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Ocular surface changes in Graves’ophthalmopathy

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 616-621页

作者： Rou Sun Hui-fang Zhou xian-qun fan Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China

Many patients with Graves’ophthalmopathy(GO)suffer from dry eye syndrome(DES),and this is one of the most common reasons of eye discomfort in patients with *** prevalence of DES in patients with GO is significantly higher than normal *** ocular surface changes involving changes in tears,cornea,conjunctiva and glands occur in GO ***,the mechanism of how DES occurs in GO still remains *** this review,the ocular surface changes were illustrated and analyzed the reasons for high prevalence of DES in GO patients.

关键词： Graves’ophthalmopathy dry eye syndrome ocular surface

Comparison of choroidal thickness in high myopic eyes after FS-LASIK versus implantable collamer lens implantation with swept-source optical coherence tomography

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International Journal of Ophthalmology(English edition) 2020年第5期13卷 773-781页

作者： Jing Zhang fang-Lin He Yan Liu xian-qun fan Department of Ophthalmology Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Disease and Ocular Oncology Shanghai 200011China

AIM:To investigate the changes in choroidal thickness(CT)in high myopic eyes after femtosecond laser-assisted in situ keratomileusis(FS-LASIK)surgery or central hole implantable collamer lens(ICL V4c)implantation using swept-source optical coherence tomography(SS-OCT).METHODS:We examined the right eyes of 116 patients with high myopia who were candidates for FS-LASIK surgery and ICL *** eyes underwent ICL V4c implantation and 56 eyes were subjected to FS-LASIK *** CT was measured with *** data were recorded preoperatively and 2 h,1 wk,1 and 3 mo *** demographic information was collected,including age,sex,uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA),spherical equivalent(SE),intraocular pressure(IOP)and axial length(AL).RESULTS:The UCVA improved in both groups and showed no significant differences between *** also were no significant differences between the two groups in postoperative BCVA and SE(P=0.581 and 0.203,respectively).The foveal CTs,inner nasal and outer nasal CTs were significantly thicker at 2 h postoperatively in both groups(P0.05).CONCLUSION:The CTs after ICL implantation and FSLASIK surgery are significantly thicker than those before operation,especially in the foveal and nasal areas,but there is no significant difference between the two methods.

关键词： choroidal thickness high myopia laser in situ keratomileusis implantable collamer lens implantation swept-source optical coherence tomography

Epidemiologic characteristics and outcomes of open globe injury in Shanghai

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International Journal of Ophthalmology(English edition) 2017年第8期10卷 1295-1300页

作者： Yong-Rong Ji Dong-Qing Zhu Hui-fang Zhou xian-qun fan Department of Ophthalmology Shanghai Ninth People'sHospital Shanghai Jiao Tong University School of MedicineShanghai 200011 China

AIM： To investigate the epidemiologic characteristics and outcomes of open globe injury in Shanghai. METHODS： A retrospective study was conducted for 148 unilateral open globe injury cases presenting to a tertiary referral hospital of Shanghai. Electronic medical records were reviewed and phone surveys were conducted to collect and analyze 1） background of patient; 2） setting of injury and clinical signs at presentation; 3） treatment procedure and outcome; 4） quality of life after injury. RESULTS： There were more male patients （77.03%） than females （22.97%）, more temporary habitants （79.05%） than residents （20.95%）. The subjects in this study presented a significantly lower constitutional status of education than that of the whole Shanghai population （P〈0.001）. Occupational injury was the first cause of injuries （39.86%）, followed by home accident （20.27%）, road accident （16.80%）, violent behavior （16.89%） and outdoor injury （6,08%）. The 143 subjects （96.62%） were not wearing spectacles at the time of injury. Of all patients, 77 subjects （52.03%） had the outcome of no vision （including enucleation）. The classification and regression tree （CART） prognosis presents 59.58% sensitivity to predict visual survival correctly and 80.19% specificity to predict no vision correctly. The patients whose injured eye had no vision reported more reduction of life quality. CONCLUSION： We found that male subject, temporary habitants, low educational status and no eyewear are risk factors of open globe injury in Shanghai. Occupational injury is the leading cause. CART analysis presents a certain agreement to the actual visual outcome. The injury imposes negative impact on quality of life especially in no vision cases. The education of eye protection may help to avoid the injury.

