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Repetitive transcranial magnetic stimulation enhanced by neuronavigation in the treatment of depressive disorder and schizophrenia

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World Journal of Psychiatry 2024年第11期14卷 1618-1622页

作者： xian-yang wang Yuan-Bei Zhang Rong-Xue Mu Long-Biao Cui Hua-Ning wang Schizophrenia Imaging Laboratory Xijing 986 HospitalFourth Military Medical UniversityXi’an 710054Shaanxi ProvinceChina Simon Fraser University Vancouver V5A1S6British ColumbiaCanada Shaanxi Provincial Key Laboratory of Clinic Genetics Fourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Radiology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Psychiatry Xijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

This editorial assesses the advancements in neuronavigation enhanced repetitive transcranial magnetic stimulation for depressive disorder and schizophrenia *** repetitive transcranial magnetic stimulation faces challenges due to the intricacies of brain anatomy and patient *** offers innovative solutions by integrating neuroimaging with three-dimensional localization to pinpoint brain regions and refine therapeutic *** systematic review of recent literature underscores the enhanced efficacy of neuronavigation in improving treatment outcomes for these *** editorial highlights the pivotal role of neuronavigation in advancing psychiatric care.

关键词： Repetitive transcranial magnetic stimulation Neuronavigation Depressive disorder Schizophrenia Psychiatric care

Magnetic Resonance Imaging-Guided and Navigated Individualized Repetitive Transcranial Magnetic Stimulation for Cognitive Impairment in Schizophrenia

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Neuroscience Bulletin 2021年第9期37卷 1365-1369页

作者： Xu-Sha Wu Tian-Cai Yan xian-yang wang yang Cao Xiao-Fan Liu Yu-Fei Fu Lin Wu Yin-Chuan Jin Hong Yin Long-Biao Cui School of Medical Technology Shaanxi University of Chinese MedicineXianyang 712046China Department of Clinical Psychology School of Medical PsychologyFourth Military Medical UniversityXi’an 710032China School of Medical Imaging Mudanjiang Medical UniversityMudanjiang 157011China Department of Radiology Xijing HospitalFourth Military Medical UniversityXi’an 710032China Department of Radiology The Second Medical CenterChinese PLA General HospitalBeijing 100853China

Schizophrenia(SZ)is a chronic,serious,and recurrent mental illness,characterized by cognitive impairment as the core symptom,which can be an important sign before the onset of psychosis[1].Furthermore,persistent cogni... 详细信息

关键词： impairment Schizophrenia patients

A Multi-faceted View of the X-Ray Spectral Variability in Seyfert Galaxy Ark 120

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Research in Astronomy and Astrophysics 2025年第1期25卷 228-239页

作者： Lu-Xin Ren Jun-xian wang Jia-Lai Kang CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China School of Astronomy and Space Science University of Science and Technology of China

Utilizing a range of techniques including multi-band light curves,softness ratio analysis,structure functions,rms spectra,cross-correlation functions,and ratios of spectra from different intervals,we present a comprehensive study of the complex X-ray spectral variability in Seyfert 1 galaxy Ark 120,through re-analyzing its six XMM-Newton observations taken between 2003 and *** find a clear“softer-when-brighter”trend in the 2–10 ke V power-law component over long timescales,with this trend being timescale dependent,as it is much weaker on shorter timescales,similar to that previously detected in NGC ***,a rare“harder-when-brighter”trend is observed during one exposure,indicating dynamic changes in the spectral variability behavior of the power-law *** exceptional exposure,with the spectral variability indeed marked by a power-law pivoting at an unusually low energy of～2 ke V,suggests intricate variations in the thermal Comptonization processes within the ***,when the data below 2 ke V are included,we identify that the soft excess component adds significant complexity to the spectral variability,such as evidenced by a transition from“harder-when-brighter”to“softer-when-brighter”during another single *** extra complexity arises because the variability of the soft excess sometimes follows and sometimes does not follow the changes in the power-law *** findings underscore the necessity of applying multiple analytic techniques to fully capture the multifaceted spectral variability of AGNs.

