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Overexpression of IQGAP1 in human pancreatic cancer

Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 540-545页

作者： xiao-Xia Wang xiao-zhong Li Li-Qin Zhai Zhi-Rong Liu xian-Jiu Chen Yi Pei Department of Biochemistry and Molecular Biology Shanxi Medical University Department of Geriatric Oncology Shanxi Academy of Medical SciencesShanxi Dayi Hospital Department of Emergency Shanxi Provincial People's Hospital Department of Pathology Shanxi Provincial People's Hospital

BACKGROUND:Pancreatic cancer is a highly aggressive malignant tumor with the lowest survival rate.A better understanding of the molecular mechanisms which contribute to pancreatic cancer occurrence and progression will aid in the development of new approaches to the early diagnosis,prevention,and treatment of this deadly *** scaffold protein IQGAP1 shows elevated levels in a variety of cancer ***,we investigated whether or not IQGAP1 is also overexpressed in pancreatic ***:IQGAP1 expression was examined in pancreatic cancer and normal tissues adjacent to cancerous tissues(adjacent tissues)by Western blotting and real-time RT-PCR as well as in paraffin sections of tissue microarray by *** correlations between IQGAP1 expression and various clinicopathological characteristics were ***:Western blotting and real-time RT-PCR revealed that the levels of IQGAP1 protein and mRNA expression in pancreatic cancer tissues were significantly increased compared with adjacent *** analysis on tissue microarray showed that IQGAP1 protein expression was significantly higher in pancreatic cancer(80.0%,48/60)compared with adjacent tissues(18.3%,11/60)(P<0.001).Moreover,overexpression of IQGAP1 was shown to be associated with the grades of tumor differentiation(P<0.05).CONCLUSION:The overexpression of IQGAP1 may play an important role in pancreatic cancer occurrence and progression,and IQGAP1 may serve as a novel molecular target for the diagnosis and treatment of pancreatic cancer.

关键词： IQGAP1 pancreatic cancer tissue microarray immunohistochemistry

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国民体质监测系统

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计算机系统应用 2017年第10期26卷 61-66页

作者：许继明赵赫王卫东张中贤李晓风周桐丁增辉中国科学院合肥物质科学研究院合肥230031 中国科学技术大学合肥230026

随着经济社会的发展,人们不仅追求更高的物质生活,也更加关注体质健康和监测自身体质信息.本文介绍了国民体质监测系统,用于集中监测用户个人信息、健康数据和基础运动数据,为健康管理和慢性病干预提供了完整的一站式服务解决方案.本系... 详细信息

随着经济社会的发展,人们不仅追求更高的物质生活,也更加关注体质健康和监测自身体质信息.本文介绍了国民体质监测系统,用于集中监测用户个人信息、健康数据和基础运动数据,为健康管理和慢性病干预提供了完整的一站式服务解决方案.本系统包含基于.NET MVC的数据统计分析子系统、基于Windows服务的数据同步服务与汇总服务以及基于Zabbix的系统监控程序等功能模块,能同时提供Web和移动终端两种访问形式.其中数据统计分析子系统用于统计用户数据,并利用数据挖掘技术给出统计分析结果和科学健身指导方案.数据同步服务用于准备数据,保证系统的数据完整性和一致性.数据汇总服务把省数据中心的地面站数据库数据汇总到中心数据库,中心数据库与数据统计分析子系统进行数据交互.系统监控程序监控服务器联网情况、IIS状态、数据库状态以及系统运行过程中可能发生的错误,并通过短信或邮件给出告警信息.本文设计开发完成的国民体质监测系统,提供了高效的国民体质监测和科学健身指导方案,有利于用户改善自己的身体机能.

关键词：数据统计分析系统 .NET MVC Zabbix 数据同步数据汇总 Windows服务

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Measurement Error in Proportional Hazards Models for Survival Data with Long-term Survivors

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Acta Mathematicae Applicatae Sinica 2012年第2期28卷 275-288页

作者： xiao-bing ZHAO xian ZHOU School of Mathematics and Statistics Zhejiang University of Finance and Economics Hangzhou 310018 China Department of Applied Finance and Actuarial Studies Macquarie University North Ryde Sydney NSW 2109Australia

This work studies a proportional hazards model for survival data with ＂long-term survivors＂, in which covariates are subject to linear measurement error. It is well known that the naive estimators from both partial and full likelihood methods are inconsistent under this measurement error model. For measurement error models, methods of unbiased estimating function and corrected likelihood have been proposed in the literature. In this paper, we apply the corrected partial and full likelihood approaches to estimate the model and obtain statistical inference from survival data with long-term survivors. The asymptotic properties of the estimators are established. Simulation results illustrate that the proposed approaches provide useful tools for the models considered.

