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Magnetic resonance-based total liver volume and magnetic resonance-diffusion weighted imaging for staging liver fibrosis in mini-pigs

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World Journal of Gastroenterology 2012年第48期18卷 7225-7233页

作者： Hang Li Tian-Wu Chen Xiao-Li Chen Xiao-Ming Zhang Zhen-Lin Li Nan-Lin Zeng Li Zhou Li-Ying Wang Hong-Jie Tang Chun-Ping Li Li Li xian-yong xie Sichuan Key Laboratory of Medical Imaging Department of RadiologyAffiliated Hospital of North Sichuan Medical College Department of Radiology West China Hospital of Sichuan University Department of Pathology Affiliated Hospital of North Sichuan Medical College

AIM:To determine whether and how magnetic resonance imaging(MRI)-based total liver volume(TLV) and diffusion weighted imaging(DWI) could predict liver ***:Sixteen experimental mature mini-pigs(6 males,10 females),weighing between 20.0 and 24.0 kg were prospectively used to model liver fibrosis induced by intraperitoneal injection of 40% CCl4 dissolved in fat emulsion twice a week for 16 wk,and by feeding 40% CCl4 mixed with maize flour twice daily for the subsequent 5 *** the survival animals underwent percutaneous liver biopsy and DWI using b = 300,500 and 800 s/mm2 followed by abdominal gadolinium-enhanced MRI at the 0,5th,9th,16th and 21st weekend after beginning of the *** was obtained on enhanced MRI,and apparent diffusion coefficient(ADC) was obtained on *** tissue specimens were stained with hematoxylin and Masson' s trichrome staining for staging liver *** specimens were scored using the human METAVIR classification *** analyses were performed to determine whether and how the TLV and ADC could be used to predict the stage of liver ***:TLV increased from stage 0 to 2 and decreased from stage 3(r = 0.211;P < 0.001).There was a difference in TLV between stage 0-1 and 2-4(P = 0.03) whereas no difference between stage 0-2 and 3-4(P = 0.71).TLV could predict stage ≥ 2 [area under receiver operating characteristic curve(AUC) = 0.682].There was a decrease in ADC values with increasing stage of fibrosis for b = 300,500 and 800 s/mm2(r =-0.418,-0.535 and-0.622,respectively;all P < 0.001).Differences were found between stage 0-1 and 2-4 in ADC values for b = 300,500 and 800 s/mm2,and between stage 0-2 and 3-4 for b = 500 or 800 s/mm2(all P < 0.05).For predicting stage ≥ 2 and ≥ 3,AUC was 0.803 and 0.847 for b = 500 s/mm2,and 0.848 and 0.887 for b = 800 s/mm2,***:ADC for b = 500 or 800 s/mm2 could be better than TLV and ADC for b = 300 s/mm2 to pre-dict fibrosis stage ≥ 2

关键词： Magnetic resonance imaging Total liver volume Liver fibrosis Apparent diffusion coefficient Stage

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期68卷 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan yong Liang Weipeng Li Chengjian Zhu Jie Han Jin xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词： gold catalysis peptide alkylation C-C coupling radical

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3D Printing of Tough Hydrogel Scaffolds with Functional Surface Structures for Tissue Regeneration

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Nano-Micro Letters 2025年第2期17卷 18-45页

作者： Ke Yao Gaoying Hong Ximin Yuan Weicheng Kong Pengcheng Xia Yuanrong Li Yuewei Chen Nian Liu Jing He Jue Shi Zihe Hu Yanyan Zhou Zhijian xie yong He State Key Laboratory of Fluid Power and Mechatronic Systems School of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Liangzhu Laboratory Zhejiang UniversityHangzhou 310027People’s Republic of China Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province College of Mechanical EngineeringZhejiang UniversityHangzhou 310027People’s Republic of China Stomatology Hospital School of StomatologyZhejiang University School of MedicineHangzhou 310027People’s Republic of China State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001People’s Republic of China Institute of Digital Medicine Nanjing First HospitalNanjing Medical UniversityNanjing 210006People’s Republic of China