关键词： galaxies: active galaxies: Seyfert X-rays: galaxies

Initial experience of occluding special type patent ductus arterioses using the Amplatzer vascular plug

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Chinese Medical Journal 2013年第18期126卷 3456-3459页

作者： ZHANG Po ZHU xian-yang wang Qi-guang ZHANG Duan-zhen HAN Xiu-min Department of Congenital Heart Disease Cardiovascular Research Institute of People's Liberation Army General Hospital of Shenyang Military Command Shenyang Liaoning 110016 China

Background Occluders licensed for clinical use are not fit for some special Krichenko E patent ductus arterioses. The Amplatzer vascular plug I （AVP1） has not been licensed for use for closure of patent ductus arteriose. We report our initial experience to occluding special type patent ductus arterioses with the AVPI-a single lobe device of single layer Nitinol mesh for short vessel landing zones. Methods Patients referred with small and long Krichenko E patent ductus arterioses 1 mm to 3 mm in diameter underwent occlusion using AVPI. All cases underwent pre-, intra- and post-procedural echocardiography and chest X-ray at the completion of the procedure, the next day and at a 30-day, 3-month and 6-month follow-up visits. Device sizing for device waist diameter and length was based on aortography. Results From April 2008 to June 2012, 26 patients with a mean age of （7.6±8.0） years （range 6 months-32 years） and a mean weight of （23.8±14.8） kg （range 7-67 kg） underwent successful patent ductus arteriose closure. The mean ductus diameter was （2.1±0.7） mm （range 1-3 mm）. Transpulmonary （22/26） and transaortic approaches （4/26） were used. No persistent patency was observed after 24 hours and after one month. No device displacement, residual flow and iatrogenic coarctation of the aorta were observed after three months and six months. Conclusions The AVP1 makes it easy to close some Krichenko E patent ductus arterioses. Smaller delivery catheter profile and symmetric cylindrical device shape allow for use for small and long Krichenko E patent ductus arterioses 1 mm to 3 mm in diameter and small patients through transaortic approaches. Broader experience is required to further delineate device and patient selection as well as to document its long-term efficacy and safety.

关键词： patent ductus arteriosus heart catheterization intervention studies therapeutic occlusion Amplatzer vascular plug I

Engineering strategies of biomaterial-assisted exosomes for skin wound repair:Latest advances and challenges

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Chinese Chemical Letters 2025年第1期36卷 99-109页

作者： yang Xu Le Ma yang wang Chunmeng Shi Institute of Rocket Force Medicine State Key Laboratory of Trauma and Chemical PoisoningThird Military Medical University(Army Medical University)Chongqing 400038China

The treatment of skin wounds,especially chronic wounds,remains a critical clinical challenge and places a heavy burden on patients and healthcare *** recent years,the engineering strategy of using biomaterial-assisted exosomes has emerged as a powerful tool for skin *** to treatments such as debridement and regular dressing changes,the design of biomaterial-assisted exosomes not only maintains the bioactivity of exosomes at the wound site but also provides an appropriate microenvironment for the repair of complex tissues,thereby accelerating wound *** review systematically introduces the general characteristics of exosomes and their functions in skin wound healing,highlights recent advances in classification of natural exosomes and engineering methods which enriching their functions in intercellular ***,various emerging and innovative approaches based on biomaterials delivery of exosomes are comprehensively *** review seeks to bring an in-depth understanding of bioactive dressings based on exosomes therapeutic strategies,aiming to facilitate new clinical application value.

关键词： Exosomes Biomaterials Hydrogel Delivery system Wound healing

Reconstructing forest and grassland cover changes in China over the past millennium

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Science China Earth Sciences 2025年第1期68卷 94-110页

作者： Fanneng HE Fan yang Yafei wang Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China Key Research Institute of Yellow River Civilization and Sustainable Development Henan UniversityKaifeng475001China University of Chinese Academy of Sciences Beijing100049China

