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丹参中甘西鼠尾新酮A通过干扰LPS与TLR4/MD2的结合发挥抗炎作用

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药学学报 2024年第6期59卷 1647-1655页

作者：王鸿颖何贤芳刘瑞秀易琼钟杭王鲁贵州大学药学院贵州贵阳550025 西南特色药用生物资源开发利用教育部工程研究中心贵州贵阳550025

研究丹参中是否存在能与Toll样受体4/髓样分化蛋白2(Toll like receptor 4/myeloid differentiation protein 2,TLR4/MD2)结合发挥抗炎活性的化合物。本文以TLR4/MD2为靶蛋白虚拟筛选了丹参已报道的化学成分,并检测了筛选出的甘西鼠尾新... 详细信息

研究丹参中是否存在能与Toll样受体4/髓样分化蛋白2(Toll like receptor 4/myeloid differentiation protein 2,TLR4/MD2)结合发挥抗炎活性的化合物。本文以TLR4/MD2为靶蛋白虚拟筛选了丹参已报道的化学成分,并检测了筛选出的甘西鼠尾新酮A(neoprzewaquinone A,Neo A)对脂多糖(lipopolysaccharide,LPS)与细胞膜上受体结合的影响、与蛋白的亲和力作用、对LPS介导细胞中TLR4与MD2二聚化的影响、对LPS所致细胞核转录因子-κB(nuclear factor-κB,NF-κB)p65蛋白磷酸化及细胞炎性因子分泌的影响。研究结果表明,丹参中Neo A与TLR4/MD2虚拟结合能最高,为−12.8 kcal·mol^(-1);Neo A可极显著抑制LPS与细胞膜上的受体结合(P<0.01),且Neo A能与rhTLR4/MD2、rhTLR4、r hMD2结合,亲和力分别为267、534、228 nmol·L^(-1);Neo A与TLR4/MD2的氨基酸残基TYR131、PHE121等位点可能存在烷基及π-烷基疏水作用;Neo A能极显著抑制LPS介导细胞中TLR4与MD2的二聚化(P<0.01),显著抑制NF-κBp65蛋白的磷酸化水平(P<0.05);Neo A能显著或极显著抑制LPS所致细胞一氧化氮(nitric oxide,NO)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白细胞介素-6(interleukin-6,IL-6)和白细胞介素-1β(interleukin-1β,IL-1β)的分泌(P<0.05,P<0.01)。综上,Neo A可通过与TLR4/MD2结合干扰LPS与TLR4/MD2结合发挥抗炎作用,可能是一种TLR4/MD2抑制剂,可用于TLR4/MD2为靶点的炎症相关疾病治疗。

关键词：丹参甘西鼠尾新酮A 脂多糖 Toll样受体4/髓样分化蛋白2 抗炎

2022年北京市城区PM_(2.5)水溶性离子含量及其变化特征

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环境科学 2024年第5期45卷 2537-2547页

作者：陈圆圆崔迪赵泽熙常淼景宽沈秀娥刘保献北京市生态环境监测中心大气颗粒物监测技术北京市重点实验室北京100048

为探究北京市大气细颗粒物(PM_(2.5))水溶性离子含量及其变化特征,有针对性地提出污染防治方案,对2022年全年PM_(2.5)水溶性离子、气态前体物(SO_(2)、NO_(2))和气象因素(温度、RH)进行分析测定.结果表明,北京市城区PM_(2.5)中占比最高... 详细信息

