检索结果-南通市图书馆

Exploring the Interplay between Local Chain Structure and Stress Distribution in Polymer Networks

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第6期42卷 874-885页

作者： Jin-Tong Xue Yang Bai Li Peng xian-bo huang Zhao-Yan Sun School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China National-certified Enterprise Technology Center Kingfa Science and Technology Co.Ltd.Guangzhou510663China

The mechanical behavior of polymer networks is intrinsically correlated with the local chain topology and chain *** this study,we delve into this relationship through the lens of coarse-grained molecular dynamics(CG-MD)*** aim is to illuminate the intricate interplay between local topology and stress distribution within polymer monomers,cross-linkers,and various components with distinct cross-link connections,thereby elucidating their collective impact on the mechanical properties of polymer *** mainly focus on how specific local structures contribute to the overall mechanical response of the *** particular,we employ local stress analysis to unravel the mechanics of these *** findings reveal the diverse responses of individual components,such as junctions,strands,cross-linkers between junctions,and dangling chain ends,when subjected to ***,we observe that these components exhibit varying degrees of deformation tolerance,underscoring the significance of their roles in determining the mechanical characteristics of the *** investigations highlight junctions as primary contributors to stress accumulation,and particles with higher local stress showing a stronger correlation between stress and Voronoi ***,our results indicate that both strands and cross-linkers between junctions exhibit heightened stress levels as strand lengths *** study enhances our understanding of the multifaceted factors governing the mechanical attributes of cross-linked polymer systems at the microstructural level.

关键词： Local chain structure Local stress Molecular dynamics simulation

The Crystallization Behavior Regulating Nature of Hydrogen bonds Interaction on Polyamide 6,6 by Poly(vinyl pyrrolidone)

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2023年第3期41卷 394-404,I0008页

作者： Yang Liu Li Peng Jie-Long Lin Yong Zhou Du-Jin Wang Charles C.Han xian-bo huang Xia Dong National-certified Enterprise Technology Center Kingfa Science and Technology Co.LTD.Guangzhou 510663China CAS Key Laboratory of Engineering Plastics Beijing National Laboratory for Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBejing 100190China University of Chinese Academy of Sciences Beijing 100049China

The crystallization behavior of polyamide 6,6(PA66) under complex flow field is of great importance for its final mechanical ***(vinyl pyrrolidone)(PVP) was applied as crystallization modifying agency to improve processability of *** regulation nature on hydrogen bonds(H-bonds) interaction of PVP was studied upon cooling *** revealed by in situ FTIR,the sample with 5 wt% PVP displays decreased enthalpy change(ΔH) for both the generation of H-bonds and the transition of H-bonds from “disordered” to “ordered” state,which illustrates the molecular mechanism for the regulation of crystallzation ***,2D-WAXD is applied to reveal the evolution of microstructure for sample under external injection *** orientation factor(f_(H)) decreases obviously with the addition of PVP,because the relaxation of chain segments is promoted as well the crystallization is *** above crystallization and microstructure changes during the processing provokes the improvement of processability without the apparent sacrifice of mechanical properties.

关键词： Polyamide 66 Poly(vinyl pyrrolidone) Hydrogen bonds interaction

流变技术在高分子表征中的应用:拉伸流变测试

在线全文

学校读者我要写书评

暂无评论

高分子学报 2023年第2期54卷 286-302页

作者：刘双黄茜陈全黄险波四川大学高分子材料工程国家重点实验室、高分子研究所成都610065 金发科技股份有限公司企业技术中心广州510000 中国科学院长春应用化学研究所、高分子物理与化学国家重点实验室长春130022

流变测试是与高分子加工和应用相关的重要表征手段.尤其在纺丝、发泡、吹膜、吹塑等以拉伸流场占主导的高分子加工工艺中,高分子的拉伸流变行为对材料聚集态结构的形成起了决定性的作用,进而影响了产品最终的使役性能.本综述第一部分介... 详细信息

流变测试是与高分子加工和应用相关的重要表征手段.尤其在纺丝、发泡、吹膜、吹塑等以拉伸流场占主导的高分子加工工艺中,高分子的拉伸流变行为对材料聚集态结构的形成起了决定性的作用,进而影响了产品最终的使役性能.本综述第一部分介绍了拉伸流场的定义、拉伸流场的分类以及各自的特征;第二部分概述了目前商业拉伸流变仪的种类,并围绕其基本原理、测试技巧以及优缺点等内容展开讲解;第三部分介绍了拉伸流变的测试模式,并举例说明了各个模式的优势;第四部分列出了在拉伸测试中存在的常见问题,并给出了相应的解决方案和建议;最后对拉伸流变与其他表征联用技术的发展趋势进行了总结和展望.