关键词： proportional hazards counting process long-term survivor measurement error corrected scorefunction

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Spatiotemporal changeof vegetationcoverage recovery and its driving factors in the Wenchuan earthquake-hit areas

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Journal of Mountain Science 2021年第11期18卷 2854-2869页

作者： SUN xiao-fei YUAN Lin-guo ZHOU Ying-zhi SHAO Huai-yong LI xian-feng zhong Ping Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengdu 611756China College of Earth Science Chengdu University of TechnologyChengdu 610059China Natural Resources and Planning Bureau of Nanchong Nanchong 637000China Department of Geography National University of SingaporeKent Ridge 117570Singapore

Vegetation coverage recovery after the Wenchuan earthquake has important implications for preventing post-seismic geohazards and soil ***,spatiotemporal changes in vegetation coverage recovery and its driving factors have not been sufficiently studied in the quake-hit *** paper aims to analyze vegetation coverage recovery and its driving factors in the quake-hit areas using monadic linear regression,coefficient of variation,and geographical ***,we used Moderate-resolution Imaging Spectroradiometer(MODIS)data to calculate the vegetation coverage from 2008 to 2018 in the quake-hit ***,we assessed the trend and stability of vegetation recovery in the quake-hit areas based on vegetation ***,combined with topography,climate,soil type,vegetation type,and human activities in the quake-hit areas,the driving factors affecting vegetation coverage recovery were *** results showed that the vegetation coverage level in the quake-hit areas recovered about 90%of that before the *** coverage recovery was mainly improved in a stepwise manner:increasing and then stabilizing,then increasing and stabilizing ***,soil type,and road density were the main factors affecting vegetation coverage recovery,and the interaction among all factors positively strengthened their impacts on vegetation coverage *** addition,the results also revealed the categories that were conducive to vegetation coverage recovery among the same environmental factors and can provide a scientific reference for vegetation coverage recovery in the quake-hit areas.

关键词： Wenchuan earthquake Vegetation coverage recovery Geographical detector Driving factors

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Recent advances and perspectives of metal/covalent-organic frameworks in metal-air batteries

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Journal of Energy Chemistry 2021年第12期30卷 113-129,I0003页

作者： Ming zhong Ming Liu Na Li xian-He Bu School of Materials Science and Engineering Tianjin Key Laboratory of Metal and Molecule-Based Material ChemistryNankai UniversityTianjin 300350China State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou 730050GansuChina College of Chemistry Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)Nankai UniversityTianjin 300071China

Metal-air batteries(MABs)have attracted considerable attention as a novel energy technology that can alleviate the severe energy crisis and environmental *** primary processes,including oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)occur on the air cathode and dominate the battery performance during battery charging and ***,metal-organic frameworks(MOFs)and covalent-organic frameworks(COFs)emerge as promising cathode catalysts due to their structure and composition *** unique characteristics of MOFs and COFs contribute to improved *** review mainly summarizes the recent applications of MOFs and COFs in a series of MABs,mainly including lithium-and zinc-air ***,some critical issues are emphasized regarding MOFs and COFs used in other MABs limited progress,their fabrication and alternatives to potential problems.

关键词： Metal-organic frameworks Covalent-organic frameworks Li-air batteries Zn-air batteries Active sites

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Design of the yielding support used highly deformable elements for a tunnel excavated in squeezing rock

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Journal of Mountain Science 2023年第5期20卷 1458-1468页

作者： TIAN Hong-ming TIAN Yun CHEN Wei-zhong TAN xian-jun SHU xiao-yun LIU Xia-lin State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China Key Laboratory of Rock Mechanics and Geohazards of Zhejiang Province School of Civil EngineeringShaoxing UniversityShaoxing 312000China College of Civil and Transportation Engineering Hohai UniversityNanjing 210024China China communications second highway survey and design institute Co. Ltd.Wuhan 430058China

Yielding support is often used in the squeezing tunnel to prevent damage to the lining induced by large deformation of the surrounding *** Deformable Elements(HDE)which is often installed along the circumferential direction of the shotcrete lining is a common type of yielding *** determine the yield parameters of HDE,the support characteristic of the lining using HDE and the ground pressure considering strain-softening of soft rock were analyzed by an analytical *** analytical solution showed that when considering the strain-softening of squeezing ground,the ground pressure has a non-zero minimum *** minimum value of ground stress can be used to determine the constant yield stress of the HDE,and the corresponding deformation of the minimum ground pressure can be used to determine the deformation capacity of the *** on the variation in the design constant yield stress and yield displacement of HDE with the in-situ stress and the mechanical parameters of the soft rock,equations were proposed for determining of the yield parameters of the HDE.