为探究北京市大气细颗粒物(PM_(2.5))水溶性离子含量及其变化特征,有针对性地提出污染防治方案,对2022年全年PM_(2.5)水溶性离子、气态前体物(SO_(2)、NO_(2))和气象因素(温度、RH)进行分析测定.结果表明,北京市城区PM_(2.5)中占比最高的水溶性离子为NO_(3)^(-)、NH_(4)^(+)和SO_(4)^(2-),占PM_(2.5)的52.7%,ρ(PM_(2.5))(33.2μg·m^(−3))和ρ(SNA)(18.9μg·m^(−3))低于历史研究结果,但SNA占比(52.7%)、SOR(0.45)和NOR(0.15)高于历史研究结果,体现出北京市细颗粒物污染得到明显改善,但仍具有较强的二次污染特征.NO_(3)^(-)/SO_(4)^(2-)为2.2,高于历史及附近省市研究结果,反映出移动源的影响不断扩大.从季节变化上看,PM_(2.5)呈现秋高夏低的变化特征,秋、春、冬这3个季节NO_(3)^(-)的占比最高,夏季SO_(4)^(2-)占比最高,而NH_(4)^(+)在各季节占比变化不大.NOR与SOR的季节变化规律几乎相反,反映出二者的转化形成因素存在差异.北京城区SNA的主要存在形式为NH_(4)NO_(3)^(-)和(NH_(4))_(2)SO_(4),其中冬季阴阳离子中和度最高,夏季阳离子NH_(4)^(+)稍显不足,而春秋两季NH_(4)^(+)处于过量状态,北京城区为富氨环境.从污染级别看,水溶性离子质量浓度均随污染加重有不同程度的增长,增长最快的是SNA,其在PM_(2.5)中占比出现先上升后稳定的变化特征.从空间分布特征来看,中心城区和东南西北部郊区的SNA质量浓度大小均为:NO_(3)^(-)>SO_(4)^(2-)>NH_(4)^(+),体现了以NO_(3)^(-)为主导的污染特征;SNA对PM_(2.5)的贡献率最高的区域发生在东部、中心城区和传输点,表明在中心城区和东部地区二次反应相对活跃,同时区域传输也是二次离子的重要来源.

关键词：大气细颗粒物(PM_(2.5)) 水溶性离子二次无机离子(SNA) 质量浓度变化特征

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制造业投入服务化对劳动收入的双向效应分析

系统工程 2024年第4期42卷 66-76页

作者：王宏森蓝管秀锋匡贤明东北大学工商管理学院辽宁沈阳110160 江西省社会科学院江西发展战略研究所江西南昌330077

制造业投入服务化是将服务要素引入制造业生产中,以提升制造业的附加值和竞争力。本文基于WIOD和WID面板数据,从理论和实证角度分析了制造业投入服务化对劳动收入的双向效应。结果表明:制造业投入服务化能够提升劳动收入份额;制造业投... 详细信息

制造业投入服务化是将服务要素引入制造业生产中,以提升制造业的附加值和竞争力。本文基于WIOD和WID面板数据,从理论和实证角度分析了制造业投入服务化对劳动收入的双向效应。结果表明:制造业投入服务化能够提升劳动收入份额;制造业投入服务化对发展中经济体劳动收入份额的积极影响大于发达经济体,制造业投入生活性服务对收入份额的拉动作用大于投入生产性服务和公共服务;全要素生产率、中间投入分别是制造业投入服务化提升和抑制劳动收入份额的中介渠道;从全产业到制造业,劳动收入份额与收入差距均呈负相关。

关键词：劳动收入份额收入差距制造业投入服务化

Enhanced photothermal dehydration of me.hanol over W_(18)O_(49)/Au/SAPO-34 catalysts with broadened light absorption

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Rare me.als 2024年第3期43卷 1139-1152页

作者： Ya-Qin Tang me.g-Xia Yan Chang-Qian Lu Shao-Yuan Li Kui-xian Wei Tao Qu Wen-HuiMa Yong-Nian Dai Kong-Zhai Li Da-Jun Luo Xue-Liang Zhang Yi-Ke Liu Faculty of me.allurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China School of Materials and Energy Engineering Guizhou Institute of TechnologyGuiyang550003China