关键词： ocular injury globe penetration epidemiology risk factors occupational injury

Smoking and the risk of dry eye: a Meta-analysis

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1480-1486页

作者： Li Xu Wei Zhang Xiao-Yu Zhu Tao Suo xian-qun fan Yao Fu Department of Ophthalmology Ninth People's HospitalShanghai Jiao Tong University School of Medicine Department of Health Statistics and Social Medicine School of Public HealthFudan University Department of Ophthalmology and Vision Science EyeEarNose and Throat HospitalShanghai Medical CollegeFudan University Department of General Surgery Zhongshan HospitalInstitute of General SurgeryFudan University

AIM： To collect the evidence to estimate the correlation between smoking and the incidence of dry eye. METHODS： The Pub Med,EMBASE,the Cochrane Central Register of Controlled Trials（CENTRAL,last issue）,CBM（Chinese Bio Medical Literature Database）,and CNKI（China National Knowledge Infrastructure/Chinese Academic Journals full-text Database） were searched for eligible studies published from January1964 to December 2015 to investigate the association of smoking with the risk of dry *** odds ratio（OR）and 95% confidence interval（CI） were summarized and *** extracted studies were pooled by the fixed-effects model or a random-effects model. RESULTS： Two cohort studies and eight cross-sectional surveys were included in our *** was no statistically significant relationship between current（OR=1.32; 95% CI： 0.99-1.76; P=0.055）or ever smoking（OR=1.12; 95% CI： 0.98-1.28; P=0.107）and the risk of dry eye among the studies,even when age and gender were adjusted（OR=1.16; 95% CI： 0.83-1.64; P=0.383）.In the sensitivity analysis in which only general population were included,the association was significant between smoking and dry eye（OR=1.50; 95%CI： 1.08-2.09; P=0.016）.CONCLUSION： This Meta-analysis suggests that smoking may associate with the risk of dry eye in general population.

关键词： dry eye smoking Meta-analysis

Effects of corneal stromal cell-and bone marrow-derived endothelial progenitor cell-conditioned media on the proliferation of corneal endothelial cells

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 332-339页

作者： Meng-Yu Zhu Qin-Ke Yao Jun-Zhao Chen Chun-Yi Shao Chen-Xi Yan Ni Ni xian-qun fan Ping Gu Yao Fu Department of Ophthalmology Shanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine

AIM： To explore the effects of conditioned media on the proliferation of corneal endothelial cells （CECa） and to compare the efficiency of different conditioned media （CM）. METHODS： Rat CECs, corneal stromal cells （CSCs）, bone marrow -derived endothelial progenitor cells （BEPCs）, and bone marrow-derived mesenchymal stem cells （BMSCs） were isolated and cultured in vitra CM was collected from CSCs, BEPCs, and BMSCSo CECs were cultivated in different culture media. Cell morphology was recorded, and gene and protein expression were analyzed.~ RESULTS： After grown in CM for 5d, CECs in each experimental group remained polygonal, in a cobblestone- like monolayer arrangement. Immunocytofluorescence revealed positive expression of Na＋/K＋-ATP, aquaporin 1 （AQP1）, and zonula occludens 1 （ZO-1）. Based on quantitative polymerase chain reaction （qPCR） analysis, Na ＋/K ＋-ATP expression in CSC-CM was notably upregulated by 1.3-fold （＋0.036）（P〈0.05, n=3）. The expression levels of ZO-1, neuron specific enolase （NSE）, Vimentin, paired homebox 6 （PAX6）, and procollagen type VII （COL8A1） were notably upregulated in each experimental group. Each CM had a positive effect on CEC proliferation, and CSC-CM had the strongest effect on proliferation.~ CONCLUSION： CSC-CM, BEPC-CM, and BMSC-CM not only stimulated the proliferation of CECs, but also maintained the characteristic differentiated phenotypes necessary for endothelial functions. CSC-CM had the most notable effect on CEC proliferation. KEYWORDS： conditioned medium; corneal endothelial cell; corneal stromal cell; bone marrow-derived endothelial progenitor cell; proliferation

关键词： conditioned medium corneal endothelialcell corneal stromal cell bone marrow-derived endothelialprogenitor cell proliferation

Evaluation of transmission risk of respiratory particles under different ventilation strategies in an elevator

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Building Simulation 2024年第5期17卷 771-784页

作者： Liangyu Zhu xian Li Bujin Feng fan Liu School of Civil Engineering and Architecture Linyi UniversityLinyi276000China College of Agriculture Shandong Agricultural UniversityTaian271018China School of Environment and Architecture University of Shanghai for Science and TechnologyShanghai200093China

People in elevators are at risk of respiratory infection because the elevator cabin is crowded and has poor *** exhaled particles may be inhaled by the susceptible person,deposited on the surface and suspended in the elevator,which can result in direct and indirect ***,whether the air vent designs adopted in the elevator can effectively reduce the transmission risk of respiratory particles remains *** this study,the dispersion of particles under four common ventilation strategies used in the commercial elevator was investigated by proven computational fluid dynamics(CFD)*** flow field was simulated with the RNG κ-ξ turbulence model and the Lagrangian method was adopted to track particle *** effects of air vent layout and airflow rate on particle transmission were *** found that more than 50% of exhaled particles(average value)were suspended in the cabin and difficult to discharge under the investigated ventilation *** deposited fraction of particles on the susceptible person reached up to 39.14% for infiltration ventilation,which led to a high risk of contact *** the ventilation rate could not significantly reduce the inhalation proportion of particles due to the poor airflow distribution inside the elevator.A more proper ventilation strategy should be explored for the elevator to control transmission risk.