Historical forest and grassland cover changes not only are critical indicators for quantifying ecological and environmental change processes but also serve as fundamental data for long-term climate change simulations and terrestrial ecosystem carbon emission ***,because of limitations in historical data,quantitative estimations and spatially gridded reconstructions of these changes remain challenging,necessitating further methodological *** study focused on China's present-day land area over the past millennium,objectively capturing the characteristics and drivers of forest and grassland cover *** this basis,using the forest transition theory and the space-for-time substitution method,we depicted the historical deforestation process as an inverted“S”curve and developed a model to reconstruct historical forest area changes based on the functional relationship between the forest area and population size ***,a gridded forest allocation model was established on the basis of deforestation *** the grassland cover,we implemented regionspecific methods,such as the cropland area deduction method and the habitat constraint method,to quantitatively reconstruct historical ***,we obtained provincial forest and grassland area changes over the past millennium and mapped 10-km-resolution gridded data of forest and grassland *** results indicated the following.(1)The methods developed using population data as a proxy objectively reproduced the spatiotemporal evolution of forest and grassland cover in China over the past *** feasible methods offer a novel pathway for the quantitative reconstruction of historical forest and grassland cover changes.(2)The data indicated that China's forest area generally decreased over the past millennium,characterized by a“decrease-then-increase”*** forest area experienced three distinct phases:a slow decline(AD 1000–1650),a rapid decline(AD 16

关键词： Land use and land cover change Forest Grassland Quantitative reconstruction Gridded reconstruction China historical period

Integrating well logs, 3D seismic, and earthquake data for comprehensive prediction of 3D in-situ stress orientations: A case study from the Weiyuan area in the Sichuan Basin, China

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Petroleum Science 2025年第1期22卷 210-221页

作者： Huan Cao yang Zhao Hai-Chao Chen Le-Le Zhang Cheng-Gang xian Ji-Dong yang Lu Liu State Key Laboratory of Petroleum Resources and Engineering and Unconventional Petroleum Research Institute China University of Petroleum (Beijing) Department of Geophysics China University of Petroleum (East China) Aramco Beijing Research Center Aramco Asia

Determining the orientation of in-situ stresses is crucial for various geoscience and engineering applications. Conventional methods for estimating these stress orientations often depend on focal mechanism solutions(FMSs) derived from earthquake data and formation micro-imager(FMI) data from well ***, these techniques can be costly, depth-inaccurate, and may lack spatial coverage. To address this issue, we introduce the use of three-dimensional(3D) seismic data(active sources) as a lateral constraint to approximate the 3D stress orientation field. Recognizing that both stress and fracture patterns are closely related to seismic velocity anisotropy, we derive the orientation of azimuthal anisotropy from multi-azimuth 3D seismic data to compensate for the lack of spatial stress orientation information. We apply our proposed workflow to a case study in the Weiyuan area of the Sichuan Basin, China, a region targeted for shale gas production. By integrating diverse datasets, including 3D seismic, earthquakes, and well logs, we develop a comprehensive 3D model of in-situ stress(orientations and magnitudes). Our results demonstrate that the estimated anisotropy orientations from 3D seismic data are consistent with the direction of maximum horizontal principal stress(SHmax) obtained from FMIs. We analyzed 12earthquakes(magnitude > 3) recorded between 2016 and 2020 for their FMSs and compressional axis(Paxis) orientations. The derived SHmax direction from our 3D stress model is 110°ES(East-South), which shows excellent agreement with the FMSs(within 3.96°). This close alignment validates the reliability and precision of our integrated method for predicting 3D SHmax orientations.

关键词： In-situ stress orientation SHmax Azimuthal velocity anisotropy Focal source mechanism Formation micro-imager

Plasma metabolomics combined with mass spectrometry imaging reveals crosstalk between tumor and plasma in gastric cancer genesis and metastasis

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Chinese Chemical Letters 2025年第1期36卷 506-512页

作者： Yanhua Chen xian Ding Jun Zhou Zhaoying wang Yunhai Bo Ying Hu Qingce Zang Jing Xu Ruiping Zhang Jiuming He Fen yang Zeper Abliz Key Laboratory of Mass Spectrometry Imaging and Metabolomics(State Ethnic Affairs Commission) Center for Imaging and Systems BiologyCollege of Life and Environmental SciencesMinzu University of ChinaBeijing 100081China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Center of Drug Clinical TrialPeking University Cancer Hospital and InstituteBeijing 100142China Beijing Engineering Research Center of Food Environment and Public Health Minzu University of ChinaBeijing 100081China Key laboratory of Ethnomedicine of Ministry of Education School of PharmacyMinzu University of ChinaBeijing 100081China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of BioBankPeking University Cancer Hospital and InstituteBeijing 100142China Pharmacy Department of Beijing Chao–yang Hospital Capital Medical UniversityBeijing 100020China