me.hanol-to-olefins(MTO)process is one of the most critical pathways to produce low carbon ***,the reaction is driven by thermal catalysis,which inevitably needs to consume.large amounts of fossil *** a new technique to substitute for the fuel burning is urgent for MTO process to improve the industry prospects and ***,we report a novel W_(18)O_(49)/Au/SAPO-34(W/Au/S),a multifunctional photothermal catalyst for the MTO reaction.A high me.hanol conversion was achieved under xenonum(Xe)lamp irradiation,yielding me.hyl ether(me.and ethylene as the main *** optimized W/Au/S catalysts showed ethylene yield as high as 250μmol in 60 min,which was 2.5 time. higher than that of Au/*** physiochemical characterization revealed that the SAPO-34 molecular sieves were surrounded by Au and W_(18)O_(49)nanoparticles,which exhibited a strong localized surface plasmon resonance excitation around 540 nm and light absorption beyond 500 *** multifunctional catalysts showed a strong photothermal effect,arising from the broadened light absorption of Au and W_(18)O_(49)nanoparticles,leading to a temperature as high as 250℃on the surface of the *** study showed that the superior ethylene selectivity of W/Au/S catalysts was attributed to the moderating acidic sites of W_(18)O_(49)for me.hanol dehydration to *** research may provide new insight for designing heterostructures to improve photo-to-chemical conversion performance and is expected to accelerate progress toward the excellent multifunctional photothermal catalysts with broad light absorption for me.hanol activation and C-C bond formation.

关键词： me.hanol conversion Ethylene Photothermal catalysis W_(18)O_(49) BrΦnsted-acid

Shugan Jieyu capsule effects on peripheral blood micro-124, micro- 132, and brain-derived neurotrophic factor in patients with mild to moderate depression

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World Journal of Psychiatry 2024年第9期14卷 1354-1363页

作者： xian Zhang Yang Liu Hua-Fei Tang Feng Jiang Chun-Liang Chen Ting-Ting Wang Hui-Zhong Gu Qiang Zhao Rui Ma Departme.t of Pharmacy The 305 Hospital of People’s Liberation ArmyBeijing 100017China

BACKGROUND To assess the effectiveness of Shugan Jieyu capsules on peripheral blood miR-124,miR-132,and brain-derived neurotrophic factor(BDNF)levels in patients with mild to moderate depression following coronary artery intervention[percuta-neous coronary intervention(PCI)]for coronary heart *** with mild-to-moderate depression of the liver-qi stagnation type after PCI for coronary heart disease at the 305th Hospital of the People’s Liberation Army were enrolled from June 2022 to November 2023 and randomly assigned to two groups:Experime.tal(treated with Shugan Jieyu capsules)and control(tr-eated with escitalopram oxalate tablets).This study compared the antidepressant effects of these treatme.ts using 17-item Hamilton Rating Scale for Depression(HAMD-17)scores,me.abolic equivalents,low-density lipoprotein cholesterol,BDNF,high-sensitivity C-reactive protein levels,miR-124 and miR-132 levels,distribution of immune-related lymphocyte subsets,and traditional Chinese me.dicine syndrome.scores before and after 6 weeks of *** No significant difference was observed in any index between the two groups before treatme.t(P>0.05).After treatme.t,the total efficacy rates were 93.33%and 90.00%in the experime.tal and control groups,*** group had significantly lower scores for the main and secondary syndrome. compared to the control group(Pme.abolic equivalents between the two groups be-fore and after treatme.t(P>0.05).The levels of low-density lipoprotein cholesterol,high-sensitivity C-reactive pro-tein,and miR-132 were significantly lower,whereas those of miR-124,BDNF,CD3+T lymphocytes,CD3+CD4+T helper lymphocytes,and CD3+CD4+/CD3+CD8+cells were significantly higher in the experime.tal group com-pared to the control group(Pme.tal group was signi-ficantly lower than that in control group(P<0.05).CONCLUSION Shugan Jieyu capsu

关键词： Shugan Jieyu capsule Coronary heart disease Depression Escitalopram oxalate tablet Micro-124 Micro-132 Brain-derived neurotrophic factor

