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Chinese Chemical Letters 2008年第10期19卷 1183-1185页

作者： Hong Wen Zhan Jin xian wang Xi Tian wang Institufe of Chemistry Department of Chemistry Northwest Normal University 967 Arming Road （E.） Lanzhou 730070 China

Fifteen dihydropyrimidinthiones have been synthesized by microwave-assisted Biginelli reactions without any solvent or catalyst. The advantages of this novel protocol include the excellent yield, operational simplicit... 详细信息

关键词： Focused microwave-assisted Catalyst- and solvent-free Synthesis Dihydropyrimidinthiones

Effect of Microstructures on Elevated-Temperature Wear Resistance of a Hot Working Die Steel

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Journal of Iron and Steel Research International 2011年第10期18卷 47-53页

作者： WEI Min-xian wang Shu-qi wang Lan CHEN Kang-min School of Materials Science and Engineering Jiangsu University Zhenjiang 212013 Jiangsu China

Elevated-temperature wear tests under atmospheric conditions at 400 ℃ were performed for a hot working die steel H21 on a pin-on-disk wear tester. The phase and morphology of worn surfaces were examined using XRD and SEM, and the relation of wear resistance to tempered microstructures was studied for H21 steel. XRD patterns exhibit that oxidative wear is a predominated wear mechanism with Fe3O4 and Fe2O3 on worn surfaces. It is found that with increasing normal load, obvious plastic deformation of substrate appears on worn surfaces. Microstructures start to affect apparently wear resistance of the steel with an increase of load. Under loads of 50--100 N, wear losses of steel retain low values and relatively approach for steels with various microstructures. As loads are increased to 150--200 N, wear losses of steel start to increase obviously and present apparent difference for steel with various microstructures. Wear resistance is found to increase in the sequence as follows., tempered sorbite, tempered martensite, tempered troostite without secondary hardening and tempered troostite with secondary hardening or upcoming one. Higher strength and microstructural stability are required for steels with excellent wear resistance.

关键词： steel heat treatment microstructure wear wear resistance

Could gastrointestinal tumor-initiating cells originate from cell-cell fusion in vivo?

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World Journal of Gastrointestinal Oncology 2021年第2期13卷 92-108页

作者： Yang Zhou Jun-Ting Cheng Zi-xian Feng Ying-Ying wang Ying Zhang Wen-Qi Cai Zi-Wen Han xian-wang wang Ying xiang Hui-Yu Yang Bing-Rong Liu Xiao-Chun Peng Shu-Zhong Cui Hong-Wu Xin Laboratory of Oncology Center for Molecular MedicineSchool of Basic MedicineHealth Science CenterYangtze UniversityJingzhou 434023Hubei ProvinceChina Department of Biochemistry and Molecular Biology School of Basic MedicineHealth Science CenterYangtze UniversityJingzhou 434023Hubei ProvinceChina Department of Oncology and Haematology Lianjiang People's HospitalGuangzhou 524400Guangdong ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000Henan ProvinceChina Department of Pathophysiology School of Basic MedicineHealth Science CenterYangtze UniversityJingzhou 434023Hubei ProvinceChina State Key Laboratory of Respiratory Disease Affiliated Cancer Hospital Institute of Guangzhou Medical UniversityGuangzhou 510095Guangdong ProvinceChina

Tumor-initiating cells(TICs)or cancer stem cells are believed to be responsible for gastrointestinal tumor initiation,progression,metastasis,and drug *** is hypothesized that gastrointestinal TICs(giTICs)might originate from cell-cell ***,we systemically evaluate the evidence that supports or opposes the hypothesis of giTIC generation from cell-cell fusion both in vitro and in *** review giTICs that are capable of initiating tumors in vivo with 5000 or fewer in vivo fused *** this restriction,there is currently little evidence demonstrating that giTICs originate from cell-cell fusion in ***,there are many reports showing that tumor generation in vitro occurs with more than 5000 fused *** addition,the mechanisms of giTIC generation via cell-cell fusion are poorly understood,and thus,we propose its potential mechanisms of *** suggest that future research should focus on giTIC origination from cell-cell fusion in vivo,isolation or enrichment of giTICs that have tumor-initiating capabilities with 5000 or less in vivo fused cells,and further clarification of the underlying *** review of the current advances in our understanding of giTIC origination from cell-cell fusion may have significant implications for the understanding of carcinogenesis and future cancer therapeutic strategies targeting giTICs.