Gastric Carcinoma(GC)is a highly fatal malignant tumor with a poor *** elevated mortality rates are primarily due to its proclivity for late-stage *** the metabolic interactions between tumor microenvironment and the systemic bloodstream could help to clearly understand the mechanisms and identify precise biomarkers of tumor growth,proliferation,and *** this study,an integrative approach that combines plasma metabolomics with mass spectrometry imaging of tumor tissue was developed to investigate the global metabolic landscape of GC tumorigenesis and *** results showed that the oxidized glutathione to glutathione ratio(GSSH/GSH)became increased in non-distal metastatic GC(M0),which means an accumulation of oxidative stress in tumor ***,it was found that the peroxidation of polyunsaturated fatty acids,such as 9,10-EpOMe,9-HOTrE,etc.,were accelerated in both plasma and tumor tissues of distal metastatic GC(M1).These changes were further confirmed the potential effect of CYP2E1 and GGT1 in metastatic potential of GC by mass spectrometry imaging(MSI)and immunohistochemistry(IHC).Collectively,our findings reveal the integrated multidimensional metabolomics approach is a clinical useful method to unravel the bloodtumor metabolic crosstalk,illuminate reprogrammed metabolic networks,and provide reliable circulating biomarkers.

关键词： Metabolomics Spatial-resolved metabolomics Gastric cancer Blood-tumor metabolic crosstalk Lipid peroxidation

Genetic diversity and population genetic structure of Paeonia suffruticosa by chloroplast DNA simple sequence repeats(cpSSRs)

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Horticultural Plant Journal 2025年第1期11卷 367-376页

作者： Qi Guo xian Xue Duoduo wang Lixia Zhang Wei Liu Erqiang wang Xiaoqiang Cui Xiaogai Hou College of Agriculture/College of Tree Peony Henan University of Science and TechnologyLuoyangHenan 471023China Luoyang Academy of Agricultural and Forestry Science LuoyangHenan 471027China Luanchuan County Agriculture and Rural Affairs Bureau Agricultural Technology Extension Service CenterLuoyangHenan 471599China

Paeonia suffruticosa *** an endemic shrub flower in China with 2n=*** study used 228 cultivars from four populations,i.e.,Jiangnan,Japan,Northwest,and Zhongyuan,as materials to explore the genetic diversity levels among different populations of tree peony *** results showed that 34 bands were amplified using five pairs of cp SSR primers,with an average of 6.8 bands per primer *** average number of different alleles(N_(a)),effective alleles(N_(e)),Shannon's information index(I),diversity(H),and polymorphic information content(PIC)were 3.600,2.053,0.708,0.433,and 0.388,*** PIC value was between 0.250 and 0.500,indicating a moderate level of polymorphism for the five cp SSR primer *** genetic diversity levels of peony cultivars varied among different populations,with the Northwest population showing relatively lower levels(I=0.590,H=0.289,and PIC=0.263).A total of 52 haplotypes were identified in the four examined populations,and the number of haplotypes per population ranged from 11 to ***-four private haplotypes were detected across populations,and the Northwest population exhibiting the highest count of private haplotypes with *** mean number of effective number of haplotypes(N_(eh)),haplotypic richness(R_(h)),and diversity(H)were 8.351,6.824,and 0.893,*** of molecular variance indicated that genetic variation within tree peony germplasm was greater than that between germplasm resources,and the main variation was found within individuals of peony *** analysis,principal coordinate analysis,and genetic structure analysis classified tree peonies from different origins into two groups,indicating a certain degree of genetic differentiation among these four tree peony cultivation *** study provides a theoretical basis for the exploration,utilization,and conservation of peony germplasm resources,as well as for research on the breeding of excellent varieties.

关键词： Paeonia suffruticosa Chloroplast microsatellites(cp SSR) Genetic diversity Haplotypes Germplasm resources