Expert consensus on the diagnosis and treatme.t of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

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World Journal of Pediatrics 2024年第9期20卷 901-914页

作者： Ying-Shuo Wang Yun-Lian Zhou Guan-Nan Bai Shu-xian Li Dan Xu Li-Na Chen Xing Chen Xiao-Yan Dong Hong-Min Fu Zhou Fu Chuang-Li Hao Jian-Guo Hong En-me. Liu Han-Min Liu Xiao-Xia Lu Zheng-xiu Luo Lan-Fang Tang Man Tian Yong Yin Xiao-Bo Zhang Jian-Hua Zhang Hai-Lin Zhang De-Yu Zhao Shun-Ying Zhao Guo-Hong Zhu Ying-Xue Zou Quan Lu Yuan-Yuan Zhang Zhi-Min Chen Departme.t of Pulmonology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Departme.t of Child Health Care Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhou 310052China Departme.t of Pediatric Pulmonology and Immunology West China Second University HospitalSichuan UniversityChengdu 610041China Departme.t of Pediatrics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021China Departme.t of Pulmonology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China Departme.t of Pulmonary and Critical Care me.icine Kunming Children’s HospitalKunming 650034China Departme.t of Respiratory me.icine Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Departme.t of Pulmonology Children’s Hospital of Soochow UniversitySuzhou 215003China Departme.t of Pediatrics Shanghai General Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200080China Departme.t of Respiratory me.icine Wuhan Children’s HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430015China Departme.t of Respiratory me.icine Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Departme.t of Respiratory me.icine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Departme.t of Respiratory me.icine Children’s Hospital of Fudan UniversityShanghai 201102China Departme.t of Pediatric Pulmonology Xinhua HospitalShanghai Jiaotong University School of MedicineShanghai 201102China Departme.t of Pediatric Respiratory me.icine The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027China National Clinical Research Center for Respiratory Diseases Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China Departme.

Background Mycoplasma pneumoniae(***)is a significant contributor to community-acquired pneumonia among *** 1968,when a strain of *** resistant to macrolide antibiotics was initially reported in Japan,macrolide-resistant ***(MRMP)has been docume.ted in many countries worldwide,with varying incidence *** infections lead to a poor response to macrolide antibiotics,frequently resulting in prolonged fever,extended antibiotic treatme.t,increased hospitalization,intensive care unit admissions,and a significantly higher proportion of patients receiving glucocorticoids or second-line *** 2000,the global incidence of MRMP has gradually increased,especially in East Asia,which has posed a serious challenge to the treatme.t of *** infections in children and attracted widespread attention from ***,there is still no global consensus on the diagnosis and treatme.t of MRMP in *** We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world’s first consensus on the diagnosis and treatme.t of pediatric MRMP pneumonia,based on evidence *** evidence searches and reviews were conducted using electronic databases,including Pubme.,Embase,Web of Science,CNKI,me.line,and the Cochrane *** used variations in terms for“macrolide-resistant”,“Mycoplasma pneumoniae”,“MP”,“***”,“pneumonia”,“MRMP”,“lower respiratory tract infection”,“Mycoplasma pneumoniae infection”,“children”,and“pediatric”.Results Epidemiology,pathogenesis,clinical manifestations,early identification,laboratory examination,principles of antibiotic use,application of glucocorticoids and intravenous immunoglobulin,and precautions for bronchoscopy are *** and rapid identification of gene mutations associated with MRMP is now available by polyme.ase chain reaction and fluorescent probe techniques in respiratory *** the resistance rate to mac

关键词： Child Macrolide-resistant Mycoplasma pneumoniae Recomme.dation Diagnosis Treatme.t

Laser-Induced Distortions and Disturbance Propagation of Delocalized Electronic States in Monatomic Carbon Chains

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Chinese Physics Letters 2012年第6期29卷 219-222页

作者： YANG Gong-xian GONG xiu-Fang School of Materials Science and Engineering Xi’an University of TechnologyXi’an 710048 Dongfang Turbine Co. LtdDeyang 618000