关键词： Gastrointestinal tumor-initiating cell Stem cell Bone marrow-derived cells In vivo Cell-cell fusion In vitro

Calcitonin gene-related peptide inhibits interleukin-1β-induced interleukin-8 secretion in human type Ⅱ alveolar epithelial cells

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Acta Pharmacologica Sinica 2006年第10期27卷 1340-1345页

作者： Wen-jing LI Teng-ke wang xian wang~2 Department of Physiology,School of Basic Medical Sciences,Peking University,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100083,China Department of Physiology School of Basic Medical Sciences Peking University Key Laboratory of Molecular Cardiovascular Science Ministry of Education Beijing China

Aim:Our previous data have shown that type Ⅱ alveolar epithelial(AEⅡ)cellsexpress neuropeptide calcitonin gene-related peptide(CGRP),and that pro-in-flammatory factor interleukin 1-β(IL-1β)induces CGRP secretion in the A549 hu-man AEⅡ cell *** the present study,we investigated the effect of endogenousand exogenous CGRP on IL-1β-induced chemokine interleukin-8(IL-8)***:We used enzyme-linked immunosorbent assay(ELISA)and RT-PCR todetect IL-8 protein and mRNA levels,respectively,siRNA and the stably trans-fected cell line were used to knock down and overexpress the CGRP gene,respectively,and chemiluminescence assay was used to detect reactive oxygenspecies(ROS)***:CGRP-1 receptor antagonist hCGRP8-37(0.1-1nmol·L-1)greatly amplified IL-1β-induced IL-8 *** inhibition of CGRPexpression by siRNA significantly increased IL-8 secretion upon IL-1β ***,cell clones stably transfected with CGRP showed significantly inhibitedmRNA and protein levels of IL-8 induced by 1L-1β.Conclusion:These data implythat AEⅡ cell-derived CGRP suppress IL-1β-induced IL-8 secretion in an autocrine/paracrine *** investigation showed that CGRP attenuated IL-1β-arousedROS formation,which is an early indication of pro-inflammatory factor signaling.

关键词： type Ⅱ alveolar epithelial cells interleukinl interleukin-8 calcitonin gene-related peptide anti-inflammation lung reactive oxygen species

SOLID-LIQUID PHASE TRANSFER AND COBALT OR PALLADIUM COMPLEX CATALYZED SYNTHESIS OF ANHYDRIDES FROM ACYL CHLORIDES

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Chinese Chemical Letters 1991年第4期2卷 339-342页

作者： Jin xian wang(Chin Hsien wang) Yu Lai HU Wen Feng CUI Institute of Chemistry,Department of Chemistry,Northwest Normal University,Lanzhou 730070

Acyl chloride can efficiently be converted into anhydride under solid liquid phase transfer catalysis by using bis(triphenylphosphine)cobalt dichloride or bis(triphenylphospine)palladium dichloride as the catalyst.

关键词： In wang SOLID-LIQUID PHASE TRANSFER AND COBALT OR PALLADIUM COMPLEX CATALYZED SYNTHESIS OF ANHYDRIDES FROM ACYL CHLORIDES

STUDIES ON THE REACTION OF SULFUR,SELENIUM AND TELLURIUM WITH SODIUM HYDROXIDE UNDER PHASE TRANSFER CATALYSIS(Ⅱ).A CONVENIENT METHOD FOR THE SYNTHESIS OF BI(ACYL)DISULFIDES

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Chinese Chemical Letters 1990年第3期1卷 193-196页

作者： Jin-xian wang(Chin-Hsien wang) Wenfeng CUI Yulai HU Kai ZHAO Institute of Chemistry,Department of Chemistry,Northwest Normal University,Lanzhou,730070

A simple and general method for the synthesis of bi(acyl)disulfides is *** is allowed to react with sodium hydroxide to give sodium disulfide at 65℃ under PTC,which can react with acyl halides to afford bi(acyl)disul... 详细信息

关键词： In wang ACYL)DISULFIDES STUDIES ON THE REACTION OF SULFUR,SELENIUM AND TELLURIUM WITH SODIUM HYDROXIDE UNDER PHASE TRANSFER CATALYSIS A CONVENIENT METHOD FOR THE SYNTHESIS OF BI PEG OC Ph

Polycystic Ovarian Syndrome and Female Infertility

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Yangtze Medicine 2020年第1期4卷 11-27页

作者： Syed Manzar Abbas Shah Naqvi Januka Bhusal Bhattarai Hui Li xian wang wang The Second School of Clinical Medicine Health Science Center Yangtze University Jingzhou China Department of Obstetrics and Gynecology The Second Affiliated Hospital of Yangtze University & Jingzhou Central Hospital Jingzhou China