Hydrogel scaffolds have numerous potential applications in the tissue engineering ***,tough hydrogel scaffolds implanted in vivo are seldom reported because it is difficult to balance biocompatibility and high mechanical *** by Chinese ramen,we propose a universal fabricating method(printing-P,training-T,cross-linking-C,PTC&PCT)for tough hydrogel scaffolds to fill this ***,3D printing fabricates a hydrogel scaffold with desired structures(P).Then,the scaffold could have extraordinarily high mechanical properties and functional surface structure by cycle mechanical training with salting-out assistance(T).Finally,the training results are fixed by photo-cross-linking processing(C).The tough gelatin hydrogel scaffolds exhibit excellent tensile strength of 6.66 MPa(622-fold untreated)and have excellent ***,this scaffold possesses functional surface structures from nanometer to micron to millimeter,which can efficiently induce directional cell ***,this strategy can produce bionic human tissue with mechanical properties of 10 kPa-10 MPa by changing the type of salt,and many hydrogels,such as gelatin and silk,could be improved with PTC or PCT *** experiments show that this scaffold can effectively promote the new generation of muscle fibers,blood vessels,and nerves within 4 weeks,prompting the rapid regeneration of large-volume muscle loss injuries.

关键词： 3D printing Tough hydrogel scaffold Functional surface structure Tissue regeneration Biomaterials

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Design and test of cesium atomic concentration detection system based on TDLAS*1

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Optoelectronics Letters 2025年第3期21卷 167-171页

作者： LIANG Lizhen LIU Shanhu WU yong WEI Jianglong xie Yahong Hefei Institutes of Physical Science Chinese Academy of Sciences School of Science Shandong Jianzhu University School of Electronic and Information Engineering Anhui Jianzhu University

In order to better build the neutral beam injector with negative ion source (NNBI), the pre-research on key technologies has been carried out for the comprehensive research facility for fusion technology (CRFFT). Cesium seeding into negative-ion sources is a prerequisite to obtain the required negative hydrogen ion. The performance of ion source largely depends on the cesium conditions in the source. It is very necessary to quantitatively measure the amount of cesium in the source during the plasma on and off periods (vacuum stage).

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Characteristics of gut microbiota dysbiosis in patients with colorectal polyps

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 13-21页

作者： xian-Rong Wu Xiao-Hong He yong-Fang xie School of Life Health Information Science and Engineering Chongqing Post and Communications UniversityChongqing 400065China

This editorial,inspired by a recent study published in the World Journal of Gastrointestinal Oncology,covers the research findings on microbiota changes in various *** recurrent colorectal polyps,the abundances of Klebsiella,Parvimonas,and Clostridium increase,while those of Bifidobacterium and Lactoba-cillus *** dysbiosis may promote the formation and recurrence of *** microbial changes have also been observed in colorectal cancer,inflammatory bowel disease,autism spectrum disorder,and metabolic syndrome,indicating the role of increased pathogens and decreased probiotics in these *** the gut microbiota,particularly by increasing probiotic levels,may help prevent polyp recurrence and promote gut *** microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.

关键词： Recurrent colorectal polyps Gut microbiota dysbiosis Klebsiella Probiotics Intestinal inflammation Microbial intervention strategy

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Geometric Phase in a Time-Dependent A-Type Jaynes-Cummings Model

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Communications in Theoretical Physics 2009年第3期51卷 407-410页

作者： QIN xian-Ming YU Zbao-xian JIAO Zhi-yong xie Bing-Hao Department of Mathematics and Physics Chongqing University of Science and Technology Chongqing 400042 China Department of Physics Beijing Information Science and Technology University Beijing 100192 China Department of Physics China University of Petroleum （East China） Dongying 257061 China

By using the Lewis-Riesenfeld invariant theory, we have studied the dynamical and the geometric phases in a generalized time-dependent A-type Jaynes Cummings model. We lind that, compared with the dynamical phases, the geometric phases in a cycle case are independent of the frequency of the photon field, the coupling coefficient between photons and atoms, and the atom transition frequency. It is pointed out that the geometric phases in a cycle ease can be measured under the case of a stronger time-dependent photon field and a stronger coupling photon-atom system. On the other hand, the geometric phases of the model may be measured in the composition of cold atoms.

关键词： geometric phase generalized Jaynes-Cummings model

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基于核心素养的初中语文项目化写作教学策略

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语文教学之友 2025年第1期44卷 43-45页

作者：赵永先甘肃省武威第二十四中学

写作是语文教学的重要板块。在语文教学中,强化学生的写作水平,提升写作教学的品质,对学生语文综合素养的提升和发展有着积极的影响。实施项目化写作教学,通过以学生为本位,以完成具体项目为目标实施教学,可以提升写作教学水平,促进学... 详细信息