Tight-binding electron-ion dynamics of carbon chains pumped by intense laser pulses are performe. to study the interactions between monatomic carbon chains and ***-induced distortions of carbon chains,which are enhanced by a long wavelength laser,are *** carbon chains with a strong laser beam focused on one terminal are simulated to study the disturbance of electronic *** the superposition of delocalized π band states,the disturbance propagates from the illuminated area to the non-illuminated area in a velocity ofabout 106 m/s at 0 K,and this velocity is weakened at room temperature due to the localization effect of thermal fluctuation.

关键词： pumped chains atomic

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产教融合驱动下职业教育发展创新的探讨

湖北开放职业学院学报 2024年第16期37卷 6-9页

作者：叶惠仙郭秀华福建农业职业技术学院福建福州350007

本研究旨在探讨职业教育改革的方向,关注高职院校产教融合发展中存在的问题,以提出可促进经济社会发展的解决方案。分析高职院校产教融合中的问题,包括“重教轻产”、制度的“重表轻里”和供需渠道的“重量轻质”。研究以“人才-技能-发... 详细信息

本研究旨在探讨职业教育改革的方向,关注高职院校产教融合发展中存在的问题,以提出可促进经济社会发展的解决方案。分析高职院校产教融合中的问题,包括“重教轻产”、制度的“重表轻里”和供需渠道的“重量轻质”。研究以“人才-技能-发展-保障”为核心路线,探讨如何通过学科与产业同步发展、专业与需求相契合,实现职业教育闭环系统。研究结果表明,采用“人才-技能-发展-保障”核心路线,通过学科与产业同步、专业与需求契合,能有效解决高职院校产教融合中的问题。这一创新职业教育体系有助于推动社会经济可持续发展。

关键词：职业教育改革产教融合人才培养

基于制剂原料及中间体理化性质的中药凝胶贴膏成型规律研究

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中国中药杂志 2024年第3期49卷 634-643页

作者：杨光朱森发田文秀李文杰鲜洁晨洪燕龙上海中医药大学上海中医健康服务协同创新中心上海201203 南昌市洪都中医院上海201203 上海中医药大学创新中药研究院上海201203 中药现代制剂技术教育部工程研究中心江西南昌330006

以中药饮片细粉为制剂原料,研究制剂原料及中间体理化性质与中药凝胶贴膏成型质量之间的相关性及其成型规律。选取48种中药复方为模型处方制备凝胶贴膏,使用旋转流变仪分别测定各处方膏体的储能模量(G′)、损耗模量(G″)、屈服应力(τ)... 详细信息

以中药饮片细粉为制剂原料,研究制剂原料及中间体理化性质与中药凝胶贴膏成型质量之间的相关性及其成型规律。选取48种中药复方为模型处方制备凝胶贴膏,使用旋转流变仪分别测定各处方膏体的储能模量(G′)、损耗模量(G″)、屈服应力(τ)、蠕变柔量[J(t)]等流变学参数。通过主观评分和客观评分对制备的中药凝胶贴膏进行质量评价,对各处方膏体的特征物理性质进行聚类、主成分等统计分析。以膏体的流变学性质对贴膏成型质量进行预测,贴膏7 d后成型质量预测准确率为83.72%,对30 d后的贴膏成型质量预测准确率达88.37%。当膏体G′、G″等参数较大且J(t)较小时,贴膏成型质量较好;当膏体的涂布点≥3时,膏体涂布困难。此外,当处方中含金属离子中药占比较高时,主要影响贴膏30 d成型质量,黏性较低。当处方中含酸性化学成分占比较高时,主要影响贴膏7 d成型质量,残留较多。研究结果提示基于膏体的流变学性质,可预测中药饮片细粉凝胶贴膏的成型质量,为中药凝胶贴膏的处方开发提供参考。

关键词：凝胶贴膏特征物理性质成型质量旋转流变仪