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, associated with chronic anovulation and hyperandrogenism. The cause of PCOS is multi-factorial and the mechanism is still unclear. A number of complications are closely related with PCOS such as infertility, hairy and obesity. Approximately up to one-third of females with PCOs have issues with infertility. Obesity is an independent factor which exacerbates infertility in PCOS, reduces the efficacy of infertility treatment and provokes a greater risk of miscarriage. Preconception counseling and guidelines play an initial major role in infertility treatment. The option of the most appropriate treatment depends upon various factors such as age, tubal patency, quality of sperm, experience, and duration of previous treatments and the level of anxiety of the couple. Tubal patency test and semen analysis are mandatory to decide the suitable treatment. Treatment modalities have two measures—non-pharmacological and the pharmacological. Oral clomiphene citrate remains the first line treatment to trigger ovulation. Gonadotrophin and laparoscopic ovarian drilling (LOD) surgery are the other treatment option. In vitro fertilization (IVF) and embryo transfer are the third line treatment and IVF remains the first option in the patient with diagnosed and established bilateral tubal occlusion and/or concentration of recovered motile sperm less than or equal to 5 million. Here, etiology, pathophysiology and molecular mechanisms of PCOS are reviewed, and perspectives are given for further research. The recent development, treatment, and diagnosis of PCOS are also highlighted. The summary will be of guiding significance in the prevention and treatment of PCOS.

关键词： Polycystic Ovary Syndrome (PCOS) Anovulation Clomiphene Citrate Infertility

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智能神经网络组成原理在汉字识别中的应用

小型微型计算机系统 2000年第10期21卷 1032-1034页

作者：冷丽琴李涛王先旺王海兵四川大学(西区)计算机系成都610065

应用智能神经网络组成原理 ,研究了将传统神经网络完成的复杂任务划分为子任务 ,分配给功能专一、结构简单的较小的智能神经网络完成 ,在此基础上 ,构筑功能完善的较大的智能神经网络的方法 .同时 ,通过加入推理规则 ,提高了神经网络获... 详细信息

应用智能神经网络组成原理 ,研究了将传统神经网络完成的复杂任务划分为子任务 ,分配给功能专一、结构简单的较小的智能神经网络完成 ,在此基础上 ,构筑功能完善的较大的智能神经网络的方法 .同时 ,通过加入推理规则 ,提高了神经网络获取知识的速度 .实验表明 ,智能神经网络组成原理为解决大规模。

关键词：汉字识别智能神经网络组成原理符号推理

智能神经网络系统原理在印刷体汉字识别中的应用

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四川大学学报（工程科学版） 2001年第2期33卷 103-105页

作者：王先旺李涛冷丽琴王海兵张炜四川大学计算机学院四川成都610065

在印刷体汉字识别中的实验中 ,提出了一种解决在网络学习时 ,随样本数的增加 ,学习时间会按指数级增加的方案 :应用智能神经网络系统原理 ,先训练好各个功能专一、结构简单的小智能神经网络 ,然后联合小智能神经网络构成功能复杂的大智... 详细信息

在印刷体汉字识别中的实验中 ,提出了一种解决在网络学习时 ,随样本数的增加 ,学习时间会按指数级增加的方案 :应用智能神经网络系统原理 ,先训练好各个功能专一、结构简单的小智能神经网络 ,然后联合小智能神经网络构成功能复杂的大智能神经网络。实验表明 ,智能神经网络系统原理为克服传统神经网络收敛速度慢的缺点 ,同时不增加网络负担提供了一种有效方案。

关键词：智能神经网络系统 INNS 印刷体汉字识别 BP网络

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送风量影响外源颗粒物室内扩散试验研究

科学技术与工程 2016年第34期16卷 325-329页

作者：王献王玄玉中国人民解放军防化学院北京102205 国民核生化灾害防护国家重点实验室北京102205

为了研究送风量对外源颗粒物室内扩散的影响规律,在7.6 m×5.6 m×4.6 m(长×宽×高)的试验空间内,使用旋流施放装置向送风管道内施放示踪剂、控制送风量和采用立体多时段采样化学分析法,对不同送风条件下外源颗粒物室内扩散进行了试验... 详细信息

为了研究送风量对外源颗粒物室内扩散的影响规律,在7.6 m×5.6 m×4.6 m(长×宽×高)的试验空间内,使用旋流施放装置向送风管道内施放示踪剂、控制送风量和采用立体多时段采样化学分析法,对不同送风条件下外源颗粒物室内扩散进行了试验研究。结果表明,外源有害颗粒物通过通风管路进入室内,送风量对外源颗粒物室内扩散有明显的影响,随送风量增大,室内悬浮颗粒物浓度相对均方差减小,平均浓度、危害面积以及危害体积呈现先增大后趋于稳定的趋势;颗粒物污染事故发生后,为减轻受影响建筑室内的危害程度,及时关闭送风是有效处置措施之一。

关键词：送风量外源颗粒物室内环境扩散试验