写作是语文教学的重要板块。在语文教学中,强化学生的写作水平,提升写作教学的品质,对学生语文综合素养的提升和发展有着积极的影响。实施项目化写作教学,通过以学生为本位,以完成具体项目为目标实施教学,可以提升写作教学水平,促进学生的深度学习与发展。立足《学写传记》的写作主题,从搭设教学情境、密切联系主题等角度出发,探讨核心素养视角下初中语文项目化写作教学的有效策略。

关键词：核心素养项目化写作教学有效策略

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Dendritic cells pulsed with hsp70-peptide complexes derived from human hepatocellular carcinoma induce specific anti-tumor immune responses

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World Journal of Gastroenterology 2005年第36期11卷 5614-5620页

作者： xian-Hua Wang, Yan Qin Mei-Hao Hu yong xie College of Life Sciences Peking University Beijing 100871 China candidate of Peking University Department of Biology The Hong Kong University of Science and Technology Hong KongChina

AIM： To investigate the anti-tumor effect of dendritic cells （DCs） pulsed with hsp70-peptide complexes derived from human hepatocellular carcinoma （HCC） cells on human T cells. METHODS： Hsp70-peptide complexes were purified from human HCC cells with column chromatography using ADP-agarose and DEAE-Sepharose. DCs were derived from peripheral blood mononuclear cells of healthy donors in the presence of human GM-CSF and IL-4. The anti-tumor effect of DCs pulsed with hsp70-peptide complexes on human T-cell was assayed by CTL and enzyme-linked immunospot （ELISPOT） tests. RESULTS： Hsp70-peptide complexes derived from human HCC cells activated phenotypic and functional maturation of DCs. The matured DCs stimulated a high level of autologous T-cell proliferation and type Ⅰ cytokine secretion, and induced HCC-specific cytotoxic T lymphocytes （CTLs）, which specifically killed HCC cells by a MHC class Ⅰ restricted mechanism. CONCLUSION： Hsp70-peptide complexes derived from human HCC cells can serve as a potent tumor antigen source for pulsing DCs, the pulsed DCs are very effective in activating specific T-cell responses against HCC cells. 2005 The WJG Press and Elsevier Inc. All rights reserved

关键词： Hsp70-peptidde complexes Dendritic Cytotoxic T lymphocytes ELISPOT assay Hepatocellular carcinoma

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Time Dependence of Entropy Flux and Entropy Production of a Dissipative Dynamical System Driven by Non-Gaussian Noise

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Communications in Theoretical Physics 2008年第6期49卷 1561-1566页

作者： GUO yong-Feng XU Wei LI Dong-Xi xie Wen-xian Department of Applied Mathematics Northwestern Polytechnical University Xi＇an 710072 China

A stochastic dissipative dynamical system driven by non-Gaussian noise is investigated. A general approximate Fokker-Planck equation of the system is derived through a path-integral approach. Based on the definition of Shannon＇s information entropy, the exact time dependence of entropy flux and entropy production of the system is calculated both in the absence and in the presence of non-equilibrium constraint. The present calculation can be used to interpret the interplay of the dissipative constant and non-Gaussian noise on the entropy flux and entropy production.

关键词： information entropy entropy flux and entropy production non-Gaussian noise Fokker-Planck equation

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Synthesis of Planar-Chiral[2.2]Paracyclophane-Based Oxazole-Pyrimidine Ligands and Application in Nickel-Catalyzed 1,2-Reduction ofα,β-Unsaturated Ketones

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Chinese Journal of Chemistry 2024年第7期42卷 705-710页

作者： Juan Wang Qing-xian xie xiang Li Chang-Bin Yu yong-Gui Zhou School of Chemistry Dalian University of Technology2 Linggong RoadDalianLiaoning 116024China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalianLiaoning 116023China

The planar-chiral ligands have been widely applied as a class of unique and significant ligands in asymmetric *** them,chiral[2.2]paracycyclophane has emerged as a privileged type of planar-chiral framework and has been utilized as an important toolbox due to their structural ***,we design and synthesize[2.2]paracyclophane-derived oxazole-pyrimidine ligands(abberviated as PYMCOX).These N,N-ligands with stable properties,rigid structure and large steric hindrance performed successfully in nickel-catalyzed asymmetric 1,2-reduction ofα,β-unsaturated ketones,affording the chiral allylic alcohols with up to 99%yield and 99%***,this reduction reaction could be conducted on gram-scale without loss of activity and enantioselectivity,and the chiral ligand could be conveniently recovered with high yield.

关键词： Oxazole-pyrimidine ligands Planar chirality Nickel Hydroboration Asymmetric synthesis

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