关键词：流变学拉伸流场拉伸流变仪拉伸测试

Current rice production is highly vulnerable to insect-borne viral diseases

在线全文

学校读者我要写书评

暂无评论

National Science Review 2022年第9期9卷 142-144页

作者： Jian-guo Wu Guo-yi Yang Shan-shan Zhao Shuai Zhang Bi-xia Qin Yong-sheng Zhu Hui-ting Xie Qing Chang Lu Wang Jie Hu Chao Zhang Bao-gang Zhang Da-li Zeng Jian-fu Zhang xian-bo huang Qian Qian Shou-wei Ding Yi Li Vector-borne Virus Research Center Fujian Province Key Laboratory of Plant Virology Institute of Plant Virology Fujian Agriculture and Forestry University Institute of Plant Protection Guangxi Academy of Agricultural Sciences Rice Research Institute Fujian Academy of Agricultural Sciences State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural Sciences Rice Research Institute Sanming Academy of Agricultural Sciences Department of Microbiology and Plant Pathology Center for Plant Cell Biology Institute for Integrative Genome Biology University of California The State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University

Rice is one of the most important food crops and feeds more than half of the world’s population [1]. Arthropod-borne rice viruses have caused devastating epidemics in Asian countries and are a major threat to food security [2]. However,lile is known about the vulnerability of rice crops to viral pathogens [3,4], especially southern rice black-streaked dwarf virus (SRBSDV), rice black-streaked dwarf virus (RBSDV) and rice gall dwarf virus (RGDV), known to induce annual outbreaks by insect transmission in some localities in Asia.

关键词：

Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen bo An Wen-Cheng An Gang Fu Wei huang Hui-xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

Insights into spinal muscular atrophy from molecular biomarkers

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong Xing Xinzhu Liu xiandeng Li Mi Li xian Wu Xiaohui huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-bo Guo Di Wang Zhao-xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

The potential mechanism and clinical application value of remote ischemic conditioning in stroke

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1613-1627页

作者： Yajun Zhu Xiaoguo Li Xingwei Lei Liuyang Tang Daochen Wen bo Zeng Xiaofeng Zhang Zichao huang Zongduo Guo The First Affiliated Hospital of Chongqing Medical University ChongqingChina

Some studies have confirmed the neuroprotective effect of remote ischemic conditioning against stroke. Although numerous animal researches have shown that the neuroprotective effect of remote ischemic conditioning may be related to neuroinflammation, cellular immunity, apoptosis, and autophagy, the exact underlying molecular mechanisms are unclear. This review summarizes the current status of different types of remote ischemic conditioning methods in animal and clinical studies and analyzes their commonalities and differences in neuroprotective mechanisms and signaling pathways. Remote ischemic conditioning has emerged as a potential therapeutic approach for improving stroke-induced brain injury owing to its simplicity, non-invasiveness, safety, and patient tolerability. Different forms of remote ischemic conditioning exhibit distinct intervention patterns, timing, and application range. Mechanistically, remote ischemic conditioning can exert neuroprotective effects by activating the Notch1/phosphatidylinositol 3-kinase/Akt signaling pathway, improving cerebral perfusion, suppressing neuroinflammation, inhibiting cell apoptosis, activating autophagy, and promoting neural regeneration. While remote ischemic conditioning has shown potential in improving stroke outcomes, its full clinical translation has not yet been achieved.

关键词： Akt apoptosis autophagy cerebral perfusion cerebral vascular stenosis clinical transformation hemorrhagic stroke ischemic stroke neuroinflammation neuroprotection Notch1 PI3K remote ischemic conditioning stroke

Prediction and stratification for the surgical adverse events after minimally invasive esophagectomy:A two-center retrospective study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第3期31卷 50-61页

作者： Qi-Hong Zhong Jiang-Shan huang Fei-Long Guo Jing-Yu Wu Mao-Xiu Yuan Jia-Fu Zhu Wen-Wei Lin Sui Chen Zhen-Yang Zhang Jiang-bo Lin Department of Thoracic Surgery Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina The Graduate School Fujian Medical UniversityFuzhou 350001Fujian ProvinceChina Department of Thoracic Surgery Affiliated Hospital of Jinggangshan UniversityJi’an 343000Jiangxi ProvinceChina

BACKGROUND Minimally invasive esophagectomy(MIE)is a widely accepted treatment for esophageal cancer,yet it is associated with a significant risk of surgical adverse events(SAEs),which can compromise patient recovery and long-term *** preoperative identification of high-risk patients is critical for improving *** To establish and validate a risk prediction and stratification model for the risk of SAEs in patients with *** This retrospective study included 747 patients who underwent MIE at two centers from January 2019 to February *** were separated into a train set(n=549)and a validation set(n=198).After screening by least absolute shrinkage and selection operator regression,multivariate logistic regression analyzed clinical and intraoperative variables to identify independent risk factors for SAEs.A risk stratification model was constructed and validated to predict the probability of *** SAEs occurred in 10.2%of patients in train set and 13.6%in the validation *** with SAE had significantly higher complication rate and a longer hospital stay after *** key independent risk factors identified included chronic obstructive pulmonary disease,a history of alcohol consumption,low forced expiratory volume in the first second,and low albumin *** stratification model has excellent prediction accuracy,with an area under the curve of 0.889 for the training set and an area under the curve of 0.793 for the validation *** The developed risk stratification model effectively predicts the risk of SAEs in patients undergoing MIE,facilitating targeted preoperative interventions and improving perioperative management.

关键词： Surgical adverse events Minimally invasive esophagectomy Esophageal cancer Stratification model Perioperative management