关键词： particle dispersion transmission risk elevator ventilation strategy computational fluid dynamics(CFD)

RFFsNet-SEI:a multidimensional balanced-RFFs deep neural network framework for specific emitter identification

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Journal of Systems Engineering and Electronics 2024年第3期35卷 558-574,F0002页

作者： fan Rong SI Chengke HAN Yi WAN qun School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China Institute of Electronic and Electrical Engineering Civil Aviation Flight University of ChinaGuanghan 618307China

Existing specific emitter identification(SEI)methods based on hand-crafted features have drawbacks of losing feature information and involving multiple processing stages,which reduce the identification accuracy of emitters and complicate the procedures of *** this paper,we propose a deep SEI approach via multidimensional feature extraction for radio frequency fingerprints(RFFs),namely,***,we extract multidimensional physical RFFs from the received signal by virtue of variational mode decomposition(VMD)and Hilbert transform(HT).The physical RFFs and I-Q data are formed into the balanced-RFFs,which are then used to train *** introducing model-aided RFFs into neural network,the hybrid-driven scheme including physical features and I-Q data is *** improves physical interpretability of ***,since RFFsNet-SEI identifies individual of emitters from received raw data in end-to-end,it accelerates SEI implementation and simplifies procedures of ***,as the temporal features and spectral features of the received signal are both extracted by RFFsNet-SEI,identification accuracy is ***,we compare RFFsNet-SEI with the counterparts in terms of identification accuracy,computational complexity,and prediction *** results illustrate that the proposed method outperforms the counterparts on the basis of simulation dataset and real dataset collected in the anechoic chamber.

关键词： specific emitter identification(SEI) deep learning(DL) radio frequency fingerprint(RFF) multidimensional feature extraction(MFE) variational mode decomposition(VMD)

Review of the research on the development and utilization of clay-type lithium resources

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Particuology 2024年第4期87卷 46-53页

作者： Ruiqi Xie Zhihui Zhao Xiong Tong xian Xie Qiang Song Peiqiang fan Faculty of Land Resource Engineering Kunming University of Science and TechnologyKunming650093China Yunnan Engineering Research Center for Metal Tailings Resource Utilization Kunming650093China

Since the demands for lithium have been in explosive growth recently and several great clay lithium resources were founded in China,the development and utilization of clay-type lithium resources become a hot *** order to provide a guidance for the concentration and extracting lithium of clay-type lithium resources,this review systematically summarized the main types and characteristics of clay-type lithium resources and the research status of lithium extraction from clay lithium ***,the flotation research status of the main mineral of clay lithium ore was also ***,we discussed the difficulties in the development and utilization of clay-type lithium ore and put forward the subsequent research *** paper can provide a guidance for the con-centration and extracting lithium of clay-type lithium resources in the future.

关键词： Clay lithium Clay mineral flotation Lithium extraction Leaching

Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2225-2232页

作者： xian-Shuai Kou fan-fan Li Yun Meng Jian-Ming Zhao Sheng-Fen Liu Lan Zhang The First Clinical Medical College Gansu University of Chinese MedicineLanzhou 730000Gansu ProvinceChina Department of Thoracic Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Surgery Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina Department of Orthopedics Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC),a major contributor to cancer-related deaths,is particularly prevalent in Asia,largely due to hepatitis B virus *** prognosis is generally *** case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration,particularly in patients with massive HCC complicated by ruptured bleeding,a scenario not extensively documented *** SUMMARY The patient presented with large HCC complicated by intratumoral *** involved a multidisciplinary approach,providing individualized *** strategy included drug-eluting bead transarterial chemoembolization,sorafenib-targeted therapy,laparoscopic partial hepatectomy,and standardized sintilimab monoclonal antibody *** months after treatment,the patient achieved complete radiological remission,with significant symptom *** studies showed no lesions or recurrence,and clinical assessments confirmed complete *** report is notable as possibly the first docu-mented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts,offering new insights and a reference for future similar *** This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding,providing insights for future similar cases.

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Sorafenib Translational therapy Multidisciplinary team Case report