiao State Key Laboratory of Organic Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China University of Chinese Academy of Sciences Beijing 100082China

The mineral composition of copper tailings was examined, and the phase analysis of gallium was conducted for recovery of the rare scattered metal gallium from copper tailings. The reaction characteristics and kinetics of gallium in the chlorination roasting of copper tailings were investigated in a tube furnace apparatus under different conditions, including roasting temperature, quantity of chlorination agent,roasting time, and airflow. Calcium chloride was chosen for the chlorination reaction because it is highly effective for volatilization of metals. The results show that gallium mainly exists in limonites in the form of oxides, and increases in roasting temperature, quantity of chlorination agent, and roasting time are conducive to increasing the chloridizing volatilization rate of gallium. The tailings gradually melt when the roasting temperature exceeds 900℃, resulting in a decrease in the chloridizing volatilization rate of gallium. The chloridizing volatilization rate of gallium reaches 78.86%at roasting temperature of 900℃ for 40 min, airflow of 0.1 m^(3)·h^(-1), and calcium content of 33.33 wt%. Study of the reaction kinetics of gallium in chlorination roasting shows that the values of activation energy both for chemically controlled anddiffusion-controlled reactionsare44.64and11.93 kJ·mol^(-1), respectively. This indicates that the chemical reaction serves an important function in the chlorination volatilization of gallium. Taken together, the results reveal the usefulness of tailings as a source of rare metals and provide a basis for gallium recovery and environmentally friendly disposal of copper tailings.

关键词： Copper tailings Gallium recovery Chlorination roasting Calcium chloride Kinetics

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The scaling laws of cabin structures subjected to internal blast loading:Experimental and numerical studies

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Defence Technology（防务技术） 2022年第5期18卷 811-822页

作者： xian-ben Ren Zhi-xin huang Yong-bo Jiang Zi-hao Chen Xiao-fei Cao Tian Zhao Ying Li Beijing Key Laboratory of Lightweight Multi-functional Composite Materials and Structures Institute of Advanced Structure TechnologyBeijing Institute of TechnologyBeijing100081China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China

This paper presents a combination of experimental and numerical investigations on the dynamic response of scaling cabin structures under internal blast *** purpose of this study is to modify the similar relationship between the scaled-down model and the prototype of the cabin structures under internal blast *** to the Hopkinson’s scaling law,three sets of cabin structure models with different scaling factors combined with different explosive masses were designed for the experimental *** dynamic deformation process of the models was recorded by a three-dimensional digital imaging correlation(DIC)method and a 3D scanning technology was used to reconstruct the deformation modes of the *** addition,a finite element model was developed for the modification of the scaling *** experimental results showed that the final deflection-to-thickness ratio was increased with the increase of the model size despite of the similar trend of their deformation *** reason for this inconsistency was discussed based on the traditional scaling law and a modified formula considering of the effects of size and strain-rate was provided.

关键词： Internal blast Cabin structure Scaling law Experimental study Numerical simulation

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Breeding cotton with superior fiber quality:identification and utilization of multiple elite loci and exotic genetic resources

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Science China(Life Sciences) 2021年第7期64卷 1197-1198页

作者： Gai huang Yu-xian Zhu State Key Laboratory of Protein and Plant Gene Research School of Life SciencesPeking UniversityBeijing 100871China Institute for Advanced Studies Wuhan UniversityWuhan 430072China

In the last decade,cotton genomics had great progress in genome assembling(Li et al.,2015;huang et al.,2020)and agriculturally important locus identification(Du et al.,2018;Ma et al.,2018;Li et al.,2021).Upland cotton(Gossypium hirsutum)is one of the most important cash crops cultivated *** fiber quality of cotton directly determines its economic value,and therefore enhancing fiber quality is always the primary task in cotton breeding practices(Xia et al.,2019;huang et al.,2021).

关键词： fiber elite cotton

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Materials and applications of bioresorbable electronics

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Journal of Semiconductors 2018年第1期39卷 38-47页

作者： xian huang Biomedical Engineering School of Precision Instrument and Opto-Electronic Engineering Tianjin University

Bioresorbable electronics is a new type of electronics technology that can potentially lead to biodegradable and dissolvable electronic devices to replace current built-to-last circuits predominantly used in implantable devices and consumer electronics. Such devices dissolve in an aqueous environment in time periods from seconds to months, and generate biological safe products. This paper reviews materials, fabrication techniques, and applications of bioresorbable electronics, and aims to inspire more revolutionary bioresorbable systems that can generate broader social and economic impact. Existing challenges and potential solutions in developing bioresorbable electronics have also been presented to arouse more joint research efforts in this field to build systematic technology framework.

关键词： bioresorbable electronics bioresorbable materials flexible electronics implantable devices

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椎体骨皮质强化差异对骨质疏松性椎体压缩性骨折生物力学的影响

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中国组织工程研究 2025年第21期29卷 4430-4438页

作者：方伟黄兴桦屈波杨红胜重庆市云阳县中医院骨伤科重庆市404500 成都医学院附属第一医院骨科四川省成都市610500

背景:骨质疏松性椎体压缩性骨折经皮椎体成形过程中骨水泥在椎体内的骨皮质强化区域对脊柱生物力学及临床疗效有重要影响,但以往研究大多局限于二维层面。目的:采用有限元分析法探讨经皮椎体成形过程中骨水泥在椎体三维层面内骨皮质强... 详细信息

背景:骨质疏松性椎体压缩性骨折经皮椎体成形过程中骨水泥在椎体内的骨皮质强化区域对脊柱生物力学及临床疗效有重要影响,但以往研究大多局限于二维层面。目的:采用有限元分析法探讨经皮椎体成形过程中骨水泥在椎体三维层面内骨皮质强化差异对骨质疏松性椎体压缩性骨折椎体、邻近椎间盘及终板生物力学分布的影响,以评估其效果。方法:建立T12椎体骨质疏松性压缩性骨折行经皮椎体成形治疗的有限元模型,从横断面、矢状面、冠状面对骨水泥有无皮质强化情况进行分组分析,研究不同体位变化下,骨皮质强化对T12椎体松质骨、皮质骨、T11/T12椎间盘、T12/L1椎间盘、T11下终板、L1上终板生物力学的影响。结果与结论:(1)在垂直压缩力作用下,经皮椎体成形过程中有或无骨水泥皮质强化在不同体位变化下除伤椎皮质骨以外结构应力变化均不明显;(2)伤椎皮质骨Von Mises应力值在人体前屈、左/右侧弯和左/右轴向旋转时差异显著,同一平面内骨皮质完全强化组较无骨皮质强化组最大Von Mises应力值明显变小,随着骨皮质强化越广泛Von Mises应力值整体呈下降趋势;(3)提示行经皮椎体成形治疗时,横断面内骨水泥应尽量广泛对称水平分布于椎体骨皮质边缘,矢状面内骨水泥应广泛纵向分布且靠近上下终板及前后壁,冠状面内骨水泥应广泛分布于中线两侧同时对称接触上下终板及侧壁,可有效避免伤椎再骨折风险且不增加邻椎骨折、残留盘源性疼痛风险。

关键词：经皮椎体成形骨皮质强化骨质疏松性椎体压缩性骨折邻近椎间盘终板三维有限元分析生物力学

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