关键词： Highly deformable elements Squeezing tunnel Yielding support Strain-softening behavior

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Photocatalytic Synthesis of Hydrocarbon Oxygenates from C_2H_6 and CO_2 over Pd-MoO_3/SiO_2 Catalyst

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Journal of Natural Gas Chemistry 2007年第2期16卷 173-178页

作者： Xitao Wang zhong He Shunhe zhong Xiufen xiao College of Chemical Engineering and Technology Tianjin University Tianjin 300072 China

Pd-MoO3/SiO2 catalyst has been prepared using the method of incipient wetness impregnation. The photo absorbing behaviors and chemisorbing properties of the catalyst have been characterized by UV-vis spectra and TPD-MS experiments. The results indicated that metal Pd loaded on MoOa/SiO2 has a significant effect on the photo absorbing performance of MoOa/SiO2, and an obvious blue shift of the absorption edge is produced. Under UV irradiation, the chemisorption state of CO2 undergoes decomposing process to form CO at 481 K, and a two-site adsorption state of ethane can be formed at around 496 K. Photo-oxidation of ethane using carbon dioxide can mainly produce propanal, ethanol and acetaldehyde in the temperature range of 353-423 K. The presence of metal Pd improves the catalytic activity remarkably.

关键词： photo-catalysis carbon dioxide ethane hydrocarbon oxygenates Pd-MoOa/SiO2 catalyst

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Improving energetics in an ideal baroclinic instability case with a Physical Conserving Fidelity model

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Frontiers of Earth Science 2013年第3期7卷 341-350页

作者： Qi zhong Qing zhong Ziniu xiao China Meteorological Administration Training Centre Beijing 100081 China Institute of Atmospheric Physics Chinese Academy of sciences Beijing 100029 China

To improve the energetics in the life cycle of an ideal baroclinic instability case, we develop a Physical Conserving Fidelity model （F-model）, and we compare the simulations from the F-model to those of the traditional global spectral semi-implicit model （control model）. The results for spectral kinetic energy and its budget indicate different performances at smaller scales in the two models. A two-way energy flow emerges in the generation and rapid growth stage of the baroclinic disturbance in the F-model. However, only a downscale mechanism dominates in the control model. In the F-model, the meso- and smaller scales are energized initially, and then an active upscale nonlinear cascade occurs. Thus, disturbances at prior scales are forced by both downscale and upscale energy cascades and by conversion from potential energy. An analysis of the eddy kinetic energy budget also shows remarkable enhancement of the energy conversion rate in the F-model. As a result, characteristics of the ideal baroclinic wave are greatly improved in the F-model, in terms of both intensity and time of formation.

关键词： energy conversion energy cascade ideal baroclinic instability high order total energy conservation time-split scheme

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Approximate Controllability of Second-order Semilinear Evolution Systems with Finite Delay

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Acta Mathematicae Applicatae Sinica 2021年第3期37卷 573-589页

作者： xiao-feng SU xian-long FU School of Mathematical Sciences Fudan UniversityShanghai 200433China School of Mathematical Sciences Shanghai Key Laboratory of PMMPEast China Normal UniversityShanghai200241China

In this work,we study the approximate controllability for a class of semilinear second-order control systems with finite *** conditions for approximate controllability are established by constructing fundamental solutions and using the resolvent condition and techniques on cosine family of linear *** illustrate the applications of the obtained results,an example is provided in the end.

关键词： approximate controllability second-order evolution equation fundamental solution cosine operator

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Characteristics of alumina particles in dispersion-strengthened copper alloys

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International Journal of Minerals,Metallurgy and Materials 2014年第11期21卷 1115-1119页

作者： Xue-hui Zhang xiao-xian Li School of Materials Science and Engineering Jiangxi University of Science and Technology School of Metallurgical and Chemical Engineering Jiangxi University of Science and Technology

Two types of alumina dispersion-strengthened copper（ADSC） alloys were fabricated by a novel in-situ reactive synthesis（IRS） and a traditional internal oxidation（IO） process. The features of alumina dispersoids in these ADSC alloys were investigated by X-ray diffraction, scanning electron microscopy, and high-resolution transmission electron microscopy. It is found that nano-sized γ-Al2O3 particles of approximately 10 nm in diameter are homogeneously distributed in the IRS-ADSC composites. Meanwhile, larger-sized, mixed crystal structure alumina with rod-shaped morphology is embedded in the IO-ADSC alloy. The IRS-ADSC composites can obtain better mechanical and physical properties than the IO-ADSC composites; the tensile strength of the IRS-ADSC alloy can reach 570 MPa at room temperature, its electrical conductivity is 85% IACS, and the Rockwell hardness can reach 86 HRB.

关键词： metallic matrix composites alumina copper in-situ reactive synthesis internal oxidation

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